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1. 发明申请

WO2006136990A2 CARTRIDGE, SYSTEM AND METHOD FOR AUTOMATED MEDICAL DIAGNOSTICS 审中-公开
标题翻译： CARTRIDGE，SYSTEM AND METHOD FOR AUTOMATED MEDICAL DIAGNOSTICS
公开(公告)号：WO2006136990A2
公开(公告)日：2006-12-28
申请号：PCT/IB2006/051941
申请日：2006-06-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN HAAG, Chris , JONGERIUS, Michiel, J. , SCHAEFER, Danny, G., A. , VAN DEN BIJGAART, Adrianus, W., D., M. , DE GIER, Ronald, C. , DE JONG, Michiel , PROSS, Gerhard , BACHER, Johannes , BOOS, Andreas , LUEDKE, Gerd , SEHER, Jens-Peter
发明人： VAN HAAG, Chris , JONGERIUS, Michiel, J. , SCHAEFER, Danny, G., A. , VAN DEN BIJGAART, Adrianus, W., D., M. , DE GIER, Ronald, C. , DE JONG, Michiel , PROSS, Gerhard , BACHER, Johannes , BOOS, Andreas , LUEDKE, Gerd , SEHER, Jens-Peter
IPC分类号： B01L3/00 , G01N1/28 , G01N21/76 , G01N35/00 , G01N33/487
CPC分类号： B01L7/52 , B01L3/502715 , B01L3/502738 , B01L3/545 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2300/02 , B01L2300/087 , B01L2300/1805 , G01N21/6428 , G01N35/00069 , G01N2035/00158
摘要： Disclosed is a cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a generic part and one or more separate application-specific parts, which are connectable to the generic part. Also disclosed is a system for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. This system comprising a reusable apparatus, wherein said apparatus is configured to receive a cartridge and to control a process for the detection of the presence, absence and/or amount of a target nucleotide sequence in the sample, being present in said cartridge.
摘要翻译：公开了用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或量的盒。盒包括通用部分和一个或多个单独的应用特定部分，其可连接到通用部分。还公开了用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或数量的系统。该系统包括可重复使用的装置，其中所述装置被配置为接收盒并且控制用于检测存在于所述盒中的样品中目标核苷酸序列的存在，不存在和/或量的过程。

2. 发明申请

WO2007020582A1 SYSTEM FOR AUTOMATICALLY PROCESSING A BIOLOGICAL SAMPLE 审中-公开
标题翻译：自动处理生物样品的系统
公开(公告)号：WO2007020582A1
公开(公告)日：2007-02-22
申请号：PCT/IB2006/052782
申请日：2006-08-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , SCHAEFER, Danny, G., A. , VAN DEN BIJGAART, Adrianus, W., D., M. , DE JONG, Michiel , DE GIER, Ronald, C. , MOLENAAR, Jacobus, F. , MAESSEN, Ralph, T., H. , WEHRENS, Roger, M., H., G. , BOUMA, Peter, H. , VAN HAAG, Chris
发明人： SCHAEFER, Danny, G., A. , VAN DEN BIJGAART, Adrianus, W., D., M. , DE JONG, Michiel , DE GIER, Ronald, C. , MOLENAAR, Jacobus, F. , MAESSEN, Ralph, T., H. , WEHRENS, Roger, M., H., G. , BOUMA, Peter, H. , VAN HAAG, Chris
IPC分类号： B01L3/00
CPC分类号： G01N35/00029 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L9/527 , B01L2200/10 , B01L2200/16 , B01L2300/021 , B01L2300/087 , B01L2400/0478 , B01L2400/0487 , B01L2400/0644 , G01N2035/00237
摘要： The invention provides a system (10), a processing apparatus (30), a sample unit (20), a reagent unit (25) and a method for processing a biological sample inside the sample unit. The system comprises at least a processing apparatus and a sample unit, the sample unit comprises a plurality of microfluidic elements, the processing apparatus comprises actuation means capable of actuating at the microfluidic elements such that a quick, inexpensive and accurate analysis of the biological sample is possible.
摘要翻译：本发明提供一种系统（10），处理装置（30），样品单元（20），试剂单元（25）以及用于处理样品单元内的生物样品的方法。该系统至少包括一个处理设备和一个样品单元，该样品单元包括多个微流体元件，该处理设备包括能够致动微流体元件的致动装置，使得生物样品的快速，便宜且准确的分析是可能。

3. 发明申请

WO2007004103A1 CARTRIDGE FOR AUTOMATED MEDICAL DIAGNOSTICS 审中-公开
标题翻译：自动化医疗诊断用卡
公开(公告)号：WO2007004103A1
公开(公告)日：2007-01-11
申请号：PCT/IB2006/052074
申请日：2006-06-26
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DE GIER, Ronald, C. , SCHAEFER, Danny, G., A. , VAN DEN BIJGAART, Adrianus, W., D., M. , VAN HAAG, Chris , DE JONG, Michiel
发明人： DE GIER, Ronald, C. , SCHAEFER, Danny, G., A. , VAN DEN BIJGAART, Adrianus, W., D., M. , VAN HAAG, Chris , DE JONG, Michiel
IPC分类号： B01L3/00 , G01N1/28 , G01N21/76 , G01N35/00 , G01N33/487
CPC分类号： B01L3/502738 , B01L3/50273 , B01L2200/025 , B01L2200/026 , B01L2200/028 , B01L2200/04 , B01L2200/10 , B01L2300/123 , B01L2300/1827 , B01L2400/0481
摘要： The present invention relates to a cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a first component and a second component being connectable to each other, the first component comprising at least a first fluid opening and a first sealing surface and the second component comprising at least a second fluid opening and a second sealing surface. Upon connection of the first and second component the first and second fluid opening are placeable in fluid communication and the first and second sealing surfaces are placeable against each other to seal the fluid communication between the first and second fluid opening. The invention is characterized in that the cartridge comprises biasing means for biasing the second sealing surface in the direction of the first sealing surface.
摘要翻译：本发明涉及用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或数量的盒。所述盒包括可彼此连接的第一部件和第二部件，所述第一部件至少包括第一流体开口和第一密封表面，所述第二部件至少包括第二流体开口和第二密封表面。在连接第一和第二部件时，第一和第二流体开口可以流体连通地放置，并且第一和第二密封表面彼此相对放置以密封第一和第二流体开口之间的流体连通。本发明的特征在于，该盒包括用于沿第一密封表面的方向偏置第二密封表面的偏置装置。

4. 发明申请

WO2006136996A2 APPARATUS FOR MOVING MAGNETIC PARTICLES 审中-公开
标题翻译：移动磁性颗粒的装置
公开(公告)号：WO2006136996A2
公开(公告)日：2006-12-28
申请号：PCT/IB2006/051955
申请日：2006-06-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN DEN BIJGAART, Adrianus, W., D., M. , DE GIER, Ronald, C. , DE GROOT, Antonius, F., J. , VAN HAAG, Chris
发明人： VAN DEN BIJGAART, Adrianus, W., D., M. , DE GIER, Ronald, C. , DE GROOT, Antonius, F., J. , VAN HAAG, Chris
CPC分类号： G01N33/54333 , B01F13/0809 , G01N35/0098
摘要： The invention provides an apparatus for moving magnetic particles in a liquid medium, a system comprising an apparatus, a method for moving magnetic particles and a method for moving and for fixing the magnetic particles. The apparatus comprises a first magnetic means generating a first magnetic field, the apparatus further comprising a second magnetic means generating a second magnetic field, the first magnetic field having a first main axis, the second magnetic field having a second main axis, wherein the first and second main axes are inclined relative to each other by an acute angle of inclination.
摘要翻译：本发明提供了一种用于在液体介质中移动磁性颗粒的装置，包括装置，用于移动磁性颗粒的方法的系统和用于移动和固定磁性颗粒的方法。该装置包括产生第一磁场的第一磁性装置，该装置还包括产生第二磁场的第二磁性装置，所述第一磁场具有第一主轴，所述第二磁场具有第二主轴，其中所述第一磁场并且第二主轴相对于彼此倾斜锐角。

5. 发明申请

WO2006136999A1 DEVICE FOR MIXING A LIQUID MEDIUM 审中-公开
标题翻译：用于混合液体介质的装置
公开(公告)号：WO2006136999A1
公开(公告)日：2006-12-28
申请号：PCT/IB2006/051958
申请日：2006-06-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN DEN BIJGAART, Adrianus, W., D., M. , DE GIER, Ronald, C. , SHULEPOV, Sergei , VAN HAAG, Chris
发明人： VAN DEN BIJGAART, Adrianus, W., D., M. , DE GIER, Ronald, C. , SHULEPOV, Sergei , VAN HAAG, Chris
IPC分类号： B01F11/00 , B01F13/00 , B01L3/00
CPC分类号： B01F13/0059 , B01F11/0045 , B01L3/508
摘要： The invention provides a device for mixing a liquid medium, an apparatus for mixing a liquid medium, a system comprising a device and an apparatus and a method for mixing a liquid medium. The device comprises a flexible membrane (12) and a structural part (16), which device further comprises an actuation part (14) located on a first side of the membrane, which device further comprises a mixing chamber (20) located on a second side of the membrane, wherein at least a partial inclination of the membrane results from an inclination of the actuation part relative to the structural part.
摘要翻译：本发明提供了一种用于混合液体介质的装置，用于混合液体介质的装置，包括装置的系统和装置以及用于混合液体介质的方法。该装置包括柔性膜（12）和结构部分（16），该装置还包括位于膜的第一侧上的致动部分（14），该装置还包括位于第二侧面上的混合室（20）其中膜的至少部分倾斜度来自致动部分相对于结构部件的倾斜。

6. 发明申请

WO2008075253A1 MICRO FLUIDIC DEVICE 审中-公开
标题翻译：微流体装置
公开(公告)号：WO2008075253A1
公开(公告)日：2008-06-26
申请号：PCT/IB2007/055045
申请日：2007-12-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN HAAG, Chris , DE GIER, Ronald, C. , VAN DEN BIJGAART, Adrianus, W., D., M. , STAN, Gheorghe, S.
发明人： VAN HAAG, Chris , DE GIER, Ronald, C. , VAN DEN BIJGAART, Adrianus, W., D., M. , STAN, Gheorghe, S.
IPC分类号： F16K49/00
CPC分类号： F15C5/00 , Y10T137/0971 , Y10T137/3584 , Y10T137/3631 , Y10T137/6416
摘要： The present invention is directed to a micro fluidic device (1) comprising at least one valve/pump-unit (2) with reduced dead volume, wherein the micro fluid device comprises: - a substrate (3), wherein on the lower surface of said substrate (3) at least two micro channels (4) are arranged to direct a fluid sample (5) flow on the substrate (3), whereby said two micro channels (4) are not end-to-end connected and spaced apart by a valve area (6) of said substrate (3); - at least one flexible membrane (7), wherein the flexible membrane (7) is arranged on the lower surface of said substrate (3); - an actuating element (8) with an upper surface (9) adjacent arranged to the flexible membrane (7); - at least one cover element (10) arranged on the lower surface of the flexible membrane (7), wherein the cover element (10) comprises at least one through going cut-out (11) for receiving an actuating element (8), so that movement of said actuating element (8) causes a pump and/or valve action of the adjacent arranged flexible membrane area to cause or stop a directed fluid flow on said substrate (3); so that a fluid flow between said two not end-to-end connected micro channels is directed among the valve area (6) of the lower surface of the substrate (3) and the upper surface of the flexible membrane (7) through a temporally formable channel (12) formed by the flexible membrane (7) covering the valve area (6), whereby a movement of the actuating element (8) towards to the lower surface of the substrate causes a valve action and a movement opposite to the lower surface of the substrate releases a space in a chamber (13) into which the flexible membrane (7) can engage to form the temporally channel (12) and the upper surface (9) of the actuating element (8) covers at least partly the membrane surface (7) at the valve area (6).
摘要翻译：本发明涉及一种微流体装置（1），其包括具有减小的死体积的至少一个阀/泵单元（2），其中所述微流体装置包括： - 基底（3），其中在所述衬底（3）至少两个微通道（4）布置成将流体样品（5）流动引导到衬底（3）上，由此所述两个微通道（4）不是端到端连接并且间隔开通过所述基板（3）的阀区域（6）; - 至少一个柔性膜（7），其中所述柔性膜（7）布置在所述基底（3）的下表面上; - 具有与所述柔性膜（7）相邻布置的上表面（9）的致动元件（8）; - 布置在所述柔性膜（7）的下表面上的至少一个覆盖元件（10），其中所述盖元件（10）包括用于接收致动元件（8）的至少一个贯穿切口（11）使得所述致动元件（8）的运动导致相邻布置的柔性膜区域的泵和/或阀动作引起或停止所述衬底（3）上的定向流体流动; 使得所述两个未端对端连接的微通道之间的流体流动通过时间上被引导到基板（3）的下表面的阀区域（6）和柔性膜（7）的上表面之间由柔性膜（7）形成的可覆盖阀区域（6）的可形成通道（12），由此致动元件（8）朝向基板的下表面的运动导致阀动作和与下部衬底的表面释放腔室（13）中的空间，柔性膜（7）可以接合以形成时间通道（12）并且致动元件（8）的上表面（9）至少部分地覆盖在阀区域（6）处的膜表面（7）。

7. 发明申请

WO2009107065A1 REACTOR SYSTEM 审中-公开
标题翻译：反应器系统
公开(公告)号：WO2009107065A1
公开(公告)日：2009-09-03
申请号：PCT/IB2009/050745
申请日：2009-02-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LOOIJEN, Jeroen , VAN DEN BIJGAART, Adrianus, W., D., M. , DE GIER, Ronald, C. , BROERS, Sander, C. , DOBRUSSKIN, Christoph , BOUMA, Peter, H.
发明人： LOOIJEN, Jeroen , VAN DEN BIJGAART, Adrianus, W., D., M. , DE GIER, Ronald, C. , BROERS, Sander, C. , DOBRUSSKIN, Christoph , BOUMA, Peter, H.
IPC分类号： B01L3/00 , B01L7/00 , B01J19/00
CPC分类号： B01L7/52 , B01L3/50851 , B01L2300/123 , B01L2300/1805 , B01L2300/1883
摘要： A reactor system (100) for carrying out a reaction, comprising at least one reaction chamber (110) for holding reactants of the reaction; a thermal element (120) for heating or cooling the reactants of the reaction chamber (110); and an insulator (130), wherein the insulator (130) has a substantially high thermal resistance along a first axis (152) as compared to the thermal resistance along a second axis (154). The varying thermal resistance of the insulator (130) ensures a homogeneous temperature throughout the reaction chamber (110).
摘要翻译：一种用于进行反应的反应器系统（100），包括至少一个用于保持反应的反应物的反应室（110）; 用于加热或冷却反应室（110）的反应物的热元件（120）; 和绝缘体（130），其中与沿着第二轴线（154）的热阻相比，绝缘体（130）沿着第一轴线（152）具有基本上高的热阻。绝缘体（130）的变化的热阻确保了整个反应室（110）中的均匀温度。

8. 发明申请

WO2007004105A1 VALVE DEVICE 审中-公开
标题翻译：阀门设备
公开(公告)号：WO2007004105A1
公开(公告)日：2007-01-11
申请号：PCT/IB2006/052078
申请日：2006-06-26
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN DEN BIJGAART, Adrianus, W., D., M. , DE GIER, Ronald, C.
发明人： VAN DEN BIJGAART, Adrianus, W., D., M. , DE GIER, Ronald, C.
IPC分类号： F16K7/12
CPC分类号： F16K7/16 , F15C3/04 , F15C5/00 , F16K7/126 , F16K99/0001 , F16K99/0015 , F16K99/0034 , F16K99/0057 , F16K2099/0084 , Y10T137/7895
摘要： The present invention relates to a valve device (10) comprising a substrate (12) and an elastic membrane (13), the membrane being joined at least around a valve area to the substrate. The substrate comprises a first channel (16) and a second channel (17), both ending in the valve area, the first channel having in the valve area a first channel end surface (19) and the second channel having in the valve area a second channel end surface (21), wherein the area of the first channel end surface is substantially larger than the area of the second channel end surface.
摘要翻译：本发明涉及一种阀装置（10），其包括基板（12）和弹性膜（13），所述膜至少围绕阀区域连接到所述基板。衬底包括第一通道（16）和第二通道（17），两者都终止在阀区域中，第一通道在阀区域中具有第一通道端面（19），并且第二通道在阀区域第二通道端面（21），其中第一通道端面的面积基本上大于第二通道端面的面积。

9. 发明申请

WO2008068663A1 NEEDLE INTERFACE FOR FLUID CONNECTIONS 审中-公开
标题翻译：用于流体连接的针式接口
公开(公告)号：WO2008068663A1
公开(公告)日：2008-06-12
申请号：PCT/IB2007/054762
申请日：2007-11-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , AALDERS, Arnold , VAN DEN BIJGAART, Adrianus, W., D., M. , VERSLEEGERS, Jozef, C., M. , DE GIER, Ronald, C. , TIMMERMANS, Petrus, H., M.
发明人： AALDERS, Arnold , VAN DEN BIJGAART, Adrianus, W., D., M. , VERSLEEGERS, Jozef, C., M. , DE GIER, Ronald, C. , TIMMERMANS, Petrus, H., M.
IPC分类号： G01N30/18
CPC分类号： G01N30/18 , G01N2030/185
摘要： The invention relates to a coupling system that can particularly be applied for interfacing a consumable component with a sample chamber to a laboratory instrument for processing a sample fluid. The coupling system comprises a female interface module (10) integrated into the consumable component that has an elastic 5 sealing component (12) with a preformed channel (12a). Moreover, it comprises a male interface module (20) integrated into the instrument and comprising a hollow needle (23) fixed in a first section (22a) of a bush (22), wherein the flexible free end of said needle (23) is partially surrounded by a second section (22b) of the bush that limits the lateral movement of the needle. The diameter of the channel in the sealing 10 component (12) is preferably smaller than the diameter (d) of the needle (23), thus providing an airtight connection and a self-cleaning effect.
摘要翻译：本发明涉及一种耦合系统，其特别可应用于将消耗部件与样品室连接到用于处理样品流体的实验室仪器。联接系统包括集成到消耗部件中的阴接口模块（10），其具有带有预制通道（12a）的弹性5密封部件（12）。此外，它包括集成在仪器中并包括固定在衬套（22）的第一部分（22a）中的中空针（23）的阳接口模块（20），其中所述针（23）的柔性自由端是部分地被衬套的第二部分（22b）包围，这限制了针的横向移动。密封10部件（12）中的通道的直径优选小于针（23）的直径（d），从而提供气密连接和自清洁效果。

10. 发明申请

WO2011161623A1 LIGHTING DEVICE 审中-公开
标题翻译：照明设备
公开(公告)号：WO2011161623A1
公开(公告)日：2011-12-29
申请号：PCT/IB2011/052710
申请日：2011-06-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN DEN BIJGAART, Adrianus, W., D., M. , MARTIN, Genevieve , DE VRIES, Jorrit, E.
发明人： VAN DEN BIJGAART, Adrianus, W., D., M. , MARTIN, Genevieve , DE VRIES, Jorrit, E.
IPC分类号： F21V7/16 , F21V17/06 , F21V17/10
CPC分类号： F21V7/10 , F21V7/0008 , F21V7/0025 , F21V7/16 , F21V14/04 , F21V17/02 , F21V17/105 , F21Y2115/10
摘要： A lighting device (1) comprising a housing (5) with holding means (7) for fixation of an adjustable reflector (3) inside the housing and comprising a light emission window (9) opposite the reflector. The reflector is provided with fixation means (19) having a fitting structure (21)with respect to the holding means and enabling adjustment of the reflector within the housing. The adjustment comprises a change in shape of the reflector and/or a change in the mutual position of the reflector and a contacting element (15).
摘要翻译：一种照明装置（1），包括具有保持装置（7）的壳体（5），用于将可调节反射器（3）固定在壳体内部并且包括与反射器相对的发光窗口（9）。反射器设置有相对于保持装置具有装配结构（21）的固定装置（19），并且能够调节壳体内的反射器。该调整包括反射器的形状的改变和/或反射器和接触元件（15）的相互位置的变化。

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