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    • 2. 发明申请
    • ENERGY SPECTRUM RECONSTRUCTION
    • 能源光谱重建
    • WO2008008663A2
    • 2008-01-17
    • PCT/US2007/072694
    • 2007-07-02
    • KONINKLIJKE PHILIPS ELECTRONICS, N.V.U.S. PHILIPS CORPORATIONZIEGLER, AndyPROKSA, Roland
    • ZIEGLER, AndyPROKSA, Roland
    • G01T1/2985
    • A computed tomography system includes an x-ray source (108) that rotates about and emits radiation through an imaging region (116). At least one finite energy resolution detector (112) detects the emitted radiation. The at least one finite resolution detector (112) includes a plurality of sub-detectors (204). Each of the plurality of sub-detectors (204) is associated with one or more different energy thresholds. Each of the energy thresholds is used to count a number of incident photons based on a corresponding energy level. A reconstruction system (136) reconstructs the photon counts to generate one or more images of a subject residing within the imaging region (116).
    • 计算机断层摄影系统包括绕着成像区域(116)旋转并发射辐射的x射线源(108)。 至少一个有限能量分辨率检测器(112)检测发射的辐射。 所述至少一个有限分辨率检测器(112)包括多个子检测器(204)。 多个子检测器(204)中的每一个与一个或多个不同的能量阈值相关联。 每个能量阈值用于根据相应的能级对一些入射光子进行计数。 重建系统(136)重建光子计数以产生驻留在成像区域(116)内的对象的一个​​或多个图像。
    • 3. 发明申请
    • MULTI-TUBE IMAGING SYSTEM RECONSTRUCTION
    • 多管成像系统重建
    • WO2007140093A1
    • 2007-12-06
    • PCT/US2007/068538
    • 2007-05-09
    • KONINKLIJKE PHILIPS ELECTRONICS, N.V.U.S. PHILIPS CORPORATIONZIEGLER, Andy
    • ZIEGLER, Andy
    • A61B6/03
    • A61B6/4014A61B6/032A61B6/508G06T11/005
    • A tomographic apparatus (10) includes at least two x-ray sources (14) that rotate about and alternately emit radiation into an imaging region (22). The at least two x-ray sources (14) emit radiation from a first set of angular positions during a first data acquisition cycle and from a different set of angular positions during a subsequent data acquisition cycle. At least two sets of detectors (24) detect primary radiation emitted by a corresponding one of the at least two x-ray sources (14) and produce data representative of the detected radiation. An interleaver (32) interleaves the data associated with the first and the subsequent data acquisition cycles for each of the at least two x-ray sources (14).
    • 断层摄影装置(10)包括至少两个X射线源(14),其围绕并交替地将辐射发射到成像区域(22)中。 所述至少两个X射线源(14)在第一数据采集周期期间从第一组角位置发射辐射,并且在随后的数据采集周期期间从不同的一组角度位置发射辐射。 至少两组检测器(24)检测由所述至少两个X射线源(14)中的相应一个发射的主辐射,并产生表示检测到的辐射的数据。 交织器(32)对于至少两个x射线源(14)中的每一个交织与第一和随后的数据采集周期相关联的数据。
    • 4. 发明申请
    • DIFFUSE OPTICAL TOMOGRAPHY WITH MARKERS CONTAINING FLUORESCENT MATERIAL
    • 含有荧光材料标记的DIFFUSE光学图像
    • WO2008059434A2
    • 2008-05-22
    • PCT/IB2007/054593
    • 2007-11-12
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBHZIEGLER, AndyKOEHLER, ThomasNIELSEN, TimVAN DER MARK, Martinus, B.VAN BEEK, Michael, C.
    • ZIEGLER, AndyKOEHLER, ThomasNIELSEN, TimVAN DER MARK, Martinus, B.VAN BEEK, Michael, C.
    • A61B5/00G01J3/44
    • A61B5/4312A61B5/0091G01N21/4795G01N21/6456
    • The invention relates to a system, a medical image acquisition system, and a method for imaging an interior of a turbid medium (25). The invention also relates to a marker (60) for use in the method for imaging an interior of a turbid medium (25). The system, the medical image acquisition system, and the method may be used for obtaining an image of an interior of a turbid medium (25) by: accommodation of a turbid medium (25) inside a receiving volume (20); irradiation of the receiving volume (20) with light from a light source; detection of light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with light from the light source through the use of a photodetector unit. The detected light is then used to reconstruct an image of an interior of the turbid medium (25). According to the invention, the system, the medical acquisition system, and the method are adapted such that during a measurement the receiving volume (20) comprises at least one marker (60) comprising a predetermined concentration of a chosen fluorescent agent. The light source is arranged for generating excitation light that causes fluorescent emission in the marker (60) and the photodetector is arranged to detect light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with excitation light. The use of a marker (60) according to the invention enables obtaining information relating to the geometry of the turbid medium (25). If the turbid medium (25) comprises an unknown concentration of a second fluorescent agent, and the light source and the photodetector unit are arranged for causing fluorescence in the second fluorescent agent and detecting the resulting fluorescence light, respectively, the use of a marker (60) according to the invention enables calibration of the signal resulting from this fluorescence light.
    • 本发明涉及一种系统,医学图像采集系统和用于对浑浊介质(25)的内部进行成像的方法。 本发明还涉及一种用于对浑浊介质(25)的内部进行成像的方法中使用的标记(60)。 该系统,医学图像采集系统和该方法可以用于通过以下方式获得浑浊介质的内部的图像:通过在接收容积(20)内容纳混浊介质(25); 用来自光源的光照射接收体积(20); 通过使用光电检测器单元对来自光源的光照射接收体积(20)的结果来检测从接收体积(20)发出的光。 然后使用检测到的光来重建混浊介质(25)的内部的图像。 根据本发明,适配系统,医疗采集系统和方法,使得在测量期间,接收体积(20)包括至少一个包含预定浓度的所选荧光剂的标记物(60)。 光源被布置成产生在标记(60)中引起荧光发射的激发光,并且光电检测器被布置成通过用激发光照射接收体积(20)来检测从接收体积(20)发出的光。 使用根据本发明的标记(60)能够获得与混浊介质(25)的几何形状有关的信息。 如果混浊介质(25)包含未知浓度的第二荧光剂,并且将光源和光检测器单元布置成在第二荧光剂中引起荧光并分别检测所得到的荧光,则使用标记物 60)根据本发明可以校准由该荧光产生的信号。
    • 6. 发明申请
    • IMAGING METHOD WITH BACK PROJECTION
    • 具有后投影的成像方法
    • WO2006000997A2
    • 2006-01-05
    • PCT/IB2005/052090
    • 2005-06-24
    • PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBHKONINKLIJKE PHILIPS ELECTRONICS N.V.NIELSEN, TimZIEGLER, AndyKOEHLER, ThomasPROKSA, Roland
    • NIELSEN, TimZIEGLER, AndyKOEHLER, ThomasPROKSA, Roland
    • G06T15/00
    • G06T11/006A61B6/027G06T2211/421Y10S378/901
    • The invention relates to an imaging method, especially a computerized tomography method, with which an object is penetrated by rays from different directions and measured values, which depend upon the intensity of the rays after penetrating the object, are acquired by a detector unit. From these measured values, an object image is reconstructed by means of back projection of measured-value-dependent back projection values. Therein, the object image is divided into overlapping, quasi-spherically symmetric image segments, each being defined by an image value and a quasi-spherically symmetric base function. Furthermore, during the back projection, the back projection values are added in proportions to the image values, wherein the proportion of a back projection value, which is added during the back projection to an image value, is dependent on a proportionality factor, which is equal to the average value of the line integrals of the base function belonging to the respective image value along those rays that have generated the measured value, on which the respective back projection value is dependent.
    • 本发明涉及一种成像方法,特别是计算机断层摄影方法,其中物体被来自不同方向的光线穿透,并且测量值取决于穿透物体之后的光线的强度,由检测器单元获取。 从这些测量值,通过背投影测量值依赖的反投影值重建对象图像。 其中,对象图像被划分为重叠的准球形对称图像片段,每个片段由图像值和准球形对称的基本功能定义。 此外,在背投影期间,反投影值以与图像值成比例的方式相加,其中在后投影中添加的反投影值与图像值的比例取决于比例因子,即比例因子 等于属于相应图像值的基本功能的线积分的平均值,沿着相应的背投影值依赖于已经产生测量值的那些射线。
    • 7. 发明申请
    • METHOD FOR RECONSTRUCTING A FLUORESCENT IMAGE OF THE INTERIOR OF A TURBID MEDIUM AND DEVICE FOR IMAGING THE INTERIOR OF A TURBID MEDIUM
    • 用于重建涡轮介质内部的荧光图像的方法和用于成像涡轮介质的内部的装置
    • WO2009118672A1
    • 2009-10-01
    • PCT/IB2009/051179
    • 2009-03-20
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBHZIEGLER, RonnyZIEGLER, AndyNIELSEN, Tim
    • ZIEGLER, RonnyZIEGLER, AndyNIELSEN, Tim
    • A61B5/00G01N21/49G01N21/64
    • A61B5/4312A61B5/0091G01N21/4795G01N21/6428
    • A method for reconstructing a fluorescence image of the interior of a turbid medium is provided. The method comprises the step: accommodating a turbid medium (1) to which a fluorescent contrast agent has been administered in a measurement volume (4). The fluorescent contrast agent is capable of emitting light in a first range of wavelengths upon irradiation with light. The method further comprises: performing attenuation measurements at a plurality of different wavelengths (λi,..., λk) by subsequently irradiating the turbid medium (1) with light from a plurality of different source positions and detecting light emanating from the turbid medium (1) in a plurality of detection positions for each source position; reconstructing absorption properties (μa(r, λ)) as a function of the position in the interior of the turbid medium (1) for the plurality of different wavelengths from the attenuation measurements; calculating absorption properties as a function of the position in the interior of the turbid medium (1) for wavelengths of the first range of wavelengths; performing a fluorescence measurement by subsequently irradiating the turbid medium (1) with light causing the fluorescent contrast agent to emit light in the first range of wavelengths from the plurality of source positions and detecting the light emanating from the fluorescent contrast agent in the plurality of detection positions for each source position; and reconstructing a fluorescence image of the spatial distribution of the fluorescent contrast agent in the interior of the turbid medium (1) from the fluorescence measurement using the calculated absorption properties.
    • 提供了一种用于重建浑浊介质内部的荧光图像的方法。 该方法包括以下步骤:在测量体积(4)中容纳已投与荧光造影剂的混浊介质(1)。 荧光造影剂能够在照射光时在第一波长范围内发光。 该方法还包括:通过随后用来自多个不同源位置的光照射混浊介质(1)并检测从浑浊发出的光,在多个不同波长(λi,...,θk)处进行衰减测量 介质(1)在每个源位置的多个检测位置中; 根据衰减测量,重建作为多个不同波长的混浊介质(1)内部位置的函数的吸收特性(μa(r,θ)); 计算作为第一波长范围波长的混浊介质(1)内部位置的函数的吸收特性; 通过随后用引起荧光对比剂的光在多个源位置的第一波长范围内发射光,并在多个检测中检测从荧光对比剂发出的光,进行荧光测量 每个来源职位的职位; 以及使用所计算的吸收特性,从所述荧光测量重建所述浑浊介质(1)内的所述荧光造影剂的空间分布的荧光图像。
    • 10. 发明申请
    • NOISE REDUCTION IN DUAL-ENERGY X-RAY IMAGING
    • 双能量X射线成像中的噪声减少
    • WO2007110794A1
    • 2007-10-04
    • PCT/IB2007/050877
    • 2007-03-14
    • PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBHKONINKLIJKE PHILIPS ELECTRONICS N.V.RÖSSL, EwaldZIEGLER, Andy
    • RÖSSL, EwaldZIEGLER, Andy
    • G06T5/50
    • G06T5/50A61B6/027A61B6/583
    • It is described a method for reducing noise of X-ray attenuation data related to a first and second spectral X-ray data acquisition. The method comprises the steps of (a) acquiring data representing the X-ray attenuation behavior of a region of interest, (b) determining a first and a second attenuation-base line integral for the first and the second X-ray acquisition, respectively, and (c) calculating expected first and second signal to noise ratios for the first and the second attenuation-base line integral based on given signal to noise ratios for the first and second spectral X-ray data acquisition, respectively. The method further comprises the steps of (d) repeating the above mentioned steps of determining the attenuation-base line integrals and calculating the expected signal to noise ratios for a further first spectral X-ray data acquisition and (e) selecting improved spectral X-ray data acquisitions in order to enhance the overall signal to noise ratio of a final X-ray image.
    • 描述了一种用于降低与第一和第二光谱X射线数据采集相关的X射线衰减数据的噪声的方法。 该方法包括以下步骤:(a)获取表示感兴趣区域的X射线衰减特性的数据,(b)分别确定第一和第二X射线采集的第一和第二衰减基线积分 ,以及(c)分别基于用于第一和第二频谱X射线数据采集的给定信噪比来计算第一和第二衰减基线积分的期望的第一和第二信噪比。 该方法还包括以下步骤:(d)重复上述步骤以确定衰减基线积分并计算进一步的第一光谱X射线数据采集的预期信噪比,以及(e)选择改进的光谱X- 以提高最终X射线图像的整体信噪比。