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1. 发明申请

WO2006054240A2 ULTRASOUND CONTRAST AGENTS FOR MOLECULAR IMAGING 审中-公开
标题翻译：用于分子成像的超声对比剂
公开(公告)号：WO2006054240A2
公开(公告)日：2006-05-26
申请号：PCT/IB2005053763
申请日：2005-11-15
申请人： KONINKL PHILIPS ELECTRONICS NV , WILLARD NICOLAAS P , VAN BOMMEL TIES
发明人： WILLARD NICOLAAS P , VAN BOMMEL TIES
CPC分类号： A61K49/225 , A61K47/6907 , A61K47/6923 , A61K47/6929 , A61K47/6941 , B82Y5/00
摘要： A new type of contrast agent is described, which comprises matrix particles with a plurality of metal nanoparticles as well as the method of imaging therewith. A plurality of metal nanoparticles are encapsulated in a non-proteinaceous biocompatible or biodegradable matrix particle and/or attached to a non-proteinaceous biocompatible or biodegradable matrix particle, the matrix of the matrix particles being selected from the group consisting of a carbohydrate, a lipid, a synthetic polymer, an aqueous liquid, a surfactant and an organic liquid, or a mixture thereof. The matrix particles are biocompatible and/or biodegradable and can be coupled to targeting molecules for targeted visualization.
摘要翻译：描述了一种新型造影剂，其包括具有多个金属纳米颗粒的基质颗粒以及与其成像的方法。多个金属纳米颗粒被包封在非蛋白质生物相容性或可生物降解的基质颗粒中和/或附着于非蛋白质生物相容或可生物降解的基质颗粒上，所述基质颗粒的基质选自碳水化合物，脂质，合成聚合物，水性液体，表面活性剂和有机液体，或其混合物。基质颗粒是生物相容的和/或可生物降解的并且可以与靶向分子偶联以用于目标可视化。

2. 发明申请

WO2006114765A3 MRI INVOLVING CONTRAST AGENT WITH TIME MODULATED CONTRAST ENHANCEMENT 审中-公开
标题翻译： MRI涉及具有时间调制对比度增强的对比剂
公开(公告)号：WO2006114765A3
公开(公告)日：2007-05-03
申请号：PCT/IB2006051286
申请日：2006-04-25
申请人： KONINKL PHILIPS ELECTRONICS NV , WILLARD NICOLAAS P , WEGH RENE T , PIKKEMAAT JEROEN A , GRUELL HOLGER , SCHAEFFTER TOBIAS , LAMERICHS RUDOLF M J N
发明人： WILLARD NICOLAAS P , WEGH RENE T , PIKKEMAAT JEROEN A , GRUELL HOLGER , SCHAEFFTER TOBIAS , LAMERICHS RUDOLF M J N
IPC分类号： G01R33/28
CPC分类号： G01R33/5601 , A61K49/124 , G01R33/5605
摘要： The present invention provides a method of MRI imaging. By applying a time modulation to the contrast enhancement of an MRI contrast agent such as a CEST contrast agent, the method according to the invention leads to images with improved signal-to-noise ratio in the contrast-enhanced areas, strongly suppressed unwanted signal in the unenhanced areas, and reduced artefacts, such as motion artefacts .
摘要翻译：本发明提供一种MRI成像方法。通过对诸如CEST造影剂的MRI造影剂的对比度增强应用时间调制，根据本发明的方法导致在对比度增强区域中具有改善的信噪比的图像，强烈地抑制不需要的信号未增加的地区，减少的文物，如运动文物。

3. 发明申请

WO2006114739A3 METHOD FOR USING CEST CONTRAST AGENTS IN MRI 审中-公开
标题翻译：在MRI中使用CEST对比剂的方法
公开(公告)号：WO2006114739A3
公开(公告)日：2007-07-12
申请号：PCT/IB2006051237
申请日：2006-04-21
申请人： KONINKL PHILIPS ELECTRONICS NV , WEGH RENE T , PIKKEMAAT JEROEN A , WILLARD NICOLAAS P
发明人： WEGH RENE T , PIKKEMAAT JEROEN A , WILLARD NICOLAAS P
IPC分类号： G01R33/28 , G01R33/48
CPC分类号： G01R33/5601 , G01R33/4804
摘要： The invention relates to a method for mapping of a physico-chemical parameter such as pH, temperature, pO 2 or metabolite concentration using a chemical exchange saturation transfer contrast agent in Magnetic Resonance Imaging. This method is a modification of the known ratiometric method and may be used with agents having only one exchangeable entity pool, e.g. proton pool, by applying two different RF frequencies for pre-saturation of the contrast agent.
摘要翻译：本发明涉及一种使用化学交换饱和转移造影剂在磁共振成像中映射物理化学参数如pH，温度，pO 2或代谢物浓度的方法。该方法是已知比例法的修改，并且可以与仅具有一个可交换实体池的代理一起使用。质子池，通过应用两种不同的RF频率来预处理造影剂。

4. 发明申请

WO2008093263A2 BREATH ANALYSIS DEVICE 审中-公开
标题翻译：呼吸分析装置
公开(公告)号：WO2008093263A2
公开(公告)日：2008-08-07
申请号：PCT/IB2008050253
申请日：2008-01-24
申请人： KONINKL PHILIPS ELECTRONICS NV , VINK TEUNIS J , VAN KESTEREN HANS W , WILLARD NICOLAAS P
发明人： VINK TEUNIS J , VAN KESTEREN HANS W , WILLARD NICOLAAS P
IPC分类号： A61B5/08
CPC分类号： A61B5/082
摘要： A breath analysis device (10) comprising an inlet (11) for receiving a breath of a user, an analyzer (12) for determining a concentration of at least one element in the breath and output (15) for indicating the health zone corresponding to the concentration. The device also comprises a database for comprising previously determined concentrations and corresponding times at which the previously determined concentrations have been stored in the database and a processor (14) for storing in the concentrations in the database, comparing a measured concentration to at least one threshold for determining a health zone and recalculating the at least one threshold, based on the concentration and at least one of the previously determined concentrations.
摘要翻译：一种呼吸分析装置（10），包括用于接收用户呼吸的入口（11），用于确定所述呼吸和输出（15）中的至少一个元素的浓度的分析器（12），用于指示对应于浓度该装置还包括数据库，用于包括先前确定的浓度和先前确定的浓度已经存储在数据库中的相应时间;以及用于以数据库中的浓度存储的处理器（14），将测量的浓度与至少一个阈值用于基于所述浓度和所述先前确定的浓度中的至少一个来确定健康区并重新计算所述至少一个阈值。

5. 发明申请

WO2006114738A3 MRI CONTRAST AGENTS COMPRISING CEST ACTIVE PARAMAGNETIC COMPLEX 审中-公开
标题翻译： MRI对比剂包括CEST主动参与复合物
公开(公告)号：WO2006114738A3
公开(公告)日：2007-06-21
申请号：PCT/IB2006051235
申请日：2006-04-21
申请人： KONINKL PHILIPS ELECTRONICS NV , WILLARD NICOLAAS P , WEGH RENE T , PIKKEMAAT JEROEN A , GRUELL HOLGER
发明人： WILLARD NICOLAAS P , WEGH RENE T , PIKKEMAAT JEROEN A , GRUELL HOLGER
IPC分类号： A61K49/12
CPC分类号： A61K49/124 , A61K49/1812 , A61K49/1821
摘要： The invention provides MRI contrast agents which provide a high sensitivity and which have an optimised body retention time. These agents enable the mapping of the local pH, temperature, oxygen concentration or other metabolites in a patient's body by the use of Chemical Exchange Saturation Transfer (CEST). Particularly pH and temperature mapping are useful for the detection of small cancer lesions and localised inflammation respectively.
摘要翻译：本发明提供了提供高灵敏度并且具有优化的身体保留时间的MRI造影剂。这些试剂可以通过使用化学交换饱和转移（CEST）来测定患者体内的局部pH，温度，氧浓度或其他代谢物。特别是pH和温度映射可用于分别检测小癌病变和局部炎症。

6. 发明申请

WO2009147576A3 BREATH COLLECTION DEVICE AND METHOD 审中-公开
标题翻译：肠道收集装置和方法
公开(公告)号：WO2009147576A3
公开(公告)日：2010-05-14
申请号：PCT/IB2009052219
申请日：2009-05-27
申请人： KONINKL PHILIPS ELECTRONICS NV , VINK TEUNIS J , COENE WILLEM M J M , WILLARD NICOLAAS P
发明人： VINK TEUNIS J , COENE WILLEM M J M , WILLARD NICOLAAS P
IPC分类号： A61B5/097
CPC分类号： A61B5/097
摘要： The present invention relates to a simple, efficient and accurate breath collection device and a corresponding method for collecting the breath of a patient for analysis. The device comprises a gas mixture container (1) containing a gas mixture for inhalation by the patient, and a breathing unit (2) containing an inlet (21) connected to said gas mixture container (1) for letting in gas from the gas mixture container (1), an outlet (22) for letting out gas exhaled by the patientand a breathing element (23) for inhaling gas from the inlet (21) and exhaling gas to the outlet (22). The gas mixture container (1) contains a gas mixture containing a predetermined set of volatile organic compounds (VOC) markers.
摘要翻译：本发明涉及一种简单，有效和准确的呼吸收集装置和用于收集患者呼吸以进行分析的相应方法。所述装置包括含有用于由患者吸入的气体混合物的气体混合物容器（1）和包含连接到所述气体混合物容器（1）的入口（21）的呼吸单元（2），用于从气体混合物容器（1），用于排出患者呼出的气体的出口（22）和用于从入口（21）吸入气体的呼吸元件（23）并将气体排出到出口（22）。气体混合容器（1）含有含有预定的挥发性有机化合物（VOC）标记物的气体混合物。

7. 发明申请

WO2006085258A3 DISPLAY DEVICE WITH WATER-BASED ELECTROLYTE 审中-公开
标题翻译：具有水基电解质的显示装置
公开(公告)号：WO2006085258A3
公开(公告)日：2006-10-26
申请号：PCT/IB2006050380
申请日：2006-02-06
申请人： KONINKL PHILIPS ELECTRONICS NV , WILLARD NICOLAAS P , JAGT HENRI
发明人： WILLARD NICOLAAS P , JAGT HENRI
IPC分类号： G02F1/15 , G02F1/155
CPC分类号： G02F1/155 , G02F1/15 , G02F2001/1502 , G02F2001/1515 , G02F2001/1519 , G02F2001/1557
摘要： A display device 1 comprises a base layer 2 and a top layer 4. A conduction layer 5 is applied to the base layer in a pattern, to form electrodes 6 and 8. These can be made of ITO coated with conductive PEDOT. An insulating isolation layer 14 is then applied in a pattern on top of the conduction layer 5 and fills in the spaces between the electrodes 6, 8 of the conduction layer 5. Gaps in the isolation layer 14 extend over a part of the electrodes. A conductive electrochromic material is deposited and fills in these gaps, to form redox centres 16 and 18 each in electrical contact with one of the electrodes 6 and 8. Sealing 20 defines a cavity, which is filled with a water- based electrolyte 22. The isolation layer 14 and the redox centres 16, 18 protect the electrodes 6,8 from the electrolyte. Providing a light source and using transparent materials for all of the base layer 2, the top layer 4, the electrodes 6 and 8, and the isolation layer 14 allows the device 1 to be used for the transmission of light. Alternatively, one of the top and base layers 2, 4 can be reflective and the other transparent, in which case the device 1 can be used for light reflection. By selecting suitable materials, a washable and flexible display device can be constructed.
摘要翻译：显示装置1包括基底层2和顶层4.导电层5以图案形式施加到基底层上，以形成电极6和8.这些可以由涂覆有导电PEDOT的ITO制成。然后将绝缘隔离层14以导电层5的顶部上的图案施加，并填充在导电层5的电极6,8之间的空间中。隔离层14中的间隙在电极的一部分上延伸。导电电致变色材料被沉积并填充在这些间隙中，以形成各自与电极6和8中的一个电接触的氧化还原中心16和18.密封20限定了一个填充有水基电解质22的空腔。隔离层14和氧化还原中心16,18保护电极6,8免受电解质的影响。为所有基层2，顶层4，电极6和8以及隔离层14提供光源并使用透明材料允许装置1用于透光。或者，顶层和底层2,4中的一个可以是反射的，另一个是透明的，在这种情况下，装置1可以用于光反射。通过选择合适的材料，可以构建可洗涤和柔性的显示装置。

8. 发明申请

WO9962075A2 X-RAY EXAMINATION APPARATUS INCLUDING AN X-RAY FILTER 审中-公开
标题翻译： X射线检查装置，包括X射线滤镜
公开(公告)号：WO9962075A2
公开(公告)日：1999-12-02
申请号：PCT/IB9900879
申请日：1999-05-14
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS SVENSKA AB
发明人： PRINS MENNO W J , GIESBERS JACOBUS B , WEEKAMP JOHANNES W , JANS THEODORUS J A M , WELTERS WILHELMUS J J , WILLARD NICOLAAS P
IPC分类号： G21K3/00 , A61B6/00 , B29C37/00 , B29D99/00 , G21K1/10
CPC分类号： B29D99/0089 , B29C37/0075 , G21K1/10
摘要： The X-ray examination apparatus (1) comprises and X-ray source (2), an X-ray detector (5) and an X-ray filter (6) which is located between the X-ray source (2) and the X-ray detector (5). The X-ray filter (6) includes filter elements (7), notably capillary tubes, and the X-ray absorption of separate filter elements can be controlled by controlling a quantity of X-ray absorbing liquid (32) in the respective filter elements (7). The quantity of X-ray absorbing liquid in the individual filter elements is controlled by way of electric voltages applied to the individual filter elements. The filter elements (7) are formed as spaces between deformed foils (10) which are arranged in a stack which is expanded in the direction transversely of the foils. Adjacent foils are locally attached to one another along seams (30). The stack is arranged between rigid plates (11) and buffer elements (12) are provided between the rigid plates and the stack. The buffer elements are contractable in the direction transversely of the direction of expansion of the stack. The shape of the cross section of the capillary tubes is dependent on the ratio of the width of the seams to the spacing of the seams.
摘要翻译： X射线检查装置（1）包括位于X射线源（2）和X射线检测器（2）之间的X射线源（2），X射线检测器（5）和X射线滤波器（6） X光检测器（5）。 X射线过滤器（6）包括过滤器元件（7），特别是毛细管，并且可以通过控制各个过滤器元件中的X射线吸收液体（32）的量来控制单独的过滤元件的X射线吸收（7）。通过施加到各个过滤元件的电压来控制各个过滤器元件中的X射线吸收液体的量。过滤器元件（7）形成为沿着横向于箔的方向膨胀的堆叠中的变形箔（10）之间的空间。相邻的箔沿着接缝（30）局部地彼此连接。堆叠被布置在刚性板（11）之间，并且缓冲元件（12）设置在刚性板和堆叠之间。缓冲元件可以沿着堆叠方向的横向方向收缩。毛细管横截面的形状取决于接缝的宽度与接缝的间距的比值。

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