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    • 1. 发明申请
    • DEVICES AND METHODS FOR MICROARRAY SELECTION
    • MICROARRAY选择的设备和方法
    • WO2011027268A3
    • 2011-06-16
    • PCT/IB2010053839
    • 2010-08-26
    • KONINKL PHILIPS ELECTRONICS NVVAN DER ZAAG PIETER JANFEITSMA HARMA MARTINEDEN TOONDER JACOB MARINUS JANWIMBERGER-FRIEDL REINHOLD
    • VAN DER ZAAG PIETER JANFEITSMA HARMA MARTINEDEN TOONDER JACOB MARINUS JANWIMBERGER-FRIEDL REINHOLD
    • C12Q1/68
    • C12Q1/6834C12Q2537/149C12Q2527/107
    • The present invention relates to a device for the specific selection of target molecules, comprising: (a) at least one reaction zone comprising a microarray, wherein the microarray comprises a substrate, on which one or more species of capture molecules are immobilized, comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone; (b) at least one non-reaction zone comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone, which is in fluid connection with the reaction zone; and (c) at least one transportation means capable of generating and/or regulating a fluid flow between said reaction zone (a) and said non-reaction zone comprising one or more temperature control and/or regulating units (b). The present invention further relates to a device for the specific selection of target molecules wherein the immobilized capture molecules are organized in the microarray in the form of spots, elongated spots and/or lines. In a further aspect the present invention relates to a method of specifically selecting target molecules, comprising the introducing a medium to such a device, performing interaction reactions in a reaction zone, transporting not interacted or not bound target molecules to a zone allowing reactivation of the target molecules and performing additional interaction reactions with the reactivated target molecules at the reaction zone, as well as the use of such a device for specifically selecting target molecules, e.g. for target enrichment also referred to as microarray based genome selection (MGS) in the literature.
    • 本发明涉及用于特异性选择靶分子的装置,其包括:(a)包含微阵列的至少一个反应区,其中所述微阵列包含其上固定有一种或多种捕获分子的底物,其包含一个 或更多温度控制和/或调节单元,用于控制和/或调节该区域内的温度; (b)至少一个非反应区,包括一个或多个温度控制和/或调节单元,用于控制和/或调节与反应区流体连通的区域内的温度; 和(c)能够产生和/或调节所述反应区(a)和包括一个或多个温度控制和/或调节单元(b)的所述非反应区之间的流体流动的至少一个输送装置。 本发明还涉及用于特异性选择靶分子的装置,其中固定的捕获分子以斑点,细长斑点和/或线的形式组织在微阵列中。 在另一方面,本发明涉及一种特异性选择靶分子的方法,包括向这种装置中引入培养基,在反应区中进行相互作用反应,将不相互作用或不结合的靶分子传输到允许重新激活 目标分子,并在反应区域与再活化的靶分子进行额外的相互作用反应,以及使用这种用于特异性选择靶分子的装置,例如 对于目标富集,文献中也称为基于微阵列的基因组选择(MGS)。
    • 3. 发明申请
    • DEVICES AND METHODS FOR MICROARRAY SELECTION
    • 用于微阵列选择的装置和方法
    • WO2011027268A2
    • 2011-03-10
    • PCT/IB2010/053839
    • 2010-08-26
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.VAN DER ZAAG, Pieter, JanFEITSMA, Harma, MartineDEN TOONDER, Jacob, Marinus, JanWIMBERGER-FRIEDL, Reinhold
    • VAN DER ZAAG, Pieter, JanFEITSMA, Harma, MartineDEN TOONDER, Jacob, Marinus, JanWIMBERGER-FRIEDL, Reinhold
    • C12Q1/68
    • C12Q1/6834C12Q2537/149C12Q2527/107
    • The present invention relates to a device for the specific selection of target molecules, comprising: (a) at least one reaction zone comprising a microarray, wherein the microarray comprises a substrate, on which one or more species of capture molecules are immobilized, comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone; (b) at least one non-reaction zone comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone, which is in fluid connection with the reaction zone; and (c) at least one transportation means capable of generating and/or regulating a fluid flow between said reaction zone (a) and said non-reaction zone comprising one or more temperature control and/or regulating units (b). The present invention further relates to a device for the specific selection of target molecules wherein the immobilized capture molecules are organized in the microarray in the form of spots, elongated spots and/or lines. In a further aspect the present invention relates to a method of specifically selecting target molecules, comprising the introducing a medium to such a device, performing interaction reactions in a reaction zone, transporting not interacted or not bound target molecules to a zone allowing reactivation of the target molecules and performing additional interaction reactions with the reactivated target molecules at the reaction zone, as well as the use of such a device for specifically selecting target molecules, e.g. for target enrichment also referred to as microarray based genome selection (MGS) in the literature.
    • 本发明涉及用于特异性选择靶分子的装置,其包含:(a)至少一个包含微阵列的反应区,其中所述微阵列包含底物,一种或多种物质 捕捉分子被固定,包括一个或多个温度控制和/或调节单元,用于控制和/或调节区域内的温度; (b)至少一个非反应区,其包含一个或多个温度控制和/或调节单元,用于控制和/或调节与反应区流体连通的区域内的温度; 和(c)至少一个能够产生和/或调节所述反应区(a)和包含一个或多个温度控制和/或调节单元(b)的所述非反应区之间的流体流动的运输工具。 本发明进一步涉及用于特异性选择靶分子的装置,其中固定的捕获分子以点,细长点和/或线的形式在微阵列中组织。 在另一方面,本发明涉及特异性选择靶分子的方法,包括将介质引入这样的装置,在反应区中进行相互作用反应,将未相互作用或未结合的靶分子转运至允许再激活 靶分子并且在反应区与再活化的靶分子进行另外的相互作用反应,以及使用这样的装置用于特异性选择靶分子,例如 目标富集在文献中也被称为基于微阵列的基因组选择(MGS)。
    • 7. 发明申请
    • DEVICE AND METHOD FOR TRANSPORTING MAGNETIC OR MAGNETISABLE BEADS
    • 用于运输磁性或可磁化珠的装置和方法
    • WO2011030272A1
    • 2011-03-17
    • PCT/IB2010/053991
    • 2010-09-06
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.DEN TOONDER, Jacob Marinus JanVAN DER ZAAG, Pieter, JanCHAO, Hao, Chieh
    • DEN TOONDER, Jacob Marinus JanVAN DER ZAAG, Pieter, JanCHAO, Hao, Chieh
    • B01L3/00B01F13/00G01N35/00
    • B03C1/034B01L3/502761B01L2200/0668B01L2400/043B03C1/0335B03C1/24B03C2201/18
    • The present invention relates to a device (24) for transporting magnetic or magnetisable beads (10) over a transport surface (12). It comprises a chamber (26) comprising magnetic or magnetisable beads (10) in a fluid (28), a transport element (14) including said transport surface (12) within said chamber (26) over which said beads (10) shall be transported, a current wire structure (20) comprising at least two sets (20a, 20b, 20c) of meandering current wires arranged on a side of said transport element (14) opposite to said transport surface (12), said at least two sets (20a, 20b, 20c) being displaced with respect to each other in at least two directions, and a switching unit (32) for individually switching currents (1a, 1b, 1c) individually applied to said sets of current wires according to a current driving scheme resulting in a transport of said beads (10) over said transport surface (12). In preferred embodiments a stationary substantially uniform magnetic field (30) in a direction substantially parallel to the transport surface (12) is additionally provided.
    • 本发明涉及一种用于在输送表面(12)上输送磁性或可磁化珠(10)的装置(24)。 其包括在流体(28)中包括磁性或可磁化珠(10)的腔室(26),包括在所述腔室(26)内的所述输送表面(12)的输送元件(14),所述珠子 传送的电流线结构(20)包括布置在与所述输送表面(12)相对的所述输送元件(14)的一侧的曲折电流线的至少两组(20a,20b,20c),所述至少两组 (20a,20b,20c)在至少两个方向上相对于彼此移位;以及开关单元(32),用于根据电流单独地切换电流(1a,1b,1c),分别施加到所述电流线组 驱动方案导致所述小珠(10)在所述输送表面(12)上的运输。 在优选实施例中,额外地提供了在基本上平行于输送表面(12)的方向上的固定的基本均匀的磁场(30)。