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1. 发明申请

WO2016187585A1 DEIMMUNIZED LINKER AND METHODS OF USE 审中-公开
标题翻译：消除链接器和使用方法
公开(公告)号：WO2016187585A1
公开(公告)日：2016-11-24
申请号：PCT/US2016/033629
申请日：2016-05-20
申请人： VIVENTIA BIO INC.
发明人： CHOONIEDASS, Shilpa , DILLON, Rachelle L. , CIZEAU, Jeannick , PREMSUKH, Arjune , MACDONALD, Glen
IPC分类号： A61K47/48 , C07K19/00
CPC分类号： C07K7/08 , C07K16/30 , C07K16/32 , C07K2317/55 , C07K2317/626 , C07K2319/55 , C12N9/6454 , C12Y304/21075
摘要： The present disclosure is directed to novel deimmunized furin protease-sensitive peptide linkers that have been specifically engineered to lack T-cell epitopes and therefore elicit reduced immune response. The present disclosure also relates to immunotoxins comprising such linkers and methods of use of said immunotoxins comprising such linkers.
摘要翻译：本公开涉及新型解除免疫的弗林蛋白酶蛋白酶敏感性肽接头，其已经被特异性工程化以缺乏T细胞表位，因此引起降低的免疫应答。本公开还涉及包含这种接头的免疫毒素以及包含这种接头的所述免疫毒素的使用方法。

2. 发明申请

WO2012177741A1 PCSK9-BINDING POLYPEPTIDES AND METHODS OF USE 审中-公开
标题翻译： PCSK9-结合多肽及其使用方法
公开(公告)号：WO2012177741A1
公开(公告)日：2012-12-27
申请号：PCT/US2012/043315
申请日：2012-06-20
申请人： GENENTECH, INC. , F. HOFFMANN-LA ROCHE AG , KIRCHHOFER, Daniel , LI, Wei , PETERSON, Andrew Scott , ZHANG, Yingnan , ZHOU, Lijuan , KONG-BELTRAN, Monica
发明人： KIRCHHOFER, Daniel , LI, Wei , PETERSON, Andrew Scott , ZHANG, Yingnan , ZHOU, Lijuan , KONG-BELTRAN, Monica
IPC分类号： C07K14/705 , C07K19/00 , A61K38/17 , A61K31/22 , A61P9/10 , A61P3/06 , C12N15/63
CPC分类号： C07K16/40 , A61K31/40 , A61K38/1808 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2300/00 , C07K14/485 , C07K2317/70 , C07K2319/30 , C12N9/6454 , A61K31/22 , A61K31/365 , A61K31/366 , A61K31/404 , A61K31/505
摘要： The invention provides PCSK9-binding polypeptides and methods of using the same.
摘要翻译：本发明提供PCSK9结合多肽及其使用方法。

3. 发明申请

WO2012131504A1 PCSK9 VACCINE 审中-公开
公开(公告)号：WO2012131504A1
公开(公告)日：2012-10-04
申请号：PCT/IB2012/050924
申请日：2012-02-28
申请人： PFIZER INC. , CHAMPION, Brian, Robert , FRASER, James, Downey , SMITH, George, Joseph , LEES, Clare
发明人： CHAMPION, Brian, Robert , FRASER, James, Downey , SMITH, George, Joseph , LEES, Clare
IPC分类号： A61K39/00 , C07K17/00 , C07K7/04 , C07K14/47 , C12N9/64
CPC分类号： C12N9/6424 , A61K39/0005 , A61K2039/55505 , A61K2039/55561 , A61K2039/6037 , A61K2039/627 , C07K14/4747 , C12N9/6454 , C12Y304/21061
摘要： The present invention relates to the provision of novel immunogens comprising an antigenic PCSK9 peptide containing a phosphorylation site (with or without phosphorylation of the site) linked to an immunogenic carrier for the prevention, treatment or alleviation of PCSK9-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositions thereof and their use in medicine.
摘要翻译：本发明涉及提供包含与免疫原性载体连接的磷酸化位点（有或没有磷酸化位点）的抗原性PCSK9肽，用于预防，治疗或缓解PCSK9介导的病症。本发明还涉及这些药物的生产方法，免疫原性组合物及其药物组合物及其在药物中的用途。

4. 发明申请

WO2008141824A2 PREPARATIVE PURIFICATION PROCESS FOR HUMAN FURIN 审中-公开
标题翻译：人民币的准备性净化程序
公开(公告)号：WO2008141824A2
公开(公告)日：2008-11-27
申请号：PCT/EP2008/004090
申请日：2008-05-21
申请人： BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE S.A. , MATTHIESSEN, Peter , ROMEDER-FINGER, Stefan , TURECEK, Peter , SCHWARZ, Hans-Peter
发明人： MATTHIESSEN, Peter , ROMEDER-FINGER, Stefan , TURECEK, Peter , SCHWARZ, Hans-Peter
IPC分类号： C12N9/64
CPC分类号： C12N9/6454 , B01D15/363 , C12Y304/21075
摘要： Recombinant truncated human furin was expressed in CHO cells and concentrated approximately 50 -fold by ultrafiltration and diafiltration. The concentrate was purified by column chromatography on Capto-MMC™ resulting in a 30-50 fold purification factor and a yield of at least 60%. The at least 20% pure preparation obtained after Capto-MMC™ chromatography had already a purification degree allowing on-column maturation of pro-VWF. Then an additional Arginine Sepharose chromatography purification was carried out. This two column process for purification of truncated human furin resulted in an almost pure furin preparation with a specific activity of approximately 290,000 U furin/mg protein and a yield of about 50%.
摘要翻译：重组截短的人弗林蛋白在CHO细胞中表达，并通过超滤和渗滤浓缩约50倍。浓缩物通过Capto-MMC柱色谱纯化，得到30-50倍纯化因子，产率至少为60％。在Capto-MMC色谱上获得的至少20％的纯制剂已经具有允许原VWF的柱上成熟的纯化程度。然后进行额外的精氨酸琼脂糖层析纯化。用于纯化截短的人弗林蛋白酶的这种两柱方法产生几乎纯的弗林蛋白酶制剂，其具有约290,000U弗林蛋白/ mg蛋白质的比活性，约50％的产率。

5. 发明申请

WO2008066734A2 TRANSGENIC MAMMALS MODIFIED BRI PROTEIN EXPRESSION 审中-公开
标题翻译：转基因改造的BRI蛋白表达
公开(公告)号：WO2008066734A2
公开(公告)日：2008-06-05
申请号：PCT/US2007/024241
申请日：2007-11-20
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY , D'ADAMIO, Luciano , GILIBERTO, Luca
发明人： D'ADAMIO, Luciano , GILIBERTO, Luca
IPC分类号： A01K67/027
CPC分类号： A01K67/0278 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/0312 , A01K2267/0318 , C07K14/4711 , C07K14/705 , C12N9/6454 , C12N15/8509 , C12N2800/30 , C12N2830/008
摘要： Provided are non-human mammals comprising a transgenic nucleic acid sequence capable of causing an alteration of expression of Bri2 or Bri3 in the mammal. Also provided are non-human mammals comprising a Bri2 or Bri3 gene under the control of the native Bri2 or Bri3 promoter. Additionally provided are non-human mammals genetically engineered to lack expression of a Bri2 or Bri3 gene. Further, non-human mammals comprising a transgene encoding a Bri2 or Bri3 protein under the control of the αCaMK11 promoter are provided. Non- human mammals comprising a transgene encoding a furin protein are additionally provided. Embryonic stem cells of any of the above-described non-human mammals are further provided. Methods of screening a compound for treatment of a disease characterized by cerebral amyloidosis are additionally provided. Also provided are methods of making transgenic non- human mammals. Nucleic acids capable of causing an alteration of expression of Bri2 or BH3 if transfected into a mouse are additionally provided, as are comprising a sequence capable of causing an alteration of expression of Bri2 or Bri3 if transfected into a mouse.
摘要翻译：提供包含能够引起哺乳动物中Bri2或Bri3表达改变的转基因核酸序列的非人哺乳动物。还提供了包含在天然Bri2或Bri3启动子控制下的Bri2或Bri3基因的非人哺乳动物。另外提供了遗传工程化以减少Bri2或Bri3基因表达的非人类哺乳动物。此外，提供了包含编码aCaMK11启动子控制下的Bri2或Bri3蛋白的转基因的非人哺乳动物。另外提供了包含编码弗林蛋白蛋白的转基因的非人哺乳动物。进一步提供任何上述非人哺乳动物的胚胎干细胞。另外提供筛选用于治疗特征为脑淀粉样变性疾病的化合物的方法。还提供了制备转基因非人哺乳动物的方法。另外提供了如果转染到小鼠中能够引起Bri2或BH3表达改变的核酸，如同包含能够引起Bri2或Bri3表达改变的序列转染入小鼠的那样。

6. 发明申请

WO2007046781A8 FURIN INHIBITORS 审中-公开
标题翻译： FURIN抑制剂
公开(公告)号：WO2007046781A8
公开(公告)日：2007-07-26
申请号：PCT/US2005026086
申请日：2005-07-22
申请人： SMITH JUDITH
发明人： SMITH ROBERT E
IPC分类号： A61K38/00
CPC分类号： C07K7/06 , A61K38/00 , C12N9/6454
摘要： Inhibitors for the endoprotease furin are provided for the prevention, diagnosis, treatment, and study of human and animal pathologies, which involve furin activity. These pathologies include infections caused by bacteria and virus that exploit host furin activity. These pathologies also include diseases that involve the expression of host proproteins that are processed by furin as a part of growth, development, and maintenance of the host organism including certain cancers of the head and neck.
摘要翻译：内切蛋白酶弗林蛋白酶抑制剂用于预防，诊断，治疗和研究涉及弗林蛋白酶活性的人类和动物病理学。这些病理学包括由利用弗林蛋白酶宿主活性的细菌和病毒引起的感染。这些病理还包括涉及表达由弗林蛋白酶加工的宿主蛋白质的疾病，作为包括某些头颈部癌症的宿主生物体的生长，发育和维持的一部分。

7. 发明申请

WO2004101740A2 CLOTTING FACTOR-FC CHIMERIC PROTEINS TO TREAT HEMOPHILIA 审中-公开
标题翻译： CLOTTING因子-FC CHIMERIC蛋白质治疗HEMOPHILIA
公开(公告)号：WO2004101740A2
公开(公告)日：2004-11-25
申请号：PCT/US2004/013940
申请日：2004-05-06
申请人： SYNTONIX PHARMACEUTICALS, INC. , RIVERA, Daniel, S. , PETERS, Robert, T. , BITONTI, Alan, J.
发明人： RIVERA, Daniel, S. , PETERS, Robert, T. , BITONTI, Alan, J.
IPC分类号： C12N
CPC分类号： C12N9/6437 , A61K38/36 , A61K38/4846 , A61K45/06 , A61K47/6815 , A61K47/6835 , A61K2039/60 , C07K14/745 , C07K16/18 , C07K2319/30 , C12N9/644 , C12N9/6454 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to a chimeric protein comprising at least one clotting factor and at least a portion of an immunoglobulin constant region. The invention relates to a method of treating a hemostatic disorder comprising administering a therapeutically effective amount of a chimeric protein wherein the chimeric protein comprises at least one clotting factor and at least a portion of an immunoglobulin constant region.
摘要翻译：本发明涉及包含至少一种凝血因子和至少一部分免疫球蛋白恒定区的嵌合蛋白。本发明涉及治疗止血障碍的方法，包括施用治疗有效量的嵌合蛋白，其中所述嵌合蛋白包含至少一种凝血因子和至少一部分免疫球蛋白恒定区。

8. 发明申请

WO01072991A1 A NEW POLYPEPTIDE-HUMAN ATP-DEPENDENT SERINE PROTEASE 9.8 AND THE POLYNUCLEOTIDE ENCODING IT 审中-公开
公开(公告)号：WO01072991A1
公开(公告)日：2001-10-04
申请号：PCT/CN2001/000509
申请日：2001-03-26
IPC分类号： A61K38/00 , C12N9/64 , C12N15/55 , C12N9/50 , A61K38/48 , A61P35/00 , A61P37/00 , C12N15/12 , C12N15/63 , C12N15/85
CPC分类号： C12N9/6454 , A61K38/00
摘要： The present invention discloses a new polypeptide-human ATP-dependent serine protease 9.8, the polynucleotide encoding it and a method producing the polypeptide by DNA recombinant technology. The present invention further discloses a method treating various disorders, e.g., malignant neoplasm, hematopathy, HIV infection and immunological disease and various inflammations etc.. The present invention also discloses an antagonist of the polypeptide and its therapeutic action. The present invention further discloses the use of the polynucleotide encoding the new human ATP-dependent serine protease 9.8

9. 发明申请

WO01068862A1 INSULIN HOMOLOG POLYPEPTIDE ZINS4 审中-公开
标题翻译：胰岛素同源多肽ZINS4
公开(公告)号：WO01068862A1
公开(公告)日：2001-09-20
申请号：PCT/US2001/004199
申请日：2001-02-09
IPC分类号： C12N15/09 , A61K38/00 , A61P9/00 , A61P15/00 , A61P15/04 , A61P15/08 , A61P25/00 , C07K14/62 , C07K14/64 , C07K16/26 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/64 , C12N15/17 , C12P21/02
CPC分类号： C12N9/6454 , C07K14/62 , C07K14/64
摘要： The present invention relates to polynucleotide and polypeptide molecules for zins4, a novel polypeptide having homology to the relaxins. The polynucleotides encoding zins4, may, for example, be used to identify a region of the genome associated with human diesease states. The present invention also includes methods for producing the protein, uses thereof and antibodies thereto.
摘要翻译：本发明涉及zins4的多核苷酸和多肽分子，一种与松弛素具有同源性的新型多肽。编码zins4的多核苷酸可以例如用于鉴定与人类死亡状态相关的基因组的区域。本发明还包括生产蛋白质的方法，其用途和抗体。

10. 发明申请

WO0009677A3 STEROL-REGULATED SITE-1 PROTEASE AND ASSAYS OF MODULATORS THEREOF 审中-公开
标题翻译： STEROL-调节的SITE-1蛋白酶及其调节剂的测定
公开(公告)号：WO0009677A3
公开(公告)日：2000-06-15
申请号：PCT/US9918544
申请日：1999-08-13
申请人： UNIV TEXAS , BROWN MICHAEL S , CHENG DONG , ESPENSHADE PETER J , GOLDSTEIN JOSEPH L , RAWSON ROBERT B , SAKAI JURO
发明人： BROWN MICHAEL S , CHENG DONG , ESPENSHADE PETER J , GOLDSTEIN JOSEPH L , RAWSON ROBERT B , SAKAI JURO
IPC分类号： C12N9/64 , C12N15/57 , A01K67/027 , A61K38/55 , C07K14/81 , C12N5/10
CPC分类号： C12N9/6454 , A01K2217/05 , C07K2319/00
摘要： The invention provides assays for the identification of modulators of Site-1 protease. Further provided by the invention are expression constructs and the transgenic cells useful for the development of such assays for Site-1 specific protease. The cells allow the implementation of both in vivo and in vitro assays for potential modulators of Site-specific proteases. Still further provided by the invention are in vitro assays employing Site-1 protease which has been isolated from cells.
摘要翻译：本发明提供了用于鉴定位点-1蛋白酶调节剂的测定。本发明进一步提供了表达构建体和用于开发用于Site-1特异性蛋白酶的这种测定的转基因细胞。该细胞允许实施位点特异性蛋白酶潜在调节剂的体内和体外测定。本发明进一步提供的是采用从细胞分离的Site-1蛋白酶的体外测定。

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