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1. 发明申请

WO2006063294A3 NOVEL INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE 审中-公开
标题翻译：新型抗组蛋白去乙酰化酶治疗疾病的新型抑制剂
公开(公告)号：WO2006063294A3
公开(公告)日：2006-09-21
申请号：PCT/US2005044743
申请日：2005-12-09
申请人： KALYPSYS INC , MALECHA JAMES , NOBLE STEWART , HASSIG CHRISTIAN , WASH PAUL , WILEY BRANDON , LAWRENCE CHARLES , HOFFMAN TIMOTHY , BONNEFOUS CELINE , SMITH NICHOLAS
发明人： MALECHA JAMES , NOBLE STEWART , HASSIG CHRISTIAN , WASH PAUL , WILEY BRANDON , LAWRENCE CHARLES , HOFFMAN TIMOTHY , BONNEFOUS CELINE , SMITH NICHOLAS
IPC分类号： C07C323/22 , A61K31/145 , A61K31/4402 , A61K31/47 , A61K31/472 , A61P35/00 , C07D213/38 , C07D215/38 , C07D217/04
CPC分类号： C07D213/74 , C07C327/22 , C07C327/28 , C07C327/30 , C07C327/32 , C07D213/32 , C07D213/70 , C07D215/36 , C07D215/38 , C07D231/38 , C07D241/44 , C07D295/192 , C07D295/26 , C07D319/18
摘要： Disclosed herein are carbonyl compounds of Formula: (I) as described herein. Compounds as modulators of histone deacetylase (HDAC), pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译：本文公开了如本文所述的式（I）的羰基化合物。公开了作为组蛋白脱乙酰酶（HDAC）的调节剂的化合物，包含其的药物组合物以及使用该组合物治疗疾病的方法。

2. 发明申请

WO2005123089A3 MULTICYCLIC SULFONAMIDE COMPOUNDS AS INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE 审中-公开
标题翻译：作为治疗疾病的HISTONE脱乙酰壳多糖的多效磺酰胺化合物
公开(公告)号：WO2005123089A3
公开(公告)日：2006-03-30
申请号：PCT/US2005020769
申请日：2005-06-09
申请人： KALYPSYS INC , MALECHA JAMES , NOBLE STEWART , HASSIG CHRISTIAN , WASH PAUL , WILEY BRANDON , LAWRENCE CHARLES , HOFFMAN TIMOTHY
发明人： MALECHA JAMES , NOBLE STEWART , HASSIG CHRISTIAN , WASH PAUL , WILEY BRANDON , LAWRENCE CHARLES , HOFFMAN TIMOTHY
IPC分类号： A61K31/19 , A61K31/401 , A61K31/445 , A61K31/55 , C07C323/49 , C07C327/30 , C07D209/08 , C07D209/16 , C07D215/36 , C07D217/06 , C07D221/04 , C07D241/42 , C07D307/82 , C07D317/62 , C07D319/18 , C07D333/54 , C07D333/62 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07F9/165 , A61K31/16 , A61K31/34 , A61K31/40 , A61K31/44 , C07C303/00 , C07D209/04 , C07D317/44 , C07D453/02
CPC分类号： C07D221/04 , C07C323/49 , C07C327/30 , C07D209/08 , C07D209/16 , C07D215/36 , C07D217/06 , C07D241/42 , C07D307/82 , C07D317/62 , C07D319/18 , C07D333/54 , C07D333/62 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07F9/1653
摘要： Disclosed herein are carbonyl compounds of Formula (I) as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
摘要翻译：本文公开的是本文所述的式（I）的羰基化合物。公开了用于治疗疾病状态的方法和组合，包括但不限于癌症，自身免疫性疾病，组织损伤，中枢神经系统疾病，神经变性疾病，纤维化，骨病，多聚谷氨酰胺重复病症，贫血，地中海贫血，炎性病症，心血管疾病以及使用本发明化合物的血管发生在发病机理中起作用的病症。此外，还公开了调节组蛋白脱乙酰酶（HDAC）的活性的方法。

3. 发明申请

WO2005120515A3 NOVEL SULFONAMIDES AS INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE 审中-公开
标题翻译：作为治疗疾病的组胺脱乙酰酶的抑制剂的新型磺酰胺
公开(公告)号：WO2005120515A3
公开(公告)日：2006-03-30
申请号：PCT/US2005020770
申请日：2005-06-09
申请人： KALYPSYS INC , MALECHA JAMES , NOBLE STEWART , HASSIG CHRISTIAN , WASH PAUL , WILEY BRANDON , LAWRENCE CHARLES , HOFFMAN TIMOTHY
发明人： MALECHA JAMES , NOBLE STEWART , HASSIG CHRISTIAN , WASH PAUL , WILEY BRANDON , LAWRENCE CHARLES , HOFFMAN TIMOTHY
IPC分类号： A61K31/19 , A61K31/401 , A61K31/445 , A61K31/55 , C07C327/30 , C07C329/06 , C07D209/08 , C07D213/70 , C07D213/76 , C07D231/18 , C07D239/40 , C07D239/42 , C07D251/22 , C07D261/10 , C07D263/50 , C07D271/06 , C07D271/07 , C07D307/64 , C07D333/34 , C07D333/36 , C07D409/12 , C07D413/12 , C07D417/12 , C07F9/165 , A61K47/00 , A61K31/40 , A61K31/42 , A61K31/505 , C07C303/00 , C07D209/12 , C07D211/84 , C07D239/02 , C07D261/04
CPC分类号： C07D213/70 , C07C327/30 , C07C329/06 , C07D209/08 , C07D213/76 , C07D231/18 , C07D239/40 , C07D239/42 , C07D251/22 , C07D261/10 , C07D263/50 , C07D271/07 , C07D307/64 , C07D333/34 , C07D333/36 , C07D409/12 , C07D413/12 , C07D417/12 , C07F9/1653
摘要： Disclosed herein are carbonyl compounds of having the structural formula (I) or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
摘要翻译：本文公开了具有结构式（I）的羰基化合物或其药学上可接受的盐，酰胺，酯或前药。公开了用于治疗疾病状态的方法和组合物，包括但不限于癌症，自身免疫疾病，组织损伤，使用本发明的化合物，中枢神经系统疾病，神经退行性疾病，纤维化，骨病，聚谷氨酰胺重复病症，贫血，地贫，炎性病症，心血管疾病和血管发生在发病机理中发挥作用的病症。此外，还公开了调节组蛋白脱乙酰酶（HDAC）的活性的方法。

4. 发明申请

WO2011082364A2 PROVIDING TELEVISION BROADCASTS OVER A MANAGED NETWORK AND INTERACTIVE CONTENT OVER AN UNMANAGED NETWORK TO A CLIENT DEVICE 审中-公开
标题翻译：通过未经管理的网络向客户端设备提供电视广播
公开(公告)号：WO2011082364A2
公开(公告)日：2011-07-07
申请号：PCT/US2010062602
申请日：2010-12-30
申请人： ACTIVEVIDEO NETWORKS INC , DAHLBY JOSHUA , MARSAVIN ANDREY , LAWRENCE CHARLES , PAVLOVSKAIA LENA Y
发明人： DAHLBY JOSHUA , MARSAVIN ANDREY , LAWRENCE CHARLES , PAVLOVSKAIA LENA Y
IPC分类号： H04N7/24 , H04N7/173
CPC分类号： H04N7/17318 , H04N19/23 , H04N19/48 , H04N19/527 , H04N21/23412 , H04N21/23424 , H04N21/2343 , H04N21/2365 , H04N21/2402 , H04N21/4316 , H04N21/4347 , H04N21/44012 , H04N21/4722 , H04N21/631 , H04N21/812 , H04N21/8173 , H04N21/8543
摘要： A client device receives a broadcast content signal containing an interactive identifier over a managed network. The interactive identifier may be a trigger that is included in a header or embedded within the digital video data. In response to identification of the trigger, the client device sends a user request for interactive content over an unmanaged network. For example, the managed network may be a one-way satellite television network, IP-television network or cable television network and the unmanaged network may be the Internet. The client device switches between receiving data from the managed network to receiving data from the unmanaged network. Video encoding parameters of the interactive content are varied based on detected variations in the audio transmission bandwidth.
摘要翻译：客户端设备在托管网络上接收包含交互标识符的广播内容信号。交互标识符可以是包含在标题中或嵌入在数字视频数据中的触发器。响应于触发器的识别，客户端设备通过非管理网络发送对交互式内容的用户请求。例如，管理网络可以是单向卫星电视网络，IP电视网络或有线电视网络，并且非管理网络可以是互联网。客户端设备在从受管理网络接收数据到从非管理网络接收数据之间切换。交互式内容的视频编码参数基于检测到的音频传输带宽中的变化而变化。

5. 发明申请

WO2010044926A3 PROVIDING TELEVISION BROADCASTS OVER A MANAGED NETWORK AND INTERACTIVE CONTENT OVER AN UNMANAGED NETWORK TO A CLIENT DEVICE 审中-公开
标题翻译：通过管理的网络提供电视广播和通过客户端设备的无人网络的互动内容
公开(公告)号：WO2010044926A3
公开(公告)日：2010-06-17
申请号：PCT/US2009048171
申请日：2009-06-22
申请人： ACTIVE VIDEO NETWORKS INC , PAVLOVSKAIA LENA Y , LENNARTSSON ANDREAS , LAWRENCE CHARLES , DAHLBY JOSHUA , MARSAVIN ANDREY , BROWN GREGORY E , EDMONDS JEREMY , LI HSUEHMIN , SHAMGIN VLAD
发明人： PAVLOVSKAIA LENA Y , LENNARTSSON ANDREAS , LAWRENCE CHARLES , DAHLBY JOSHUA , MARSAVIN ANDREY , BROWN GREGORY E , EDMONDS JEREMY , LI HSUEHMIN , SHAMGIN VLAD
IPC分类号： H04N7/173 , H04N7/20 , H04N7/24
CPC分类号： H04N7/17318 , H04N19/23 , H04N19/48 , H04N19/527 , H04N21/23412 , H04N21/23424 , H04N21/2343 , H04N21/2365 , H04N21/4316 , H04N21/4622 , H04N21/4722 , H04N21/812 , H04N21/8543 , H04N21/8586
摘要： A client device receives a broadcast content signal containing an interactive identifier over a managed network at a client device. The interactive identifier may be a trigger that is included in a header or embedded within the digital video data. The trigger may have a temporal component, wherein the trigger can expire after a certain period of time. In response to identification of the trigger, the client device sends a user request for interactive content over an unmanaged network. For example, the managed network may be a one-way satellite television network, IP -television network or cable television network and the unmanaged network may be the Internet. The client device switches between receiving data from the managed network to receiving data from the unmanaged network.
摘要翻译：客户端设备在客户端设备处通过受管网络接收包含交互式标识符的广播内容信号。交互式标识符可以是包括在头部中或嵌入在数字视频数据内的触发器。触发器可以具有时间分量，其中触发器可以在一定时间段之后过期。响应于触发的识别，客户端设备通过非托管网络发送用于交互式内容的用户请求。例如，被管理网络可以是单向卫星电视网络，IP电视网络或有线电视网络，并且非托管网络可以是因特网。客户端设备在从被管理网络接收数据到从非托管网络接收数据之间切换。

6. 发明申请

WO2010054136A2 SYSTEM, METHOD, AND COMPUTER PROGRAM PRODUCT FOR TRANSLATING AN ELEMENT OF A STATIC ENCODED IMAGE IN THE ENCODED DOMAIN 审中-公开
标题翻译：系统，方法和计算机程序产品，用于翻译编码域中静态编码图像的元素
公开(公告)号：WO2010054136A2
公开(公告)日：2010-05-14
申请号：PCT/US2009063471
申请日：2009-11-06
申请人： ACTIVEVIDEO NETWORKS INC , ZHANG DENGHI , LAWRENCE CHARLES
发明人： ZHANG DENGHI , LAWRENCE CHARLES
IPC分类号： H04N7/24
CPC分类号： H04N21/23412 , H04N19/176 , H04N19/182 , H04N19/48 , H04N19/60 , H04N21/4316 , H04N21/4886
摘要： A computer-implemented method for creating in the encoded domain one or more video frames from a compressed still video image wherein image content in the created video frames is translated in location by panning or scrolling or a combination thereof on a non- block basis (i.e. pixel-level). A new block formed from portions of two other blocks is created by processing the original two blocks with identity matrices based upon the shift amount. By performing the creation process in the encoded domain processing power requirements are reduced and image quality is increased.
摘要翻译：一种计算机实现的方法，用于在编码域中创建来自压缩静止视频图像的一个或多个视频帧，其中所创建的视频帧中的图像内容通过平移或滚动或其组合在非块基础上被翻译（例如，像素级）。通过基于移位量处理具有单位矩阵的原始两个块来创建由两个其他块的部分形成的新块。通过在编码域中执行创建处理，处理能力降低，图像质量提高。

7. 发明申请

WO2005020123A3 INFORMATION SYSTEM FOR BIOLOGICAL AND LIFE SCIENCES RESEARCH 审中-公开
标题翻译：生物和生命科学研究信息系统
公开(公告)号：WO2005020123A3
公开(公告)日：2005-09-09
申请号：PCT/US2004026147
申请日：2004-08-12
申请人： APPLERA CORP , CYRUS RAMIN , DI TOMMASO MATTEO , KERLAVAGE ANTHONY R , LAWRENCE CHARLES
发明人： CYRUS RAMIN , DI TOMMASO MATTEO , KERLAVAGE ANTHONY R , LAWRENCE CHARLES
IPC分类号： G06F19/28 , G06F19/00
CPC分类号： G06F19/28
摘要： An online life science research environment and virtual community focusing on design and analysis of biological experiments includes a life sciences laboratory system employing at least one networked computer system defining a virtual research environment. Users access the system through a portal associated with the networked computer system(s). The virtual research environment has a data coupling mechanism by which the user designates a set of user-specified data for bioinformatics processing. A processor(s) associated with the networked computer system(s) performs bioinformatics services upon the user-specified data. In one embodiment, the data coupling mechanism enables transfer of the user-specified data to a memory space that is mediated or accessed by the processor performing the bioinformatics processing. Users may thus exploit bioinformatics processing resources not deployed on users' local computer environments, and to store and organize information relating to life sciences research in a secure, online workspace.
摘要翻译：一个专注于生物实验设计和分析的在线生命科学研究环境和虚拟社区包括一个生命科学实验室系统，该系统至少使用一个定义虚拟研究环境的联网计算机系统。用户通过与联网计算机系统相关的入口访问系统。虚拟研究环境具有数据耦合机制，通过该机制用户指定一组用于生物信息学处理的用户指定数据。与联网的计算机系统相关联的处理器在用户指定的数据上执行生物信息学服务。在一个实施例中，数据耦合机制使得能够将用户指定的数据传送到由执行生物信息学处理的处理器介导或访问的存储空间。因此，用户可以利用未部署在用户本地计算机环境中的生物信息学处理资源，并且在安全的在线工作空间中存储和组织与生命科学研究有关的信息。

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