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1. 发明申请

WO2022060536A1 AN AUTONOMOUS MICROFLUIDIC DEVICE FOR SAMPLE PREPARATION 审中-公开
公开(公告)号：WO2022060536A1
公开(公告)日：2022-03-24
申请号：PCT/US2021/047081
申请日：2021-08-23
申请人： INTELLIGENT VIRUS IMAGING INC
发明人： HAUSER, Janosch , KYLBERG, Gustaf , STEMME, Göran , SINTORN, Ida-Maria , ROXHED, Niclas
IPC分类号： B01L3/502738 , G01N1/30 , G01N1/31 , H01J37/16 , H01J37/20 , H01J37/252
摘要： The microfluidic device (100, 200) has a first reservoir (102, 202) that preferably includes a first liquid (108, 208). The first liquid (108, 208) is being held by a capillary stop valve (228, 230) in the first reservoir (102, 202). A second reservoir (104, 204) is in fluid communication with the first reservoir (102, 202). The second reservoir (104, 204) has a second liquid (110, 210) and a sample support (116, 216) disposed therein. The second reservoir (104, 204) has an inlet opening (145, 236) defined therein. A draining unit (106, 206) is adjacent to the second reservoir (104, 204). The draining unit (106, 206) is in fluid communication with the second reservoir (104, 204). The draining unit (106, 206) has a first absorption member (158, 218, 858) disposed therein.

2. 发明申请

WO2018063785A1 METHOD FOR QUANTIFICATION OF PURITY OF SUB-VISIBLE PARTICLE SAMPLES 审中-公开
标题翻译：用于量化次可见颗粒样品纯度的方法
公开(公告)号：WO2018063785A1
公开(公告)日：2018-04-05
申请号：PCT/US2017/050962
申请日：2017-09-11
申请人： INTELLIGENT VIRUS IMAGING INC.
发明人： SINTORN, Ida-Maria , RYNER, Martin , KYLBERG, Gustaf , NILSSON, Josefina
IPC分类号： B01D11/00 , C12Q1/70
摘要： The method is for quantification of purity of sub-visible particle samples. A sample to be analyzed is place in an electron microscope to obtain an electron microscopy image (100) of the sample. The sample contains objects (114). The objects (114) that have sizes being different from a size range of primary particles (120) and sizes being within the size range of primary particles (120) are enhanced. The objects (114) are detected as being primary particles (120) or debris (106). The detected primary particles (120) are excluded from the objects (114) so that the objects (114) contain debris (106) but no primary particles (120). A first total area (T1) of the detected debris (106) is measured. A second total area (T2) of the detected primary particles (120) is measured.
摘要翻译：该方法用于量化亚可见颗粒样品的纯度。将要分析的样品置于电子显微镜中以获得样品的电子显微镜图像（100）。该样本包含对象（114）。具有与一次颗粒（120）的尺寸范围不同且尺寸在一次颗粒（120）的尺寸范围内的尺寸的物体（114）被增强。物体（114）被检测为初级颗粒（120）或碎片（106）。检测到的初级颗粒（120）从对象（114）中排除，使得对象（114）包含碎片（106）但不包含初级颗粒（120）。测量检测到的碎片（106）的第一总面积（T1）。测量所检测的初级颗粒（120）的第二总面积（T2）。

3. 发明申请

WO2022060537A1 AN AUTONOMOUS MICROFLUIDIC DEVICE FOR SAMPLE PREPARATION 审中-公开
公开(公告)号：WO2022060537A1
公开(公告)日：2022-03-24
申请号：PCT/US2021/047085
申请日：2021-08-23
申请人： INTELLIGENT VIRUS IMAGING INC
发明人： HAUSER, Janosch , KYLBERG, Gustaf , STEMME, Göran , SINTORN, Ida-Maria , ROXHED, Niclas
IPC分类号： B01L3/502738 , G01N1/30 , G01N1/31 , H01J37/16 , H01J37/20 , H01J37/252
摘要： The method is for preparing a sample in a microfluidic device. The microfluidic device is provided that has a first reservoir in fluid communication with a second reservoir in fluid communication with and adjacent to a draining unit that has a first absorbing member disposed therein. The first reservoir contains a first liquid that is held in the first reservoir by a capillary stop valve connecting the first and second reservoirs. The second reservoir has a sample support disposed therein. A second liquid, containing substances, is added to the second reservoir. The second liquid contacts the first liquid and the first absorbing member. The first absorbing member absorbs the second liquid and the first liquid. The substances adhere to the sample support.

4. 发明申请

WO2017105625A1 HIGH PRECISION QUANTIFICATION OF SUB-VISIBLE PARTICLES 审中-公开
标题翻译：子可见粒子的高精度量化
公开(公告)号：WO2017105625A1
公开(公告)日：2017-06-22
申请号：PCT/US2016/058011
申请日：2016-10-21
申请人： INTELLIGENT VIRUS IMAGING INC.
发明人： NORDSTROM, Rickard , SINTORN, Ida-Maria , HAAG, Lars
IPC分类号： B01D11/00
CPC分类号： G01N1/4077 , G01N15/14 , G01N15/1468 , G01N2001/4088 , G01N2015/0038 , G01N2015/1486
摘要： The method is for quantification of sub-visible particles. A filter membrane (116) is provided that has a plurality of pores (138) defined there through. The filter membrane (116) is in operational engagement with a vacuum chamber (104). The pores are sealed with a sealant (140). A sample droplet (126), containing a liquid (144) and sub-visible particles (142), is applied onto the filter membrane (116). The liquid (144) dissolves the sealant (140) in pores (138e-138h) disposed directly below the sample droplet (126). The liquid (144) flows through the pores in which the sealant (140) has been dissolved and the sub-visible particles (142) remain on top of the filter membrane (116). The particles (142) are enumerated in an electron microscopy.
摘要翻译：
该方法用于量化次可见颗粒。提供过滤膜（116），其具有限定在其中的多个孔（138）。过滤膜（116）与真空室（104）处于操作接合。孔用密封剂（140）密封。包含液体（144）和亚可见颗粒（142）的样品液滴（126）被施加到过滤膜（116）上。液体（144）将密封剂（140）溶解在设置在样品液滴（126）正下方的孔（138e-138h）中。液体（144）流过其中已经溶解密封剂（140）的孔并且亚可见颗粒（142）保留在过滤膜（116）的顶部上。颗粒（142）在电子显微镜下列举。

5. 发明申请

WO2006112928A3 METHOD OF ANALYZING CELL STRUCTURES AND THEIR COMPONENTS 审中-公开
公开(公告)号：WO2006112928A3
公开(公告)日：2006-10-26
申请号：PCT/US2006/005571
申请日：2006-02-17
申请人： INTELLIGENT VIRUS IMAGING INC. , HOMMAN, Mohammed , SINTORN, Ida-Maria
发明人： HOMMAN, Mohammed , SINTORN, Ida-Maria
IPC分类号： G06F19/00
摘要： A cell (14) is provided that contains a plurality of virus particles (16). A first image (20) of a first virus particle (22) and a second image (32) of a second virus particle (34) are taken by electron microscopy technology. The first virus particle is characterized as being in a first maturity stage and the second virus particle as being in a second maturity stage. The first image (20) and the second image (32) are transformed to first and second gray scale profiles (24, 46), respectively, based on pixel data. The first and second gray scale profiles (24, 36) are then saved as first and second templates, respectively. A third virus particle in a third image is identified. The third image is transformed into a third gray scale profile. The third gray scale is compared to the first and second template to determine a maturity stage of the third virus particle.

6. 发明申请

WO2023283411A2 METHOD FOR MACHINE-LEARNING BASED TRAINING AND SEGMENTATION OF OVERLAPPING OBJECTS 审中-公开
公开(公告)号：WO2023283411A2
公开(公告)日：2023-01-12
申请号：PCT/US2022/036470
申请日：2022-07-08
申请人： INTELLIGENT VIRUS IMAGING INC.
发明人： PIHLSTRÖM, Max , SINTORN, Ida-Maria
IPC分类号： G06V10/26 , G06T7/00 , G06V20/69 , G06T7/70 , G06V20/695
摘要： The method is for training and automatically segmenting overlapping objects (102, 104) in images such as overlapping objects in images acquired with an imaging device such as a microscope. The overlapping objects are divided into non-overlapping connected components and overlapping segments. The method includes combinatorial set theory in a training scheme and at inference of a machine learning approach for automatic segmentation of overlapping objects (102, 104) imaged with an electron microscope.

7. 发明申请

WO2016014177A1 METHOD FOR AUTOMATIC CORRECTION OF ASTIGMATISM 审中-公开
标题翻译：自动校正方法
公开(公告)号：WO2016014177A1
公开(公告)日：2016-01-28
申请号：PCT/US2015/036117
申请日：2015-06-17
申请人： INTELLIGENT VIRUS IMAGING INC. , SINTORN, Ida-Maria , NORDSTROM, Rickard , KYLBERG, Gustaf
发明人： SINTORN, Ida-Maria , NORDSTROM, Rickard , KYLBERG, Gustaf
IPC分类号： H01J37/153
CPC分类号： H01J37/153 , H01J2237/1532 , H01J2237/223
摘要： The method is for automatic astigmatism correction of a lens system. A first image (96) is provided that is not in focus at a first stigmator setting of a set of lenses. A calculating device calculates a corresponding first Fourier spectrum image (312). A distribution and direction of pixels of the Fourier spectrum image (128, 130, 312) are determined by calculating a first vector (132) and a second vector (134). The first vector (132) is compared with the second vector (134). The lens system is changed from a first stigmator setting to a second stigmator setting to provide a second image (98). A corresponding Fourier spectrum image (314) is calculated. The distribution and direction of pixels of the second Fourier spectrum image (314) is determined by calculating a third vector and a fourth vector. The third vector is compared to the fourth vector. The image that has the lowest vector ratio is selected.
摘要翻译：该方法用于透镜系统的自动散光校正。提供第一图像（96），其在一组透镜的第一施放器设置处不聚焦。计算装置计算对应的第一傅立叶光谱图像（312）。通过计算第一矢量（132）和第二矢量（134）来确定傅里叶谱图像（128,130,312）的像素的分布和方向。将第一矢量（132）与第二矢量（134）进行比较。透镜系统从第一施压器设置改变为第二施放器设置以提供第二图像（98）。计算相应的傅立叶光谱图像（314）。通过计算第三矢量和第四矢量来确定第二傅立叶光谱图像（314）的像素的分布和方向。将第三个向量与第四个向量进行比较。选择具有最低矢量比的图像。

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