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1. 发明申请

WO2006114765A3 MRI INVOLVING CONTRAST AGENT WITH TIME MODULATED CONTRAST ENHANCEMENT 审中-公开
标题翻译： MRI涉及具有时间调制对比度增强的对比剂
公开(公告)号：WO2006114765A3
公开(公告)日：2007-05-03
申请号：PCT/IB2006051286
申请日：2006-04-25
申请人： KONINKL PHILIPS ELECTRONICS NV , WILLARD NICOLAAS P , WEGH RENE T , PIKKEMAAT JEROEN A , GRUELL HOLGER , SCHAEFFTER TOBIAS , LAMERICHS RUDOLF M J N
发明人： WILLARD NICOLAAS P , WEGH RENE T , PIKKEMAAT JEROEN A , GRUELL HOLGER , SCHAEFFTER TOBIAS , LAMERICHS RUDOLF M J N
IPC分类号： G01R33/28
CPC分类号： G01R33/5601 , A61K49/124 , G01R33/5605
摘要： The present invention provides a method of MRI imaging. By applying a time modulation to the contrast enhancement of an MRI contrast agent such as a CEST contrast agent, the method according to the invention leads to images with improved signal-to-noise ratio in the contrast-enhanced areas, strongly suppressed unwanted signal in the unenhanced areas, and reduced artefacts, such as motion artefacts .
摘要翻译：本发明提供一种MRI成像方法。通过对诸如CEST造影剂的MRI造影剂的对比度增强应用时间调制，根据本发明的方法导致在对比度增强区域中具有改善的信噪比的图像，强烈地抑制不需要的信号未增加的地区，减少的文物，如运动文物。

2. 发明申请

WO2007113759A2 MAGNETIC RESONANCE DEVICE AND METHOD 审中-公开
标题翻译：磁共振装置及方法
公开(公告)号：WO2007113759A2
公开(公告)日：2007-10-11
申请号：PCT/IB2007051146
申请日：2007-03-30
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , KEUPP JOCHEM , LAMERICHS RUDOLF M J N , SCHAEFFTER TOBIAS
发明人： KEUPP JOCHEM , LAMERICHS RUDOLF M J N , SCHAEFFTER TOBIAS
IPC分类号： G01R33/485
CPC分类号： G01R33/485
摘要： The invention relates to a device for magnetic resonance imaging of a body (7) placed in an examination volume, the device (1) comprising means (2) for establishing a substantially homogeneous main magnetic field in the examination volume, means (3, 4, 5) for generating switched magnetic field gradients superimposed upon the main magnetic field, means (6) for radiating RF pulses towards the body (7), control means (12) for controlling the generation of the magnetic field gradients and the RF pulses, means (10) for receiving and sampling magnetic resonance signals, and reconstruction means (14) for forming MR images from the signal samples. According to the invention, the device (1) is arranged to a) generate a series of MR echo signals from a nuclear spin species having two or more spectral lines by subjecting at least a portion of the body (7) to an MR imaging pulse sequence using multiple time-encoding echo time values, b) acquire the MR echo signals for reconstructing a series of time- encoded MR images therefrom, each time-encoded MR image being associated with one of the time-encoding echo time values, c) superimpose the MR images for obtaining a final image.
摘要翻译：本发明涉及一种用于放置在检查体积中的身体（7）的磁共振成像装置，该装置（1）包括用于在检查体积中建立基本均匀的主磁场的装置（2），装置（3,4），5），用于产生叠加在主磁场上的开关磁场梯度，用于向身体（7）辐射RF脉冲的装置（6），用于控制磁场梯度和RF脉冲的产生的控制装置（12）用于接收和采样磁共振信号的装置（10），以及用于从信号样本形成MR图像的重构装置（14）。根据本发明，设备（1）被布置成：a）通过使身体（7）的至少一部分经受MR成像脉冲，从而产生具有两条或更多条光谱线的核自旋物种的一系列MR回波信号使用多个时间编码回波时间值的序列，b）获取用于重构一系列时间编码的MR图像的MR回波信号，每个时间编码的MR图像与时间编码回波时间值之一相关联，c）叠加MR图像以获得最终图像。

3. 发明申请

WO2007113721A3 SYSTEMS AND METHODS FOR CELL MEASUREMENT UTILIZING ULTRASHORT T2* RELAXOMETRY 审中-公开
标题翻译：使用超声波T2 *电感测量的电池测量的系统和方法
公开(公告)号：WO2007113721A3
公开(公告)日：2009-02-19
申请号：PCT/IB2007051013
申请日：2007-03-22
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , LIU WEI , DAHNKE HANNES , SCHAEFFTER TOBIAS
发明人： LIU WEI , DAHNKE HANNES , SCHAEFFTER TOBIAS
IPC分类号： A61K49/18 , A61B5/055 , G01R33/54
CPC分类号： A61K49/1896 , A61K49/1866 , B82Y5/00
摘要： The present disclosure is directed to a new technique for MR measurement of ultrashort T2 * relaxation utilizing spin-echo acquisition. The ultrashort T2 * relaxometry can be used for the quantification of highly concentrated iron labeled cells in cell trafficking and therapy. In an exemplary embodiment, a signal is induced by a low flip angle RF pulse. Following excitation pulse, a gradient readout is applied to form an echo. The time between the RF pulse and the center of the gradient readout is defined as TE. In tissues with highly concentrated iron labeled cells, T2 * could be below 1 millisecond. Therefore, the signal can be decayed to a noise level with an echo time of a couple milliseconds. Because T2 * is much longer in SPIO labeled cells, the signal acquired by spin echo is much bigger than that from the gradient echo, thus avoiding the negative effects associated with the massive signal loss in the image. The ultrashort T2 * relaxation map can then by overlaid on the regular T2 * map to generate the final T2 * map of the field of view.
摘要翻译：本公开涉及一种利用自旋回波采集的超短T2 *弛豫的MR测量的新技术。超短T2 *松弛测定可用于定量细胞运输和治疗中高度浓缩的铁标记细胞。在示例性实施例中，信号由低翻转RF脉冲引起。在激发脉冲之后，应用梯度读数以形成回波。 RF脉冲与梯度读数中心之间的时间定义为TE。在具有高浓度铁标记细胞的组织中，T2 *可能低于1毫秒。因此，信号可以衰减到具有几毫秒的回波时间的噪声水平。因为T2 *在SPIO标记的细胞中长得多，所以通过自旋回波获取的信号比梯度回波的信号大得多，从而避免了与图像中的大量信号丢失相关的负面影响。然后可以将超短T2 *弛豫图覆盖在常规T2 *图上，以产生视场的最终T2 *图。

4. 发明申请

WO2007031910A3 MULTIPLE CONTRAST AGENT INJECTION FOR IMAGING 审中-公开
标题翻译：多个对比剂注射成像
公开(公告)号：WO2007031910A3
公开(公告)日：2007-10-18
申请号：PCT/IB2006053143
申请日：2006-09-07
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , DAHNKE HANNES , SCHAEFFTER TOBIAS
发明人： DAHNKE HANNES , SCHAEFFTER TOBIAS
IPC分类号： A61B5/055 , A61B6/00 , A61K49/00 , G01R33/28 , G01R33/56
CPC分类号： A61B5/055 , A61B6/481 , A61K49/1818 , B82Y5/00 , G01R33/50 , G01R33/5601 , G01R33/56366
摘要： MRI based molecular imaging is strongly supported by the accurate quantification of contrast agents. According to an exemplary embodiment of the present invention, contrast agent is applied on the basis of a multiple injection application scheme, during which changes in relaxation rate are determined. This may provide for an accurate determination of tumor vascularity via MRI relaxometry.
摘要翻译：通过造影剂的准确定量强烈支持基于MRI的分子成像。根据本发明的示例性实施方案，在多次注射施用方案的基础上应用造影剂，在此期间确定松弛率的变化。这可以通过MRI弛豫测定来准确地确定肿瘤血管。

5. 发明申请

WO2006129248A3 DETERMINATION OF DISTRIBUTION INFORMATION OF A CONTRAST AGENT BY MR MOLECULAR IMAGING 审中-公开
标题翻译：通过MR分子成像确定对比剂的分布信息
公开(公告)号：WO2006129248A3
公开(公告)日：2007-03-22
申请号：PCT/IB2006051657
申请日：2006-05-24
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , DAHNKE HANNES , SCHAEFFTER TOBIAS
发明人： DAHNKE HANNES , SCHAEFFTER TOBIAS
IPC分类号： G01R33/028 , G01R33/50
CPC分类号： G01R33/5601 , G01R33/50
摘要： MR based molecular imaging is used for the quantification of contrast agent concentrations. According to an exemplary embodiment of the present invention, a difference between R2 and R2* relaxation rates of a contrast agent is determined on the basis of data measured after contrast agent application. This may provide for an in vivo information relating to a compartmentalization or binding status of the contrast agent, and thus may improve the significance of the examination result.
摘要翻译：基于MR的分子成像用于定量造影剂浓度。根据本发明的一个示例性实施方案，根据造影剂施用后测量的数据确定造影剂的R2和R2 *松弛率之间的差异。这可以提供与造影剂的分隔或结合状态相关的体内信息，从而可以提高检查结果的重要性。

6. 发明申请

WO2007122527A3 DETERMINATION OF SUSCEPTIBILITY- INDUCED MAGNETIC FIELD GRADIENTS BY MAGNETIC RESONANCE 审中-公开
标题翻译：通过磁共振测定可触觉磁感应磁场梯度
公开(公告)号：WO2007122527A3
公开(公告)日：2008-01-10
申请号：PCT/IB2007051176
申请日：2007-04-02
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , DAHNKE HANNES , SCHAEFFTER TOBIAS
发明人： DAHNKE HANNES , SCHAEFFTER TOBIAS
IPC分类号： G01R33/28 , G01R33/3875 , G01R33/48
CPC分类号： G01R33/286 , G01R33/3875 , G01R33/48 , G01R33/56536
摘要： The invention relates to a device for magnetic resonance imaging of a body (7). The device (1) comprises means (2) for establishing a substantially homogeneous main magnetic field in the examination volume, means (3, 4, 5) for generating switched magnetic field gradients superimposed upon the main magnetic field, means (6) for radiating RF pulses towards the body (7), control means (12) for controlling the generation of the magnetic field gradients and the RF pulses, means (10) for receiving and sampling magnetic resonance signals, and reconstruction means (14) for forming MR images from the signal samples. In accordance with the invention, the device is arranged to a) generate a series of MR echo signals (20) by subjecting at least a portion of the body (7) to an MR imaging sequence of RF pulses and switched magnetic field gradients, b) acquire the MR echo signals for reconstructing an MR image data set (21) therefrom, c) calculate a gradient map (22) by computing echo shift parameters (SP x , SP y , SP z ) from subsets of the MR image data set, the echo shift parameters (SP x , SP y , SP z ) indicating magnetic field gradient induced shifts of the echo positions in k-space, wherein each subset comprises a number (n) of spatially adjacent pixel or voxel values of the MR image data set (21).
摘要翻译：本发明涉及一种用于身体（7）的磁共振成像的装置。装置（1）包括用于在检查体积中建立基本均匀的主磁场的装置（2），用于产生叠加在主磁场上的开关磁场梯度的装置（3,4,5），用于辐射的装置（6）朝向身体的射频脉冲（7），用于控制磁场梯度和RF脉冲的产生的控制装置（12），用于接收和采样磁共振信号的装置（10）和用于形成MR图像的重构装置（14）从信号样本。根据本发明，该装置被设置成：a）通过使身体（7）的至少一部分经受RF脉冲和切换的磁场梯度的MR成像序列来产生一系列MR回波信号（20），b 获取用于重构MR图像数据集（21）的MR回波信号，c）通过计算回波移位参数（SP＆lt; x＆gt;，SP＆gt; 回波移位参数（SP＆lt; SUB＆gt;，SP＆lt; SUB＆gt;，SP＆lt; SUB＆gt; 指示磁场梯度引起k空间中的回波位置的移位，其中每个子集包括MR图像数据集（21）的空间相邻像素的数量（n）或体素值。

7. 发明申请

WO2007015190A3 OPTICAL IMAGING 审中-公开
标题翻译：光学成像
公开(公告)号：WO2007015190A3
公开(公告)日：2007-08-30
申请号：PCT/IB2006052543
申请日：2006-07-25
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , NIELSEN TIM , VAN STEVENDAAL UDO , GLEICH BERNHARD , SCHAEFFTER TOBIAS , HAAKER PAUL , MAZURKEWITZ PETER , WEISS STEFFEN
发明人： NIELSEN TIM , VAN STEVENDAAL UDO , GLEICH BERNHARD , SCHAEFFTER TOBIAS , HAAKER PAUL , MAZURKEWITZ PETER , WEISS STEFFEN
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/0059 , A61B5/05
摘要： An optical imaging apparatus (100) for examination of an object of interest (101), the optical imaging apparatus (100) comprising an optical radiation source (102) adapted to emit a primary optical radiation beam onto the object of interest (101), an optical radiation detector (106) adapted to detect a secondary optical radiation beam emitted by the object of interest (101) upon absorbing the primary optical radiation beam, a magnetic field generating element (107) adapted to generate an inhomogeneous magnetic field varying along an extension of the object of interest (101), and a determination unit (108) adapted to determine information concerning the object of interest (101) based on an analysis of the detected secondary optical radiation beam in combination with an analysis of the inhomogeneous magnetic field.
摘要翻译：一种用于检查感兴趣物体（101）的光学成像设备（100），所述光学成像设备（100）包括适于将主要光学辐射束发射到感兴趣对象（101）上的光学辐射源（102）适于在吸收主光辐射束时检测由感兴趣物体（101）发射的次级光辐射束的光学辐射检测器（106），适于产生沿着所述第一光辐射束变化的非均匀磁场的磁场产生元件（107）感兴趣对象的扩展（101），以及确定单元（108），其适于基于对所检测到的次级光辐射束的分析来确定与感兴趣对象（101）有关的信息，以及非均匀磁场的分析。

8. 发明申请

WO03096274A2 METHOD FOR IMPROVING THE IMAGE QUALITY 审中-公开
标题翻译：改善图像质量的方法
公开(公告)号：WO03096274A2
公开(公告)日：2003-11-20
申请号：PCT/IB0301665
申请日：2003-04-29
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , GRAESSLIN INGMAR , SCHAEFFTER TOBIAS
发明人： GRAESSLIN INGMAR , SCHAEFFTER TOBIAS
IPC分类号： A61B6/03 , A61B5/055 , G06T1/00 , G06T5/00 , G06T5/50
CPC分类号： G06T5/50 , G06T5/003 , G06T2207/10081 , G06T2207/10088 , G06T2207/20201 , G06T2207/30101
摘要： The invention relates to a method for the processing of a series of raw images (1), notably for coronary MR or CT angiography. A reference image (3) is selected from the series of raw images (1) is found by matching a selected image region of interest within the reference image (3) with individual raw images from the series of raw images (1). The reference image (3) and the image (4) which is similar to the reference image are then processed so as to form an image of improved image quality (8). In order to obtain images which are as faithful and sharp as possible, the invention proposes to form the image of improved image quality (8) by weighted averaging of the intensity values of corresponding pixels within the reference image (3) and the image (4) which is similar to the reference image.
摘要翻译：本发明涉及用于处理一系列原始图像（1）的方法，特别是用于冠状动脉MR或CT血管造影术。通过将参考图像（3）内的所选择的感兴趣图像区域与来自原始图像序列（1）的各个原始图像进行匹配，从一系列原始图像（1）中选择参考图像（3）。然后处理与参考图像相似的参考图像（3）和图像（4），以形成改善的图像质量的图像（8）。为了获得尽可能忠实和清晰的图像，本发明提出通过对参考图像（3）和图像（4）内的相应像素的强度值进行加权平均来形成改进图像质量的图像（8）），它与参考图像相似。

9. 发明申请

WO0109633A3 MAGNETIC RESONANCE IMAGING CONTROLLED BY THE POSITION OF A MOVEABLE RF COIL 审中-公开
标题翻译：由可移动射频线圈的位置控制的磁共振成像
公开(公告)号：WO0109633A3
公开(公告)日：2001-08-09
申请号：PCT/EP0006976
申请日：2000-07-20
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS CORP INTELLECTUAL PTY
发明人： BOERNERT PETER , SCHAEFFTER TOBIAS , WEISS STEFFEN
IPC分类号： G01R33/34 , A61B5/055 , G01R33/28 , G01R33/32 , G01R33/341
CPC分类号： G01R33/341 , G01R33/34007 , G01R33/3806 , G01R33/543 , G01R33/546 , G01R33/58
摘要： This invention includes means for generating MR images by a moveable RF coil which can be moved across a patient during an MR examination. The MR apparatus includes a position detection system which detects the current position and orientation of the moveable RF coil. The coil can be hand held for manual movement or can be attached to mechanical manipulators for controlled movement. The imaging methods determine and generate magnetic gradient and RF pulse sequences to excite nuclear magnetization in a 3D region determined with respect to the current 3D position and 3D orientation of the moveable RF coil. The invention also includes moveable RF coils for receiving and transmitting which are configured and sized for convenient manipulation by an operator. A preferable moveable RF coil assembly includes markers necessary to interact with a particular position detection system, display means for displaying reconstructed images in real-time, and control means for operator entry of signals controlling the MR apparatus.
摘要翻译：本发明包括用于通过可移动RF线圈产生MR图像的装置，其可以在MR检查期间跨越患者移动。 MR装置包括检测可动RF线圈的当前位置和方向的位置检测系统。线圈可以手持进行手动运动，也可以连接到机械操纵器上以进行控制运动。成像方法确定并产生磁梯度和RF脉冲序列，以在相对于可移动RF线圈的当前3D位置和3D取向确定的3D区域中激发核磁化。本发明还包括用于接收和发送的可移动RF线圈，其被配置和大小以便操作者方便操作。优选的可动RF线圈组件包括与特定位置检测系统相互作用所必需的标记，用于实时显示重建图像的显示装置和用于操作者输入控制该MR装置的信号的控制装置。

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