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1. 发明申请

WO2011027268A3 DEVICES AND METHODS FOR MICROARRAY SELECTION 审中-公开
标题翻译： MICROARRAY选择的设备和方法
公开(公告)号：WO2011027268A3
公开(公告)日：2011-06-16
申请号：PCT/IB2010053839
申请日：2010-08-26
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN DER ZAAG PIETER JAN , FEITSMA HARMA MARTINE , DEN TOONDER JACOB MARINUS JAN , WIMBERGER-FRIEDL REINHOLD
发明人： VAN DER ZAAG PIETER JAN , FEITSMA HARMA MARTINE , DEN TOONDER JACOB MARINUS JAN , WIMBERGER-FRIEDL REINHOLD
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6834 , C12Q2537/149 , C12Q2527/107
摘要： The present invention relates to a device for the specific selection of target molecules, comprising: (a) at least one reaction zone comprising a microarray, wherein the microarray comprises a substrate, on which one or more species of capture molecules are immobilized, comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone; (b) at least one non-reaction zone comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone, which is in fluid connection with the reaction zone; and (c) at least one transportation means capable of generating and/or regulating a fluid flow between said reaction zone (a) and said non-reaction zone comprising one or more temperature control and/or regulating units (b). The present invention further relates to a device for the specific selection of target molecules wherein the immobilized capture molecules are organized in the microarray in the form of spots, elongated spots and/or lines. In a further aspect the present invention relates to a method of specifically selecting target molecules, comprising the introducing a medium to such a device, performing interaction reactions in a reaction zone, transporting not interacted or not bound target molecules to a zone allowing reactivation of the target molecules and performing additional interaction reactions with the reactivated target molecules at the reaction zone, as well as the use of such a device for specifically selecting target molecules, e.g. for target enrichment also referred to as microarray based genome selection (MGS) in the literature.
摘要翻译：本发明涉及用于特异性选择靶分子的装置，其包括：（a）包含微阵列的至少一个反应区，其中所述微阵列包含其上固定有一种或多种捕获分子的底物，其包含一个或更多温度控制和/或调节单元，用于控制和/或调节该区域内的温度; （b）至少一个非反应区，包括一个或多个温度控制和/或调节单元，用于控制和/或调节与反应区流体连通的区域内的温度; 和（c）能够产生和/或调节所述反应区（a）和包括一个或多个温度控制和/或调节单元（b）的所述非反应区之间的流体流动的至少一个输送装置。本发明还涉及用于特异性选择靶分子的装置，其中固定的捕获分子以斑点，细长斑点和/或线的形式组织在微阵列中。在另一方面，本发明涉及一种特异性选择靶分子的方法，包括向这种装置中引入培养基，在反应区中进行相互作用反应，将不相互作用或不结合的靶分子传输到允许重新激活目标分子，并在反应区域与再活化的靶分子进行额外的相互作用反应，以及使用这种用于特异性选择靶分子的装置，例如对于目标富集，文献中也称为基于微阵列的基因组选择（MGS）。

2. 发明申请

WO2008017967A1 DEVICE, SYSTEM AND METHOD FOR INTERACTING WITH A CELL OR TISSUE IN A BODY 审中-公开
标题翻译：用于与身体中的细胞或组织相互作用的装置，系统和方法
公开(公告)号：WO2008017967A1
公开(公告)日：2008-02-14
申请号：PCT/IB2007/051326
申请日：2007-04-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ZOU, Hans , KUIPER, Stein , HENDRIKS, Bernardus Hendrikus Wilhelmus , SUIJVER, Jan Frederik , PIERIK, Anke , RENSEN, Judith Margreet , DIJKSMAN, Johan Frederik , SHIMIZU, Jeff , DEN TOONDER, Jacob Marinus Jan
发明人： ZOU, Hans , KUIPER, Stein , HENDRIKS, Bernardus Hendrikus Wilhelmus , SUIJVER, Jan Frederik , PIERIK, Anke , RENSEN, Judith Margreet , DIJKSMAN, Johan Frederik , SHIMIZU, Jeff , DEN TOONDER, Jacob Marinus Jan
IPC分类号： A61B5/00
CPC分类号： A61B5/6882 , A61B1/041 , A61B5/0031 , A61B5/073 , A61B5/4839
摘要： A device or support, system and method are provided for precisely targeted and/or highly controlled interaction with a targeted cell or tissue in a body, with the support providing an ergonomic connecting interface for selectively connecting the support to a cell or tissue with at least minimal adverse affect to such cell or tissue, the system providing a remote facility that may be operatively associated with the support, and the method providing steps for employing the support and/or system so as to, inter alia, improve treatment, diagnostic and/or monitoring techniques and increase sensitivity and specificity with respect to interacting with, for example, diseased or abnormal cells or tissue without adversely effecting surrounding healthy cells or tissue, and/or the body in general.
摘要翻译：提供了一种装置或支撑件，系统和方法，用于与身体中的靶细胞或组织精确地靶向和/或高度受控的相互作用，其中所述支持物提供符合人体工程学的连接界面，用于至少选择性地将支持物连接到细胞或组织对这种细胞或组织的最小的不利影响，该系统提供可能与支持物可操作地相关联的远程设施，以及提供使用支持和/或系统的方法，以便除其他外改善治疗，诊断和/ 或监测技术，并提高与例如患病或异常细胞或组织的相互作用的灵敏度和特异性，而不会不利地影响周围的健康细胞或组织和/或身体。

3. 发明申请

WO2011027268A2 DEVICES AND METHODS FOR MICROARRAY SELECTION 审中-公开
标题翻译：用于微阵列选择的装置和方法
公开(公告)号：WO2011027268A2
公开(公告)日：2011-03-10
申请号：PCT/IB2010/053839
申请日：2010-08-26
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN DER ZAAG, Pieter, Jan , FEITSMA, Harma, Martine , DEN TOONDER, Jacob, Marinus, Jan , WIMBERGER-FRIEDL, Reinhold
发明人： VAN DER ZAAG, Pieter, Jan , FEITSMA, Harma, Martine , DEN TOONDER, Jacob, Marinus, Jan , WIMBERGER-FRIEDL, Reinhold
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6834 , C12Q2537/149 , C12Q2527/107
摘要： The present invention relates to a device for the specific selection of target molecules, comprising: (a) at least one reaction zone comprising a microarray, wherein the microarray comprises a substrate, on which one or more species of capture molecules are immobilized, comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone; (b) at least one non-reaction zone comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone, which is in fluid connection with the reaction zone; and (c) at least one transportation means capable of generating and/or regulating a fluid flow between said reaction zone (a) and said non-reaction zone comprising one or more temperature control and/or regulating units (b). The present invention further relates to a device for the specific selection of target molecules wherein the immobilized capture molecules are organized in the microarray in the form of spots, elongated spots and/or lines. In a further aspect the present invention relates to a method of specifically selecting target molecules, comprising the introducing a medium to such a device, performing interaction reactions in a reaction zone, transporting not interacted or not bound target molecules to a zone allowing reactivation of the target molecules and performing additional interaction reactions with the reactivated target molecules at the reaction zone, as well as the use of such a device for specifically selecting target molecules, e.g. for target enrichment also referred to as microarray based genome selection (MGS) in the literature.
摘要翻译：本发明涉及用于特异性选择靶分子的装置，其包含：（a）至少一个包含微阵列的反应区，其中所述微阵列包含底物，一种或多种物质捕捉分子被固定，包括一个或多个温度控制和/或调节单元，用于控制和/或调节区域内的温度; （b）至少一个非反应区，其包含一个或多个温度控制和/或调节单元，用于控制和/或调节与反应区流体连通的区域内的温度; 和（c）至少一个能够产生和/或调节所述反应区（a）和包含一个或多个温度控制和/或调节单元（b）的所述非反应区之间的流体流动的运输工具。本发明进一步涉及用于特异性选择靶分子的装置，其中固定的捕获分子以点，细长点和/或线的形式在微阵列中组织。在另一方面，本发明涉及特异性选择靶分子的方法，包括将介质引入这样的装置，在反应区中进行相互作用反应，将未相互作用或未结合的靶分子转运至允许再激活靶分子并且在反应区与再活化的靶分子进行另外的相互作用反应，以及使用这样的装置用于特异性选择靶分子，例如目标富集在文献中也被称为基于微阵列的基因组选择（MGS）。

4. 发明申请

WO2007034404A2 A MICROFLUIDIC REGULATING DEVICE 审中-公开
标题翻译：微流控制器件
公开(公告)号：WO2007034404A2
公开(公告)日：2007-03-29
申请号：PCT/IB2006053357
申请日：2006-09-19
申请人： KONINKL PHILIPS ELECTRONICS NV , WIMBERGER-FRIEDL REINHOLD , HIKMET RIFAT ATA MUSTAFA , VAN BOMMEL TIES , DEN TOONDER JACOB MARINUS JAN , YAVUZ MEIKE
发明人： WIMBERGER-FRIEDL REINHOLD , HIKMET RIFAT ATA MUSTAFA , VAN BOMMEL TIES , DEN TOONDER JACOB MARINUS JAN , YAVUZ MEIKE
IPC分类号： B01L3/00
CPC分类号： F15C3/04 , B01L3/502738 , B01L2200/12 , B01L2400/0487 , B01L2400/0633 , B01L2400/0638 , Y10T137/2191 , Y10T137/2202 , Y10T137/2213
摘要： The invention relates to a microfluidic regulating device, comprising a first layer having a first microfluidic channel defined therein, a second layer having a second microfluidic channel defined therein, a fluid flow regulating layer disposed between the first and the second microfluidic channel, which layer comprises a movable valve member which in open position allows fluid communication between the first and second channel and in closed position seals against a valve seat, whereby at least part of the valve member and of the valve seat is magnetic. The device is able to store small quantities of liquids at microfluidic cartridges and access these on demand in a well controlled and simple way.
摘要翻译：本发明涉及一种微流体调节装置，其包括具有限定在其中的第一微流体通道的第一层，其中限定有第二微流体通道的第二层，设置在第一和第二微流体通道之间的流体流动调节层，该层包括处于打开位置的可移动阀构件允许第一和第二通道之间的流体连通并且在关闭位置中密封抵靠阀座，由此阀构件和阀座的至少一部分是磁性的。该设备能够在微流控盒中储存少量液体，并以良好控制和简单的方式随时访问。

5. 发明申请

WO2007034404A3 MAGNATIC MICROFLUIDIC VALVE 审中-公开
公开(公告)号：WO2007034404A3
公开(公告)日：2007-03-29
申请号：PCT/IB2006/053357
申请日：2006-09-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WIMBERGER-FRIEDL, Reinhold , HIKMET, Rifat Ata Mustafa , VAN BOMMEL, Ties , DEN TOONDER, Jacob, Marinus, Jan , YAVUZ, Meike
发明人： WIMBERGER-FRIEDL, Reinhold , HIKMET, Rifat Ata Mustafa , VAN BOMMEL, Ties , DEN TOONDER, Jacob, Marinus, Jan , YAVUZ, Meike
IPC分类号： B01L3/00
摘要： The invention relates to a microfluidic regulating device, comprising a first layer having a first microfluidic channel defined therein, a second layer having a second microfluidic channel defined therein, a fluid flow regulating layer disposed between the first and the second microfluidic channel, which layer comprises a movable valve member which in open position allows fluid communication between the first and second channel and in closed position seals against a valve seat, whereby at least part of the valve member and of the valve seat is magnetic. The device is able to store small quantities of liquids at microfluidic cartridges and access these on demand in a well controlled and simple way.

6. 发明申请

WO2012168853A1 DEVICE FOR FRAGMENTING MOLECULES IN A SAMPLE BY ULTRASOUND 审中-公开
标题翻译：用于通过超声波在样品中分离分子的装置
公开(公告)号：WO2012168853A1
公开(公告)日：2012-12-13
申请号：PCT/IB2012/052812
申请日：2012-06-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , CRAUS, Cristian Bogdan , DEN TOONDER, Jacob Marinus Jan , PENTERMAN, Roel , VAN DER ZAAG, Pieter Jan
发明人： CRAUS, Cristian Bogdan , DEN TOONDER, Jacob Marinus Jan , PENTERMAN, Roel , VAN DER ZAAG, Pieter Jan
IPC分类号： B02C19/18 , C12M1/33 , C12M3/08 , C12N1/06
CPC分类号： B06B3/00 , B02C19/18 , C12M47/06 , G01N1/286 , Y10T29/49826
摘要： According to an aspect of the present invention, a device for fragmenting molecules in a sample by ultrasound is provided. The device comprises a planar-shaped cartridge and a fragmentation instrument that has a vessel-like shape. By means of applying under-pressure in the fragmentation instrument the cartridge is pulled towards the fragmentation instrument and therefore spatially closes a fluid compartment that is comprised by the fragmentation instrument. Afterwards, an ultrasound treatment of the sample, which is comprised in a sample compartment of the cartridge, may be processed. A sealing layer is provided in between the cartridge and the fragmentation instrument in order to hold the fixation of the cartridge tightly and in order to provide for leakage prevention out of the fluid compartment.
摘要翻译：根据本发明的一个方面，提供了一种通过超声将碎片分子分解的装置。该装置包括具有容器状形状的平面形状的盒和碎片装置。通过在破碎仪器中施加低压力，将药筒拉向碎裂仪器，因此空间上封闭由碎裂仪器组成的流体隔室。之后，可以处理包含在药筒的样品室中的样品的超声处理。密封层设置在药筒和碎裂仪器之间，以便牢固地保持药筒的固定，以便防止流体隔室泄漏。

7. 发明申请

WO2011030272A1 DEVICE AND METHOD FOR TRANSPORTING MAGNETIC OR MAGNETISABLE BEADS 审中-公开
标题翻译：用于运输磁性或可磁化珠的装置和方法
公开(公告)号：WO2011030272A1
公开(公告)日：2011-03-17
申请号：PCT/IB2010/053991
申请日：2010-09-06
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DEN TOONDER, Jacob Marinus Jan , VAN DER ZAAG, Pieter, Jan , CHAO, Hao, Chieh
发明人： DEN TOONDER, Jacob Marinus Jan , VAN DER ZAAG, Pieter, Jan , CHAO, Hao, Chieh
IPC分类号： B01L3/00 , B01F13/00 , G01N35/00
CPC分类号： B03C1/034 , B01L3/502761 , B01L2200/0668 , B01L2400/043 , B03C1/0335 , B03C1/24 , B03C2201/18
摘要： The present invention relates to a device (24) for transporting magnetic or magnetisable beads (10) over a transport surface (12). It comprises a chamber (26) comprising magnetic or magnetisable beads (10) in a fluid (28), a transport element (14) including said transport surface (12) within said chamber (26) over which said beads (10) shall be transported, a current wire structure (20) comprising at least two sets (20a, 20b, 20c) of meandering current wires arranged on a side of said transport element (14) opposite to said transport surface (12), said at least two sets (20a, 20b, 20c) being displaced with respect to each other in at least two directions, and a switching unit (32) for individually switching currents (1a, 1b, 1c) individually applied to said sets of current wires according to a current driving scheme resulting in a transport of said beads (10) over said transport surface (12). In preferred embodiments a stationary substantially uniform magnetic field (30) in a direction substantially parallel to the transport surface (12) is additionally provided.
摘要翻译：本发明涉及一种用于在输送表面（12）上输送磁性或可磁化珠（10）的装置（24）。其包括在流体（28）中包括磁性或可磁化珠（10）的腔室（26），包括在所述腔室（26）内的所述输送表面（12）的输送元件（14），所述珠子传送的电流线结构（20）包括布置在与所述输送表面（12）相对的所述输送元件（14）的一侧的曲折电流线的至少两组（20a，20b，20c），所述至少两组（20a，20b，20c）在至少两个方向上相对于彼此移位;以及开关单元（32），用于根据电流单独地切换电流（1a，1b，1c），分别施加到所述电流线组驱动方案导致所述小珠（10）在所述输送表面（12）上的运输。在优选实施例中，额外地提供了在基本上平行于输送表面（12）的方向上的固定的基本均匀的磁场（30）。

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