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1. 发明申请

WO2006081002A2 CHROMATOGRAPHIC MEDIA 审中-公开
标题翻译：色谱介质
公开(公告)号：WO2006081002A2
公开(公告)日：2006-08-03
申请号：PCT/US2005/045710
申请日：2005-12-16
申请人： MALLINCKRODT BAKER, INC. , DEORKAR, Nandu , BUSS, Robert, C. , MLADOSICH, Joseph, M. , BOUIS, Paul, A.
发明人： DEORKAR, Nandu , BUSS, Robert, C. , MLADOSICH, Joseph, M. , BOUIS, Paul, A.
CPC分类号： B01J41/14 , B01D15/327 , B01D15/363 , B01D15/364 , B01J20/261 , B01J20/262 , B01J20/265 , B01J20/28004 , B01J20/285 , B01J20/288 , B01J20/3092 , B01J20/321 , B01J20/3255 , B01J20/3272 , B01J20/328 , B01J20/3285 , B01J2220/52 , B01J2220/54 , B01J2220/58 , C07K1/165
摘要： This invention concerns the preparation and use of novel polymeric chromatographic media and preferably mixed mode polymeric chromatographic media. In accordance with the present invention, polymeric media is prepared using polymeric particles derivatized with polyethyleneimine, and preferably such polyethyleneimine derivatized polymeric particles further functionalized with appropriate reactants. The polymeric chromatographic media is especially useful for bioseparations.
摘要翻译：本发明涉及新型聚合物色谱介质和优选混合模式聚合物色谱介质的制备和使用。根据本发明，使用用聚乙烯亚胺衍生的聚合物颗粒制备聚合物介质，并且优选用适当的反应物进一步官能化的这种聚乙烯亚胺衍生的聚合物颗粒。高分子色谱介质特别适用于生物分离。

2. 发明申请

WO2007089397A1 END-CAP DEVICE FOR HIGH EFFICIENCY DISPOSABLE CHROMATOGRAPHY COLUMN 审中-公开
标题翻译：用于高效率色谱柱的端盖装置
公开(公告)号：WO2007089397A1
公开(公告)日：2007-08-09
申请号：PCT/US2007/000423
申请日：2007-01-04
申请人： MALLINCKRODT BAKER, INC. , DEORKAR, Nandu , BOUIS, Paul, A.
发明人： DEORKAR, Nandu , BOUIS, Paul, A.
IPC分类号： G01N30/60
CPC分类号： G01N30/6021 , G01N30/6026 , G01N30/603 , G01N30/6091
摘要： A low cost re-usable end-cap for disposable chromatographic columns or solid phase extraction cartridges that simultaneously provide sealing of the column and axial compression, and chromatography columns and solid phase extraction cartridges employing such re-usable end caps.
摘要翻译：用于一次性色谱柱或固相萃取柱的低成本可重复使用的端盖，其同时提供柱的密封和轴向压缩，以及使用这种可重复使用的端盖的色谱柱和固相萃取柱。

3. 发明申请

WO2011008674A1 MATERIAL AND PROCESS FOR INCORPORATION OF LOW DOSAGE ACTIVE PHARMACEUTICAL INGREDIENTS AND USE THEREOF 审中-公开
标题翻译：合并低剂量活性药物成分的材料和方法及其用途
公开(公告)号：WO2011008674A1
公开(公告)日：2011-01-20
申请号：PCT/US2010/041665
申请日：2010-07-12
申请人： MALLINCKRODT BAKER, INC. , FARINA, James , DEORKAR, Nandu , MIINEA, Liliana
发明人： FARINA, James , DEORKAR, Nandu , MIINEA, Liliana
IPC分类号： A61K9/14 , A61K9/16 , A61K9/20 , A61K31/19 , A61K31/44 , A61K31/5415
CPC分类号： A61K9/2054 , A61K9/146 , A61K9/167 , A61K9/2095 , A61K31/19 , A61K31/44 , A61K31/5415
摘要： A low dose API pharmaceutical tablet having excellent content uniformity is provided. The tablet is formed by spray coating a support excipient with the API. The resulting composition is suitable for direct compression tablet formulation without the need for an additional granulation step to uniformly coat the API onto the support excipient. The support excipient comprises microcrystalline cellulose, a binder and a disintegrant, and is formed by spraying a homogeneous slurry of the support excipient components.
摘要翻译：提供了具有优异的均匀性的低剂量API药片。片剂通过用API喷涂载体赋形剂而形成。所得组合物适用于直接压制片剂制剂，而不需要另外的制粒步骤将API均匀地涂覆在支持赋形剂上。支持赋形剂包括微晶纤维素，粘合剂和崩解剂，并且通过喷洒支持赋形剂组分的均匀浆液形成。

4. 发明申请

WO2010059534A2 DIRECTLY COMPRESSIBLE GRANULAR MICROCRYSTALLINE CELLULOSE BASED EXCIPIENT, MANUFACTURING PROCESS AND USE THEREOF 审中-公开
标题翻译：直接可压缩颗粒状微晶纤维素制品，制造工艺及其用途
公开(公告)号：WO2010059534A2
公开(公告)日：2010-05-27
申请号：PCT/US2009/064498
申请日：2009-11-16
申请人： MALLINCKRODT BAKER, INC. , DEORKAR, Nandu , FARINA, James , MIINEA, Liliana , RANDIVE, Sameer
发明人： DEORKAR, Nandu , FARINA, James , MIINEA, Liliana , RANDIVE, Sameer
IPC分类号： A61K9/22 , A61K47/38
CPC分类号： A61K9/2054 , A61K9/2027 , A61K9/2095 , A61K47/38
摘要： An improved excipient comprising substantially homogeneous particles of a compressible, high functionality granular microcrystalline cellulose based excipient is provided. The improved excipient comprises microcrystalline cellulose and a binder, and optionally a disintegrant, and is formed by spraying a homogeneous slurry of the components. The excipient provides enhanced flowability/good flow properties, excellent/high compactibility, and increased API loading and blendability as compared to the individual components, and as compared to conventional excipients formed from the same materials. The improved excipient has strong intraparticle bonding bridges between the components, resulting in a unique structural morphology including significant open structures or hollow pores. The presence of these pores provides a surface roughness that is the ideal environment for improved blending with an API.
摘要翻译：提供了包含基本上均匀的可压缩，高功能性颗粒状微晶纤维素基赋形剂颗粒的赋形剂。改进的赋形剂包括微晶纤维素和粘合剂，以及任选的崩解剂，并且通过喷涂组分的均匀浆料而形成。与各种组分相比，赋形剂与由相同材料形成的常规赋形剂相比，提供增强的流动性/良好的流动性能，优异的/高紧密性和增加的API负载量和混合性。改进的赋形剂在组分之间具有强烈的颗粒内键合桥，导致独特的结构形态，包括显着的开放结构或中空孔。这些孔的存在提供了表面粗糙度，这是改进与API混合的理想环境。

5. 发明申请

WO2009048557A1 DIRECTLY COMPRESSIBLE HIGH FUNCTIONALITY GRANULAR MICROCRYSTALLINE CELLULOSE BASED EXCIPIENT, MANUFACTURING PROCESS AND USE THEREOF 审中-公开
标题翻译：直接可控的高功能颗粒状微晶纤维素制品，制造工艺及其使用
公开(公告)号：WO2009048557A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/011555
申请日：2008-10-07
申请人： MALLINCKRODT BAKER, INC. , DEORKAR, Nandu , FARINA, James , MIINEA, Liliana , RANDIVE, Sameer
发明人： DEORKAR, Nandu , FARINA, James , MIINEA, Liliana , RANDIVE, Sameer
IPC分类号： A61K9/16 , A61K9/20
CPC分类号： A61K9/1635 , A61K9/1652 , A61K9/2027 , A61K9/2054
摘要： An improved excipient comprising substantially homogeneous particles of a compressible, high functionality granular microcrystalline cellulose based excipient is provided. The improved excipient comprises microcrystalline cellulose, a binder and a disintegrant, and is formed by spraying a homogeneous slurry of the components. The excipient provides enhanced flowability/good flow properties, excellent/high compactibility, and increased API loading and blendability as compared to the individual components, and as compared to conventional excipients formed from the same materials. The improved excipient has strong intraparticle bonding bridges between the components, resulting in a unique structural morphology including significant open structures or hollow pores. The presence of these pores provides a surface roughness that is the ideal environment for improved blending with an API.
摘要翻译：提供了包含基本上均匀的可压缩，高功能性颗粒状微晶纤维素基赋形剂颗粒的赋形剂。改进的赋形剂包括微晶纤维素，粘合剂和崩解剂，并且通过喷涂组分的均匀浆料形成。与各种组分相比，赋形剂与由相同材料形成的常规赋形剂相比，提供增强的流动性/良好的流动性能，优异的/高紧密性和增加的API负载量和混合性。改进的赋形剂在组分之间具有强烈的颗粒内键合桥，导致独特的结构形态，包括显着的开放结构或中空孔。这些孔的存在提供了表面粗糙度，这是改进与API混合的理想环境。

6. 发明申请

WO2008094237A1 CHROMATOGRAPHIC MEDIA AND CHROMATOGRAPHIC EQUIPMENT STORAGE SOLUTIONS AND USE THEREOF 审中-公开
标题翻译：色谱介质和色谱设备存储解决方案及其使用
公开(公告)号：WO2008094237A1
公开(公告)日：2008-08-07
申请号：PCT/US2007/025261
申请日：2007-12-10
申请人： MALLINCKRODT BAKER, INC. , DEORKAR, Nandu , MAGEE, Steve
发明人： DEORKAR, Nandu , MAGEE, Steve
IPC分类号： A01N31/02 , A01N31/04 , A01P1/00
CPC分类号： A01N31/02 , A01N2300/00
摘要： Buffered antimicrobial solutions of benzyl alcohol and ethanol and their use for short or long term storage of chromatographic solids.
摘要翻译：苄醇和乙醇的缓冲抗菌溶液及其用于短期或长期储存色谱固体的用途。

7. 发明申请

WO2007035410A1 PROTEIN A PRODUCTION AND PURIFICATION WITHOUT USING ANIMAL DERIVED COMPONENTS 审中-公开
标题翻译：蛋白质生产和纯化，不使用动物衍生的成分
公开(公告)号：WO2007035410A1
公开(公告)日：2007-03-29
申请号：PCT/US2006/035837
申请日：2006-09-14
申请人： MALLINCKRODT BAKER, INC. , DEORKAR, Nandu , GUO, Wei , MAGEE, Steve
发明人： DEORKAR, Nandu , GUO, Wei , MAGEE, Steve
IPC分类号： C12N1/20 , C07K14/31
CPC分类号： C07K14/31 , C12N1/20
摘要： Purification of vegetarian (non-animal derived) Protein A using a multidimensional purification process to remove undesirable non-animal derived component impurities in the Protein A from the non-animal fermentation media used to produce the Protein A so as to produce a vegetarian Protein A free of animal-origin components and essentially free of components derived from non-animal derived growth media.
摘要翻译：使用多维纯化方法纯化素（非动物衍生的）蛋白A，以从用于产生蛋白A的非动物发酵培养基中除去蛋白A中不需要的非动物衍生成分杂质，从而产生素A蛋白没有动物来源的组分，并且基本上不含源自非动物来源的生长培养基的组分。

8. 发明申请

WO2010059506A1 DIRECTLY COMPRESSIBLE HIGH FUNCTIONALITY GRANULAR DIBASIC CALCIUM PHOSPHATE BASED CO-PROCESSED EXCIPIENT 审中-公开
标题翻译：直接可控的高功能颗粒碳酸钙基磷酸钙加工方法
公开(公告)号：WO2010059506A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/064289
申请日：2009-11-13
申请人： MALLINCKRODT BAKER, INC. , DEORKAR, Nandu , FARINA, James , MIINEA, Liliana , RANDIVE, Sameer
发明人： DEORKAR, Nandu , FARINA, James , MIINEA, Liliana , RANDIVE, Sameer
IPC分类号： A61K9/16 , A61K9/20 , A61K31/196
CPC分类号： A61K31/00 , A61K9/2009 , A61K9/2095 , A61K31/196 , A61K47/02
摘要： An improved excipient comprising substantially homogeneous particles of a compressible, high functionality granular dibasic calcium phosphate based excipient is provided. The improved excipient comprises dibasic calcium phosphate, a binder and a disintegrant, and is formed by spraying a homogeneous slurry of the components. The improved excipient provides enhanced flowability/good flow properties, an increased API loading and blendability and higher compactibility as compared to the individual components, and as compared to excipients formed from the same materials by conventional methods. [0083] The improved excipient has strong intraparticle bonding bridges between the components, resulting in a unique structural morphology including significant open structures or hollow pores. The presence of these pores provides a surface roughness that is the ideal environment for improved blending with an API.
摘要翻译：提供了一种改进的赋形剂，其包含基本上均匀的可压缩，高官能度的基于磷酸钙的磷酸钙基赋形剂的颗粒。改进的赋形剂包括磷酸氢钙，粘合剂和崩解剂，并且通过喷涂组分的均匀浆料而形成。与单独组分相比，改进的赋形剂提供了增强的流动性/良好的流动性能，增加的API负载量和可混合性，并且与通过常规方法由相同材料形成的赋形剂相比具有更高的紧实性。改进的赋形剂在组分之间具有强的内部颗粒结合桥，导致独特的结构形态，包括显着的开放结构或中空孔。这些孔的存在提供了表面粗糙度，这是改进与API混合的理想环境。

9. 发明申请

WO2010017358A1 SUSTAINED RELEASE COMPOSITIONS COMPRISING GUMS AND SUGAR ALCOHOLS 审中-公开
标题翻译：持续发行包含食品和糖酒的组合物
公开(公告)号：WO2010017358A1
公开(公告)日：2010-02-11
申请号：PCT/US2009/052956
申请日：2009-08-06
申请人： MALLINCKRODT BAKER, INC. , DUMBRE, Nilesh, Tanhaji , AVACHAT, Amelia, Makarand , DEORKAR, Nandu , FARINA, James , MIINEA, Liliana
发明人： DUMBRE, Nilesh, Tanhaji , AVACHAT, Amelia, Makarand , DEORKAR, Nandu , FARINA, James , MIINEA, Liliana
IPC分类号： A61K31/16 , A61K31/20 , A61K31/135 , A61K31/137 , A61K31/196
CPC分类号： A61K9/1623 , A61K9/1652 , A61K9/2018 , A61K9/205 , A61K9/2054 , A61K31/09 , A61K31/135 , A61K31/137 , A61K31/167 , A61K31/196
摘要： A sustained release composition comprising spray dried particles of at least one polysaccharide gum and at least one polyhydric sugar alcohol, as well as methods of making the sustained released composition are provided. A sustained release pharmaceutical solid dosage form, and a method of making the solid dosage form by compression are also provided.
摘要翻译：提供包含至少一种多糖胶和至少一种多羟基糖醇的喷雾干燥颗粒的持续释放组合物，以及制备持续释放的组合物的方法。还提供了缓释药物固体剂型，以及通过压缩制备固体剂型的方法。

10. 发明申请

WO2010059550A1 NEW CHROMATOGRAPHIC MEDIA BASED ON PHENOXY ALKYL AND ALKOXY-OR PHENOXY-PHENYL ALKYL LIGANDS 审中-公开
标题翻译：基于苯氧基和烷基或苯基 - 苯基氨基酸的新色谱介质
公开(公告)号：WO2010059550A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/064536
申请日：2009-11-16
申请人： MALLINCKRODT BAKER, INC. , DEORKAR, Nandu , THIYAGARAJAN, B.
发明人： DEORKAR, Nandu , THIYAGARAJAN, B.
IPC分类号： B01J20/287 , B01J20/32 , B01D15/32 , G01N30/02
CPC分类号： B01J20/3253 , B01J20/287 , B01J20/3227 , B01J20/3242 , B01J20/3246 , B01J2220/54 , G01N30/02 , B01D15/426 , B01D15/325
摘要： A reverse phase chromatographic media selected from media of the formula: [X-C 6 H 4 -(O) m -(CH 2 ) n ] q -Z and hydrophobic end-capped media of said formula, wherein n is a numeral of from 1 to 4, and m is 0 or 1, and when m is 1 X is selected from the group H, an alkyl group having from 1 to 6 carbon atoms and a phenyl group, and when m is 0 then X is selected from an alkoxy group having from 1 to 6 carbon atoms and a phenoxy group, Z is the backbone of a silica or hydrophilic polymer chromatographic support, and q is a number equal to the number of ligands attached to the backbone of the silica or hydrophobic polymer chromatographic support, with the proviso that when said reverse phase chromatographic media of the formula is not end-capped with hydrophobic groups X is not H when m =1. These novel chromatographic media are prepared by reacting: (a) a chromatographic media support selected from (1) a silica support having hydroxyl groups on the surface of the silica backbone or (2) a hydrophilic polymer support having hydroxyl, amine or imine groups on the surface of the polymer backbone, with (b) a reactant of the formula [X-C 6 H 4 -(O) m -(CH 2 ) n ] p -Si (Y) 4-p wherein p is a numeral of from 1 to 3, Y is a chloro or alkoxy group having from 1 to 4 carbon atoms in the alkoxy group, and m, n and X are as defined above, and optionally end-capping the resulting media by reacting it with a hydrophobic end-capping reactant.. The resulting chromatographic media with these ligands attached to the backbone of the silica or hydrophilic polymer support provides chromatographic media that offers analyte separation capability in the aqueous mobile phase.
摘要翻译：选自下式的介质的反相色谱介质：[X-C6H4-（O）m-（CH2）n] qZ和所述式的疏水封端的介质，其中n为1至4的数字，以及 m为0或1，当m为1时，选自H，具有1至6个碳原子的烷基和苯基，当m为0时，X选自具有1个至6个碳原子和苯氧基，Z是二氧化硅或亲水性聚合物色谱载体的主链，q是等于与二氧化硅或疏水性聚合物色谱载体的主链连接的配体数目，数目等于当式的所述反相色谱介质未用疏水性基团封端时，当m = 1时，X不为H。这些新型色谱介质通过以下反应制备：（a）色谱介质载体，其选自（1）在二氧化硅骨架的表面上具有羟基的二氧化硅载体，或（2）具有羟基，胺或亚胺基团的亲水性聚合物载体，聚合物主链的表面与（b）式[X-C6H4-（O）m-（CH2）n] p-Si（Y）4-p的反应物，其中p是1至3的数字，Y是在烷氧基中具有1至4个碳原子的氯或烷氧基，m，n和X如上所定义，并且任选地通过使其与疏水性封端反应物反应来封端所得介质。所得到的色谱介质与这些配体连接在二氧化硅或亲水聚合物支架的主链上，提供色谱介质，在水性流动相中提供分析物分离能力。

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