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1. 发明申请

WO2008062354A1 A SYSTEM, DEVICE, METHOD, COMPUTER-READABLE MEDIUM, AND USE FOR IN VIVO IMAGING OF TISSUE IN AN ANATOMICAL STRUCTURE 审中-公开
标题翻译：系统，装置，方法，计算机可读介质和用于在解剖结构中进行组织成像的用途
公开(公告)号：WO2008062354A1
公开(公告)日：2008-05-29
申请号：PCT/IB2007/054674
申请日：2007-11-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BAKKER, Levinus, P. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , VAN DEN HAM, Rene , HENDRIKS, Bernardus, H., W. , HOFFMANN, Ralf , VAN DER VAART, Nijs, C. , VAN DER VOORT, Marjolein
发明人： BAKKER, Levinus, P. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , VAN DEN HAM, Rene , HENDRIKS, Bernardus, H., W. , HOFFMANN, Ralf , VAN DER VAART, Nijs, C. , VAN DER VOORT, Marjolein
IPC分类号： A61B5/00 , A61B8/12
CPC分类号： A61B5/0095 , A61B5/0035 , A61B5/0084 , A61B5/0086 , A61B8/12 , A61B8/4416
摘要： A system is provided that may be used for locating and diagnosing lesions in the human body in vivo. In some embodiments, once the exact position of a lesion is found, a biopsy may be taken from the lesion using e.g. ultra sound techniques for guidance of the biopsy needle. Use of the system drastically reduces the negative biopsy samples compared to currently used "blind sampling" techniques. This reduces patient discomfort and minimizes infections as the number of biopsy samples is reduced. A method and computer- readable medium is also provided.
摘要翻译：提供了可用于在体内定位和诊断人体损伤的系统。在一些实施例中，一旦发现病变的确切位置，可以使用例如病变从病变中取出活组织检查。超声技术用于指导活检针。与目前使用的“盲采”技术相比，使用该系统大大减少了活检样本的阴性。这减少了患者的不适，并使活检样本的数量减少了感染的最小程度。还提供了一种方法和计算机可读介质。

2. 发明申请

WO2008062346A1 A SYSTEM, METHOD, COMPUTER-READABLE MEDIUM AND USE FOR IMAGING OF TISSUE IN AN ANATOMICAL STRUCTURE 审中-公开
标题翻译：系统，方法，计算机可读介质和用于在解剖结构中形成组织的用途
公开(公告)号：WO2008062346A1
公开(公告)日：2008-05-29
申请号：PCT/IB2007/054626
申请日：2007-11-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , BAKKER, Levinus, P. , VAN DEN HAM, René , HENDRIKS, Bernardus, H., W. , HOFFMANN, Ralf , VAN DER VAART, Nijs, C. , VAN DER VOORT, Marjolein
发明人： VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , BAKKER, Levinus, P. , VAN DEN HAM, René , HENDRIKS, Bernardus, H., W. , HOFFMANN, Ralf , VAN DER VAART, Nijs, C. , VAN DER VOORT, Marjolein
IPC分类号： A61B5/00
CPC分类号： A61B5/4381 , A61B5/0073 , A61B5/0084 , A61B5/0086 , A61B8/12
摘要： A system for imaging of prostate cancer in a prostate in vivo is provided. The system utilizes Diffuse Optical Tomography (DOT) for creating a 3D image for the detection of suspicious prostate tissue. The DOT image may be used to guide the biopsy, thereby reducing the number of false negatives. A method, computer-readable medium and use are also provided.
摘要翻译：提供了一种用于前列腺体内前列腺癌成像的系统。该系统利用漫射光学层析成像（DOT）创建用于检测可疑前列腺组织的3D图像。 DOT图像可用于指导活组织检查，从而减少假阴性的数量。还提供了一种方法，计算机可读介质和使用。

3. 发明申请

WO2011073903A1 NOVEL TUMOR MARKERS 审中-公开
标题翻译：新肿瘤标志物
公开(公告)号：WO2011073903A1
公开(公告)日：2011-06-23
申请号：PCT/IB2010/055803
申请日：2010-12-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HOFFMANN, Ralf , VISSER, Hugo Matthieu , ROMIJN, Edwin Peter , WAANDERS, Leonie , MERKLE, Dennis , HULSEN, Tim
发明人： HOFFMANN, Ralf , VISSER, Hugo Matthieu , ROMIJN, Edwin Peter , WAANDERS, Leonie , MERKLE, Dennis , HULSEN, Tim
IPC分类号： G01N33/574
CPC分类号： G01N33/57484 , A61K39/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , G01N2800/50 , G01N2800/52 , G01N2800/56 , G01N2800/60
摘要： The present invention relates to a tumor marker or group of tumor markers associated with the progression of a cancer disease from a less progressed stage to a more progressed stage, wherein the expression of the tumor markers is modified when comparing the expression in the less progressed stage and in the more progressed stage. The present invention further relates to a composition for diagnosing, detecting, graduating, monitoring or prognosticating a cancer disease associated with a progression from a less progressed cancer stage to a more progressed cancer stage comprising affinity ligands for the expression products of the tumor markers, to corresponding methods, and to the use of said tumor markers for detecting, diagnosing, graduating, monitoring or prognosticating a cancer disease associated with a progression from a less progressed cancer stage to a more progressed cancer stage. The present invention further relates to a corresponding immunoassay, to a method of identifying an individual for eligibility for a cancer disease therapy as well as to a pharmaceutical composition based on the inhibition of the expression of said tumor markers.
摘要翻译：本发明涉及与较少进展阶段到更进展期的癌症疾病进展相关的肿瘤标志物或肿瘤标志物组，其中当比较不太进展阶段中的表达时，修饰肿瘤标志物的表达并在更进步的阶段。本发明还涉及一种用于诊断，检测，分级，监测或预测与从不太进展的癌症阶段进展到包括对肿瘤标志物的表达产物的亲和配体的更进展的癌症阶段相关的癌症疾病的组合物，相应的方法，以及所述肿瘤标志物用于检测，诊断，分级，监测或预测与从较不进展的癌症阶段到更进展的癌症阶段的进展相关的癌症疾病的用途。本发明还涉及相应的免疫测定，鉴定个体对癌症疾病治疗的资格的方法以及基于抑制所述肿瘤标志物的表达的药物组合物。

4. 发明申请

WO2011073896A1 NOVEL TUMOR MARKERS 审中-公开
标题翻译：新肿瘤标志物
公开(公告)号：WO2011073896A1
公开(公告)日：2011-06-23
申请号：PCT/IB2010/055796
申请日：2010-12-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HOFFMANN, Ralf , VISSER, Hugo, Matthieu , HULSEN, Tim , WAANDERS, Leonie , ROMIJN, Edwin, Peter
发明人： HOFFMANN, Ralf , VISSER, Hugo, Matthieu , HULSEN, Tim , WAANDERS, Leonie , ROMIJN, Edwin, Peter
IPC分类号： G01N33/574
CPC分类号： G01N33/57434 , G01N2800/56
摘要： The present invention relates to a tumor marker or group of tumor markers associated with the progression of a cancer disease from a less progressed stage to a more progressed stage, wherein the expression of the tumor markers is modified when comparing the expression in the less progressed stage and in the more progressed stage. The present invention further relates to a composition for diagnosing, detecting, graduating, monitoring or prognosticating a cancer disease associated with a progression from a less progressed cancer stage to a more progressed cancer stage comprising affinity ligands for the expression products of the tumor markers, to corresponding methods, and to the use of said tumor markers for detecting, diagnosing, graduating, monitoring or prognosticating a cancer disease associated with a progression from a less progressed cancer stage to a more progressed cancer stage. The present invention further relates to a corresponding immunoassay, to a method of identifying an individual for eligibility for a cancer disease therapy, as well as to a pharmaceutical composition based on the inhibition of the expression of said tumor markers.
摘要翻译：本发明涉及与较少进展阶段到更进展期的癌症疾病进展相关的肿瘤标志物或肿瘤标志物组，其中当比较不太进展阶段中的表达时，修饰肿瘤标志物的表达并在更进步的阶段。本发明还涉及一种用于诊断，检测，分级，监测或预测与从不太进展的癌症阶段进展到包括对肿瘤标志物的表达产物的亲和配体的更进展的癌症阶段相关的癌症疾病的组合物，相应的方法，以及所述肿瘤标志物用于检测，诊断，分级，监测或预测与从较不进展的癌症阶段到更进展的癌症阶段的进展相关的癌症疾病的用途。本发明还涉及相应的免疫测定，鉴定个体对癌症疾病治疗的资格的方法，以及基于抑制所述肿瘤标志物的表达的药物组合物。

5. 发明申请

WO2011027311A2 NOVEL TUMOR MARKERS 审中-公开
标题翻译：新肿瘤标志物
公开(公告)号：WO2011027311A2
公开(公告)日：2011-03-10
申请号：PCT/IB2010/053943
申请日：2010-09-02
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HOFFMANN, Ralf , ROMIJN, Edwin, P. , VISSER, Hugo, M. , HULSEN, Tim
发明人： HOFFMANN, Ralf , ROMIJN, Edwin, P. , VISSER, Hugo, M. , HULSEN, Tim
IPC分类号： G01N33/574
CPC分类号： G01N33/574 , G01N33/57434 , G01N2800/56
摘要： The present invention relates to a tumor marker or group of tumor markers associated with the progression of a cancer disease from a less progressed stage to a more progressed stage, wherein the expression of the tumor markers is modified when comparing the expression in the less progressed stage and in the more progressed stage. The present invention further relates to a composition for diagnosing, detecting, graduating, monitoring or prognosticating a cancer disease associated with a progression from a less progressed cancer stage to a more progressed cancer stage comprising affinity ligands for the expression products of the tumor markers, to corresponding methods, and to the use of said tumor markers for detecting, diagnosing, graduating, monitoring or prognosticating a cancer disease associated with a progression from a less progressed cancer stage to a more progressed cancer stage. The present invention further relates to a corresponding immunoassay, to a method of identifying an individual for eligibility for a cancer disease therapy, as well as to a pharmaceutical composition based on the inhibition and/or activation of the expression of said tumor markers.
摘要翻译：本发明涉及与较少进展阶段到更进展期的癌症疾病进展相关的肿瘤标志物或肿瘤标志物组，其中当比较不太进展阶段中的表达时，修饰肿瘤标志物的表达并在更进步的阶段。本发明还涉及一种用于诊断，检测，分级，监测或预测与从不太进展的癌症阶段进展到包括对肿瘤标志物的表达产物的亲和配体的更进展的癌症阶段相关的癌症疾病的组合物，相应的方法，以及所述肿瘤标志物用于检测，诊断，分级，监测或预测与从较不进展的癌症阶段到更进展的癌症阶段的进展相关的癌症疾病的用途。本发明还涉及相应的免疫测定，鉴定个体对癌症疾病治疗的资格的方法，以及基于抑制和/或激活所述肿瘤标志物的表达的药物组合物。

6. 发明申请

WO2011027308A1 NOVEL TUMOR MARKERS 审中-公开
标题翻译：新型肿瘤标志物
公开(公告)号：WO2011027308A1
公开(公告)日：2011-03-10
申请号：PCT/IB2010/053940
申请日：2010-09-02
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HOFFMANN, Ralf , ROMIJN, Edwin, P. , VISSER, Hugo, M. , HULSEN, Tim
发明人： HOFFMANN, Ralf , ROMIJN, Edwin, P. , VISSER, Hugo, M. , HULSEN, Tim
IPC分类号： G01N33/574
CPC分类号： G01N33/574 , A61K38/00 , A61K39/0011 , A61K2039/515 , A61K2039/53 , G01N33/57434 , G01N2800/56
摘要： The present invention relates to a tumor marker or group of tumor markers associated with the progression of a neoplastic disease from a less progressed stage to a more progressed stage, wherein the expression of the tumor markers is modified when comparing the expression in the less progressed stage and in the more progressed stage. The present invention further relates to a composition for diagnosing, detecting, graduating, monitoring or prognosticating a neoplastic disease associated with a progression from a less progressed cancer stage to a more progressed cancer stage comprising affinity ligands for the expression products of the tumor markers, to corresponding methods, and to the use of said tumor markers for detecting, diagnosing, graduating, monitoring or prognosticating a neoplastic disease associated with a progression from a less progressed cancer stage to a more progressed cancer stage. The present invention further relates to a corresponding immunoassay, to a method of identifying an individual for eligibility for a neoplastic disease therapy, as well as to a pharmaceutical composition based on the inhibition and/or activation of the expression of said tumor markers.
摘要翻译：本发明涉及与较晚进展期到更进展期的肿瘤性疾病进展相关的肿瘤标志物或肿瘤标志物组，其中当比较不太进展期的表达时，修饰肿瘤标志物的表达并在更进步的阶段。本发明还涉及一种用于诊断，检测，分级，监测或预测与从不太进展的癌症阶段进展到包括肿瘤标志物的表达产物的亲和配体的更进展的癌症阶段相关的肿瘤疾病的组合物，相应的方法，以及所述肿瘤标志物用于检测，诊断，分级，监测或预测与从较不进展的癌症阶段到更进展的癌症阶段的进展相关的肿瘤疾病的用途。本发明还涉及相应的免疫测定，鉴定个体对肿瘤疾病治疗的资格的方法，以及基于抑制和/或激活所述肿瘤标志物的表达的药物组合物。

7. 发明申请

WO2008059419A1 RADIATION SENSITIZERS FOR IONIZING ELECTROMAGNETIC RADIATION THERAPY AND IMAGING 审中-公开
标题翻译：用于放射电磁辐射治疗和成像的辐射敏感剂
公开(公告)号：WO2008059419A1
公开(公告)日：2008-05-22
申请号：PCT/IB2007/054563
申请日：2007-11-09
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , HUMMEL, Helga , JUESTEL, Thomas , HOFFMANN, Ralf , RONDA, Cornelis, R.
发明人： HUMMEL, Helga , JUESTEL, Thomas , HOFFMANN, Ralf , RONDA, Cornelis, R.
IPC分类号： A61K41/00
CPC分类号： A61K41/0038 , A61N5/10 , A61N2005/1098 , B82Y5/00
摘要： The invention relates to enhancing the effects of ionizing radiation (8), by providing nanoparticles (6) having material composition with a higher efficiency in producing solvated electrons or O 2 - or OH - radicals having a malicious effect in tissue. The nanoparticles (6) comprise one or more non-metallic reducing agents compounded to display electronic band structure. In one embodiment, the nanoparticles may comprise redox-active oxidic material such as TiO 2 compounded to display electronic band structure.
摘要翻译：本发明涉及通过提供具有在产生溶剂化电子中具有较高效率的材料组成的纳米颗粒（6）来增强电离辐射（8）的效果，或者O 2

8. 发明申请

WO2013011479A2 ASSESSMENT OF CELLULAR SIGNALING PATHWAY ACTIVITY USING PROBABILISTIC MODELING OF TARGET GENE EXPRESSION 审中-公开
标题翻译：利用目标基因表达的概率模型评估细胞信号通路活性
公开(公告)号：WO2013011479A2
公开(公告)日：2013-01-24
申请号：PCT/IB2012/053686
申请日：2012-07-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VERHAEGH, Wilhelmus Franciscus Johannes , VAN DE STOLPE, Anja , VAN OOIJEN, Hendrik Jan , DULLA, Kalyana, Chakravarthi , ALVES DE INDA, Marcia , HOFFMANN, Ralf
发明人： VERHAEGH, Wilhelmus Franciscus Johannes , VAN DE STOLPE, Anja , VAN OOIJEN, Hendrik Jan , DULLA, Kalyana, Chakravarthi , ALVES DE INDA, Marcia , HOFFMANN, Ralf
IPC分类号： C12Q1/68 , G06F19/24
CPC分类号： G06F19/12 , C12Q1/6809 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G06F19/18 , G06F19/20 , G06F19/24 , C12Q2537/165
摘要： The present application mainly relates to specific methods for inferring activity of one or more cellular signaling pathway(s) in tissue of a medical subject based at least on the expression level(s) of one or more target gene(s) of the cellular signaling pathway(s) measured in an extracted sample of the tissue of the medical subject, an apparatus comprising a digital compressor configured to perform such methods and a non- transitory storage medium storing instructions that are executable by a digital processing device to perform such methods.
摘要翻译：本申请主要涉及用于至少基于一个或多个靶标的表达水平来推断医学对象的组织中的一种或多种细胞信号传导途径的活性的具体方法在医学对象的组织的提取样品中测量的细胞信号传导途径的基因，包括配置成执行这样的方法的数字压缩器的装置和存储可由患者的组织执行的指令的非暂态存储介质数字处理设备来执行这种方法。

9. 发明申请

WO2010131193A1 PHOSPHODIESTERASE 9A AS PROSTATE CANCER MARKER 审中-公开
标题翻译：磷酸二酯酶9A作为前列腺癌标记物
公开(公告)号：WO2010131193A1
公开(公告)日：2010-11-18
申请号：PCT/IB2010/052069
申请日：2010-05-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW , HOFFMANN, Ralf , HOUSLAY, Miles, D. , HENDERSON, David, J., P.
发明人： HOFFMANN, Ralf , HOUSLAY, Miles, D. , HENDERSON, David, J., P.
IPC分类号： C12Q1/68 , C12Q1/44 , G01N33/574 , C12N9/16 , C12N15/11
CPC分类号： C12N15/1137 , C12N9/16 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N33/57434 , G01N2800/52
摘要： The present invention relates to phosphodiesterase 9A (PDE9A) for use as a marker for prostate cancer, and the use of PDE9A as a marker for diagnosing, detecting, monitoring or prognosticating prostate cancer or the progression of prostate cancer. The present invention also relates to a composition for diagnosing, detecting, monitoring or prognosticating prostate cancer or the progression of prostate cancer, a corresponding method and immunoassay, a method for diagnosing, monitoring or prognosticating hormone-resistant prostate cancer vs. hormone-sensitive prostate cancer, a corresponding immunoassay, a method of data acquisition, an immunoassay for diagnosing, detecting, monitoring or prognosticating prostate cancer or the progression of prostate cancer, a method of identifying an individual for eligibility for prostate cancer therapy, an immunoassay for stratifying an individual or cohort of individuals with a prostate cancer disease, an immunoassay for stratifying an individual with prostate cancer. The present invention further envisages pharmaceutical compositions and their use for the treatment of prostate cancer, in particular hormone-resistant prostate cancer.
摘要翻译：本发明涉及用作前列腺癌标志物的磷酸二酯酶9A（PDE9A），以及使用PDE9A作为诊断，检测，监测或预测前列腺癌或前列腺癌进展的标志物。本发明还涉及用于诊断，检测，监测或预测前列腺癌或前列腺癌进展的组合物，相应的方法和免疫测定，用于诊断，监测或预测激素抵抗性前列腺癌与激素敏感前列腺的方法癌症，相应的免疫测定，数据采集方法，用于诊断，检测，监测或预测前列腺癌的免疫测定或前列腺癌的进展，鉴定个体对前列腺癌治疗的资格的方法，用于分层个体的免疫测定或患有前列腺癌疾病的个体的群体，用于对患有前列腺癌的个体进行分层的免疫测定。本发明进一步设想药物组合物及其用于治疗前列腺癌，特别是激素抗性前列腺癌的用途。

10. 发明申请

WO2005104180A3 USE OF A COMPOSITE OR COMPOSITION OF DIAMOND AND OTHER MATERIAL FOR ANALYSIS OF ANALYTES 审中-公开
公开(公告)号：WO2005104180A3
公开(公告)日：2005-11-03
申请号：PCT/IB2005/051212
申请日：2005-04-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BACHMANN, Peter, K. , VAN ELSBERGEN, Volker , HOFFMANN, Ralf , HUMMEL, Helga , RIBBING, Carolina, M. , WIECHERT, Detlef, U.
发明人： BACHMANN, Peter, K. , VAN ELSBERGEN, Volker , HOFFMANN, Ralf , HUMMEL, Helga , RIBBING, Carolina, M. , WIECHERT, Detlef, U.
IPC分类号： H01J49/04
摘要： The present invention relates to the use of composites or compositions of diamond/non-diamond material, e.g. diamond/non-diamond carbon material for chemical or biological analysis. The invention further relates to the use of this material in separation adherence and detection of chemical of biological samples. Applications of either structurized substrates or mixed phase particles of this material include but are not limited to processes which involve desorption-ionization of a sample, more specifically mass spectroscopy.

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