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1. 发明申请

WO2022060536A1 AN AUTONOMOUS MICROFLUIDIC DEVICE FOR SAMPLE PREPARATION 审中-公开
公开(公告)号：WO2022060536A1
公开(公告)日：2022-03-24
申请号：PCT/US2021/047081
申请日：2021-08-23
申请人： INTELLIGENT VIRUS IMAGING INC
发明人： HAUSER, Janosch , KYLBERG, Gustaf , STEMME, Göran , SINTORN, Ida-Maria , ROXHED, Niclas
IPC分类号： B01L3/502738 , G01N1/30 , G01N1/31 , H01J37/16 , H01J37/20 , H01J37/252
摘要： The microfluidic device (100, 200) has a first reservoir (102, 202) that preferably includes a first liquid (108, 208). The first liquid (108, 208) is being held by a capillary stop valve (228, 230) in the first reservoir (102, 202). A second reservoir (104, 204) is in fluid communication with the first reservoir (102, 202). The second reservoir (104, 204) has a second liquid (110, 210) and a sample support (116, 216) disposed therein. The second reservoir (104, 204) has an inlet opening (145, 236) defined therein. A draining unit (106, 206) is adjacent to the second reservoir (104, 204). The draining unit (106, 206) is in fluid communication with the second reservoir (104, 204). The draining unit (106, 206) has a first absorption member (158, 218, 858) disposed therein.

2. 发明申请

WO2006112928A2 METHOD OF ANALYZING CELL STRUCTURES AND THEIR COMPONENTS 审中-公开
标题翻译：分析细胞结构及其组分的方法
公开(公告)号：WO2006112928A2
公开(公告)日：2006-10-26
申请号：PCT/US2006005571
申请日：2006-02-17
申请人： INTELLIGENT VIRUS IMAGING INC , HOMMAN MOHAMMED , SINTORN IDA-MARIA
发明人： HOMMAN MOHAMMED , SINTORN IDA-MARIA
IPC分类号： C12Q1/00 , G06F19/00
CPC分类号： G06K9/0014 , G01N15/1475 , G01N33/5005 , G01N33/5076
摘要： A cell (14) is provided that contains a plurality of virus particles (16). A first image (20) of a first virus particle (22) and a second image (32) of a second virus particle (34) are taken by electron microscopy technology. The first virus particle is characterized as being in a first maturity stage and the second virus particle as being in a second maturity stage. The first image (20) and the second image (32) are transformed to first and second gray scale profiles (24, 46), respectively, based on pixel data. The first and second gray scale profiles (24, 36) are then saved as first and second templates, respectively. A third virus particle in a third image is identified. The third image is transformed into a third gray scale profile. The third gray scale is compared to the first and second template to determine a maturity stage of the third virus particle.
摘要翻译：提供包含多个病毒颗粒（16）的细胞（14）。通过电子显微镜技术拍摄第一病毒颗粒（22）和第二病毒颗粒（34）的第二图像（32）的第一图像（20）。第一病毒颗粒的特征在于处于第一成熟阶段，第二病毒颗粒处于第二成熟阶段。基于像素数据，第一图像（20）和第二图像（32）分别被变换到第一和第二灰度轮廓（24,46）。然后将第一和第二灰度轮廓（24,36）分别保存为第一和第二模板。鉴定第三个图像中的第三个病毒颗粒。第三个图像被转换成第三个灰度图。将第三灰阶与第一和第二模板进行比较，以确定第三病毒颗粒的成熟期。

3. 发明申请

WO2022060537A1 AN AUTONOMOUS MICROFLUIDIC DEVICE FOR SAMPLE PREPARATION 审中-公开
公开(公告)号：WO2022060537A1
公开(公告)日：2022-03-24
申请号：PCT/US2021/047085
申请日：2021-08-23
申请人： INTELLIGENT VIRUS IMAGING INC
发明人： HAUSER, Janosch , KYLBERG, Gustaf , STEMME, Göran , SINTORN, Ida-Maria , ROXHED, Niclas
IPC分类号： B01L3/502738 , G01N1/30 , G01N1/31 , H01J37/16 , H01J37/20 , H01J37/252
摘要： The method is for preparing a sample in a microfluidic device. The microfluidic device is provided that has a first reservoir in fluid communication with a second reservoir in fluid communication with and adjacent to a draining unit that has a first absorbing member disposed therein. The first reservoir contains a first liquid that is held in the first reservoir by a capillary stop valve connecting the first and second reservoirs. The second reservoir has a sample support disposed therein. A second liquid, containing substances, is added to the second reservoir. The second liquid contacts the first liquid and the first absorbing member. The first absorbing member absorbs the second liquid and the first liquid. The substances adhere to the sample support.

4. 发明申请

WO2017105625A1 HIGH PRECISION QUANTIFICATION OF SUB-VISIBLE PARTICLES 审中-公开
标题翻译：子可见粒子的高精度量化
公开(公告)号：WO2017105625A1
公开(公告)日：2017-06-22
申请号：PCT/US2016/058011
申请日：2016-10-21
申请人： INTELLIGENT VIRUS IMAGING INC.
发明人： NORDSTROM, Rickard , SINTORN, Ida-Maria , HAAG, Lars
IPC分类号： B01D11/00
CPC分类号： G01N1/4077 , G01N15/14 , G01N15/1468 , G01N2001/4088 , G01N2015/0038 , G01N2015/1486
摘要： The method is for quantification of sub-visible particles. A filter membrane (116) is provided that has a plurality of pores (138) defined there through. The filter membrane (116) is in operational engagement with a vacuum chamber (104). The pores are sealed with a sealant (140). A sample droplet (126), containing a liquid (144) and sub-visible particles (142), is applied onto the filter membrane (116). The liquid (144) dissolves the sealant (140) in pores (138e-138h) disposed directly below the sample droplet (126). The liquid (144) flows through the pores in which the sealant (140) has been dissolved and the sub-visible particles (142) remain on top of the filter membrane (116). The particles (142) are enumerated in an electron microscopy.
摘要翻译：
该方法用于量化次可见颗粒。提供过滤膜（116），其具有限定在其中的多个孔（138）。过滤膜（116）与真空室（104）处于操作接合。孔用密封剂（140）密封。包含液体（144）和亚可见颗粒（142）的样品液滴（126）被施加到过滤膜（116）上。液体（144）将密封剂（140）溶解在设置在样品液滴（126）正下方的孔（138e-138h）中。液体（144）流过其中已经溶解密封剂（140）的孔并且亚可见颗粒（142）保留在过滤膜（116）的顶部上。颗粒（142）在电子显微镜下列举。

5. 发明申请

WO2008150588A1 A METHOD FOR COUNTING AND SEGMENTING VIRAL PARTICLES IN AN IMAGE 审中-公开
标题翻译：一种在图像中计数和分类病毒颗粒的方法
公开(公告)号：WO2008150588A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/061499
申请日：2008-04-25
申请人： INTELLIGENT VIRUS IMAGING INC. , HOMMAN, Mohammed
发明人： HOMMAN, Mohammed
IPC分类号： G06K9/00
CPC分类号： G06K9/0014
摘要： The method is for intracellular counting and segmentation of viral particles in an image. An image is provided that has a plurality of items therein. A radius range of viral particles is determined. Round items in the image having a radius within the predetermined radius range are identified. Elliptical items that are formable from the predetermined radius range are determined. The round and elliptical items identified into groups are sorted. The viral particles among the round and elliptical items are identified. For example, the method may be used for intracellular counting and segmentation of siRNA treated human cytomegaloviral particles in TEM images.
摘要翻译：该方法用于细胞内计数和图像中病毒颗粒的分割。提供其中具有多个物品的图像。确定病毒颗粒的半径范围。识别具有在预定半径范围内的半径的图像中的圆形项目。确定从预定半径范围可形成的椭圆形物品。分为组合的圆形和椭圆形物品。确定圆形和椭圆形物品中的病毒颗粒。例如，该方法可用于TEM图像中siRNA处理的人巨细胞病毒颗粒的细胞内计数和分割。

6. 发明申请

WO2007046985A2 IDENTIFICATION AND CLASSIFICATION OF VIRUS PARTICLES IN TEXTURED ELECTRON MICROGRAPHS 审中-公开
标题翻译：纹理电子显微镜中病毒颗粒的鉴定和分类
公开(公告)号：WO2007046985A2
公开(公告)日：2007-04-26
申请号：PCT/US2006/035758
申请日：2006-09-12
申请人： INTELLIGENT VIRUS IMAGING INC. , HOMMAN, Mohammed , RYNER, Martin
发明人： HOMMAN, Mohammed , RYNER, Martin
IPC分类号： G06F19/00
CPC分类号： G06K9/0014 , G06K9/6255
摘要： The method is for the identification and characterization of structures in electron micrographs. Structures in a first image are selected. The structures have a first shape type deformed in a first direction. The selected structures are transformed to a second shape type different from the first shape type. The transformed structures of the second shape type are used to form a plurality of templates. A new structure in a second image is identified. The new structure has the first shape type. The second shape type structure of each template is deformed in the first direction. It is determined which template is a preferred template that best matches the new structure.
摘要翻译：该方法用于鉴定和表征电子显微照片中的结构。选择第一个图像中的结构。该结构具有沿第一方向变形的第一形状类型。所选择的结构被转换成与第一形状类型不同的第二形状类型。第二形状类型的变换结构被用于形成多个模板。识别出第二图像中的新结构。新结构具有第一种形状类型。每个模板的第二形状类型结构在第一方向上变形。确定哪个模板是最适合新结构的首选模板。

7. 发明申请

WO2006112928A3 METHOD OF ANALYZING CELL STRUCTURES AND THEIR COMPONENTS 审中-公开
公开(公告)号：WO2006112928A3
公开(公告)日：2006-10-26
申请号：PCT/US2006/005571
申请日：2006-02-17
申请人： INTELLIGENT VIRUS IMAGING INC. , HOMMAN, Mohammed , SINTORN, Ida-Maria
发明人： HOMMAN, Mohammed , SINTORN, Ida-Maria
IPC分类号： G06F19/00
摘要： A cell (14) is provided that contains a plurality of virus particles (16). A first image (20) of a first virus particle (22) and a second image (32) of a second virus particle (34) are taken by electron microscopy technology. The first virus particle is characterized as being in a first maturity stage and the second virus particle as being in a second maturity stage. The first image (20) and the second image (32) are transformed to first and second gray scale profiles (24, 46), respectively, based on pixel data. The first and second gray scale profiles (24, 36) are then saved as first and second templates, respectively. A third virus particle in a third image is identified. The third image is transformed into a third gray scale profile. The third gray scale is compared to the first and second template to determine a maturity stage of the third virus particle.

8. 发明申请

WO2018160298A1 METHOD OF QUANTITATIVE MEASUREMENT OF PARTICLE CONTENT USING HYDRATED STATE IMAGING 审中-公开
公开(公告)号：WO2018160298A1
公开(公告)日：2018-09-07
申请号：PCT/US2018/015263
申请日：2018-01-25
申请人： INTELLIGENT VIRUS IMAGING INC.
发明人： COLOMB-DELSUC, Mathieu , HAAG, Lars , NORDSTRÖM, Rickard , RYNER, Martin
IPC分类号： C07K14/005 , C07K14/01 , C07K14/015 , G01N15/02
摘要： The method is for quantitative measurement of particle content using hydrated state imaging such as CryoTEM. A sample (100) of virus-like particles (VLPs) or virus particles is provided. Preferably, the sample (100) is rapidly frozen into a cryogenic liquid at a cryogenic temperature. While at the cryogenic temperature, the particle content of each VLP in the frozen sample is observed in the CryoTEM. An amount of the particle content of the VLPs is determined to assess whether the VLPs are empty or not.

9. 发明申请

WO2007046985B1 IDENTIFICATION AND CLASSIFICATION OF VIRUS PARTICLES IN TEXTURED ELECTRON MICROGRAPHS 审中-公开
标题翻译：纹理电子显微镜中病毒颗粒的鉴定和分类
公开(公告)号：WO2007046985B1
公开(公告)日：2007-12-21
申请号：PCT/US2006035758
申请日：2006-09-12
申请人： INTELLIGENT VIRUS IMAGING INC , HOMMAN MOHAMMED , RYNER MARTIN
发明人： HOMMAN MOHAMMED , RYNER MARTIN
IPC分类号： G06K9/00 , G06K9/42 , G06K9/46
CPC分类号： G06K9/0014 , G06K9/6255
摘要： The method is for the identification and characterization of structures in electron micrographs. Structures in a first image are selected. The structures have a first shape type deformed in a first direction. The selected structures are transformed to a second shape type different from the first shape type. The transformed structures of the second shape type are used to form a plurality of templates. A new structure in a second image is identified. The new structure has the first shape type. The second shape type structure of each template is deformed in the first direction. It is determined which template is a preferred template that best matches the new structure.
摘要翻译：该方法用于电子显微照片中结构的识别和表征。选择第一个图像中的结构。该结构具有沿第一方向变形的第一形状类型。所选择的结构被转换成与第一形状类型不同的第二形状类型。第二形状类型的变换结构被用于形成多个模板。识别出第二图像中的新结构。新结构具有第一种形状类型。每个模板的第二形状类型结构在第一方向上变形。确定哪个模板是最适合新结构的首选模板。

10. 发明申请

WO2007046985A3 IDENTIFICATION AND CLASSIFICATION OF VIRUS PARTICLES IN TEXTURED ELECTRON MICROGRAPHS 审中-公开
标题翻译：纹理电子显微镜中病毒颗粒的鉴定和分类
公开(公告)号：WO2007046985A3
公开(公告)日：2007-11-08
申请号：PCT/US2006035758
申请日：2006-09-12
申请人： INTELLIGENT VIRUS IMAGING INC , HOMMAN MOHAMMED , RYNER MARTIN
发明人： HOMMAN MOHAMMED , RYNER MARTIN
IPC分类号： G06K9/00 , G06K9/42 , G06K9/46
CPC分类号： G06K9/0014 , G06K9/6255
摘要： The method is for the identification and characterization of structures in electron micrographs. Structures in a first image are selected. The structures have a first shape type deformed in a first direction. The selected structures are transformed to a second shape type different from the first shape type. The transformed structures of the second shape type are used to form a plurality of templates. A new structure in a second image is identified. The new structure has the first shape type. The second shape type structure of each template is deformed in the first direction. It is determined which template is a preferred template that best matches the new structure.
摘要翻译：该方法用于鉴定和表征电子显微照片中的结构。选择第一个图像中的结构。该结构具有沿第一方向变形的第一形状类型。所选择的结构被转换成不同于第一形状类型的第二形状类型。第二形状类型的变换结构用于形成多个模板。识别第二个图像中的新结构。新结构具有第一种形状。每个模板的第二形状类型结构在第一方向上变形。确定哪个模板是与新结构最匹配的首选模板。

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