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1. 发明申请

WO2011159994A2 METHOD FOR ENHANCING CURRENT THROUGHPUT IN AN ELECTROCHEMICAL SYSTEM 审中-公开
标题翻译：在电化学系统中增强电流的方法
公开(公告)号：WO2011159994A2
公开(公告)日：2011-12-22
申请号：PCT/US2011/040851
申请日：2011-06-17
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , KO, Sung, Hee , KIM, Sung, Jae , HAN, Jongyoon , GAN, Hiong, Yap
发明人： KO, Sung, Hee , KIM, Sung, Jae , HAN, Jongyoon , GAN, Hiong, Yap
IPC分类号： H01M8/10
CPC分类号： G01N27/28 , B01L3/502746 , B01L2300/0816 , B01L2400/086 , H01M8/026 , H01M8/1097 , H01M2250/00 , Y10T29/49108
摘要： An electrochemical system with reduced limiting-current behavior is disclosed. The electrochemical system is useful for fuel cells and bio-sensors. In part, the invention relates a method of reducing or eliminating limiting-current behavior in the operation electrochemical systems, in particular those with ion-selective membrane or electrochemical electrodes, by spatially reducing the convection near the membrane or the electrode. The invention further relates to electrochemical systems in which micropores, microarrays or pillar arrays are used to reduce convection in comparison to conventional systems without microarrays, micropores or pillar arrays.
摘要翻译：公开了一种具有减小的限流特性的电化学系统。电化学系统可用于燃料电池和生物传感器。部分地，本发明涉及通过空间上减少膜或电极附近的对流来减少或消除操作电化学系统中的极限电流行为的方法，特别是具有离子选择性膜或电化学电极的那些。本发明还涉及与没有微阵列，微孔或柱阵列的常规系统相比，微孔，微阵列或柱阵列用于减少对流的电化学系统。

2. 发明申请

WO2011112803A1 METHOD FOR BUILDING MASSIVELY-PARALLEL PRECONCENTRATION DEVICE FOR MULTIPLEXED, HIGH-THROUGHPUT APPLICATIONS 审中-公开
标题翻译：用于建立用于多路复用，高通量应用的大规模并行预处理器件的方法
公开(公告)号：WO2011112803A1
公开(公告)日：2011-09-15
申请号：PCT/US2011/027883
申请日：2011-03-10
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , KO, Sung, Hee , KIM, Sung, Jae , HAN, Jongyoon
发明人： KO, Sung, Hee , KIM, Sung, Jae , HAN, Jongyoon
IPC分类号： G01N27/447 , B01L3/00
CPC分类号： G01N27/44791 , B01L3/502753 , B01L3/502761 , B01L3/502784 , B01L2300/0645 , B01L2300/0681 , B01L2300/0803 , B01L2300/0829 , B01L2300/0864 , B01L2300/0867 , B01L2300/0883 , B01L2300/0896 , B01L2300/161 , B01L2400/0415 , B01L2400/0487 , Y10T137/2224
摘要： A multiplexed concentration interface that can connect with a plurality of microchannels, conventional 96 well plates or other microarrays is disclosed. The interface can be used in biosensing platforms and can be designed to detect single or multiple targets such as DNA/RNA, proteins and carbohydrates/oligosaccharides. The multiplexed concentration device will provide a set of volume-matched sample preparation and detection strategies directly applicable by ordinary researchers. Furthermore, a multiplexed microfluidic concentrator without buffer channels is disclosed.
摘要翻译：公开了可与多个微通道连接的多路复用浓度界面，常规96孔板或其它微阵列。界面可用于生物传感平台，可设计用于检测单个或多个靶标，如DNA / RNA，蛋白质和碳水化合物/寡糖。复合浓缩装置将提供一套直接适用于普通研究者的体积匹配样品制备和检测策略。此外，公开了一种没有缓冲通道的复用微流控集中器。

3. 发明申请

WO2010011760A1 AMPLIFIED ELECTROKINETIC FLUID PUMPING SWITCHING AND DESALTING 审中-公开
标题翻译：放大电动液体泵浦切换和脱盐
公开(公告)号：WO2010011760A1
公开(公告)日：2010-01-28
申请号：PCT/US2009/051420
申请日：2009-07-22
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , KIM, Sung, Jae , HAN, Jongyoon
发明人： KIM, Sung, Jae , HAN, Jongyoon
IPC分类号： B01D57/02
CPC分类号： B01D57/02 , B01L3/50273 , B01L3/502753 , B01L2400/0418 , B01L2400/0487 , C02F1/469 , C02F1/4696 , C02F1/4698 , C02F2103/08 , F04B19/006 , G01N27/447 , Y02W10/37 , Y10S977/70
摘要： The present invention provides a device and methods of use thereof for desalting a solution. The methods, inter-alia , make use of a device comprising microchannels, which are linked to conduits, whereby induction of an electric field in the conduit results in the formation of a space charge layer within the microchannel. The space charge layer provides an energy barrier for salt ions and generates an ion depletion zone proximal to the linkage region between the microchannel and the conduit. The method thus enables the removal of salt ions from the region proximal to the conduit and their accumulation in a region distant from the conduit, within the microchannel.
摘要翻译：本发明提供了一种用于脱盐溶液的装置及其使用方法。所述方法尤其利用包括与通道连接的微通道的装置，由此导管中的电场导致在微通道内形成空间电荷层。空间电荷层为盐离子提供能量势垒，并产生靠近微通道和导管之间的连接区域的离子耗尽区。因此，该方法使得能够在微通道内从邻近管道的区域去除盐离子并且其在远离导管的区域中积聚。

4. 发明申请

WO2007022281A3 MICROFLUIDIC PI-BASED MOLECULAR SORTING 审中-公开
公开(公告)号：WO2007022281A3
公开(公告)日：2007-02-22
申请号：PCT/US2006/032001
申请日：2006-08-16
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , HAN, Jongyoon , SONG, Yong-Ak
发明人： HAN, Jongyoon , SONG, Yong-Ak
IPC分类号： C02F1/40 , G01N27/00 , G01N33/558
摘要： This invention is directed to methods and devices for separating molecules in a sample, based on differences in their isoelectric point (pI). The methods and devices make use of a diffusion potential created in a microfluidic chamber when a buffered solution comprising molecules, which differ in terms of their isoelectric point (pI) values and a second buffer, which differs from the buffered solution in terms of its pH or salt concentration are introduced in the chamber. The diffusion potential, in turn, enables charge-based separation of the molecules. Applications and permutations of the methods and devices are described.

5. 发明申请

WO2012170818A1 SYSTEMS AND METHODS FOR DELIVERING SUBSTANCES INTO NANOPOROUS MINERALIZED TISSUES 审中-公开
标题翻译：将物质输送到纳米矿物组织的系统和方法
公开(公告)号：WO2012170818A1
公开(公告)日：2012-12-13
申请号：PCT/US2012/041555
申请日：2012-06-08
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , UNIVERSIDADE FEDERAL DA PARAIBA , GAN, Hiongyap , HAN, Jongyoon , DE SOUSA, Frederico, Barbosa
发明人： GAN, Hiongyap , HAN, Jongyoon , DE SOUSA, Frederico, Barbosa
IPC分类号： A61C19/06 , A61N1/30
CPC分类号： A61C19/066 , A61N1/0548 , A61N1/306
摘要： Methods and systems are provided for transporting a therapeutic or cosmetic substance into nanoporous mineralized tissue structures, such as teeth. The method includes contacting the nanoporous mineralized tissue structure with an ionic solution including the therapeutic or cosmetic substance; and simultaneously applying to the nanoporous mineralized tissue structure an electrical potential effective to transport the therapeutic or cosmetic substance into the nanopores of the nanoporous mineralized tissue structure. The system includes at least one pair of electrodes which includes a first electrode configured for contacting the nanoporous mineralized tissue structure and a second electrode; and a power source and control circuitry for generating an electrical potential between the first electrode and the second electrode effective to transport a therapeutic or cosmetic substance, in an ionic solution in contact with a surface of the nanoporous mineralized tissue structure, into the nanopores of the nanoporous mineralized tissue structure.
摘要翻译：提供了用于将治疗或化妆物质运输到纳米多孔矿化组织结构（如牙齿）中的方法和系统。该方法包括使纳米多孔矿化组织结构与包含治疗或化妆物质的离子溶液接触; 并且同时向纳米多孔矿化组织结构施加有效地将治疗或化妆物质输送到纳米多孔矿化组织结构的纳米孔中的电势。该系统包括至少一对电极，其包括构造成用于接触纳米多孔矿化组织结构和第二电极的第一电极; 以及用于在第一电极和第二电极之间产生电势的电源和控制电路，其有效地将治疗或化妆品物质在与纳米多孔矿化组织结构的表面接触的离子溶液中输送到纳米孔的纳米孔中纳米多孔矿化组织结构。

6. 发明申请

WO2011109762A1 MICROFLUIDICS SORTER FOR CELL DETECTION AND ISOLATION 审中-公开
标题翻译：用于细胞检测和分离的微流控分离器
公开(公告)号：WO2011109762A1
公开(公告)日：2011-09-09
申请号：PCT/US2011/027276
申请日：2011-03-04
申请人： NATIONAL UNIVERSITY OF SINGAPORE , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , LIM, Chwee, Teck , HAN, Jongyoon , HOU, Han, Wei , BHAGAT, Ali, Asgar , VAN VLIET, Krystyn, J. , LEE, Wong, Cheng
发明人： LIM, Chwee, Teck , HAN, Jongyoon , HOU, Han, Wei , BHAGAT, Ali, Asgar , VAN VLIET, Krystyn, J. , LEE, Wong, Cheng
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： C12Q1/04 , B01L3/50273 , B01L3/502761 , B01L2200/0636 , B01L2300/0864 , B01L2400/0457 , B01L2400/086 , C12Q1/025 , G01N2015/1415 , G01N2015/149
摘要： A method of detecting one or more diseased blood cells in a blood sample includes introducing a blood sample into at least one inlet of a microfluidic device comprising one or more linear channels wherein each channel has a length and a cross-section of a height and a width defining an aspect ratio adapted to isolate diseased blood cells along at least one portion of the cross-section of the channel based on reduced deformability of diseased blood cells as compared to non-diseased blood cells, wherein diseased blood cells flow along a first portion of the channel to a first outlet and non-diseased blood cells flow along a second portion of the channel to a second outlet. The one or more channels can be adapted to isolate cells along portions of the cross-section of the channel based on cell size. In some embodiments, the one or more channels can be spiral channels.
摘要翻译：一种检测血液样本中的一种或多种患病血细胞的方法包括将血液样品引入到包括一个或多个线性通道的微流体装置的至少一个入口中，其中每个通道具有高度的长度和横截面宽度限定适于根据与非病变血细胞相比减少的患病血细胞的可变形性，沿着所述通道的横截面的至少一部分分离患病血细胞，其中患病血液细胞沿第一部分流动通道的第一出口和非患病血液细胞沿着通道的第二部分流动到第二出口。一个或多个信道可以适于基于小区大小来隔离信道横截面的部分。在一些实施例中，一个或多个通道可以是螺旋通道。

7. 发明申请

WO2008043040A2 INTEGRATED MICROFLUIDIC DEVICE FOR PRECONCENTRATION AND DETECTION OF MULTIPLE BIOMARKERS 审中-公开
标题翻译：用于预处理和检测多个生物标志物的集成微流体装置
公开(公告)号：WO2008043040A2
公开(公告)日：2008-04-10
申请号：PCT/US2007/080478
申请日：2007-10-04
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , MANALIS, Scott , HAN, Jongyoon , BURG, Thomas , DEXTRAS, Phillip , PAYER, Kristofor , WANG, Ying-chih
发明人： MANALIS, Scott , HAN, Jongyoon , BURG, Thomas , DEXTRAS, Phillip , PAYER, Kristofor , WANG, Ying-chih
CPC分类号： G01N33/54373 , B01L3/502761 , B82Y15/00
摘要： Micro fluidic device including a nanofluidic concentrator for amplifying a sample containing a biomarker until the biomarker concentration approaches the disassociation constant of a biomarker/antibody complex. A suspended microchannel resonator receives the amplified sample and generates a signal related to the number of biomarkers contained in the sample.
摘要翻译：微流体装置包括纳米流体浓缩器，用于扩增含有生物标志物的样品，直到生物标志物浓度接近生物标志物/抗体复合物的解离常数。悬浮的微通道谐振器接收放大的样品并产生与样品中包含的生物标志物数量相关的信号。

8. 发明申请

WO2007149111A3 CONTINUOUS BIOMOLECULE SEPARATION IN A NANOFILTER 审中-公开
公开(公告)号：WO2007149111A3
公开(公告)日：2007-12-27
申请号：PCT/US2006/038902
申请日：2006-10-05
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , HAN, Jongyoon , FU, Jianping
发明人： HAN, Jongyoon , FU, Jianping
IPC分类号： B03B9/06
摘要： This invention provides a method and an apparatus for quickly continuously fractionating bioraolecules, such as DNAs, proteins and carbohydrates by taking advantage of differential bidirectional transport of biomolecules with varying physico-chemical characteristics, for example size, charge, hydrophobicity, or combinations thereof, through periodic arrays of microfabricated nanofilters. The passage of biomolecules through the nanofilter is a function of both steric and electrostatic interactions between charged macromolecules and charged nanofilter walls, Continuous-flow separation through the devices of this invention are applicable for molecules varying in terms of any molecular properties (e.g., size, charge density or hydrophobicity) that can lead to differential transport across the nanofilters.

9. 发明申请

WO2012118442A1 BIOSENSOR, PALM-SIZED DEVICE AND METHOD BASED ON MAGNETIC RESONANCE RELAXOMETRY 审中-公开
标题翻译：生物传感器，PALM尺寸的设备和基于磁共振放大的方法
公开(公告)号：WO2012118442A1
公开(公告)日：2012-09-07
申请号：PCT/SG2012/000056
申请日：2012-02-27
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PENG, Weng Kung , HAN, Jongyoon , CHEN, Lan
发明人： PENG, Weng Kung , HAN, Jongyoon
IPC分类号： A61B5/055 , G01R33/20
CPC分类号： G01R33/448 , A61B5/055 , G01N24/08 , G01R33/302 , G01R33/3808 , G01R33/383 , G01R33/465 , G01R33/4828 , G01R33/50 , G01R33/543 , G01R33/546
摘要： In accordance with one aspect of this disclosure, there is provided a device for performing magnetic resonance relaxometry. The device comprises a radio-frequency spectrometer comprising at least one field-programmable gate array chip; a power amplifier electrically connected with the radio-frequency spectrometer and amplifying an electrical output of the radio-frequency spectrometer, thereby producing an amplified electrical signal comprising between about 0.1 Watts and about 10 Watts power; a duplexer configured to isolate the radio-frequency spectrometer from the amplified electrical signal during a receiving mode of the device; a radio-frequency detection probe configured to transmit radio-frequency electromagnetic radiation to excite nuclei under resonance during a transmission mode of the device, the radio-frequency detection probe comprising a detection coil comprising an inner diameter of less than about 1 millimeter; and at least one magnet supplying an external magnetic field to a detection region of the radio-frequency detection probe, the external magnetic field being less than about 3 Tesla.
摘要翻译：根据本公开的一个方面，提供了一种用于执行磁共振弛豫测量的装置。该装置包括一个包括至少一个现场可编程门阵列芯片的射频光谱仪; 功率放大器，其与所述射频光谱仪电连接并放大所述射频光谱仪的电输出，从而产生包括约0.1瓦至约10瓦功率之间的放大电信号; 双工器，被配置为在所述设备的接收模式期间将所述射频频谱仪与放大的电信号隔离; 射频检测探头，被配置为在所述设备的传输模式期间传输射频电磁辐射以在谐振下激发核，所述射频检测探针包括包含小于约1毫米的内径的检测线圈; 以及向所述射频检测探针的检测区域提供外部磁场的至少一个磁体，所述外部磁场小于约3特斯拉。

10. 发明申请

WO2011127387A1 NEURAL PROSTHETICS USING A CHEMICAL HARVESTING AND STIMULATION DEVICE 审中-公开
标题翻译：使用化学收获和刺激装置的神经前景
公开(公告)号：WO2011127387A1
公开(公告)日：2011-10-13
申请号：PCT/US2011/031751
申请日：2011-04-08
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BETH ISRAEL DEACONESS MEDICAL CENTER, INC. , HAN, Jongyoon , SONG, Yong-Ak , RABIE, Amr , SARPESHKAR, Rahul , LIN, Samuel, J.
发明人： HAN, Jongyoon , SONG, Yong-Ak , RABIE, Amr , SARPESHKAR, Rahul , LIN, Samuel, J.
IPC分类号： A61N1/30 , A61N1/36
CPC分类号： A61N1/3605 , A61N1/0553 , A61N1/36071 , A61N1/361
摘要： A neural prosthetic device is provided that includes one or more ion-selective membranes enabling electrically-controlled local modulation of ion concentrations around a nerve so as to achieve different excitability states of the nerve for electrical stimulation or inhibition of nerve signal propagation.
摘要翻译：提供神经假体装置，其包括一个或多个离子选择膜，其能够对神经周围的离子浓度进行电控局部调制，以实现用于电刺激或抑制神经信号传播的神经的不同兴奋性状态。

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