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1. 发明申请

WO0066724A2 OLIGONUCLEOTIDE DERIVATIVES DIRECTED AGAINST HUMAN BCL-XL AND HUMAN BCL-2 MRNA 审中-公开
标题翻译：针对人BCL-XL和人BCL-2 MRNA的寡核苷酸衍生物
公开(公告)号：WO0066724A2
公开(公告)日：2000-11-09
申请号：PCT/EP0003708
申请日：2000-04-26
申请人： UNIV ZUERICH , ZANGEMEISTER WITTKE UWE , LUEDKE GERD , HUESKEN DIETER
发明人： ZANGEMEISTER-WITTKE UWE , LUEDKE GERD , HUESKEN DIETER
IPC分类号： A61P35/00 , C12N15/113 , C12N15/11 , A61K31/70 , A61K48/00 , C07K14/82
CPC分类号： C12N15/1135 , C12N2310/315 , C12N2310/321 , C12N2310/33 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： The present invention relates to antisense oligonucleotide derivatives directed against human bcl-xL mRNA and being capable of modulating the biosynthesis of human bcl-xL protein. Furthermore, the present invention relates to antisense oligonucleotide derivatives directed against both human bcl-xL nRNA and human bcl-2 mRNA, and being capable of modulating the biosynthesis of both human bcl-xl protein and human bcl-2 protein. The present invention further relates to a pharmaceutical composition comprising such oligonucleotide derivatives, uses thereof and methods of treatment and diagnosis utilizing such oligonucleotide derivatives.
摘要翻译：本发明涉及针对人bcl-xL mRNA的反义寡核苷酸衍生物，能够调节人bcl-xL蛋白的生物合成。此外，本发明涉及针对人bcl-xL nRNA和人bcl-2 mRNA的反义寡核苷酸衍生物，并且能够调节人bcl-xl蛋白和人bcl-2蛋白的生物合成。本发明还涉及包含这种寡核苷酸衍生物的药物组合物，其用途以及利用这种寡核苷酸衍生物的治疗和诊断方法。

2. 发明申请

WO2007072290A2 METHOD OF PERFORMING A MICROARRAY ASSAY 审中-公开
标题翻译：执行微观测定的方法
公开(公告)号：WO2007072290A2
公开(公告)日：2007-06-28
申请号：PCT/IB2006054737
申请日：2006-12-11
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , BACHER JOHANNES , BOOS ANDREAS , LUEDKE GERD
发明人： BACHER JOHANNES , BOOS ANDREAS , LUEDKE GERD
IPC分类号： C12Q1/68
CPC分类号： G01N33/54386 , C12Q1/6837 , G01N33/544 , C12Q2565/102 , C12Q2537/143
摘要： Disclosed is a method for performing a microarray assay on one or more sample fluid(s), sais fluids comprising target biological compounds. The method comprises the step of tagging said target biological compounds with labels. The following step comprises contacting said sample fluid(s) with a substrate and detecting the presence of said labels at the surface of said substrate. The method is suitable for the simultaneous analysis, in one microarray, of one or more types of target biological compounds, in one or more sample fluid(s). To this end each of said types of biological compounds is tagged with a different label so that target biological compounds belonging to different sample fluids have different labels. Said different labels are discriminable upon detection at the surface of said substrate. Also disclosed is the use of a polymer substrate in a method for performing a microarray assay.
摘要翻译：公开了一种对一种或多种样品流体进行微阵列测定的方法，其包含靶生物化合物。该方法包括用标记标记所述靶生物化合物的步骤。接下来的步骤包括使所述样品流体与基底接触，并在所述基底的表面检测所述标记物的存在。该方法适用于在一个或多个样品流体中在一个微阵列中同时分析一种或多种类型的靶生物化合物。为此，每种所述类型的生物化合物被标记有不同的标记，使得属于不同样品流体的目标生物化合物具有不同的标记。所述不同标签在所述基板的表面检测时是可辨别的。还公开了在进行微阵列测定的方法中使用聚合物底物。

3. 发明申请

WO2006136990A3 CARTRIDGE, SYSTEM AND METHOD FOR AUTOMATED MEDICAL DIAGNOSTICS 审中-公开
标题翻译： CARTRIDGE，系统和自动化诊断方法
公开(公告)号：WO2006136990A3
公开(公告)日：2007-03-08
申请号：PCT/IB2006051941
申请日：2006-06-16
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN HAAG CHRIS , JONGERIUS MICHIEL J , SCHAEFER DANNY G A , VAN DEN BIJGAART ADRIANUS W D , DE GIER RONALD C , DE JONG MICHIEL , PROSS GERHARD , BACHER JOHANNES , BOOS ANDREAS , LUEDKE GERD , SEHER JENS-PETER
发明人： VAN HAAG CHRIS , JONGERIUS MICHIEL J , SCHAEFER DANNY G A , VAN DEN BIJGAART ADRIANUS W D , DE GIER RONALD C , DE JONG MICHIEL , PROSS GERHARD , BACHER JOHANNES , BOOS ANDREAS , LUEDKE GERD , SEHER JENS-PETER
IPC分类号： B01L3/00 , G01N1/28 , G01N21/76 , G01N33/487 , G01N35/00
CPC分类号： B01L7/52 , B01L3/502715 , B01L3/502738 , B01L3/545 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2300/02 , B01L2300/087 , B01L2300/1805 , G01N21/6428 , G01N35/00069 , G01N2035/00158
摘要： Disclosed is a cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a generic part and one or more separate application-specific parts, which are connectable to the generic part. Also disclosed is a system for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. This system comprising a reusable apparatus, wherein said apparatus is configured to receive a cartridge and to control a process for the detection of the presence, absence and/or amount of a target nucleotide sequence in the sample, being present in said cartridge.
摘要翻译：公开了用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或量的盒。墨盒包括通用部件和可以连接到通用部件的一个或多个单独的应用特定部件。还公开了用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或数量的系统。该系统包括可重复使用的装置，其中所述装置被配置为接收盒并且控制用于检测存在于所述盒中的样品中目标核苷酸序列的存在，不存在和/或量的过程。

4. 发明申请

WO2007023461A2 METHOD FOR DETECTION OF MICRO-ORGANISMS AND ANTIBIOTIC RESISTANCE MARKERS AND NUCLEIC ACID OLIGONUCLEOTIDES THEREFOR 审中-公开
标题翻译：检测微生物和抗生素抗性标记物及其核酸寡核苷酸的方法
公开(公告)号：WO2007023461A2
公开(公告)日：2007-03-01
申请号：PCT/IB2006/052919
申请日：2006-08-23
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , LUEDKE, Gerd , BACHER, Johannes , SEHER, Jens-Peter , ENGEL, Holger , LAUBER, Jürgen , BAHR, André , LUBENOW, Helge
发明人： LUEDKE, Gerd , BACHER, Johannes , SEHER, Jens-Peter , ENGEL, Holger , LAUBER, Jürgen , BAHR, André , LUBENOW, Helge
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/156 , C12Q2600/16
摘要： The present invention relates to methods of detecting one or more micro¬ organisms and/or one or more antibiotic resistance markers in a sample, comprising identifying the presence of distinct nucleic acid regions. Primers and probes suitable for use in such methods are provided.
摘要翻译：本发明涉及检测样品中一种或多种微生物和/或一种或多种抗生素抗性标记物的方法，其包括鉴定不同核酸区域的存在。提供了适用于这些方法的引物和探针。

5. 发明申请

WO2006136990A2 CARTRIDGE, SYSTEM AND METHOD FOR AUTOMATED MEDICAL DIAGNOSTICS 审中-公开
标题翻译： CARTRIDGE，SYSTEM AND METHOD FOR AUTOMATED MEDICAL DIAGNOSTICS
公开(公告)号：WO2006136990A2
公开(公告)日：2006-12-28
申请号：PCT/IB2006/051941
申请日：2006-06-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN HAAG, Chris , JONGERIUS, Michiel, J. , SCHAEFER, Danny, G., A. , VAN DEN BIJGAART, Adrianus, W., D., M. , DE GIER, Ronald, C. , DE JONG, Michiel , PROSS, Gerhard , BACHER, Johannes , BOOS, Andreas , LUEDKE, Gerd , SEHER, Jens-Peter
发明人： VAN HAAG, Chris , JONGERIUS, Michiel, J. , SCHAEFER, Danny, G., A. , VAN DEN BIJGAART, Adrianus, W., D., M. , DE GIER, Ronald, C. , DE JONG, Michiel , PROSS, Gerhard , BACHER, Johannes , BOOS, Andreas , LUEDKE, Gerd , SEHER, Jens-Peter
IPC分类号： B01L3/00 , G01N1/28 , G01N21/76 , G01N35/00 , G01N33/487
CPC分类号： B01L7/52 , B01L3/502715 , B01L3/502738 , B01L3/545 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2300/02 , B01L2300/087 , B01L2300/1805 , G01N21/6428 , G01N35/00069 , G01N2035/00158
摘要： Disclosed is a cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a generic part and one or more separate application-specific parts, which are connectable to the generic part. Also disclosed is a system for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. This system comprising a reusable apparatus, wherein said apparatus is configured to receive a cartridge and to control a process for the detection of the presence, absence and/or amount of a target nucleotide sequence in the sample, being present in said cartridge.
摘要翻译：公开了用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或量的盒。盒包括通用部分和一个或多个单独的应用特定部分，其可连接到通用部分。还公开了用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或数量的系统。该系统包括可重复使用的装置，其中所述装置被配置为接收盒并且控制用于检测存在于所述盒中的样品中目标核苷酸序列的存在，不存在和/或量的过程。

6. 发明申请

WO2007023461A3 METHOD FOR DETECTION OF MICRO-ORGANISMS AND ANTIBIOTIC RESISTANCE MARKERS AND NUCLEIC ACID OLIGONUCLEOTIDES THEREFOR 审中-公开
标题翻译：检测微生物和抗生素抗性标记物及其核酸寡核苷酸的方法
公开(公告)号：WO2007023461A3
公开(公告)日：2008-01-03
申请号：PCT/IB2006052919
申请日：2006-08-23
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , LUEDKE GERD , BACHER JOHANNES , SEHER JENS-PETER , ENGEL HOLGER , LAUBER JUERGEN , BAHR ANDRE , LUBENOW HELGE
发明人： LUEDKE GERD , BACHER JOHANNES , SEHER JENS-PETER , ENGEL HOLGER , LAUBER JUERGEN , BAHR ANDRE , LUBENOW HELGE
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/156 , C12Q2600/16
摘要： The present invention relates to methods of detecting one or more micro¬ organisms and/or one or more antibiotic resistance markers in a sample, comprising identifying the presence of distinct nucleic acid regions. Primers and probes suitable for use in such methods are provided.
摘要翻译：本发明涉及检测样品中一种或多种微生物和/或一种或多种抗生素抗性标记物的方法，其包括鉴定不同核酸区域的存在。提供了适用于这些方法的引物和探针。

7. 发明申请

WO2007072373A2 A SENSOR FOR BIOMOLECULES AND A METHOD OF ANALYSIS USING SAID SENSOR 审中-公开
标题翻译：生物分子传感器和使用传感器的分析方法
公开(公告)号：WO2007072373A2
公开(公告)日：2007-06-28
申请号：PCT/IB2006/054883
申请日：2006-12-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BACHER, Johannes , BOOS, Andreas , LUEDKE, Gerd
发明人： BACHER, Johannes , BOOS, Andreas , LUEDKE, Gerd
CPC分类号： B01L3/502 , B01L2300/0636 , B01L2300/0681
摘要： Disclosed is a method of preparing a sensor for the analysis of a sample fluid, said sample fluid containing one or more target molecules. The method comprises the step of introducing said sample fluid into a chamber equipped with a porous substrate, one or more probe molecules being applied to said porous substrate and said probes being able to specifically bind to said one or more target molecules. The method further comprises the step of moving said substrate and said chamber relatively to each other in order to force said sample fluid through the pores of said porous substrate and to capture the one or more target molecules with the one or more probe molecules. Also disclosed is a sensor for the analysis of a sample fluid.
摘要翻译：公开了一种制备用于分析样品流体的传感器的方法，所述样品流体包含一种或多种靶分子。该方法包括将所述样品流体引入配备有多孔底物的室中的步骤，将一个或多个探针分子施加到所述多孔底物上，并且所述探针能够特异性结合所述一个或多个靶分子。该方法还包括相对于彼此移动所述衬底和所述室的步骤，以便迫使所述样品流体通过所述多孔衬底的孔并且用所述一个或多个探针分子捕获所述一个或多个靶分子。还公开了用于分析样品流体的传感器。

8. 发明申请

WO2007072311A3 A SENSOR FOR BIOMOLECULES AND A METHOD FOR PREPARING AND USING THE SAME 审中-公开
公开(公告)号：WO2007072311A3
公开(公告)日：2007-06-28
申请号：PCT/IB2006/054792
申请日：2006-12-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BACHER, Johannes , BOOS, Andreas , LUEDKE, Gerd
发明人： BACHER, Johannes , BOOS, Andreas , LUEDKE, Gerd
IPC分类号： G01N33/53 , G01N33/543
摘要： Disclosed is a method of preparing a sensor for the analysis of a sample fluid, said sample fluid containing one or more target molecules. The method comprises the steps of applying a non-activated porous organic polymer membrane with probes in the form of an array of probe locations, said probes being able to specifically bind to said one or more target molecules. Furthermore, the method comprises the steps of blocking areas remaining free of probes of said porous organic polymer membrane with one or more blocking substances and forcing the sample fluid repeatedly in one or two directions through the pores of said porous organic polymer membrane. Also disclosed is a sensor for the analysis of a sample fluid.

9. 发明申请

WO2013013687A1 APPARATUS AND METHOD FOR A LYSIS OF A SAMPLE, IN PARTICULAR FOR AN AUTOMATED AND/OR CONTROLLED LYSIS OF A SAMPLE 审中-公开
标题翻译：用于样品裂解的装置和方法，特别是用于样品的自动和/或受控裂解
公开(公告)号：WO2013013687A1
公开(公告)日：2013-01-31
申请号：PCT/EP2011003770
申请日：2011-07-27
申请人： CURETIS AG , BOOS ANDREAS , LUEDKE GERD , BACHER JOHANNES
发明人： BOOS ANDREAS , LUEDKE GERD , BACHER JOHANNES
IPC分类号： G01N1/28 , G01N1/38 , G01N1/44
CPC分类号： C12M47/06 , C12N1/066 , G01N1/286 , G01N1/38 , G01N1/44 , G01N35/025 , G01N2035/00504 , G01N2035/00524 , G01N2035/0441
摘要： The present invention provides an apparatus and a method for a lysis procedure, in particular for an automated and/or controlled lysis procedure of a sample, in particular a biological sample. The apparatus comprises at least one rotation disc (31), at least one vial holder (90) which is configured to receive a vial (100), wherein the vial holder (90) is arranged on the disc (31), at least one driving device (20) which is configured to rotate the disc (31) and the vial holder (90), at least one heating device (60) which is configured to heat the sample to a determined incubation temperature, and - at least one control device (70) which is configured to control the driving device (20) and/or the heating device (60) by means of a timing and/or step control, and/or - at least one transmitting device (80) for inductive coupling for energy and signal transmission, which is configured to transmit the energy for heating to the heating device (60), and/or - wherein the driving device (20) is configured to rotate the disc (31) in a first direction (A1) and/or with a first speed, and to rotate the vial holder (90) in a second direction (A3) and/or with a second speed. The apparatus and the method are adapted for an (automated) lysis procedure, wherein the lysis can be carried out in a safe, efficient and effective manner.
摘要翻译：本发明提供用于裂解过程的设备和方法，特别是用于样品尤其是生物样品的自动化和/或受控裂解过程。该装置包括至少一个旋转盘（31），至少一个配置成接收药瓶（100）的药瓶保持器（90），其中药瓶保持器（90）布置在盘（31）上，至少一个（31）和药瓶支架（90）旋转的驱动装置（20），至少一个加热装置（60），该加热装置构造成将样品加热到确定的温育温度，以及 - 至少一个控制器（70），其被配置为借助定时和/或阶梯控制来控制所述驱动装置（20）和/或所述加热装置（60），和/或 - 至少一个发射装置（80），其用于感应耦合用于能量和信号传输，其被配置为将用于加热的能量传输到所述加热装置（60），和/或 - 其中所述驱动装置（20）被配置为沿第一方向（A1）旋转所述盘（31）和/或以第一速度旋转，并且使药瓶保持器（90）沿第二方向（A3）和/或以第二速度旋转。该装置和方法适用于（自动）裂解程序，其中裂解可以安全，有效且有效的方式进行。

10. 发明申请

WO2007072373A3 A SENSOR FOR BIOMOLECULES AND A METHOD OF ANALYSIS USING SAID SENSOR 审中-公开
标题翻译：生物分子传感器及其应用分析方法
公开(公告)号：WO2007072373A3
公开(公告)日：2007-10-18
申请号：PCT/IB2006054883
申请日：2006-12-15
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , BACHER JOHANNES , BOOS ANDREAS , LUEDKE GERD
发明人： BACHER JOHANNES , BOOS ANDREAS , LUEDKE GERD
IPC分类号： B01L3/00 , G01N33/53
CPC分类号： B01L3/502 , B01L2300/0636 , B01L2300/0681
摘要： Disclosed is a method of preparing a sensor for the analysis of a sample fluid, said sample fluid containing one or more target molecules. The method comprises the step of introducing said sample fluid into a chamber equipped with a porous substrate, one or more probe molecules being applied to said porous substrate and said probes being able to specifically bind to said one or more target molecules. The method further comprises the step of moving said substrate and said chamber relatively to each other in order to force said sample fluid through the pores of said porous substrate and to capture the one or more target molecules with the one or more probe molecules. Also disclosed is a sensor for the analysis of a sample fluid.
摘要翻译：公开了一种制备用于分析样品流体的传感器的方法，所述样品流体包含一种或多种目标分子。该方法包括将所述样品流体引入配备有多孔基底的室中的步骤，将一种或多种探针分子施加到所述多孔基底上，并且所述探针能够特异性结合所述一种或多种目标分子。该方法还包括将所述基底和所述腔室相对于彼此移动的步骤，以迫使所述样品流体通过所述多孔基底的孔并用一个或多个探针分子捕获一个或多个目标分子。还公开了一种用于分析样品流体的传感器。

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