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1. 发明申请

WO2006063294A3 NOVEL INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE 审中-公开
标题翻译：新型抗组蛋白去乙酰化酶治疗疾病的新型抑制剂
公开(公告)号：WO2006063294A3
公开(公告)日：2006-09-21
申请号：PCT/US2005044743
申请日：2005-12-09
申请人： KALYPSYS INC , MALECHA JAMES , NOBLE STEWART , HASSIG CHRISTIAN , WASH PAUL , WILEY BRANDON , LAWRENCE CHARLES , HOFFMAN TIMOTHY , BONNEFOUS CELINE , SMITH NICHOLAS
发明人： MALECHA JAMES , NOBLE STEWART , HASSIG CHRISTIAN , WASH PAUL , WILEY BRANDON , LAWRENCE CHARLES , HOFFMAN TIMOTHY , BONNEFOUS CELINE , SMITH NICHOLAS
IPC分类号： C07C323/22 , A61K31/145 , A61K31/4402 , A61K31/47 , A61K31/472 , A61P35/00 , C07D213/38 , C07D215/38 , C07D217/04
CPC分类号： C07D213/74 , C07C327/22 , C07C327/28 , C07C327/30 , C07C327/32 , C07D213/32 , C07D213/70 , C07D215/36 , C07D215/38 , C07D231/38 , C07D241/44 , C07D295/192 , C07D295/26 , C07D319/18
摘要： Disclosed herein are carbonyl compounds of Formula: (I) as described herein. Compounds as modulators of histone deacetylase (HDAC), pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译：本文公开了如本文所述的式（I）的羰基化合物。公开了作为组蛋白脱乙酰酶（HDAC）的调节剂的化合物，包含其的药物组合物以及使用该组合物治疗疾病的方法。

2. 发明申请

WO2005123089A3 MULTICYCLIC SULFONAMIDE COMPOUNDS AS INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE 审中-公开
标题翻译：作为治疗疾病的HISTONE脱乙酰壳多糖的多效磺酰胺化合物
公开(公告)号：WO2005123089A3
公开(公告)日：2006-03-30
申请号：PCT/US2005020769
申请日：2005-06-09
申请人： KALYPSYS INC , MALECHA JAMES , NOBLE STEWART , HASSIG CHRISTIAN , WASH PAUL , WILEY BRANDON , LAWRENCE CHARLES , HOFFMAN TIMOTHY
发明人： MALECHA JAMES , NOBLE STEWART , HASSIG CHRISTIAN , WASH PAUL , WILEY BRANDON , LAWRENCE CHARLES , HOFFMAN TIMOTHY
IPC分类号： A61K31/19 , A61K31/401 , A61K31/445 , A61K31/55 , C07C323/49 , C07C327/30 , C07D209/08 , C07D209/16 , C07D215/36 , C07D217/06 , C07D221/04 , C07D241/42 , C07D307/82 , C07D317/62 , C07D319/18 , C07D333/54 , C07D333/62 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07F9/165 , A61K31/16 , A61K31/34 , A61K31/40 , A61K31/44 , C07C303/00 , C07D209/04 , C07D317/44 , C07D453/02
CPC分类号： C07D221/04 , C07C323/49 , C07C327/30 , C07D209/08 , C07D209/16 , C07D215/36 , C07D217/06 , C07D241/42 , C07D307/82 , C07D317/62 , C07D319/18 , C07D333/54 , C07D333/62 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07F9/1653
摘要： Disclosed herein are carbonyl compounds of Formula (I) as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
摘要翻译：本文公开的是本文所述的式（I）的羰基化合物。公开了用于治疗疾病状态的方法和组合，包括但不限于癌症，自身免疫性疾病，组织损伤，中枢神经系统疾病，神经变性疾病，纤维化，骨病，多聚谷氨酰胺重复病症，贫血，地中海贫血，炎性病症，心血管疾病以及使用本发明化合物的血管发生在发病机理中起作用的病症。此外，还公开了调节组蛋白脱乙酰酶（HDAC）的活性的方法。

3. 发明申请

WO2005120515A3 NOVEL SULFONAMIDES AS INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE 审中-公开
标题翻译：作为治疗疾病的组胺脱乙酰酶的抑制剂的新型磺酰胺
公开(公告)号：WO2005120515A3
公开(公告)日：2006-03-30
申请号：PCT/US2005020770
申请日：2005-06-09
申请人： KALYPSYS INC , MALECHA JAMES , NOBLE STEWART , HASSIG CHRISTIAN , WASH PAUL , WILEY BRANDON , LAWRENCE CHARLES , HOFFMAN TIMOTHY
发明人： MALECHA JAMES , NOBLE STEWART , HASSIG CHRISTIAN , WASH PAUL , WILEY BRANDON , LAWRENCE CHARLES , HOFFMAN TIMOTHY
IPC分类号： A61K31/19 , A61K31/401 , A61K31/445 , A61K31/55 , C07C327/30 , C07C329/06 , C07D209/08 , C07D213/70 , C07D213/76 , C07D231/18 , C07D239/40 , C07D239/42 , C07D251/22 , C07D261/10 , C07D263/50 , C07D271/06 , C07D271/07 , C07D307/64 , C07D333/34 , C07D333/36 , C07D409/12 , C07D413/12 , C07D417/12 , C07F9/165 , A61K47/00 , A61K31/40 , A61K31/42 , A61K31/505 , C07C303/00 , C07D209/12 , C07D211/84 , C07D239/02 , C07D261/04
CPC分类号： C07D213/70 , C07C327/30 , C07C329/06 , C07D209/08 , C07D213/76 , C07D231/18 , C07D239/40 , C07D239/42 , C07D251/22 , C07D261/10 , C07D263/50 , C07D271/07 , C07D307/64 , C07D333/34 , C07D333/36 , C07D409/12 , C07D413/12 , C07D417/12 , C07F9/1653
摘要： Disclosed herein are carbonyl compounds of having the structural formula (I) or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
摘要翻译：本文公开了具有结构式（I）的羰基化合物或其药学上可接受的盐，酰胺，酯或前药。公开了用于治疗疾病状态的方法和组合物，包括但不限于癌症，自身免疫疾病，组织损伤，使用本发明的化合物，中枢神经系统疾病，神经退行性疾病，纤维化，骨病，聚谷氨酰胺重复病症，贫血，地贫，炎性病症，心血管疾病和血管发生在发病机理中发挥作用的病症。此外，还公开了调节组蛋白脱乙酰酶（HDAC）的活性的方法。

4. 发明申请

WO03050248A2 ADENINE NUCLEOTIDE-BINDING PROTEIN-DIRECTED PROBES AND METHODS OF THEIR SYNTHESIS AND USE 审中-公开
标题翻译：腺嘌呤核蛋白结合蛋白质指导的探针及其合成与使用方法
公开(公告)号：WO03050248A2
公开(公告)日：2003-06-19
申请号：PCT/US0239073
申请日：2002-12-05
申请人： ACTIVX BIOSCIENCES INC , CAMPBELL DAVID A , WASH PAUL
发明人： CAMPBELL DAVID A , WASH PAUL
IPC分类号： A61K31/7076 , C07H19/167 , C12N20060101 , C12Q1/68 , G01N33/53 , G01N33/573 , C12N
CPC分类号： G01N33/573 , G01N2333/91171
摘要： The invention relates to compositions and methods for the synthesis and use of Adenosine nucleotide binding protein-directed affinity labels. Adenosine nucleotide binding proteins may be labeled with probes comprising adenosine, or an analogue thereof, functionalized at the 5' position with reactive group capable of reacting with an amino acid side chain functionality at an adenosine nucleotide binding site, and at the 2' or 3' position with a TAG for sequestering and/or identifying the resulting conjugate. The probes may be used for determining the presence or amount of one or more adenosine nucleotide binding proteins in a complex mixture, particularly a cellular mixture, for screening for drugs, and other purposes associated with the presence of the adenine nucleotide-binding protein(s) in a cell or changes in the presence, amount, activity, or relative concentration of the active adenosine nucleotide-binding protein.
摘要翻译：本发明涉及用于合成和使用腺苷核苷酸结合蛋白质的亲和标记物的组合物和方法。腺苷核苷酸结合蛋白可以用包含腺苷或其类似物的探针进行标记，所述腺苷或其类似物在5'位被官能化，反应基能够与腺苷核苷酸结合位点处的氨基酸侧链官能团反应，而在2'或3' '位置用于螯合和/或鉴定所得缀合物。探针可用于确定复合混合物，特别是细胞混合物中用于筛选药物的一种或多种腺苷核苷酸结合蛋白的存在或量，以及与腺嘌呤核苷酸结合蛋白（s）的存在相关的其它目的）或活性腺苷核苷酸结合蛋白的存在，量，活性或相对浓度的变化。

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