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1. 发明申请

WO2011008674A1 MATERIAL AND PROCESS FOR INCORPORATION OF LOW DOSAGE ACTIVE PHARMACEUTICAL INGREDIENTS AND USE THEREOF 审中-公开
标题翻译：合并低剂量活性药物成分的材料和方法及其用途
公开(公告)号：WO2011008674A1
公开(公告)日：2011-01-20
申请号：PCT/US2010/041665
申请日：2010-07-12
申请人： MALLINCKRODT BAKER, INC. , FARINA, James , DEORKAR, Nandu , MIINEA, Liliana
发明人： FARINA, James , DEORKAR, Nandu , MIINEA, Liliana
IPC分类号： A61K9/14 , A61K9/16 , A61K9/20 , A61K31/19 , A61K31/44 , A61K31/5415
CPC分类号： A61K9/2054 , A61K9/146 , A61K9/167 , A61K9/2095 , A61K31/19 , A61K31/44 , A61K31/5415
摘要： A low dose API pharmaceutical tablet having excellent content uniformity is provided. The tablet is formed by spray coating a support excipient with the API. The resulting composition is suitable for direct compression tablet formulation without the need for an additional granulation step to uniformly coat the API onto the support excipient. The support excipient comprises microcrystalline cellulose, a binder and a disintegrant, and is formed by spraying a homogeneous slurry of the support excipient components.
摘要翻译：提供了具有优异的均匀性的低剂量API药片。片剂通过用API喷涂载体赋形剂而形成。所得组合物适用于直接压制片剂制剂，而不需要另外的制粒步骤将API均匀地涂覆在支持赋形剂上。支持赋形剂包括微晶纤维素，粘合剂和崩解剂，并且通过喷洒支持赋形剂组分的均匀浆液形成。

2. 发明申请

WO2006081002A2 CHROMATOGRAPHIC MEDIA 审中-公开
标题翻译：色谱介质
公开(公告)号：WO2006081002A2
公开(公告)日：2006-08-03
申请号：PCT/US2005/045710
申请日：2005-12-16
申请人： MALLINCKRODT BAKER, INC. , DEORKAR, Nandu , BUSS, Robert, C. , MLADOSICH, Joseph, M. , BOUIS, Paul, A.
发明人： DEORKAR, Nandu , BUSS, Robert, C. , MLADOSICH, Joseph, M. , BOUIS, Paul, A.
CPC分类号： B01J41/14 , B01D15/327 , B01D15/363 , B01D15/364 , B01J20/261 , B01J20/262 , B01J20/265 , B01J20/28004 , B01J20/285 , B01J20/288 , B01J20/3092 , B01J20/321 , B01J20/3255 , B01J20/3272 , B01J20/328 , B01J20/3285 , B01J2220/52 , B01J2220/54 , B01J2220/58 , C07K1/165
摘要： This invention concerns the preparation and use of novel polymeric chromatographic media and preferably mixed mode polymeric chromatographic media. In accordance with the present invention, polymeric media is prepared using polymeric particles derivatized with polyethyleneimine, and preferably such polyethyleneimine derivatized polymeric particles further functionalized with appropriate reactants. The polymeric chromatographic media is especially useful for bioseparations.
摘要翻译：本发明涉及新型聚合物色谱介质和优选混合模式聚合物色谱介质的制备和使用。根据本发明，使用用聚乙烯亚胺衍生的聚合物颗粒制备聚合物介质，并且优选用适当的反应物进一步官能化的这种聚乙烯亚胺衍生的聚合物颗粒。高分子色谱介质特别适用于生物分离。

3. 发明申请

WO2009048557A1 DIRECTLY COMPRESSIBLE HIGH FUNCTIONALITY GRANULAR MICROCRYSTALLINE CELLULOSE BASED EXCIPIENT, MANUFACTURING PROCESS AND USE THEREOF 审中-公开
标题翻译：直接可控的高功能颗粒状微晶纤维素制品，制造工艺及其使用
公开(公告)号：WO2009048557A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/011555
申请日：2008-10-07
申请人： MALLINCKRODT BAKER, INC. , DEORKAR, Nandu , FARINA, James , MIINEA, Liliana , RANDIVE, Sameer
发明人： DEORKAR, Nandu , FARINA, James , MIINEA, Liliana , RANDIVE, Sameer
IPC分类号： A61K9/16 , A61K9/20
CPC分类号： A61K9/1635 , A61K9/1652 , A61K9/2027 , A61K9/2054
摘要： An improved excipient comprising substantially homogeneous particles of a compressible, high functionality granular microcrystalline cellulose based excipient is provided. The improved excipient comprises microcrystalline cellulose, a binder and a disintegrant, and is formed by spraying a homogeneous slurry of the components. The excipient provides enhanced flowability/good flow properties, excellent/high compactibility, and increased API loading and blendability as compared to the individual components, and as compared to conventional excipients formed from the same materials. The improved excipient has strong intraparticle bonding bridges between the components, resulting in a unique structural morphology including significant open structures or hollow pores. The presence of these pores provides a surface roughness that is the ideal environment for improved blending with an API.
摘要翻译：提供了包含基本上均匀的可压缩，高功能性颗粒状微晶纤维素基赋形剂颗粒的赋形剂。改进的赋形剂包括微晶纤维素，粘合剂和崩解剂，并且通过喷涂组分的均匀浆料形成。与各种组分相比，赋形剂与由相同材料形成的常规赋形剂相比，提供增强的流动性/良好的流动性能，优异的/高紧密性和增加的API负载量和混合性。改进的赋形剂在组分之间具有强烈的颗粒内键合桥，导致独特的结构形态，包括显着的开放结构或中空孔。这些孔的存在提供了表面粗糙度，这是改进与API混合的理想环境。

4. 发明申请

WO2008094237A1 CHROMATOGRAPHIC MEDIA AND CHROMATOGRAPHIC EQUIPMENT STORAGE SOLUTIONS AND USE THEREOF 审中-公开
标题翻译：色谱介质和色谱设备存储解决方案及其使用
公开(公告)号：WO2008094237A1
公开(公告)日：2008-08-07
申请号：PCT/US2007/025261
申请日：2007-12-10
申请人： MALLINCKRODT BAKER, INC. , DEORKAR, Nandu , MAGEE, Steve
发明人： DEORKAR, Nandu , MAGEE, Steve
IPC分类号： A01N31/02 , A01N31/04 , A01P1/00
CPC分类号： A01N31/02 , A01N2300/00
摘要： Buffered antimicrobial solutions of benzyl alcohol and ethanol and their use for short or long term storage of chromatographic solids.
摘要翻译：苄醇和乙醇的缓冲抗菌溶液及其用于短期或长期储存色谱固体的用途。

5. 发明申请

WO2007035410A1 PROTEIN A PRODUCTION AND PURIFICATION WITHOUT USING ANIMAL DERIVED COMPONENTS 审中-公开
标题翻译：蛋白质生产和纯化，不使用动物衍生的成分
公开(公告)号：WO2007035410A1
公开(公告)日：2007-03-29
申请号：PCT/US2006/035837
申请日：2006-09-14
申请人： MALLINCKRODT BAKER, INC. , DEORKAR, Nandu , GUO, Wei , MAGEE, Steve
发明人： DEORKAR, Nandu , GUO, Wei , MAGEE, Steve
IPC分类号： C12N1/20 , C07K14/31
CPC分类号： C07K14/31 , C12N1/20
摘要： Purification of vegetarian (non-animal derived) Protein A using a multidimensional purification process to remove undesirable non-animal derived component impurities in the Protein A from the non-animal fermentation media used to produce the Protein A so as to produce a vegetarian Protein A free of animal-origin components and essentially free of components derived from non-animal derived growth media.
摘要翻译：使用多维纯化方法纯化素（非动物衍生的）蛋白A，以从用于产生蛋白A的非动物发酵培养基中除去蛋白A中不需要的非动物衍生成分杂质，从而产生素A蛋白没有动物来源的组分，并且基本上不含源自非动物来源的生长培养基的组分。

6. 发明申请

WO2017190036A1 PACKAGING SYSTEM FOR STORAGE AND SHIPMENT OF SOLIDS 审中-公开
标题翻译：用于储存和装运固体的包装系统
公开(公告)号：WO2017190036A1
公开(公告)日：2017-11-02
申请号：PCT/US2017/030169
申请日：2017-04-28
申请人： AVANTOR PERFORMANCE MATERIALS, LLC , FARINA, James , DEORKAR, Nandu
发明人： FARINA, James , DEORKAR, Nandu
IPC分类号： B65D81/26 , B65D65/38 , B65D75/38 , B65D77/04
摘要： A packaging system that maintains the free flowing characteristic of solid materials contained therein. The packaging system includes a container, a cover, a vapor permeable bag, a vapor impermeable liner and at least two desiccant snakes. The vapor permeable bag has an opening for receiving solid materials and is formed from cloth or continuous fibers of high- density polyethylene that are randomly distributed and non-directional. The vapor impermeable liner surrounds the vapor permeable bag and provides a moisture barrier. The desiccant snakes are disposed between the vapor permeable bag and the liner. Each snake includes two or more desiccant packages formed from a vapor permeable material through which moisture can freely pass. The desiccant packages contain clay, silica, or molecular sieves.
摘要翻译：保持包含在其中的固体材料的自由流动特性的包装系统。包装系统包括容器，盖子，蒸气可渗透袋，蒸气不可渗透的衬垫和至少两个干燥剂蛇。蒸气可渗透袋具有用于接收固体材料的开口，并且由布料或高密度聚乙烯的连续纤维形成，所述纤维是随机分布的和非定向的。蒸汽不可渗透的内衬围绕蒸气可渗透袋并提供防潮层。干燥剂蛇布置在蒸汽可渗透袋和衬里之间。每条蛇包括两个或更多个干燥剂包装，由湿气可以自由通过的蒸气可渗透材料形成。干燥剂包装包含粘土，二氧化硅或分子筛。

7. 发明申请

WO2012151352A3 A NOVEL CHROMATOGRAPHIC MEDIA BASED ON ALLYLAMINE AND ITS DERIVATIVE FOR PROTEIN PURIFICATION 审中-公开
标题翻译：基于全蛋白的新型色谱介质及其衍生物用于蛋白质纯化
公开(公告)号：WO2012151352A3
公开(公告)日：2014-05-08
申请号：PCT/US2012036237
申请日：2012-05-03
申请人： AVANTOR PERFORMANCE MAT INC , THIYAGARAJAN BHAKTAVACHALAM , GUO WEI , DEORKAR NANDU
发明人： THIYAGARAJAN BHAKTAVACHALAM , GUO WEI , DEORKAR NANDU
IPC分类号： B01D15/08
CPC分类号： B01D15/206 , B01D15/327 , B01D15/362 , B01D15/363 , B01J20/286 , B01J20/3248 , B01J20/327 , B01J20/3278 , B01J20/328 , B01J39/26 , B01J41/20 , B01J2220/52 , G01N2030/525
摘要： Chromatographic media of porous media particles derivatized with allylamine or polyallylamine obtained directly or through intermolecular polymerization on the surface thereof and such media functionalized with further functionalization groups. Such media are particularly useful for separating biomolecules.
摘要翻译：通过直接或通过其表面上的分子间聚合获得的烯丙胺或聚烯丙基胺衍生的多孔介质颗粒的色谱介质和用另外的官能团官能化的介质。这种培养基特别适用于分离生物分子。

8. 发明申请

WO2011126957A1 PROCESS FOR TRYPSIN AND CHYMOTRYPSIN PURIFICATION UTILIZING HYDROPHOBIC INTERACTION CHROMATOGRAPHY 审中-公开
标题翻译：采用水解相互作用色谱法研究紫杉醇和氯霉素的纯化方法
公开(公告)号：WO2011126957A1
公开(公告)日：2011-10-13
申请号：PCT/US2011/031036
申请日：2011-04-04
申请人： AVANTOR PERFORMANCE MATERIALS, INC. , THIYAGARAJAN, Bhaktavachalam , MAGEE, Steve , DEORKAR, Nandu
发明人： THIYAGARAJAN, Bhaktavachalam , MAGEE, Steve , DEORKAR, Nandu
IPC分类号： C12N9/76 , C07K1/20
CPC分类号： C12N9/6427
摘要： A method for the separation and purification of trypsin and chymotrypsin in which a crude mixture of trypsin and chymotrypsin is passed through a hydrophobic interaction chromatography media in a chromatographic column. The hydrophobic interaction chromatography media is preferably one having weak anion exchange functionality and alkyl, alkanoyl, phenyl, benzoyl, phenylalkyl or phenylalkanoyl functional groups, such that chymotrypsin is bound to the chromatographic hydrophobic interaction chromatography media and trypsin passes through the media without binding to said media to produce purified trypsin, and thereafter bound chymotrypsin is eluted from the media to produce purified chymotrypsin.
摘要翻译：胰蛋白酶和胰凝乳蛋白酶的分离和纯化方法，其中胰蛋白酶和糜蛋白酶的粗混合物通过色谱柱中的疏水相互作用层析介质。疏水相互作用层析介质优选为具有弱阴离子交换官能团和烷基，烷酰基，苯基，苯甲酰基，苯基烷基或苯基烷酰基官能团的那些，使得胰凝乳蛋白酶与色谱疏水相互作用色谱介质结合，胰蛋白酶通过介质而不与所述培养基以产生纯化的胰蛋白酶，然后从培养基中洗脱出结合的糜蛋白酶以产生纯化的胰凝乳蛋白酶。

9. 发明申请

WO2010059506A1 DIRECTLY COMPRESSIBLE HIGH FUNCTIONALITY GRANULAR DIBASIC CALCIUM PHOSPHATE BASED CO-PROCESSED EXCIPIENT 审中-公开
标题翻译：直接可控的高功能颗粒碳酸钙基磷酸钙加工方法
公开(公告)号：WO2010059506A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/064289
申请日：2009-11-13
申请人： MALLINCKRODT BAKER, INC. , DEORKAR, Nandu , FARINA, James , MIINEA, Liliana , RANDIVE, Sameer
发明人： DEORKAR, Nandu , FARINA, James , MIINEA, Liliana , RANDIVE, Sameer
IPC分类号： A61K9/16 , A61K9/20 , A61K31/196
CPC分类号： A61K31/00 , A61K9/2009 , A61K9/2095 , A61K31/196 , A61K47/02
摘要： An improved excipient comprising substantially homogeneous particles of a compressible, high functionality granular dibasic calcium phosphate based excipient is provided. The improved excipient comprises dibasic calcium phosphate, a binder and a disintegrant, and is formed by spraying a homogeneous slurry of the components. The improved excipient provides enhanced flowability/good flow properties, an increased API loading and blendability and higher compactibility as compared to the individual components, and as compared to excipients formed from the same materials by conventional methods. [0083] The improved excipient has strong intraparticle bonding bridges between the components, resulting in a unique structural morphology including significant open structures or hollow pores. The presence of these pores provides a surface roughness that is the ideal environment for improved blending with an API.
摘要翻译：提供了一种改进的赋形剂，其包含基本上均匀的可压缩，高官能度的基于磷酸钙的磷酸钙基赋形剂的颗粒。改进的赋形剂包括磷酸氢钙，粘合剂和崩解剂，并且通过喷涂组分的均匀浆料而形成。与单独组分相比，改进的赋形剂提供了增强的流动性/良好的流动性能，增加的API负载量和可混合性，并且与通过常规方法由相同材料形成的赋形剂相比具有更高的紧实性。改进的赋形剂在组分之间具有强的内部颗粒结合桥，导致独特的结构形态，包括显着的开放结构或中空孔。这些孔的存在提供了表面粗糙度，这是改进与API混合的理想环境。

10. 发明申请

WO2010017358A1 SUSTAINED RELEASE COMPOSITIONS COMPRISING GUMS AND SUGAR ALCOHOLS 审中-公开
标题翻译：持续发行包含食品和糖酒的组合物
公开(公告)号：WO2010017358A1
公开(公告)日：2010-02-11
申请号：PCT/US2009/052956
申请日：2009-08-06
申请人： MALLINCKRODT BAKER, INC. , DUMBRE, Nilesh, Tanhaji , AVACHAT, Amelia, Makarand , DEORKAR, Nandu , FARINA, James , MIINEA, Liliana
发明人： DUMBRE, Nilesh, Tanhaji , AVACHAT, Amelia, Makarand , DEORKAR, Nandu , FARINA, James , MIINEA, Liliana
IPC分类号： A61K31/16 , A61K31/20 , A61K31/135 , A61K31/137 , A61K31/196
CPC分类号： A61K9/1623 , A61K9/1652 , A61K9/2018 , A61K9/205 , A61K9/2054 , A61K31/09 , A61K31/135 , A61K31/137 , A61K31/167 , A61K31/196
摘要： A sustained release composition comprising spray dried particles of at least one polysaccharide gum and at least one polyhydric sugar alcohol, as well as methods of making the sustained released composition are provided. A sustained release pharmaceutical solid dosage form, and a method of making the solid dosage form by compression are also provided.
摘要翻译：提供包含至少一种多糖胶和至少一种多羟基糖醇的喷雾干燥颗粒的持续释放组合物，以及制备持续释放的组合物的方法。还提供了缓释药物固体剂型，以及通过压缩制备固体剂型的方法。

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