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1. 发明申请

WO2011073381A1 POWER DRILL WITH ADVANCE SPEED SHIFTING MEANS 审中-公开
标题翻译：电动钻具具有先进的速度移动方式
公开(公告)号：WO2011073381A1
公开(公告)日：2011-06-23
申请号：PCT/EP2010/070053
申请日：2010-12-17
申请人： ATLAS COPCO TOOLS AB , JACOBSSON, WILHELM Mattias , ERIKSSON, Ulf Mikael
发明人： JACOBSSON, WILHELM Mattias , ERIKSSON, Ulf Mikael
IPC分类号： B23Q5/32 , B23Q5/40 , F16H25/20
CPC分类号： B23Q5/402 , B23Q5/326
摘要： A power drill including a housing (10,14), a drill spindle (12) carrying a drill bit (13), a drive unit (11) arranged to rotate and move the drill spindle (12) longitudinally between a forward end position and a rear end position, a drive unit (11) arranged to apply a rotational as well as longitudinal movement on the drill spindle (12), a control system for governing the operation of the drive unit (11) and comprising a first switching device (21) arranged to be activated in the forward end position of the drill spindle (12) by a first cam element (20) attached to the drill spindle (12), a second switching device (23) arranged to be activated in the rear end position of the drill spindle (12) by a second cam element (22) attached to the drill spindle (12), and a third switching device (25) adjustably attached to the housing (10,14) and arranged to be activated by the first cam element (20) in a desired advance speed shifting position of the drill spindle (12).
摘要翻译：一种动力钻，包括壳体（10,14），承载钻头（13）的钻轴（12），驱动单元（11），其布置成在前端位置和后端位置，驱动单元（11），被布置成在所述钻轴（12）上施加旋转和纵向运动;控制系统，用于控制所述驱动单元（11）的操作并且包括第一开关装置 21），其布置成通过附接到所述钻轴（12）的第一凸轮元件（20）在所述钻轴（12）的前端位置中被致动;第二开关装置（23），被布置成在所述后端钻头主轴（12）由安装在钻杆（12）上的第二凸轮元件（22）的位置，以及第三开关装置（25），可调节地连接到壳体（10,14）上，所述第一凸轮元件（20）处于所述钻轴（12）的期望的前进变速位置。

2. 发明申请

WO2007136679A3 TARGETING VEGF-B REGULATION OF FATTY ACID TRANSPORTERS TO MODULATE HUMAN DISEASES 审中-公开
标题翻译：针对脂肪酸转运蛋白调控人类疾病的VEGF-B调控
公开(公告)号：WO2007136679A3
公开(公告)日：2008-12-11
申请号：PCT/US2007011788
申请日：2007-05-17
申请人： LUDWIG INST CANCER RES , ERIKSSON ULF
发明人： ERIKSSON ULF
IPC分类号： A61K39/395 , C07K16/00 , C07K16/22 , C12P21/08
CPC分类号： A61K39/3955 , A61K31/7088 , A61K45/06 , A61K2039/505 , C07K16/22
摘要： The present invention provides materials and methods for modulating FATP expression and/or activity in
摘要翻译：本发明提供用于调节FATP表达和/或活性的材料和方法

3. 发明申请

WO2007124308A2 METHODS AND COMPOSITIONS FOR MODULATION OF BLOOD-NEURAL BARRIER 审中-公开
标题翻译：血液 - 神经阻滞剂调制方法及组合物
公开(公告)号：WO2007124308A2
公开(公告)日：2007-11-01
申请号：PCT/US2007/066804
申请日：2007-04-17
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , ERIKSSON, Ulf , LAWRENCE, Daniel , SU, Enming, Joe , STRICKLAND, Dudley , YEPPES, Manuel , FREDRIKSSON, Linda
发明人： ERIKSSON, Ulf , LAWRENCE, Daniel , SU, Enming, Joe , STRICKLAND, Dudley , YEPPES, Manuel , FREDRIKSSON, Linda
CPC分类号： C07K16/2863 , A61K9/0019 , A61K38/43 , A61K39/39533 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/76 , C12N9/6454
摘要： Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-α antagonist.
摘要翻译：用于调节血液神经屏障（BNB）的方法和组合物用于治疗中枢神经系统疾病如水肿，以及用于增加穿过BNB的药物递送功效。本发明还涉及改善的缺血性脑血管和相关疾病的tPA治疗以及PDGF信号通路的拮抗作用。本发明的方法和组合物特别适用于使用tPA和抗PDGF-C拮抗剂或抗PDGFR-a拮抗剂的缺血性卒中的联合治疗。

4. 发明申请

WO2005040194A3 METHODS AND COMPOSITIONS FOR PDGF-C ACTIVATION AND INHIBITION 审中-公开
标题翻译： PDGF-C激活和抑制的方法和组合
公开(公告)号：WO2005040194A3
公开(公告)日：2007-06-28
申请号：PCT/US2004035248
申请日：2004-10-25
申请人： LUDWIG INST CANCER RES , FREDRIKSSON LINDA , LI HONG , FIEBER CHRISTINA , LI XURI , ERIKSSON ULF
发明人： FREDRIKSSON LINDA , LI HONG , FIEBER CHRISTINA , LI XURI , ERIKSSON ULF
IPC分类号： A61K39/395 , A61K38/16 , A61K38/43 , C07K20060101 , C07K14/49 , C07K16/22 , C07K16/40 , C12N9/72 , C12N9/99
CPC分类号： C07K16/22 , A61K2039/505 , C07K14/49 , C07K14/8132 , C07K16/40 , C12N9/6459 , C12N9/99 , C12Y304/21069
摘要： Methods for inhibiting angiogenesis comprising administering tissue-plasminogen activator (tPA) inhibitors, and pharmaceutical compositions suitable for the methods comprising the tPA inhibitors. Also provided are methods for stimulating angiogenesis comprising administering tPA to a patient in need thereof, and pharmaceutical compositions comprising an effective amount of tPA for the methods of stimulation. The present invention discloses that tPA is a specific PDGF-C activating protease, and that the CUB-domains in PDGF-CC directly interact with the protease, are required for efficient proteolysis, and released CUB-domains are tPA inhibitors. Preferably, the method and compositions of the present invention are used for simultaneously stimulating, or simultaneously inhibiting, thrombolysis and angiogenesis.
摘要翻译：抑制血管发生的方法包括施用组织纤溶酶原激活剂（tPA）抑制剂和适用于包含tPA抑制剂的方法的药物组合物。还提供了用于刺激血管生成的方法，其包括向有需要的患者施用tPA，以及包含用于刺激方法的有效量的tPA的药物组合物。本发明公开了tPA是特异性PDGF-C活化蛋白酶，PDGF-CC中的CUB结构域与蛋白酶直接相互作用，是有效的蛋白水解所必需的，而释放的CUB结构域是tPA抑制剂。优选地，本发明的方法和组合物用于同时刺激或同时抑制溶栓和血管发生。

5. 发明申请

WO2006074830A1 A PRE-HEATER FOR AN APPARATUS FOR THE PRODUCTION OF CARBON BLACK 审中-公开
标题翻译：一种用于生产炭黑的装置的预热器
公开(公告)号：WO2006074830A1
公开(公告)日：2006-07-20
申请号：PCT/EP2005/055205
申请日：2005-10-12
申请人： SANDVIK INTELLECTUAL PROPERTY AB , ERIKSSON, Ulf , DAHLSTEDT, Fredrik
发明人： ERIKSSON, Ulf , DAHLSTEDT, Fredrik
IPC分类号： F28F9/007 , F28D7/16 , C09C1/48
CPC分类号： C09C1/48 , F28D7/16 , F28F9/007 , F28F2265/26
摘要： A pre-heater for an apparatus for the production of carbon black, is adapted to pre-heat air by heat exchange (1) to a temperature of at least 800°C, comprises an elongated jacket (10) arranged substantially and having a top end and a bottom end, said jacket defining a space, a plurality of tubings (23) arranged inside said space, said tubings having a diametre of 85 to 90 mm, said jacket (10) being provided with an air inlet and an air outlet, for allowing said air to enter and exit said space, a smoke inlet chamber (24) and a smoke collection chamber (27b) for allowing smoke to enter and exit said tubing (23) . Said jacket (10) is supported by a suspension means (26) between said top and bottom ends excluding at the top end as such, such that the jacket is allowed to expand upwards above and downwards below said suspension means (26) .
摘要翻译：用于生产炭黑的设备的预热器适于通过热交换（1）将空气预热至至少800℃的温度，包括基本上布置有顶部的细长护套（10）端部和底端，所述护套限定空间;布置在所述空间内的多个管道（23），所述管道的直径为85至90mm，所述护套（10）设置有空气入口和空气出口，用于允许所述空气进入和离开所述空间，烟雾入口室（24）和烟雾收集室（27b），用于允许烟雾进入和离开所述管道（23）。所述夹套（10）由顶部和底部端部之间的顶端和底端之间的悬挂装置（26）支撑，使得所述夹套允许在所述悬挂装置（26）下方向上和向下扩展。

6. 发明申请

WO2005086684A2 METHOD FOR MODULATING, REGULATING AND/OR STABILIZING ANGIOGENESIS 审中-公开
标题翻译：调节，调节和/或稳定血管生成的方法
公开(公告)号：WO2005086684A2
公开(公告)日：2005-09-22
申请号：PCT/US2005/007065
申请日：2005-03-08
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , ALITALO, Kari , ERIKSSON, Ulf , UUTELA, Marko, J. T.
发明人： ALITALO, Kari , ERIKSSON, Ulf , UUTELA, Marko, J. T.
IPC分类号： A61K38/18 , A61K48/00
CPC分类号： A61K38/1858 , A61K48/00
摘要： A method of modulating, regulating and/or stabilizing angiogenesis in a mammal in which an active PDGF-D or a polynucleotide encoding an active PDGF-D is administered to the mammal. The PDGF-D is advantageously co-adminstered with an angiogenic growth factor, such as a member of the VEGF family of growth factors. The claimed method inhibits leakage of blood vessels and is useful, inter alia, for treatment of edemas.
摘要翻译：在哺乳动物中调节，调节和/或稳定血管发生的方法，其中向哺乳动物施用活性PDGF-D或编码活性PDGF-D的多核苷酸。 PDGF-D有利地与血管生成生长因子共同施用，例如VEGF家族生长因子的成员。所要求保护的方法抑制血管渗漏，尤其用于治疗水肿。

7. 发明申请

WO2005084329A2 METHOD FOR INHIBITING TUMOR FORMATION AND GROWTH 审中-公开
标题翻译：抑制肿瘤形成和增长的方法
公开(公告)号：WO2005084329A2
公开(公告)日：2005-09-15
申请号：PCT/US2005006725
申请日：2005-03-02
申请人： LUDWIG INST CANCER RES , LI XURI , ERIKSSON ULF
发明人： LI XURI , ERIKSSON ULF
IPC分类号： A61K39/395 , C07K16/22 , C07K16/30
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/30 , C07K2317/76
摘要： Method for inhibiting tumor cell formation or tumor cell growth, the method comprising administering to a patient in need thereof an antagonist to VEGF-B. Preferably, the antagonist is an anti-VEGF-B antibody, an antisense molecule, an RNAi molecule, a molecule for forming a triplex nucleic acid molecule with a VEGF-B encoding polynucleotide. Also disclosed are pharmaceutical compositions comprising the same.
摘要翻译：用于抑制肿瘤细胞形成或肿瘤细胞生长的方法，所述方法包括向有需要的患者施用VEGF-B的拮抗剂。优选地，拮抗剂是抗VEGF-B抗体，反义分子，RNAi分子，用于形成具有VEGF-B编码多核苷酸的三重核酸分子的分子。还公开了包含其的药物组合物。

8. 发明申请

WO2005040194A2 METHODS AND COMPOSITIONS FOR PDGF-C ACTIVATION AND INHIBITION 审中-公开
标题翻译： PDGF-C激活和抑制的方法和组合
公开(公告)号：WO2005040194A2
公开(公告)日：2005-05-06
申请号：PCT/US2004/035248
申请日：2004-10-25
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , FREDRIKSSON, Linda , LI, Hong , FIEBER, Christina , LI, Xuri , ERIKSSON, Ulf
发明人： FREDRIKSSON, Linda , LI, Hong , FIEBER, Christina , LI, Xuri , ERIKSSON, Ulf
IPC分类号： C07K
CPC分类号： C07K16/22 , A61K2039/505 , C07K14/49 , C07K14/8132 , C07K16/40 , C12N9/6459 , C12N9/99 , C12Y304/21069
摘要： Methods for inhibiting angiogenesis comprising administering tissue-plasminogen activator (tPA) inhibitors, and pharmaceutical compositions suitable for the methods comprising the tPA inhibitors. Also provided are methods for stimulating angiogenesis comprising administering tPA to a patient in need thereof, and pharmaceutical compositions comprising an effective amount of tPA for the methods of stimulation. The present invention discloses that tPA is a specific PDGF-C activating protease, and that the CUB-domains in PDGF-CC directly interact with the protease, are required for efficient proteolysis, and released CUB-domains are tPA inhibitors. Preferably, the method and compositions of the present invention are used for simultaneously stimulating, or simultaneously inhibiting, thrombolysis and angiogenesis.
摘要翻译：抑制血管发生的方法包括施用组织纤溶酶原激活剂（tPA）抑制剂和适用于包含tPA抑制剂的方法的药物组合物。还提供了用于刺激血管生成的方法，其包括向有需要的患者施用tPA，以及包含用于刺激方法的有效量的tPA的药物组合物。本发明公开了tPA是特异性PDGF-C活化蛋白酶，PDGF-CC中的CUB结构域与蛋白酶直接相互作用，是有效的蛋白水解所必需的，而释放的CUB结构域是tPA抑制剂。优选地，本发明的方法和组合物用于同时刺激或同时抑制溶栓和血管发生。

9. 发明申请

WO2005084329A8 METHOD FOR INHIBITING TUMOR FORMATION AND GROWTH 审中-公开
标题翻译：抑制肿瘤形成和增长的方法
公开(公告)号：WO2005084329A8
公开(公告)日：2008-05-02
申请号：PCT/US2005006725
申请日：2005-03-02
申请人： LUDWIG INST CANCER RES , LI XURI , ERIKSSON ULF
发明人： LI XURI , ERIKSSON ULF
IPC分类号： A61K39/395 , A61K31/713 , A61K39/44 , A61K49/16 , C07K16/22 , C07K16/30
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/30 , C07K2317/76
摘要： Method for inhibiting tumor cell formation or tumor cell growth, the method comprising administering to a patient in need thereof an antagonist to VEGF-B. Preferably, the antagonist is an anti-VEGF-B antibody, an antisense molecule, an RNAi molecule, a molecule for forming a triplex nucleic acid molecule with a VEGF-B encoding polynucleotide. Also disclosed are pharmaceutical compositions comprising the same.
摘要翻译：用于抑制肿瘤细胞形成或肿瘤细胞生长的方法，所述方法包括向有需要的患者施用VEGF-B的拮抗剂。优选地，拮抗剂是抗VEGF-B抗体，反义分子，RNAi分子，用于形成具有VEGF-B编码多核苷酸的三重核酸分子的分子。还公开了包含其的药物组合物。

10. 发明申请

WO2007136679A2 TARGETING VEGF-B REGULATION OF FATTY ACID TRANSPORTERS TO MODULATE HUMAN DISEASES 审中-公开
标题翻译：针对脂肪酸转运蛋白调控人类疾病的VEGF-B调控
公开(公告)号：WO2007136679A2
公开(公告)日：2007-11-29
申请号：PCT/US2007/011788
申请日：2007-05-17
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , ERIKSSON, Ulf
发明人： ERIKSSON, Ulf
IPC分类号： A61K39/395
CPC分类号： A61K39/3955 , A61K31/7088 , A61K45/06 , A61K2039/505 , C07K16/22
摘要： The present invention provides materials and methods for modulating FATP expression and/or activity in vivo . The materials and methods have numerous diagnostic, prophylactic, and therapeutic applications for various diseases and conditions that are influenced by FATPs, or characterized by excessive or inadequate FATP expression or activity.
摘要翻译：本发明提供了用于在体内调节FATP表达和/或活性的材料和方法。

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