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1. 发明申请

WO2011133756A1 MONOCLONAL ANTIBODIES WHICH SPECIFICALLY BIND AND NEUTRALIZE HUMAN PDGF-DD 审中-公开
标题翻译：特异性结合和中和人PDGF-DD的单克隆抗体
公开(公告)号：WO2011133756A1
公开(公告)日：2011-10-27
申请号：PCT/US2011/033405
申请日：2011-04-21
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH, LTD. , ERIKSSON, Ulf
发明人： ERIKSSON, Ulf
IPC分类号： C12N5/12
CPC分类号： C07K16/22 , C07K2317/33 , C07K2317/76
摘要： The invention relates to monoclonal antibodies, which bind specifically to full length human PDGF-DD, and inhibit its processing to the active form of the molecule. Also described are the hybridomas, which produce these monoclonal antibodies, methods for identifying them, and methods for using them to inhibit the processing event.
摘要翻译：本发明涉及与全长人PDGF-DD特异性结合并抑制其加工成分子活性形式的单克隆抗体。还描述了产生这些单克隆抗体的杂交瘤，鉴定它们的方法和使用它们抑制加工事件的方法。

2. 发明申请

WO2018005904A3 METHODS AND COMPOSITIONS FOR PDGF-CC INHIBITION 审中-公开
公开(公告)号：WO2018005904A3
公开(公告)日：2018-01-04
申请号：PCT/US2017/040170
申请日：2017-06-30
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH LTD
发明人： ERIKSSON, Ulf , LI, Hong , SCOTT, Andrew , ALLAN, Laura
IPC分类号： C07K16/22 , C07K16/18 , A61K39/395
摘要： The present invention relates, in part, to isolated antibodies that specifically interact with and show measurable binding affinity to an epitope of platelet derived growth factor C (PDGF-C). Such antibodies may be used for the modulation of PDGF-C activity in or secreted from a cell to study its effects on cell function and, in certain embodiments, for the treatment and/or prevention of a disease or condition associated with PDGF-C signing pathway.

3. 发明申请

WO2018005904A2 METHODS AND COMPOSITIONS FOR PDGF-CC INHIBITION 审中-公开
标题翻译： PDGF-CC抑制的方法和组合物
公开(公告)号：WO2018005904A2
公开(公告)日：2018-01-04
申请号：PCT/US2017/040170
申请日：2017-06-30
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH LTD
发明人： ERIKSSON, Ulf , LI, Hong , SCOTT, Andrew , ALLAN, Laura
IPC分类号： A61K39/395 , C07K16/26
摘要： The present invention relates, in part, to isolated antibodies that specifically interact with and show measurable binding affinity to an epitope of platelet derived growth factor C (PDGF-C). Such antibodies may be used for the modulation of PDGF-C activity in or secreted from a cell to study its effects on cell function and, in certain embodiments, for the treatment and/or prevention of a disease or condition associated with PDGF-C signing pathway.
摘要翻译：本发明部分涉及与血小板衍生的生长因子C（PDGF-C）的表位特异性相互作用并显示出可测量的结合亲和力的分离的抗体。此类抗体可用于调节细胞中PDGF-C活性或从细胞分泌，以研究其对细胞功能的作用，并且在某些实施方案中用于治疗和/或预防与PDGF-C标签相关的疾病或病症通路。

4. 发明申请

WO2014045266A1 TREATMENT OF TYPE 2 DIABETES AND RELATED CONDITIONS 审中-公开
标题翻译：治疗2型糖尿病及相关情况
公开(公告)号：WO2014045266A1
公开(公告)日：2014-03-27
申请号：PCT/IB2013/058822
申请日：2013-09-24
申请人： ERIKSSON, Ulf
发明人： ERIKSSON, Ulf
IPC分类号： C07K16/22 , A61K39/395 , A61P3/10 , A61P3/06
CPC分类号： A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K2317/76 , A61K2300/00
摘要： The present disclosure provides methods of treating diabetic conditions, restoring insulin sensitivity and/or improving regulation of glycemia using an antagonist of VEGF-B, particularly in combination with other anti-diabetic agents such as insulin secretagogues. Compositions are also provided comprising one or more VEGF-B antagonists, particularly in combination with other anti-diabetic agents such as insulin secretagogues. In particular embodiments, the VEGF-B antagonist is an anti-VEGF-B antibody. In further particular embodiments, the other anti-diabetic agent or insulin secretagogue is a DPP-4 inhibitor or a GLP-1R agonist.
摘要翻译：本公开提供了使用VEGF-B的拮抗剂，特别是与其它抗糖尿病药如胰岛素促分泌素组合治疗糖尿病状况，恢复胰岛素敏感性和/或改善血糖调节的方法。还提供了包含一种或多种VEGF-B拮抗剂的组合物，特别是与其它抗糖尿病药如胰岛素促分泌素组合。在具体实施方案中，VEGF-B拮抗剂是抗VEGF-B抗体。在另外的具体实施方案中，其它抗糖尿病剂或胰岛素促分泌素是DPP-4抑制剂或GLP-1R激动剂。

5. 发明申请

WO2007022287A2 MODIFIED VEGF-A WITH IMPROVED ANGIOGENIC PROPERTIES 审中-公开
标题翻译：改良的VEGF-A具有改善的血管生成特性
公开(公告)号：WO2007022287A2
公开(公告)日：2007-02-22
申请号：PCT/US2006/032012
申请日：2006-08-15
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , LICENTIA LTD. , ALITALO, Kari , TAMMELA, Tuomas , KESKITALO, Salla , PAJUSOLA, Katri , JELTSCH, Markku, M. , YLA-HERTTUALA, Seppo , KARPANEN, Terhi , ERIKSSON, Ulf , UUTELA, Marko, J., T.
发明人： ALITALO, Kari , TAMMELA, Tuomas , KESKITALO, Salla , PAJUSOLA, Katri , JELTSCH, Markku, M. , YLA-HERTTUALA, Seppo , KARPANEN, Terhi , ERIKSSON, Ulf , UUTELA, Marko, J., T.
IPC分类号： C07K14/515 , A61K38/18
CPC分类号： C07K14/52 , A61K38/00
摘要： The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.
摘要翻译：本发明涉及制备和使用包含VEGFR-2配体的嵌合多肽的方法和组合物。与天然VEGF-A相比，本发明的嵌合分子保持VEGFR-2结合活性和增强的血管生成活性。

6. 发明申请

WO2006122144A2 METHODS AND COMPOSITIONS FOR PDGF-D ACTIVATION AND INHIBITION 审中-公开
标题翻译： PDGF-D激活和抑制的方法和组合
公开(公告)号：WO2006122144A2
公开(公告)日：2006-11-16
申请号：PCT/US2006/017964
申请日：2006-05-10
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , ERIKSSON, Ulf
发明人： ERIKSSON, Ulf
IPC分类号： C12Q1/68
CPC分类号： C07K16/22 , A61K38/1858
摘要： Methods for inhibiting angiogenesis comprising administering urokinase plasminogen activator (uPA) inhibitors, and pharmaceutical compositions suitable for the methods comprising the uPA inhibitors. Also provided are methods for stimulating angiogenesis comprising administering uPA or an agonist thereof to a patient in need thereof, and pharmaceutical compositions comprising an effective amount of uPA or an agonist thereof for the methods of stimulation. The present invention discloses that uPA is a specific PDGF-D activatin rotease.
摘要翻译：用于抑制血管发生的方法包括施用尿激酶纤溶酶原激活物（uPA）抑制剂和适用于包含uPA抑制剂的方法的药物组合物。还提供了用于刺激血管发生的方法，其包括向有需要的患者施用uPA或其激动剂，以及包含有效量的uPA或其激动剂的用于刺激方法的药物组合物。本发明公开了uPA是特定的PDGF-D激活质素。

7. 发明申请

WO2008147287A1 TELESCOPIC SHAFT 审中-公开
标题翻译： TELESCOPIC轴
公开(公告)号：WO2008147287A1
公开(公告)日：2008-12-04
申请号：PCT/SE2008/000362
申请日：2008-05-28
申请人： FUJI AUTOTECH AB , ERIKSSON, Ulf , FREDRIKSSON, Hans
发明人： ERIKSSON, Ulf , FREDRIKSSON, Hans
IPC分类号： F16C3/035 , B62D1/185
CPC分类号： F16C3/035 , B62D1/16 , B62D1/185 , B62D1/20 , F16C2326/24
摘要： The invention relates to a telescopic shaft for vehicles comprising an inner shaft (14) axially movable in an outer shaft (16), where the telescopic shaft (4) comprises at least two rows (35, 37) of balls (36, 38) with at least one ball (36, 38) a row (35, 37) between the inner shaft (14) and the outer shaft (16), where a row (35) of balls (36) is arranged on at least one ball race (40) arranged against the inner shaft (14), where the ball race (40) is wedge shaped on its against the inner shaft (14) facing surface and that the telescopic shaft (4) comprises a prestress mechanism (46) which pushes the ball race (40) along a wedge unit (48) axially in relation to and radially in the direction against the outer shaft (16) whereby the telescopic shaft (48) is prestressed and that the prestress mechanism (46) is arranged to release the prestress when the alteration in length of the telescopic shaft (4) exceeds a predetermined length.
摘要翻译：本发明涉及一种用于车辆的伸缩轴，包括可在外轴（16）中可轴向移动的内轴（14），其中伸缩轴（4）包括至少两排（35,37）的球（36,38）在内轴（14）和外轴（16）之间具有至少一个球（36,38）一排（35,37），其中一排（35）的球（36）布置在至少一个球（40）抵靠所述内轴（14）布置，其中所述球座（40）在其抵靠所述内轴（14）面向表面上是楔形的，并且所述伸缩轴（4）包括预应力机构（46），所述预应力机构沿着楔形单元（48）沿相对于径向方向相对于外轴（16）的方向推动球座（40），由此伸缩轴（48）被预应力，并且预应力机构（46）被布置成当伸缩轴（4）的长度变化超过预定长度时，释放预应力。

8. 发明申请

WO2007050004A1 STEERlNG WHEEL ARRANGEMENT 审中-公开
标题翻译： STEERlNG轮式安排
公开(公告)号：WO2007050004A1
公开(公告)日：2007-05-03
申请号：PCT/SE2005/001628
申请日：2005-10-28
申请人： VOLVO LASTVAGNAR AB , FUJI AUTOTECH AB , ANDERSSON, Björn , OMARAIN, Hassan , GUNNARSSON, Andreas , PAULSSON, Thomas , FREDRIKSSON, Hans , ERIKSSON, Ulf , HYVÖNEN, Pentti
发明人： ANDERSSON, Björn , OMARAIN, Hassan , GUNNARSSON, Andreas , PAULSSON, Thomas , FREDRIKSSON, Hans , ERIKSSON, Ulf , HYVÖNEN, Pentti
IPC分类号： B62D1/184 , B62D1/189
CPC分类号： B62D1/18 , B62D1/184 , B62D1/187 , Y10T74/20414
摘要： A Steering wheel arrangement (10) for a motor vehicle, comprises a steering column (12) having a first end for cooperation with a steering wheel (14) and a second end for cooperation with a vehicle steering mechanism. The steering wheel arrangement further comprises a suspension arrangement for said steering column (12). The suspension arrangement comprises two pivot joints (18, 22) and is pivotally connected to said steering column (12) via a third pivot joint (24), said first, second and third pivot joints (18, 22, 24) comprising first, second and third locking arrangements (29, 30, 31 ), respectively. The steering wheel arrangement has thus three adjustable pivot points where only one or two of the three pivot joints are adjustable in a first step depressing a foot pedal (32) to a first position and only the remaining of the three pivot joints are adjustable in a second step depressing the foot pedal to a second position which implies that the adjustments can be made in a secure way by the driver during the ride.
摘要翻译：一种用于机动车辆的方向盘装置（10），包括具有与方向盘（14）配合的第一端的转向柱（12）和用于与车辆转向机构协作的第二端。方向盘装置还包括用于所述转向柱（12）的悬挂装置。所述悬挂装置包括两个枢轴接头（18,22），并且经由第三枢转接头（24）枢转地连接到所述转向柱（12），所述第一，第二和第三枢转接头（18,22,24）包括第一，第二和第三锁定装置（29,30,31）。因此，方向盘装置具有三个可调枢轴点，其中三个枢轴接头中只有一个或两个在第一步骤中可调节，第一步骤将脚踏板（32）压下到第一位置，并且只有剩余的三个枢轴接头可以在第二步骤将脚踏板压下到第二位置，这意味着驾驶员在乘坐期间可以以安全的方式进行调整。

9. 发明申请

WO2007124308A2 METHODS AND COMPOSITIONS FOR MODULATION OF BLOOD-NEURAL BARRIER 审中-公开
标题翻译：血液 - 神经阻滞剂调制方法及组合物
公开(公告)号：WO2007124308A2
公开(公告)日：2007-11-01
申请号：PCT/US2007/066804
申请日：2007-04-17
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , ERIKSSON, Ulf , LAWRENCE, Daniel , SU, Enming, Joe , STRICKLAND, Dudley , YEPPES, Manuel , FREDRIKSSON, Linda
发明人： ERIKSSON, Ulf , LAWRENCE, Daniel , SU, Enming, Joe , STRICKLAND, Dudley , YEPPES, Manuel , FREDRIKSSON, Linda
CPC分类号： C07K16/2863 , A61K9/0019 , A61K38/43 , A61K39/39533 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/76 , C12N9/6454
摘要： Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-α antagonist.
摘要翻译：用于调节血液神经屏障（BNB）的方法和组合物用于治疗中枢神经系统疾病如水肿，以及用于增加穿过BNB的药物递送功效。本发明还涉及改善的缺血性脑血管和相关疾病的tPA治疗以及PDGF信号通路的拮抗作用。本发明的方法和组合物特别适用于使用tPA和抗PDGF-C拮抗剂或抗PDGFR-a拮抗剂的缺血性卒中的联合治疗。

10. 发明申请

WO2006074830A1 A PRE-HEATER FOR AN APPARATUS FOR THE PRODUCTION OF CARBON BLACK 审中-公开
标题翻译：一种用于生产炭黑的装置的预热器
公开(公告)号：WO2006074830A1
公开(公告)日：2006-07-20
申请号：PCT/EP2005/055205
申请日：2005-10-12
申请人： SANDVIK INTELLECTUAL PROPERTY AB , ERIKSSON, Ulf , DAHLSTEDT, Fredrik
发明人： ERIKSSON, Ulf , DAHLSTEDT, Fredrik
IPC分类号： F28F9/007 , F28D7/16 , C09C1/48
CPC分类号： C09C1/48 , F28D7/16 , F28F9/007 , F28F2265/26
摘要： A pre-heater for an apparatus for the production of carbon black, is adapted to pre-heat air by heat exchange (1) to a temperature of at least 800°C, comprises an elongated jacket (10) arranged substantially and having a top end and a bottom end, said jacket defining a space, a plurality of tubings (23) arranged inside said space, said tubings having a diametre of 85 to 90 mm, said jacket (10) being provided with an air inlet and an air outlet, for allowing said air to enter and exit said space, a smoke inlet chamber (24) and a smoke collection chamber (27b) for allowing smoke to enter and exit said tubing (23) . Said jacket (10) is supported by a suspension means (26) between said top and bottom ends excluding at the top end as such, such that the jacket is allowed to expand upwards above and downwards below said suspension means (26) .
摘要翻译：用于生产炭黑的设备的预热器适于通过热交换（1）将空气预热至至少800℃的温度，包括基本上布置有顶部的细长护套（10）端部和底端，所述护套限定空间;布置在所述空间内的多个管道（23），所述管道的直径为85至90mm，所述护套（10）设置有空气入口和空气出口，用于允许所述空气进入和离开所述空间，烟雾入口室（24）和烟雾收集室（27b），用于允许烟雾进入和离开所述管道（23）。所述夹套（10）由顶部和底部端部之间的顶端和底端之间的悬挂装置（26）支撑，使得所述夹套允许在所述悬挂装置（26）下方向上和向下扩展。

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