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1. 发明申请

WO2008062354A1 A SYSTEM, DEVICE, METHOD, COMPUTER-READABLE MEDIUM, AND USE FOR IN VIVO IMAGING OF TISSUE IN AN ANATOMICAL STRUCTURE 审中-公开
标题翻译：系统，装置，方法，计算机可读介质和用于在解剖结构中进行组织成像的用途
公开(公告)号：WO2008062354A1
公开(公告)日：2008-05-29
申请号：PCT/IB2007/054674
申请日：2007-11-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BAKKER, Levinus, P. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , VAN DEN HAM, Rene , HENDRIKS, Bernardus, H., W. , HOFFMANN, Ralf , VAN DER VAART, Nijs, C. , VAN DER VOORT, Marjolein
发明人： BAKKER, Levinus, P. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , VAN DEN HAM, Rene , HENDRIKS, Bernardus, H., W. , HOFFMANN, Ralf , VAN DER VAART, Nijs, C. , VAN DER VOORT, Marjolein
IPC分类号： A61B5/00 , A61B8/12
CPC分类号： A61B5/0095 , A61B5/0035 , A61B5/0084 , A61B5/0086 , A61B8/12 , A61B8/4416
摘要： A system is provided that may be used for locating and diagnosing lesions in the human body in vivo. In some embodiments, once the exact position of a lesion is found, a biopsy may be taken from the lesion using e.g. ultra sound techniques for guidance of the biopsy needle. Use of the system drastically reduces the negative biopsy samples compared to currently used "blind sampling" techniques. This reduces patient discomfort and minimizes infections as the number of biopsy samples is reduced. A method and computer- readable medium is also provided.
摘要翻译：提供了可用于在体内定位和诊断人体损伤的系统。在一些实施例中，一旦发现病变的确切位置，可以使用例如病变从病变中取出活组织检查。超声技术用于指导活检针。与目前使用的“盲采”技术相比，使用该系统大大减少了活检样本的阴性。这减少了患者的不适，并使活检样本的数量减少了感染的最小程度。还提供了一种方法和计算机可读介质。

2. 发明申请

WO2008062346A1 A SYSTEM, METHOD, COMPUTER-READABLE MEDIUM AND USE FOR IMAGING OF TISSUE IN AN ANATOMICAL STRUCTURE 审中-公开
标题翻译：系统，方法，计算机可读介质和用于在解剖结构中形成组织的用途
公开(公告)号：WO2008062346A1
公开(公告)日：2008-05-29
申请号：PCT/IB2007/054626
申请日：2007-11-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , BAKKER, Levinus, P. , VAN DEN HAM, René , HENDRIKS, Bernardus, H., W. , HOFFMANN, Ralf , VAN DER VAART, Nijs, C. , VAN DER VOORT, Marjolein
发明人： VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , BAKKER, Levinus, P. , VAN DEN HAM, René , HENDRIKS, Bernardus, H., W. , HOFFMANN, Ralf , VAN DER VAART, Nijs, C. , VAN DER VOORT, Marjolein
IPC分类号： A61B5/00
CPC分类号： A61B5/4381 , A61B5/0073 , A61B5/0084 , A61B5/0086 , A61B8/12
摘要： A system for imaging of prostate cancer in a prostate in vivo is provided. The system utilizes Diffuse Optical Tomography (DOT) for creating a 3D image for the detection of suspicious prostate tissue. The DOT image may be used to guide the biopsy, thereby reducing the number of false negatives. A method, computer-readable medium and use are also provided.
摘要翻译：提供了一种用于前列腺体内前列腺癌成像的系统。该系统利用漫射光学层析成像（DOT）创建用于检测可疑前列腺组织的3D图像。 DOT图像可用于指导活组织检查，从而减少假阴性的数量。还提供了一种方法，计算机可读介质和使用。

3. 发明申请

WO2004057285A1 OPTICAL ANALYSIS SYSTEM 审中-公开
标题翻译：光学分析系统
公开(公告)号：WO2004057285A1
公开(公告)日：2004-07-08
申请号：PCT/IB2003/006089
申请日：2003-12-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , SCHUURMANS, Frank, J., P. , VAN BEEK, Michael, C. , BAKKER, Levinus, P. , RENSEN, Wouter, H., J. , HENDRIKS, Bernardus, H., W. , HENDRIKS, Robert, F., M. , STEFFEN, Thomas
发明人： SCHUURMANS, Frank, J., P. , VAN BEEK, Michael, C. , BAKKER, Levinus, P. , RENSEN, Wouter, H., J. , HENDRIKS, Bernardus, H., W. , HENDRIKS, Robert, F., M. , STEFFEN, Thomas
IPC分类号： G01J3/28
CPC分类号： G01J3/02 , G01J3/0205 , G01J3/021 , G01J3/10 , G01J3/28 , G01J3/36 , G01N21/274 , G01N21/31 , G01N2021/3196 , G01N2201/129
摘要： The optical analysis system (20) for determining an amplitude of a principal component of an optical signal comprises a multivariate optical element (10) for reflecting the optical signal and thereby weighing the optical signal by a spectral weighing function, and a detector (9, 9P, 9N) for detecting the weighed optical signal. The optical analysis system (20) may further comprise a dispersive element (2) for spectrally dispersing the optical signal, the multivariate optical element being arranged to receive the dispersed optical signal. The blood analysis system (40) comprises the optical analysis system (20) according to the invention.
摘要翻译：用于确定光信号的主分量的幅度的光学分析系统（20）包括用于反射光信号并由此通过光谱称重功能称重光信号的多元光学元件（10） 9P，9N），用于检测加权的光信号。光学分析系统（20）还可以包括用于光谱分散光学信号的色散元件（2），所述多元光学元件被布置成接收分散的光信号。血液分析系统（40）包括根据本发明的光学分析系统（20）。

4. 发明申请

WO2010058344A1 NEEDLE WITH OPTICAL FIBERS 审中-公开
标题翻译：带有光纤的针
公开(公告)号：WO2010058344A1
公开(公告)日：2010-05-27
申请号：PCT/IB2009/055128
申请日：2009-11-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HENDRIKS, Bernardus, H., W. , BRAUN, Augustinus, L. , HARBERS, Rik , VAN DER VOORT, Marjolein , DESJARDINS, Adrien, E. , NACHABE, Rami
发明人： HENDRIKS, Bernardus, H., W. , BRAUN, Augustinus, L. , HARBERS, Rik , VAN DER VOORT, Marjolein , DESJARDINS, Adrien, E. , NACHABE, Rami
IPC分类号： A61B5/00 , A61B10/00
CPC分类号： A61B5/0084 , A61B5/0075 , A61B5/1459 , A61B5/6848 , A61B10/0233 , A61B10/0283 , A61B17/3401 , A61B18/1477 , A61B2017/00057 , A61B2018/1425
摘要： Needle interventions are widely used in the field of oncology for taking biopsies of tissue in order to inspect whether tissue is cancerous or not. To make these interventions more reliable feedback of what kind of tissue is in front of the needle is required. A way to achieve this is by making use of optical spectroscopy. This requires integration of fibers into the needle. These fibers are used to deliver light to illuminate the tissue in front of the needle and to collect back the reflected light from the tissue. The present invention proposes to integrate the fiber distal ends in the slanted bevel of the needle in such a way that at least one source-detector fiber pair has a distance that is larger than the outer diameter of the needle.
摘要翻译：针刺干预广泛用于肿瘤学领域，用于检查组织的活组织检查，以检查组织是否是癌性的。要使这些干预措施更加可靠，就需要针头前面的什么样的组织的反馈信息。实现这一目标的一个方法是利用光谱学。这需要将纤维整合到针中。这些纤维用于传递光以照射针前面的组织并收集来自组织的反射光。本发明提出将光纤远端整合到针的倾斜斜面中，使得至少一个源 - 检测器光纤对的距离大于针的外径。

5. 发明申请

WO2010058302A1 NEEDLE WITH INTEGRATED FIBERS 审中-公开
标题翻译：带有集成纤维的针头
公开(公告)号：WO2010058302A1
公开(公告)日：2010-05-27
申请号：PCT/IB2009/052539
申请日：2009-06-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BRAUN, Augustinus, L. , HENDRIKS, Bernardus, H., W. , HARBERS, Rik , VAN DER VOORT, Marjolein , DESJARDINS, Adrien, E. , NACHABE, Rami , WASSINK, Bernardus, W., J. , VAN GAAL, Franciscus, M., A., M. , MIHAJLOVIC, Nenad , BABIC, Drazenko
发明人： BRAUN, Augustinus, L. , HENDRIKS, Bernardus, H., W. , HARBERS, Rik , VAN DER VOORT, Marjolein , DESJARDINS, Adrien, E. , NACHABE, Rami , WASSINK, Bernardus, W., J. , VAN GAAL, Franciscus, M., A., M. , MIHAJLOVIC, Nenad , BABIC, Drazenko
IPC分类号： A61B5/00
CPC分类号： A61B5/6848 , A61B5/0075 , A61B5/0084
摘要： Needles equipped with fibres allow tissue inspection based on optical spectroscopy to diagnose whether tissue is cancerous or not. This requires integration of optical fibers into needles. The problem is how to manufacture the needle having at least one fiber exit at the distal end of the needle, where the fiber does not obstruct the hollow part of the needle if present as well as does not extend beyond the outer cylinder geometry. To solve this problem we propose to manufacture the needle consisting of four parts: an inner cylinder tube, an outer hollow cylinder tube, a needle tip part with integrated fiber exit and a holder part, wherein the hollow spacing between the inner and the outer cylinder is larger or equal to the outer diameter of the fibers, the inner and the outer cylinder are mounted in the holder part and where the tip part is mounted on the two cylinders.
摘要翻译：配备纤维的针头允许基于光谱的组织检查来诊断组织是否是癌变的。这需要将光纤集成到针中。问题是如何制造在针的远端具有至少一个纤维出口的针，其中纤维不会阻塞针的中空部分，如果存在，并且不延伸超出外筒几何形状。为了解决这个问题，我们建议制造由四个部分组成的针：内筒管，外中空筒管，具有集成纤维出口的针尖部分和保持器部分，其中内筒和外筒之间的中空间隔大于或等于纤维的外径，内筒和外筒安装在保持器部分中，并且尖端部分安装在两个气缸上。

6. 发明申请

WO2009050667A1 TUMOR DEMARCATION USING TARGETED FLUORESCENT PROBE AND PHOTONIC NEEDLE 审中-公开
标题翻译：使用指定的荧光探针和光子针头进行肿瘤分解
公开(公告)号：WO2009050667A1
公开(公告)日：2009-04-23
申请号：PCT/IB2008/054253
申请日：2008-10-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN DER MARK, Martinus, B. , HENDRIKS, Bernardus, H., W.
发明人： VAN DER MARK, Martinus, B. , HENDRIKS, Bernardus, H., W.
IPC分类号： A61B5/00
CPC分类号： A61B90/39 , A61B2090/306 , A61B2090/3908 , A61B2090/3941
摘要： The present invention refers to the field of image-guided percutaneous needle biopsies, in particular to a light guiding hook wire comprising a light-guiding optical fiber (LGM, LGHW) for transferring light from one end on which a beam of input light are incident to another end placed in a cancerous tissue region around the tip of the hookwire, thereby providing an output light assignable to the intensity of the input light; and a liquid guiding device for providing a liquid to the region of interest. The present invention further refers to a method for excising non-palpable pathological tissue regions in the interior of a patient's body, especially tissue regions indicative of breast or prostate cancer, by using such a hookwire. A targeted contrast agent fluorescent in the visible or near-infrared spectrum of light can be used to mark cancerous tissue anomalies, and a light-guiding optical fiber (LGM, LGHW) may provide the light needed for an excitation of this tissue.
摘要翻译：本发明涉及图像引导的经皮针活检领域，特别涉及一种导光钩线，其包括用于从输入光束入射的一端传输光的导光光纤（LGM，LGHW）到另一端放置在钩线尖端周围的癌组织区域中，从而提供可分配给输入光强度的输出光; 以及用于向感兴趣区域提供液体的液体引导装置。本发明还涉及通过使用这种钩线来切除患者身体内部，特别是指示乳腺癌或前列腺癌的组织区域中的不可触知的病理组织区域的方法。在可见光或近红外光谱中荧光的靶向对比剂可用于标记癌组织异常，并且导光光纤（LGM，LGHW）可提供激发该组织所需的光。

7. 发明申请

WO2010084445A1 OPTICAL EXAMINATION DEVICE ADAPTED TO BE AT LEAST PARTIALLY INSERTED INTO A TURBID MEDIUM 审中-公开
标题翻译：光学检查装置适用于至少部分插入涡轮介质
公开(公告)号：WO2010084445A1
公开(公告)日：2010-07-29
申请号：PCT/IB2010/050208
申请日：2010-01-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DESJARDINS, Adrien, E. , VAN DER MARK, Martinus, B. , HENDRIKS, Bernardus, H., W. , 'T HOOFT, Gert
发明人： DESJARDINS, Adrien, E. , VAN DER MARK, Martinus, B. , HENDRIKS, Bernardus, H., W. , 'T HOOFT, Gert
IPC分类号： A61B5/00
CPC分类号： A61B5/0075 , A61B5/0062 , A61B5/0084 , A61B5/6848
摘要： An optical examination device (10) adapted to be at least partially inserted into a turbid medium is provided. The optical examination device comprises a shaft portion (21) adapted to be inserted into the turbid medium, the shaft portion (21) comprising a tip portion (22) adapted to be the foremost portion during insertion into the turbid medium. At least one light source device adapted to emit abeam (11) of broad-band light is provided in the region of the tip portion (21). The beam (11) of broad-band light comprises different wavelength bands (2a, 2b,..., 2n) which are differently modulated. At least one photodetector (27a, 27b, 27c) for detecting broad-band light is provided in a region adapted to be inserted into the turbid medium of the shaft portion (21).
摘要翻译：提供了适于至少部分地插入混浊介质中的光学检查装置（10）。光学检查装置包括适于插入混浊介质的轴部分（21），该轴部分（21）包括在插入混浊介质期间适于最前部分的末端部分（22）。在尖端部分（21）的区域中设置适于发射宽带光的光束（11）的至少一个光源装置。宽带光束（11）包括不同调制的不同波长带（2a，2b，...，2n）。用于检测宽带光的至少一个光电检测器（27a，27b，27c）设置在适于插入到轴部（21）的混浊介质中的区域中。

8. 发明申请

WO2010136922A1 RE-CALIBRATION OF PRE-RECORDED IMAGES DURING INTERVENTIONS USING A NEEDLE DEVICE 审中-公开
标题翻译：使用针头装置进行干预时预先记录的图像重新校准
公开(公告)号：WO2010136922A1
公开(公告)日：2010-12-02
申请号：PCT/IB2010/052030
申请日：2010-05-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BAKKER, Levinus, P. , HENDRIKS, Bernardus, H., W. , DESJARDINS, Adrien, E.
发明人： BAKKER, Levinus, P. , HENDRIKS, Bernardus, H., W. , DESJARDINS, Adrien, E.
IPC分类号： A61B5/00 , G06T7/00 , A61B19/00 , A61B6/12
CPC分类号： A61B8/0841 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0071 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6848 , A61B6/12 , A61B6/5247 , A61B8/00 , A61B8/5238 , A61B17/34 , A61B17/3403 , A61B17/3417 , A61B2090/3614 , A61B2090/374 , A61B2090/376 , A61B2090/378 , A61B2090/3784
摘要： Re-calibration of pre-recorded images during interventions is proposed, utilizing an interventional system comprising an imaging device providing images of an object, a needle device, and a processing device. The needle device comprises a sensor for providing data corresponding to tissue properties. The processing device is adapted to perform an overlay registration of pre-recorded images and live images provided by the imaging device, utilizing the data from the sensor. Thus, the accuracy of an overlay of images is increased.
摘要翻译：提出了在干预期间重新校准预先记录的图像，利用包括提供物体，针装置和处理装置的图像的成像装置的介入系统。针装置包括用于提供对应于组织性质的数据的传感器。处理装置适用于利用来自传感器的数据来执行由成像装置提供的预先记录的图像和实况图像的重叠注册。因此，图像的重叠的精度增加。

9. 发明申请

WO2004101258A1 METHOD OF PRODUCING A PLURALITY OF BODIES 审中-公开
标题翻译：生产多样化身体的方法
公开(公告)号：WO2004101258A1
公开(公告)日：2004-11-25
申请号：PCT/IB2004/050624
申请日：2004-05-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HENDRIKS, Robert, F., M. , STALLINGA, Sjoerd , GOOSSENS, Hendrik, J. , 'T HOOFT, Gert, W. , VAN DER LEE, Alexander, M. , SCHUURMANS, Frank, J., P. , VULLERS, Rudolf, J., M. , KURT, Ralph , HENDRIKS, Bernardus, H., W. , BAKKER, Levinus, P.
发明人： HENDRIKS, Robert, F., M. , STALLINGA, Sjoerd , GOOSSENS, Hendrik, J. , 'T HOOFT, Gert, W. , VAN DER LEE, Alexander, M. , SCHUURMANS, Frank, J., P. , VULLERS, Rudolf, J., M. , KURT, Ralph , HENDRIKS, Bernardus, H., W. , BAKKER, Levinus, P.
IPC分类号： B29C59/02
CPC分类号： B29C59/022 , B29C2059/023 , B29D17/005 , B29L2017/003 , G11B7/00736 , G11B7/263
摘要： In the described method of producing a plurality of bodies bearing equal imprints of a stamp as optical structures, a stamp (13) is initially produced, by attaching particles (14) to a surface (15) of an auxiliary body (16); then, the stamp (13) is used to produce an imprint (11) on a plurality of bodies (10). Optical structures can be irradiated, producing on a screen a speckle pattern indicative of a key. It is substantially impossible to clone a given optical structure with current technological means. Optical structures represent physical One-Way Functions, easy to compute in the forward sense but unfeasible to reverse. Thus, they can be used to build an access/copy protection system of user information contained in an information carrier associated with the body 10. The reproducibility of the optical structures makes this method suitable for optical disks.
摘要翻译：在所述制造多个承载有印模作为光学结构印记的物体的方法中，通过将颗粒（14）附着在辅助体（16）的表面（15）上，最初产生印模（13）。那么印章（13）用于在多个主体（10）上产生印记（11）。可以照射光学结构，在屏幕上产生指示关键的斑点图案。以目前的技术手段克隆给定的光学结构是完全不可能的。光学结构表示物理单向函数，容易在正向方面计算，但不可逆转。因此，它们可以用于构建包含在与主体10相关联的信息载体中的用户信息的访问/复制保护系统。光学结构的再现性使得该方法适合于光盘。

10. 发明申请

WO2010131180A1 SYSTEM FOR DETECTING GLOBAL PATIENT MOVEMENT DURING IMAGING PROCEDURES 审中-公开
标题翻译：在成像过程中检测全球患者运动的系统
公开(公告)号：WO2010131180A1
公开(公告)日：2010-11-18
申请号：PCT/IB2010/052042
申请日：2010-05-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HENDRIKS, Bernardus, H., W. , VAN BEEK, Michael, C. , REDERT, Peter-Andre , DE BRUIJN, Frederik, J. , BABIC, Drazenko , HOMAN, Robert, J., F. , BRASPENNING, Ralph , LEE, Wei, P. , VAN BREE, Karl, C. , SHAN, Caifeng
发明人： HENDRIKS, Bernardus, H., W. , VAN BEEK, Michael, C. , REDERT, Peter-Andre , DE BRUIJN, Frederik, J. , BABIC, Drazenko , HOMAN, Robert, J., F. , BRASPENNING, Ralph , LEE, Wei, P. , VAN BREE, Karl, C. , SHAN, Caifeng
IPC分类号： A61B6/00 , A61B6/02 , A61B19/00
CPC分类号： A61B6/025 , A61B6/4423 , A61B6/4441 , A61B6/5247 , A61B90/361 , A61B90/39 , A61B2090/376
摘要： The invention provides a system (102) for accurately detecting a patient's (114) movement during imaging procedures. The system comprises a camera (126) for providing a stream of camera images of a part of a patient's exterior (206). The system (102) furthermore comprises a fiducial element (116), which fiducial element (116) is mountable on said part of the patient's exterior (206), and which fiducial element (116) is detectable in the stream of camera images, and an image processor (128) for detecting a displacement of the fiducial element based on consecutive camera images comprised in at least the stream of camera images and for generating an output signal (129) indicative for said displacement. Herein, the fiducial element (116) has an in-plane stiffness which is substantially larger than an in-plane stiffness of said part of the patient's exterior. In addition, the fiducial element (116) and said part of the patient's exterior are provided with substantially equal outer in-plane dimensions.
摘要翻译：本发明提供一种用于在成像过程期间准确地检测患者（114）运动的系统（102）。该系统包括用于提供患者外部（206）的一部分的相机图像流的照相机（126）。所述系统（102）还包括基准元件（116），所述基准元件（116）可安装在所述患者外部部分（206）的所述部分上，并且所述基准元件（116）在相机图像流中是可检测的，以及图像处理器（128），用于基于包括在至少相机图像流中的连续相机图像来检测基准元素的位移，并且用于生成指示所述位移的输出信号（129）。这里，基准元件（116）具有的面内刚度基本上大于患者外部部分的平面内刚度。此外，基准元件（116）和患者外部的所述部分设置有基本上相等的外部平面外尺寸。

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