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1. 发明申请

WO2007072373A2 A SENSOR FOR BIOMOLECULES AND A METHOD OF ANALYSIS USING SAID SENSOR 审中-公开
标题翻译：生物分子传感器和使用传感器的分析方法
公开(公告)号：WO2007072373A2
公开(公告)日：2007-06-28
申请号：PCT/IB2006/054883
申请日：2006-12-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BACHER, Johannes , BOOS, Andreas , LUEDKE, Gerd
发明人： BACHER, Johannes , BOOS, Andreas , LUEDKE, Gerd
CPC分类号： B01L3/502 , B01L2300/0636 , B01L2300/0681
摘要： Disclosed is a method of preparing a sensor for the analysis of a sample fluid, said sample fluid containing one or more target molecules. The method comprises the step of introducing said sample fluid into a chamber equipped with a porous substrate, one or more probe molecules being applied to said porous substrate and said probes being able to specifically bind to said one or more target molecules. The method further comprises the step of moving said substrate and said chamber relatively to each other in order to force said sample fluid through the pores of said porous substrate and to capture the one or more target molecules with the one or more probe molecules. Also disclosed is a sensor for the analysis of a sample fluid.
摘要翻译：公开了一种制备用于分析样品流体的传感器的方法，所述样品流体包含一种或多种靶分子。该方法包括将所述样品流体引入配备有多孔底物的室中的步骤，将一个或多个探针分子施加到所述多孔底物上，并且所述探针能够特异性结合所述一个或多个靶分子。该方法还包括相对于彼此移动所述衬底和所述室的步骤，以便迫使所述样品流体通过所述多孔衬底的孔并且用所述一个或多个探针分子捕获所述一个或多个靶分子。还公开了用于分析样品流体的传感器。

2. 发明申请

WO2007072311A3 A SENSOR FOR BIOMOLECULES AND A METHOD FOR PREPARING AND USING THE SAME 审中-公开
公开(公告)号：WO2007072311A3
公开(公告)日：2007-06-28
申请号：PCT/IB2006/054792
申请日：2006-12-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BACHER, Johannes , BOOS, Andreas , LUEDKE, Gerd
发明人： BACHER, Johannes , BOOS, Andreas , LUEDKE, Gerd
IPC分类号： G01N33/53 , G01N33/543
摘要： Disclosed is a method of preparing a sensor for the analysis of a sample fluid, said sample fluid containing one or more target molecules. The method comprises the steps of applying a non-activated porous organic polymer membrane with probes in the form of an array of probe locations, said probes being able to specifically bind to said one or more target molecules. Furthermore, the method comprises the steps of blocking areas remaining free of probes of said porous organic polymer membrane with one or more blocking substances and forcing the sample fluid repeatedly in one or two directions through the pores of said porous organic polymer membrane. Also disclosed is a sensor for the analysis of a sample fluid.

3. 发明申请

WO2007072290A3 METHOD OF PERFORMING A MICROARRAY ASSAY 审中-公开
公开(公告)号：WO2007072290A3
公开(公告)日：2007-06-28
申请号：PCT/IB2006/054737
申请日：2006-12-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BACHER, Johannes , BOOS, Andreas , LUEDKE, Gerd
发明人： BACHER, Johannes , BOOS, Andreas , LUEDKE, Gerd
IPC分类号： C12Q1/68
摘要： Disclosed is a method for performing a microarray assay on one or more sample fluid(s), sais fluids comprising target biological compounds. The method comprises the step of tagging said target biological compounds with labels. The following step comprises contacting said sample fluid(s) with a substrate and detecting the presence of said labels at the surface of said substrate. The method is suitable for the simultaneous analysis, in one microarray, of one or more types of target biological compounds, in one or more sample fluid(s). To this end each of said types of biological compounds is tagged with a different label so that target biological compounds belonging to different sample fluids have different labels. Said different labels are discriminable upon detection at the surface of said substrate. Also disclosed is the use of a polymer substrate in a method for performing a microarray assay.

4. 发明申请

WO2006136990A2 CARTRIDGE, SYSTEM AND METHOD FOR AUTOMATED MEDICAL DIAGNOSTICS 审中-公开
标题翻译： CARTRIDGE，SYSTEM AND METHOD FOR AUTOMATED MEDICAL DIAGNOSTICS
公开(公告)号：WO2006136990A2
公开(公告)日：2006-12-28
申请号：PCT/IB2006/051941
申请日：2006-06-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN HAAG, Chris , JONGERIUS, Michiel, J. , SCHAEFER, Danny, G., A. , VAN DEN BIJGAART, Adrianus, W., D., M. , DE GIER, Ronald, C. , DE JONG, Michiel , PROSS, Gerhard , BACHER, Johannes , BOOS, Andreas , LUEDKE, Gerd , SEHER, Jens-Peter
发明人： VAN HAAG, Chris , JONGERIUS, Michiel, J. , SCHAEFER, Danny, G., A. , VAN DEN BIJGAART, Adrianus, W., D., M. , DE GIER, Ronald, C. , DE JONG, Michiel , PROSS, Gerhard , BACHER, Johannes , BOOS, Andreas , LUEDKE, Gerd , SEHER, Jens-Peter
IPC分类号： B01L3/00 , G01N1/28 , G01N21/76 , G01N35/00 , G01N33/487
CPC分类号： B01L7/52 , B01L3/502715 , B01L3/502738 , B01L3/545 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2300/02 , B01L2300/087 , B01L2300/1805 , G01N21/6428 , G01N35/00069 , G01N2035/00158
摘要： Disclosed is a cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a generic part and one or more separate application-specific parts, which are connectable to the generic part. Also disclosed is a system for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. This system comprising a reusable apparatus, wherein said apparatus is configured to receive a cartridge and to control a process for the detection of the presence, absence and/or amount of a target nucleotide sequence in the sample, being present in said cartridge.
摘要翻译：公开了用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或量的盒。盒包括通用部分和一个或多个单独的应用特定部分，其可连接到通用部分。还公开了用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或数量的系统。该系统包括可重复使用的装置，其中所述装置被配置为接收盒并且控制用于检测存在于所述盒中的样品中目标核苷酸序列的存在，不存在和/或量的过程。

5. 发明申请

WO2007129256A2 INTEGRATED TEMPERATURE SENSOR 审中-公开
标题翻译：集成温度传感器
公开(公告)号：WO2007129256A2
公开(公告)日：2007-11-15
申请号：PCT/IB2007/051610
申请日：2007-05-01
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , DEN TOONDER, Jacob, M., J. , BOOS, Andreas
发明人： DEN TOONDER, Jacob, M., J. , BOOS, Andreas
CPC分类号： G01K5/486
摘要： A biochip has an integrated temperature sensor comprising a micro mechanical actuator (20) having a deformation dependent on temperature, and a detector (30) arranged to output a signal according to a deformation of the actuator. The actuator can be formed of LC material in an elastomeric network. The detector (30) can be optical, magnetic or capacitive. The actuator can be arranged as a layer and the deformation be a curling of the layer.
摘要翻译：生物芯片具有集成的温度传感器，其包括具有取决于温度的变形的微机械致动器（20），以及检测器（30），其布置成根据致动器的变形输出信号。致动器可以由弹性体网络中的LC材料形成。检测器（30）可以是光学的，磁性的或电容的。致动器可以被布置为层，并且变形是层的卷曲。

6. 发明申请

WO2003005905A1 SYSTEM FOR POINT OF CARE DIAGNOSIS AND/OR ANALYSIS 审中-公开
标题翻译：护理点诊断和/或分析系统
公开(公告)号：WO2003005905A1
公开(公告)日：2003-01-23
申请号：PCT/IB2002/003004
申请日：2002-07-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BOOS, Andreas , BACHER, Johannes , PROSS, Gerhard , SEHER, Jens-Peter
发明人： BOOS, Andreas , BACHER, Johannes , PROSS, Gerhard , SEHER, Jens-Peter
IPC分类号： A61B5/15
CPC分类号： A61B5/157 , A61B5/0002 , A61B5/150022 , A61B5/150786 , A61B5/15087
摘要： The present invention relates to a system for point of care diagnosis and/or analysis of body fluids of a patient, comprising:- a cartridge (2),- a diagnosis and/or analysis apparatus (3),- means (6) for measurement of the concentration of at least one specific component of a sample of the body fluids,- connecting means (8, 13) providing communication for electrical and/or optical values between the cartridge (2) and the diagnosis and/or analysis apparatus (3), wherein said values correlate with at least one of the respective concentrations,- diagnosing and/or analyzing means (14) measuring the respective concentration value via the connecting means (8, 13),- storage means (10) for storing cartridge specific data and/or information,- reading means (15) for reading the data and/or information out of the storage means (10),- wherein the diagnosing and/or analyzing means (14) evaluate the respective concentration values in accordance to the cartridge specific data and/or information.
摘要翻译：本发明涉及一种用于患者体液诊断和/或分析的系统，包括： - 盒（2）， - 诊断和/或分析装置（3）， - 用于测量体液样品的至少一个特定组分的浓度; - 连接装置（8,13），用于提供盒（2）和诊断和/或分析装置之间的电和/或光学值的通信（ 3），其中所述值与各自浓度中的至少一个相关联， - 经由连接装置（8,13）测量相应浓度值的诊断和/或分析装置（14）， - 存储装置（10）特定数据和/或信息， - 用于从存储装置（10）读出数据和/或信息的读取装置（15），其中诊断和/或分析装置（14）根据墨盒特定数据和/或信息。

7. 发明申请

WO2002085209A1 MEASUREMENT OF PATIENT DATA REQUIRING OPERATOR AND PATIENT IDENTIFICATION 审中-公开
标题翻译：需要操作者和患者识别的患者数据的测量
公开(公告)号：WO2002085209A1
公开(公告)日：2002-10-31
申请号：PCT/IB2002/001166
申请日：2002-04-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BOOS, Andreas
发明人： BOOS, Andreas
IPC分类号： A61B5/117
CPC分类号： A61B90/90
摘要： Disclosed is a system for measuring a physiological parameter of a patient. A measuring means (12) measures a signal representative for the physiological parameter of the patient, and an operator identification means (10) provides an operator identification signal for identifying an operator performing or helping to perform the measurement. The measured signal is associated with the operator identification signal for identifying the measured signal and thus providing an operator identified measuring signal (14).
摘要翻译：公开了一种用于测量患者的生理参数的系统。测量装置（12）测量代表患者的生理参数的信号，并且操作员识别装置（10）提供用于识别执行或有助于执行测量的操作者的操作者识别信号。所测量的信号与用于识别测量信号的操作者识别信号相关联，从而提供操作者识别的测量信号（14）。

8. 发明申请

WO2006061771A2 PATIENT IDENTIFICATION FOR POINT OF CARE DIAGNOSTICS 审中-公开
标题翻译：诊断点的患者识别
公开(公告)号：WO2006061771A2
公开(公告)日：2006-06-15
申请号：PCT/IB2005/054057
申请日：2005-12-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , U.S. PHILIPS CORPORATION , WENDT, Matthias , BOOS, Andreas , SPEKOWIUS, Gerhard , BACHMANN, Peter, K. , NIKOL, Hans , HUMMEL, Helga
发明人： WENDT, Matthias , BOOS, Andreas , SPEKOWIUS, Gerhard , BACHMANN, Peter, K. , NIKOL, Hans , HUMMEL, Helga
CPC分类号： G06F21/32 , A61B5/0002 , A61B5/117 , A61B5/1172 , A61B5/150022 , A61B5/150389 , A61B5/150503 , A61B5/150786 , A61B5/15105 , A61B5/15186 , A61B10/0045 , A61B10/007 , A61B90/90 , G06F19/00 , G16H10/20
摘要： A patient presses a finger concurrently against a needle (14) of a collection container (12) and a fingerprint surface (22, 52). In one embodiment, the patient's fingerprint is read electronically by a scanner (24) and correlated with a container serial number (16). In another embodiment, the patient's fingerprint is embossed in a foil layer (52). An analyzer assembly (40, 40' 40") analyzes the biological sample and reads either the container serial number or scans the fingerprint carrying layer (52) and sends the test results and either the fingerprint or container identification to a patient memory (30). Using the fingerprint information, a processor (32) correlates the test results with a record (60) of a corresponding patient. Alternately or additionally, the analyzer assembly includes a DNA analyzer (70) which measures preselected DNA characteristics (76) of the sample. The processor (32) compares the measured DNA subset characteristics with DNA subset characteristics (66) in the patient records to correlate or confirm the correlation of the analysis results with the proper patient.
摘要翻译：患者同时按压收集容器（12）的针（14）和指纹表面（22,52）。在一个实施例中，通过扫描仪（24）以电子方式读取患者的指纹并与容器序列号（16）相关联。在另一个实施例中，患者的指纹压印在箔层（52）中。分析器组件（40,40'，40“）分析生物样品并读取容器序列号或扫描指纹携带层（52），并将测试结果以及指纹或容器标识发送到患者存储器（30）。使用指纹信息，处理器（32）将测试结果与相应患者的记录（60）相关联。可选地或另外地，分析器组件包括测量样本的预先选择的DNA特征（76）的DNA分析器（70）。处理器（32）将测量的DNA子集特征与患者记录中的DNA子集特征（66）进行比较，以关联或确认分析结果与适当患者的相关性。

9. 发明申请

WO2013013687A8 APPARATUS AND METHOD FOR A LYSIS OF A SAMPLE, IN PARTICULAR FOR AN AUTOMATED AND/OR CONTROLLED LYSIS OF A SAMPLE 审中-公开
公开(公告)号：WO2013013687A8
公开(公告)日：2013-01-31
申请号：PCT/EP2011/003770
申请日：2011-07-27
申请人： CURETIS AG , BOOS, Andreas , LÜDKE, Gerd , BACHER, Johannes
发明人： BOOS, Andreas , LÜDKE, Gerd , BACHER, Johannes
IPC分类号： G01N1/28 , G01N1/38 , G01N1/44
摘要： The present invention provides an apparatus and a method for a lysis procedure, in particular for an automated and/or controlled lysis procedure of a sample, in particular a biological sample. The apparatus comprises at least one rotation disc (31), at least one vial holder (90) which is configured to receive a vial (100), wherein the vial holder (90) is arranged on the disc (31), at least one driving device (20) which is configured to rotate the disc (31) and the vial holder (90), at least one heating device (60) which is configured to heat the sample to a determined incubation temperature, and - at least one control device (70) which is configured to control the driving device (20) and/or the heating device (60) by means of a timing and/or step control, and/or - at least one transmitting device (80) for inductive coupling for energy and signal transmission, which is configured to transmit the energy for heating to the heating device (60), and/or - wherein the driving device (20) is configured to rotate the disc (31) in a first direction (A1) and/or with a first speed, and to rotate the vial holder (90) in a second direction (A3) and/or with a second speed. The apparatus and the method are adapted for an (automated) lysis procedure, wherein the lysis can be carried out in a safe, efficient and effective manner.

10. 发明申请

WO2011144345A1 REACTION VESSEL FOR PCR DEVICE AND METHOD OF PERFORMING PCR 审中-公开
标题翻译：用于PCR装置的反应容器和执行PCR的方法
公开(公告)号：WO2011144345A1
公开(公告)日：2011-11-24
申请号：PCT/EP2011/002507
申请日：2011-05-19
申请人： CURETIS AG , LÜDKE, Gerd , BOOS, Andreas , MOTEJADDED, Hassan , BACHER, Johannes
发明人： LÜDKE, Gerd , BOOS, Andreas , MOTEJADDED, Hassan , BACHER, Johannes
IPC分类号： B01L3/00 , B01L7/00 , C12Q1/68 , G01N33/543
CPC分类号： B01L7/52 , B01L3/502 , B01L2200/0631 , B01L2200/10 , B01L2300/047 , B01L2300/0636 , B01L2300/0681 , B01L2300/087 , B01L2400/0487 , B01L2400/049
摘要： The present invention provides a reaction vessel (20) for a PCR device. The reaction vessel (20) comprises a sample vial (32) defining a reaction chamber (33) for performing PCR and a storage vessel (62) defining a storage chamber (63) for optical detection. The reaction chamber (33) is in fluid communication with a liquid supply port (34) for supplying a liquid sample containing at least one target DNA to the reaction chamber (33). The reaction chamber (33) and the storage chamber (63) are in fluid communication via a spacer element (42) and a porous membrane (51) for hybridization of the at least one target DNA within the liquid sample onto specific immobilised hybridization probes. The lower end of the spacer element (42) extends into the reaction chamber (33), but does not reach the bottom thereof. The upper end of the spacer element (42) is located in proximity of the porous membrane (51), which is made from a material having different physical properties in a dry state and a wet state. In the dry state the porous membrane (51) allows air as well as liquid to pass therethrough. In the wet state the porous membrane (51) still allows the passage of liquid therethrough, but not of air, such that during a PCR the liquid sample remains in the reaction chamber (33) and after the PCR the reaction vessel (20) is configured to force the liquid sample via the spacer element (42) to the porous membrane (51 ) for hybridization and detection of the at least one target DNA in the liquid sample. Moreover, a PCR device comprising such a reaction vessel (20) as well as a method for performing PCR are described.
摘要翻译：本发明提供一种用于PCR装置的反应容器（20）。反应容器（20）包括限定用于进行PCR的反应室（33）的样品瓶（32）和限定用于光学检测的储存室（63）的储存容器（62）。反应室（33）与用于将含有至少一种目标DNA的液体样品供应到反应室（33）的液体供应口（34）流体连通。反应室（33）和储存室（63）经由间隔元件（42）和多孔膜（51）流体连通，用于将液体样品中的至少一个目标DNA杂交到特定的固定化杂交探针上。间隔元件（42）的下端延伸到反应室（33）中，但不到达其底部。间隔元件（42）的上端位于多孔膜（51）附近，该多孔膜由在干燥状态和湿态下具有不同物理性质的材料制成。在干燥状态下，多孔膜（51）允许空气以及液体通过。在湿状态下，多孔膜（51）仍然允许液体通过而不是空气通过，使得在PCR期间液体样品保留在反应室（33）中，并且在PCR之后，反应容器（20）是被配置为将液体样品经由间隔元件（42）强制到多孔膜（51），用于杂交和检测液体样品中的至少一种靶DNA。此外，描述了包含这种反应容器（20）的PCR装置以及用于进行PCR的方法。

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