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1. 发明申请

WO2009077913A1 MICROFLUIDIC DEVICE AND METHOD OF MANUFACTURING THE SAME AND SENSOR INCORPORATING THE SAME 审中-公开
标题翻译：微流体装置及其制造方法和与其同时进行的传感器
公开(公告)号：WO2009077913A1
公开(公告)日：2009-06-25
申请号：PCT/IB2008/055142
申请日：2008-12-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WIMBERGER-FRIEDL, Reinhold , PENTERMAN, Roel , KURT, Ralph , PEETERS, Emiel
发明人： WIMBERGER-FRIEDL, Reinhold , PENTERMAN, Roel , KURT, Ralph , PEETERS, Emiel
IPC分类号： B01L3/00 , C12M1/34
CPC分类号： B01L3/5023 , B01L3/502753 , B01L2200/12 , B01L2300/0636 , B01L2300/0654 , B01L2300/0681 , B01L2300/069 , B01L2300/0887 , B01L2300/168 , B01L2400/0406 , B01L2400/0487 , B01L2400/065 , Y10T29/49826
摘要： The present invention provides a microf luidic device, for instance for molecular sieving or for detecting a target substance in a sample fluid. The device comprises a first substrate (120) having a substantially flat first surface that is provided with first recesses (124), and a second substrate (128) having a substantially flat second surface that is provided with second recesses (130). At least some of the first recesses are filled with a porous material (114). Alternate first recesses and second recesses form a meandering channel for a sample fluid. The second recesses may be filled with a further porous material. In an embodiment, a capture substance for binding a target substance is arranged in or on the porous material.
摘要翻译：本发明提供微流控装置，例如用于分子筛或用于检测样品流体中的目标物质。该装置包括具有基本上平坦的第一表面的第一基底（120），第一基底具有第一凹槽（124），第二基底（128）具有基本平坦的第二表面，该第二基底具有第二凹槽（130）。至少一些第一凹部填充有多孔材料（114）。替代的第一凹槽和第二凹槽形成用于样品流体的曲折通道。第二凹部可以被另外的多孔材料填充。在一个实施方案中，用于结合目标物质的捕获物质被布置在多孔材料中或其上。

2. 发明申请

WO2008020397A2 PHASE-SEPARATED COMPOSITE FOR MICROFLUIDIC APPLICATIONS 审中-公开
标题翻译：用于微流体应用的相分离复合材料
公开(公告)号：WO2008020397A2
公开(公告)日：2008-02-21
申请号：PCT/IB2007/053217
申请日：2007-08-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PENTERMAN, Roel , WIMBERGER-FRIEDL, Reinhold , KURT, Ralph , BROER, Dirk, J. , PEETERS, Emiel , DE KONING, Hendrik
发明人： PENTERMAN, Roel , WIMBERGER-FRIEDL, Reinhold , KURT, Ralph , BROER, Dirk, J. , PEETERS, Emiel , DE KONING, Hendrik
IPC分类号： B81C1/00 , B01L3/00
CPC分类号： B81C1/00071 , B01L3/502707 , B01L2200/12 , B01L2300/12 , Y10T428/24612
摘要： The invention relates to phase-separated composite for microfluidic applications, whereby the polymerization /phase separation is performed in such a way that a top-layer of a certain ratio to the height of the composite is achieved in order to ensure the stability of the composite.
摘要翻译：本发明涉及用于微流体应用的相分离复合物，其中聚合/相分离是以这样的方式进行的，即相对于复合物的高度达到一定比例的顶层为了确保复合材料的稳定性。

3. 发明申请

WO2011048521A1 MICROFLUIDIC CARTRIDGE WITH PARALLEL PNEUMATIC INTERFACE PLATE 审中-公开
标题翻译：具有平行气动界面板的微流体盒
公开(公告)号：WO2011048521A1
公开(公告)日：2011-04-28
申请号：PCT/IB2010/054520
申请日：2010-10-06
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WIMBERGER-FRIEDL, Reinhold , PENTERMAN, Roel , VAN AMERONGEN, Hendrik, Halling , LORING, Theodorus, Antonius, Johannes , VAN UDEN, Martijn, Jochem
发明人： WIMBERGER-FRIEDL, Reinhold , PENTERMAN, Roel , VAN AMERONGEN, Hendrik, Halling , LORING, Theodorus, Antonius, Johannes , VAN UDEN, Martijn, Jochem
IPC分类号： B01L3/00 , F04B19/00 , F16K99/00
CPC分类号： B01L3/502738 , B01L3/502715 , B01L3/50273 , B01L2300/0809 , B01L2300/0874 , B01L2300/123 , B01L2300/1805 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , F04B19/006 , F04B43/043 , F04B43/06 , F16K99/0001 , F16K99/0015 , F16K99/0059 , F16K2099/0084 , Y10T137/85978
摘要： The invention relates to a design of an interface plate (101) between a microfluidic cartridge (100) and an instrument (102) for fluid actuation in the disposable cartridge. Pneumatic actuation is carried out through a reversible pneumatic interconnection between instrument and cartridge. Pneumatic drivers are integrated in the instrument for a low cost and reliable solution. The actuation of the fluid in the cartridge is achieved by a flexible membrane (105) attached to the major surface of the disposable cartridge forming closed compartments only when attached to the instrument. The pressure, in these compartments determines the deflection of the membrane which in turn actuates the fluid. This approach takes advantage of the high power and large stroke of pneumatic actuation while at the same time keeping the disposable cartridge simple and low cost and allowing easy introduction of other physical transport across the interface plate, like heat or acoustic vibration. A large number of actuators can be integrated easily into the flat interface plate as no individual fixation, like tubing, is required for the pneumatic actuation.
摘要翻译：本发明涉及一种用于在一次性盒中流体致动的微流体盒（100）和仪器（102）之间的界面板（101）的设计。通过仪器和墨盒之间的可逆气动连接进行气动启动。气动驱动器集成在仪器中，成本低廉可靠。药筒中的流体的致动是通过附接到一次性药筒的主表面的柔性膜（105）来实现的，所述柔性膜仅在附接到器械时形成闭合隔间。在这些隔室中的压力决定了膜的偏转，其又致动流体。这种方法利用了气动致动的大功率和大冲程，同时保持了一次性盒的简单和低成本，并且允许容易地通过界面板引入其他物理传输，如热或声振动。大量的致动器可以容易地集成到平面接口板中，因为气动致动不需要单独的固定，如管道。

4. 发明申请

WO2012098214A1 MICRO-PUMP OR NORMALLY-OFF MICRO-VALVE 审中-公开
标题翻译：微型泵或常规微型阀
公开(公告)号：WO2012098214A1
公开(公告)日：2012-07-26
申请号：PCT/EP2012/050835
申请日：2012-01-20
申请人： BIOCARTIS S.A. , PENTERMAN, Roel , VAN EEMEREN, Johannes , WIMBERGER-FRIEDL, Reinhold , VAN AMERONGEN, Henrik
发明人： PENTERMAN, Roel , VAN EEMEREN, Johannes , WIMBERGER-FRIEDL, Reinhold , VAN AMERONGEN, Henrik
IPC分类号： F16K99/00
CPC分类号： F16K51/00 , B01L3/502738 , B01L2300/0874 , B01L2300/0887 , B01L2400/0655 , F16K99/0001 , F16K99/0015 , F16K99/0057 , F16K99/0059 , F16K2099/008 , F16K2099/0084 , F16K2099/0094 , Y10T137/794
摘要： The invention relates to a micro valve for use in a biosensor, a micro fluidic device, use of such a device, and a micro fluidic element. Biosensors are used for detection of molecules and/or ions, such as protein, drug, DNA, RNA, hormone, glucose, insulin, enzyme, fungus, bacterium, etc., in a biological sample. The sensor can be used for diagnostic application, but for instance also drugs, either therapeutic or abuse, may be detected in for instance blood, urine and saliva.
摘要翻译：本发明涉及用于生物传感器的微型阀，微流体装置，这种装置的使用以及微流体元件。生物传感器用于检测生物样品中的分子和/或离子，例如蛋白质，药物，DNA，RNA，激素，葡萄糖，胰岛素，酶，真菌，细菌等。该传感器可以用于诊断应用，但是例如也可以在例如血液，尿液和唾液中检测治疗或滥用的药物。

5. 发明申请

WO2010049883A1 BIOSENSOR WITH MULTI-CHAMBER CARTRIDGE 审中-公开
标题翻译：生物传感器与多个盒子
公开(公告)号：WO2010049883A1
公开(公告)日：2010-05-06
申请号：PCT/IB2009/054740
申请日：2009-10-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NEIJZEN, Jacobus, H., M. , WIMBERGER-FRIEDL, Reinhold , MAAS, Joost, H. , NIEUWENHUIS, Jeroen, H. , BRULS, Dominique, M. , IMMINK, Albert, H., J. , OVSYANKO, Mikhail, M.
发明人： NEIJZEN, Jacobus, H., M. , WIMBERGER-FRIEDL, Reinhold , MAAS, Joost, H. , NIEUWENHUIS, Jeroen, H. , BRULS, Dominique, M. , IMMINK, Albert, H., J. , OVSYANKO, Mikhail, M.
IPC分类号： G01N33/543 , G01N35/00 , G01R33/00
CPC分类号： G01N33/54326 , B01L3/502761 , B82Y25/00 , G01N27/745 , G01R33/093 , G01R33/1269
摘要： The present invention provides a biosensor comprising a cartridge for accommodating a fluid sample, the cartridge comprising at least two chambers, wherein each chamber comprises a sensor surface with one or more binding sites. The biosensor further comprises means for generating a magnetic field at the binding sites of the sensor surfaces of the at least two chambers. The biosensor also comprises means for detecting particles accumulated at/and or proximate the binding sites of the sensor surfaces of the at least two chambers. Therein, the magnetic field at the binding sites has a sufficiently large gradient to actuate magnetic label particles towards the binding sites.
摘要翻译：本发明提供了一种生物传感器，其包括用于容纳流体样品的盒，所述盒包括至少两个室，其中每个室包括具有一个或多个结合位点的传感器表面。生物传感器还包括用于在至少两个室的传感器表面的结合位置处产生磁场的装置。生物传感器还包括用于检测在至少两个室的传感器表面的结合位点处和/或附近堆积的颗粒的装置。其中，结合位点处的磁场具有足够大的梯度以朝向结合位点致动磁性标记颗粒。

6. 发明申请

WO2009098624A1 ANALYSIS SYSTEM AND METHOD 审中-公开
标题翻译：分析系统和方法
公开(公告)号：WO2009098624A1
公开(公告)日：2009-08-13
申请号：PCT/IB2009/050397
申请日：2009-02-02
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN DIJK, Erik, M., H., P. , BOAMFA, Marinus, I. , WIMBERGER-FRIEDL, Reinhold
发明人： VAN DIJK, Erik, M., H., P. , BOAMFA, Marinus, I. , WIMBERGER-FRIEDL, Reinhold
IPC分类号： G01N21/64 , G01J3/44 , C12Q1/68
CPC分类号： G01N21/6428 , G01J3/10 , G01J3/36 , G01J3/4406 , G01J2003/104 , G01N21/645 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6471 , G01N2201/0221 , G01N2201/0627 , G01N2201/0691
摘要： An analysis system (101, 102) detects multiple radiation outputs from a sample (400) being analyzed. A radiation source (101, 102) generates input radiation comprising frequency components in multiple frequency bands, with the frequency components being independently controllable. A plurality of detectors (701, 702) are used and a (fixed) filter arrangement (601, 602) with multiple pass bands is associated with each detector. The detector signals can be processed to determine the levels of output radiation from the sample at a plurality of frequencies greater in number than the number of detectors, without having to move any filters.
摘要翻译：分析系统（101,102）检测来自被分析的样品（400）的多个辐射输出。辐射源（101,102）产生包括多个频带中的频率分量的输入辐射，频率分量是独立可控的。使用多个检测器（701,702），并且具有多个通带的（固定）滤波器装置（601,602）与每个检测器相关联。可以处理检测器信号以确定来自样品的输出辐射的水平，其数量大于检测器的数量，而不必移动任何滤波器。

7. 发明申请

WO2006123267A3 FUNCTIONAL ASSEMBLY AND METHOD OF OBTAINING IT 审中-公开
公开(公告)号：WO2006123267A3
公开(公告)日：2006-11-23
申请号：PCT/IB2006/051401
申请日：2006-05-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WIMBERGER-FRIEDL, Reinhold
发明人： WIMBERGER-FRIEDL, Reinhold
IPC分类号： B01L3/00 , G01N35/10
摘要： The invention relates to a functional assembly, for instance a biosensor , and to a method to obtain it . The assembly comprises a functional element (2) , aimed to interact at its functional side with a sample fluid, and, electrically connected thereto through electrical connection means , an interconnect substrate (4) for supporting the element and transmitting signals . The interconnect substrate is provided with, an opening that gives access to the functional side of the functional element. The transition of the opening to the functional element is formed by a sidewall (5a) , extending subs tantially over the circumference of the opening , whereby the average slope of the sidewall (5a) with respect to the plane (5b) of the functional element is less than 60 degrees. The assembly provides a transition to the functional element (2), having smooth and self-stratifying sidewalls, which allows a homogeneous filling of only small amounts of sample fluids .

8. 发明申请

WO2005057255A3 COLLIMATOR 审中-公开
公开(公告)号：WO2005057255A3
公开(公告)日：2005-06-23
申请号：PCT/IB2004/052708
申请日：2004-12-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HIKMET, Rifat, A., M. , VAN BOMMEL, Ties , VAN DE WITTE, Peter , WIMBERGER-FRIEDL, Reinhold , BURDINSKI, Dirk
发明人： HIKMET, Rifat, A., M. , VAN BOMMEL, Ties , VAN DE WITTE, Peter , WIMBERGER-FRIEDL, Reinhold , BURDINSKI, Dirk
IPC分类号： G02B5/00
摘要： A collimator panel comprises: a solid panel having a first face for receiving uncollimated radiation and a second opposite face for providing collimated radiation; and a plurality of elongate particles disposed in the panel and orientated to provide the collimating function. A method of manufacturing a collimator panel comprises the steps of: suspending a plurality of elongate particles in a liquid; applying an electric or magnetic field to the suspension to orientate the particles; and solidifying the liquid to fix the orientation of the particles, thereby forming a collimator panel. A method of manufacturing the elongate particles is also provided.

9. 发明申请

WO2012127413A1 METHOD FOR PERFORMING MOLECULAR REACTIONS BY USING IMMISCIBLE INTERMEDIATE FLUIDS 审中-公开
标题翻译：通过使用可疑中间流体进行分子反应的方法
公开(公告)号：WO2012127413A1
公开(公告)日：2012-09-27
申请号：PCT/IB2012/051319
申请日：2012-03-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WIMBERGER-FRIEDL, Reinhold , VAN DER ZAAG, Pieter, Jan , SERVOLI, Eva
发明人： WIMBERGER-FRIEDL, Reinhold , VAN DER ZAAG, Pieter, Jan , SERVOLI, Eva
IPC分类号： B01L3/00 , C12Q1/68 , B01J19/00 , G01N35/08
CPC分类号： C12Q1/6869 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2200/16 , B01L2300/0636 , B01L2300/088 , B01L2400/0487 , G01N35/08
摘要： The present invention relates to a method for performing molecular reactions in a device comprising the steps of (a) introducing one or more reagent solution(s) and an immiscible intermediate fluid into the device, wherein the device comprises a substrate, on which chemically or biochemically recognizable entities are immobilized; (b) performing molecular reactions between the immobilized chemically or biochemically recognizable entities and the reagent solution(s); or on the immobilized chemically or biochemically recognizable entities in the presence of the reagent solution(s); (c) displacing the reagent solution(s) present on the substrate by the immiscible intermediate fluid; (d) separating the immiscible intermediate fluid and the reagent solution(s); and reusing the reagent solution(s) and/or immiscible intermediate fluid for one or more repetitions of steps (a) to (e). The invention further relates to a device for performing a molecular reaction, comprising a reaction zone, reservoirs and liquid connections and a collection and regeneration zone wherein the immiscible intermediate fluid and the reagent solution(s) are separable by gravitational separation; or a redirection and distribution module, wherein the immiscible intermediate fluid and reagent solution(s) are separated. The invention also relates to the use of an immiscible intermediate fluid for displacing a reagent solution present in a reaction zone in a microfluidic device, as well as the use of a corresponding device for performing a sequencing reaction or a nucleic acid synthesis reaction.
摘要翻译：本发明涉及一种在器件中进行分子反应的方法，包括以下步骤：（a）将一种或多种试剂溶液和不混溶的中间体流体引入该装置，其中该装置包括基底，化学或生化鉴定实体被固定化; （b）在固定的化学或生化学可识别的实体和试剂溶液之间进行分子反应; 或在试剂溶液存在下在固定的化学或生物化学可识别的实体上; （c）通过不混溶的中间流体置换存在于基板上的试剂溶液; （d）分离不混溶的中间体液体和试剂溶液; 以及重复使用所述试剂溶液和/或不混溶的中间体流体以进行一个或多个重复的步骤（a）至（e）。本发明还涉及一种用于进行分子反应的装置，包括反应区，储存器和液体连接以及收集和再生区，其中不混溶的中间流体和试剂溶液可通过重力分离而分离; 或重定向和分配模块，其中不混溶的中间流体和试剂溶液被分离。本发明还涉及不混溶中间体液体用于置换微流体装置中反应区中存在的试剂溶液的用途，以及使用相应的装置进行测序反应或核酸合成反应。

10. 发明申请

WO2011027268A2 DEVICES AND METHODS FOR MICROARRAY SELECTION 审中-公开
标题翻译：用于微阵列选择的装置和方法
公开(公告)号：WO2011027268A2
公开(公告)日：2011-03-10
申请号：PCT/IB2010/053839
申请日：2010-08-26
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN DER ZAAG, Pieter, Jan , FEITSMA, Harma, Martine , DEN TOONDER, Jacob, Marinus, Jan , WIMBERGER-FRIEDL, Reinhold
发明人： VAN DER ZAAG, Pieter, Jan , FEITSMA, Harma, Martine , DEN TOONDER, Jacob, Marinus, Jan , WIMBERGER-FRIEDL, Reinhold
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6834 , C12Q2537/149 , C12Q2527/107
摘要： The present invention relates to a device for the specific selection of target molecules, comprising: (a) at least one reaction zone comprising a microarray, wherein the microarray comprises a substrate, on which one or more species of capture molecules are immobilized, comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone; (b) at least one non-reaction zone comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone, which is in fluid connection with the reaction zone; and (c) at least one transportation means capable of generating and/or regulating a fluid flow between said reaction zone (a) and said non-reaction zone comprising one or more temperature control and/or regulating units (b). The present invention further relates to a device for the specific selection of target molecules wherein the immobilized capture molecules are organized in the microarray in the form of spots, elongated spots and/or lines. In a further aspect the present invention relates to a method of specifically selecting target molecules, comprising the introducing a medium to such a device, performing interaction reactions in a reaction zone, transporting not interacted or not bound target molecules to a zone allowing reactivation of the target molecules and performing additional interaction reactions with the reactivated target molecules at the reaction zone, as well as the use of such a device for specifically selecting target molecules, e.g. for target enrichment also referred to as microarray based genome selection (MGS) in the literature.
摘要翻译：本发明涉及用于特异性选择靶分子的装置，其包含：（a）至少一个包含微阵列的反应区，其中所述微阵列包含底物，一种或多种物质捕捉分子被固定，包括一个或多个温度控制和/或调节单元，用于控制和/或调节区域内的温度; （b）至少一个非反应区，其包含一个或多个温度控制和/或调节单元，用于控制和/或调节与反应区流体连通的区域内的温度; 和（c）至少一个能够产生和/或调节所述反应区（a）和包含一个或多个温度控制和/或调节单元（b）的所述非反应区之间的流体流动的运输工具。本发明进一步涉及用于特异性选择靶分子的装置，其中固定的捕获分子以点，细长点和/或线的形式在微阵列中组织。在另一方面，本发明涉及特异性选择靶分子的方法，包括将介质引入这样的装置，在反应区中进行相互作用反应，将未相互作用或未结合的靶分子转运至允许再激活靶分子并且在反应区与再活化的靶分子进行另外的相互作用反应，以及使用这样的装置用于特异性选择靶分子，例如目标富集在文献中也被称为基于微阵列的基因组选择（MGS）。

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