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1. 发明申请

WO2007148038A1 RETINAL PROSTHETIC DEVICES 审中-公开
标题翻译：后置放射性装置
公开(公告)号：WO2007148038A1
公开(公告)日：2007-12-27
申请号：PCT/GB2007/002019
申请日：2007-06-01
申请人： IMPERIAL INNOVATIONS LIMITED , DEGENAAR, Patrick , HANKINS, Mark , DRAKAKIS, Emannuel , TOUMAZOU, Christofer , NIKOLIC, Konstantin , KENNARD, Christopher , HUANG, Yan
发明人： DEGENAAR, Patrick , HANKINS, Mark , DRAKAKIS, Emannuel , TOUMAZOU, Christofer , NIKOLIC, Konstantin , KENNARD, Christopher , HUANG, Yan
IPC分类号： A61F9/00
CPC分类号： A61F9/08
摘要： A retinal prosthetic device comprises image capture means (20) arranged to capture an image, light producing means (30) arranged to define a plurality of light paths along each of which a light beam can be directed towards a respective position on a retina, and control means (24) arranged to process the captured image and control the light producing means so as to produce a stimulating array of light beams along a group of the light paths, the group being dependent upon the captured image.
摘要翻译：视网膜假体装置包括布置成捕获图像的图像捕获装置（20），光产生装置（30），布置成限定沿着每个光路的多个光路，光束可以被引导到视网膜上的相应位置，以及控制装置（24）被布置成处理所捕获的图像并控制发光装置，以便产生沿着一组光路的光束的刺激阵列，该组取决于所捕获的图像。

2. 发明申请

WO2011095767A1 METHOD AND APPARATUS FOR OPTICALLY OUTPUTTING INFORMATION FROM A SEMICONDUCTOR DEVICE 审中-公开
标题翻译：用于从半导体器件的光输出信息的方法和装置
公开(公告)号：WO2011095767A1
公开(公告)日：2011-08-11
申请号：PCT/GB2011/000132
申请日：2011-02-01
申请人： IMPERIAL INNOVATIONS LIMITED , NIKOLIC, Konstantin , CONSTANDINOU, Timothy , TOUMAZOU, Christofer
发明人： NIKOLIC, Konstantin , CONSTANDINOU, Timothy , TOUMAZOU, Christofer
IPC分类号： G02F1/015
CPC分类号： H04B10/501 , G02F1/015 , G02F2001/0156 , G02F2201/17 , G02F2202/105
摘要： A method of optically outputting information ( e.g. digital data) from a semiconductor device, the method comprising: providing a semiconductor device having a semiconducting p-n junction, the p-n junction having a region of reduced free charge carrier density; applying an electrical signal to modulate the extent of the said region, the electrical signal being representative of the information to be outputted; arranging incident light to pass through at least part of the said region, such that the light is at least partially absorbed in dependence upon the modulated extent of the said region, thereby producing intensity-modulated output light; and detecting the intensity of the output light and thereby determining the outputted information. Also provided is an electro-optical assembly, a package module for mounting a semiconductor device on a printed circuit board, and an integrated circuit chip.
摘要翻译：一种从半导体器件光学输出信息（例如数字数据）的方法，所述方法包括：提供具有半导体p-n结的半导体器件，所述p-n结具有减小的自由电荷载流子密度的区域; 施加电信号来调制所述区域的范围，所述电信号表示要输出的信息; 使入射光穿过所述区域的至少一部分，使得光根据所述区域的调制范围至少部分地被吸收，由此产生强度调制的输出光; 并检测输出光的强度，从而确定输出的信息。还提供了一种电光学组件，用于将半导体器件安装在印刷电路板上的封装模块和集成电路芯片。

3. 发明申请

WO2010142734A1 A GLUCAGON PUMP CONTROLLER 审中-公开
标题翻译： GLUCAGON泵控制器
公开(公告)号：WO2010142734A1
公开(公告)日：2010-12-16
申请号：PCT/EP2010/058101
申请日：2010-06-09
申请人： IMPERIAL INNOVATIONS LIMITED , GEORGIOU, Pantelis , LIM, Kok Thay , TOUMAZOU, Christofer
发明人： GEORGIOU, Pantelis , LIM, Kok Thay , TOUMAZOU, Christofer
IPC分类号： A61M5/172
CPC分类号： A61M5/1723 , A61M2005/14208 , G06F19/00 , G06F19/3468
摘要： According to a first aspect of the present invention there is provided a controller for controlling a glucagon pump. The controller comprises an input 8 for receiving an input signal indicative of a measured blood glucose concentration, an output 9 for providing a pulsed glucagon pump drive signal, each pulse being arranged to cause a glucagon pump to deliver a volume of glucagon, and a processing unit 10 for setting the pulse frequency of the pump drive signal in dependence upon the input signal, such that when the input signal indicates that the measured blood glucose concentration is above a threshold concentration the pulse frequency is zero and when the input signal indicates that the measured blood glucose concentration is below the threshold concentration the pulse frequency is increased as the measured blood glucose concentration decreases.
摘要翻译：根据本发明的第一方面，提供了一种用于控制胰高血糖素泵的控制器。控制器包括用于接收指示测量的血糖浓度的输入信号的输入8，用于提供脉冲胰高血糖素泵驱动信号的输出9，每个脉冲被布置成使胰高血糖素泵输送一定量的胰高血糖素，以及处理单元10，用于根据输入信号设置泵驱动信号的脉冲频率，使得当输入信号指示所测量的血糖浓度高于阈值浓度时，脉冲频率为零，并且当输入信号指示测量血糖浓度低于阈值浓度，脉搏频率随着测量血糖浓度的降低而增加。

4. 发明申请

WO2008007065A3 METHOD AND APPARATUS FOR MEASURING ACTIVITY IN THE PERIPHERAL NERVOUS SYSTEM 审中-公开
公开(公告)号：WO2008007065A3
公开(公告)日：2008-01-17
申请号：PCT/GB2007/002552
申请日：2007-07-05
申请人： IMPERIAL INNOVATIONS LIMITED , TRIANTIS, Iasonas , TOUMAZOU, Christofer
发明人： TRIANTIS, Iasonas , TOUMAZOU, Christofer
IPC分类号： A61B5/04
摘要： A method and apparatus for measuring activity in the peripheral nervous system comprises a nerve cuff (40) having an array (62) of chemical detectors such as chemFETS or ISFETS. Activity within the nerve causes chemical responses which can be detected. The use of chemical rather than electrical detection minimises interference problems and allows the cuffs to be made smaller.

5. 发明申请

WO2013024044A2 INSULIN PUMP 审中-公开
标题翻译：胰岛素泵
公开(公告)号：WO2013024044A2
公开(公告)日：2013-02-21
申请号：PCT/EP2012/065725
申请日：2012-08-10
申请人： GENE ONYX LIMITED , TOUMAZOU, Christofer , GEORGIOU, Pantelis , VINAS, Pau Herrero , SIM, Calvin
发明人： TOUMAZOU, Christofer , GEORGIOU, Pantelis , VINAS, Pau Herrero
IPC分类号： G06F19/00
CPC分类号： A61M5/1723 , A61M5/142 , A61M2005/14208 , A61M2005/1726 , A61M2205/52 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： The present invention relates to a controller unit and methods for controlling an insulin pump. The controller unit includes a user input that receives a gain factor. The gain factor has been calculated based on historical data in relation to a patient. The controller unit includes a measurement input for receiving data representative of a measured blood glucose level for the patient. Processing logic of the controller unit is configured to apply the measured blood glucose level to a pancreatic beta-cell insulin secretion computational model to predict an insulin output level, apply the gain factor to the predicted insulin output level to determine a patient insulin deficiency level, and calculate a control signal for controlling the insulin output level of the insulin pump based on the patient insulin deficiency level. Methods are provided for optimising the gain factor based on the historical data in relation to the patient.
摘要翻译：用于控制胰岛素泵的控制器单元和方法技术领域本发明涉及用于控制胰岛素泵的控制器单元和方法。控制器单元包括接收增益因子的用户输入。增益因子是根据与患者相关的历史数据计算出来的。控制器单元包括用于接收代表患者的测量的血糖水平的数据的测量输入。控制器单元的处理逻辑被配置为将测量的血糖水平应用于胰腺β-细胞胰岛素分泌计算模型以预测胰岛素输出水平，将增益因子应用于预测的胰岛素输出水平以确定患者胰岛素缺乏水平，并基于患者胰岛素缺乏水平计算用于控制胰岛素泵的胰岛素输出水平的控制信号。提供了基于与患者有关的历史数据优化增益因子的方法。

6. 发明申请

WO2011110873A1 DETECTION OF METHYLATED DNA 审中-公开
标题翻译：检测甲基化DNA
公开(公告)号：WO2011110873A1
公开(公告)日：2011-09-15
申请号：PCT/GB2011/050501
申请日：2011-03-14
申请人： DNA ELECTRONICS LTD , TOUMAZOU, Christofer , KALOFONOU, Melpomeni
发明人： TOUMAZOU, Christofer , KALOFONOU, Melpomeni
IPC分类号： C12Q1/68 , G01N27/414
CPC分类号： G01N27/4145 , C12Q1/6825 , C12Q1/6827 , C12Q1/6858 , C12Q1/6869 , C12Q2523/125 , C12Q2527/119 , C12Q2565/607
摘要： The use of ion sensitive field effect transistor (ISFET) to detect methylated nucleotides in a DNA sample is described. A method of detecting methylated nucleotides in a DNA sample may include the steps of treating a sample of DNA with a reagent which discriminates between methylated and non-methylated nucleotides to provide treated DNA, amplifying the treated DNA and optionally sequencing the amplified DNA. An ISFET is used to monitor the addition of one or more dNTPs in the strand extension reactions during the amplification and/or sequencing step. Suitable apparatus is also provided.
摘要翻译：描述了使用离子敏感场效应晶体管（ISFET）来检测DNA样品中的甲基化核苷酸。检测DNA样品中的甲基化核苷酸的方法可以包括用鉴别甲基化和非甲基化核苷酸之间的试剂处理DNA样品以提供处理的DNA，扩增经处理的DNA和任选地对扩增的DNA进行测序的步骤。 ISFET用于监测在扩增和/或测序步骤期间在链延伸反应中添加一种或多种dNTP。还提供了合适的装置。

7. 发明申请

WO2003017180A1 HYBRID DIGITAL/ANALOG PROCESSING CIRCUIT 审中-公开
标题翻译：混合数字/模拟处理电路
公开(公告)号：WO2003017180A1
公开(公告)日：2003-02-27
申请号：PCT/GB2002/003796
申请日：2002-08-16
申请人： TOUMAZ TECHNOLOGY LIMITED , BURDETT, Alison , TOUMAZOU, Christofer
发明人： BURDETT, Alison , TOUMAZOU, Christofer
IPC分类号： G06J1/00
CPC分类号： G06J1/00
摘要： A circuit comprising a digital processor, analogue processing means, a digital to analogue converter for converting digital values output from the digital processor into analogue values which are processed by the analogue processing means, and an analogue to digital converter for converting resulting analogue values into digital values for input to the digital processor, wherein the analogue processing means comprises one or more analogue processors, and the circuit is dynamically reconfigurable under the control of the digital processor, such that analogue values are processed according to a first function by the analogue processing means, and following reconfiguration, analogue values are processed according to a second function by the analogue processing means.
摘要翻译：一种包括数字处理器，模拟处理装置，用于将从数字处理器输出的数字值转换成由模拟处理装置处理的模拟值的数模转换器的电路，以及用于将所得到的模拟值转换为数字用于输入到数字处理器的值，其中所述模拟处理装置包括一个或多个模拟处理器，并且所述电路在数字处理器的控制下动态地可重新配置，使得模拟值根据模拟处理装置根据第一功能被处理，并且在重新配置之后，通过模拟处理装置根据第二功能处理模拟值。

8. 发明申请

WO2012098409A1 CHEMICAL SENSOR 审中-公开
标题翻译：化学传感器
公开(公告)号：WO2012098409A1
公开(公告)日：2012-07-26
申请号：PCT/GB2012/050125
申请日：2012-01-20
申请人： DNA ELECTRONICS LTD , PRODROMAKIS, Themistoklis , TOUMAZOU, Christofer
发明人： PRODROMAKIS, Themistoklis , TOUMAZOU, Christofer
IPC分类号： G01N27/414
CPC分类号： G01N27/4148
摘要： A chemical sensor having a substrate, an electrode formed on or within the substrate, a chemical sensing area formed on the electrode, and coupling means on the substrate to couple the electrode to an active device arranged to receive a signal from the electrode. The active device comprises a transducer arranged to receive the signal from the electrode and provide an output signal. The signal corresponds to the concentration of ions in a sample in contact with the sensor. The sensor may be used to detect neural transmitters in a neural tissue.
摘要翻译：具有衬底，形成在衬底上或衬底内的电极的化学传感器，形成在电极上的化学感测区域以及衬底上的耦合装置，以将电极耦合到被布置成从电极接收信号的有源器件。有源器件包括被布置成从电极接收信号并提供输出信号的换能器。该信号对应于与传感器接触的样品中的离子浓度。传感器可用于检测神经组织中的神经传递器。

9. 发明申请

WO2012017424A1 CHEMICAL SENSOR 审中-公开
标题翻译：化学传感器
公开(公告)号：WO2012017424A1
公开(公告)日：2012-02-09
申请号：PCT/IB2011/053900
申请日：2011-09-06
申请人： DNA ELECTRONICS LTD , PRODROKAKIS, Themistoklis , TOUMAZOU, Christofer
发明人： PRODROKAKIS, Themistoklis , TOUMAZOU, Christofer
IPC分类号： G01N27/12 , G01N27/327 , G01N33/543
CPC分类号： G01N27/60 , G01N27/127 , G01N27/3278 , G01N33/5438
摘要： A sensor comprising a memory device having a first electrode and a first chemical- sensing layer coupled to the first electrode. The chemical-sensing layer, in the presence of an analyte, is arranged to change a property of the Memristive device. The sensor can detect an analyte by providing a sample to be detected proximate the chemical sensing layer, observing the state of the memory element; and determining a property of the sample by comparing the observed state of the memory element with a previous state. The sensor is manufactured by depositing a second electrode on a surface, depositing an active layer or layers onto said second electrode, depositing a first electrode onto said active layer(s), and coupling a chemically sensitive layer to the first electrode.
摘要翻译：一种传感器，包括具有第一电极和耦合到第一电极的第一化学感测层的存储器件。在分析物存在下的化学感测层被布置成改变记忆装置的性质。传感器可以通过在化学感测层附近提供要检测的样本来检测分析物，观察存储元件的状态; 以及通过将所述存储元件的观察状态与先前状态进行比较来确定所述样本的属性。通过在表面上沉积第二电极来制造传感器，将活性层沉积到所述第二电极上，在第一电极上沉积第一电极，以及将化学敏感层耦合到第一电极。

10. 发明申请

WO2004042931A2 CONFIGURABLE FUNCTION IMPLEMENTING SYSTEM AND DIGITAL TO ANALOGUE CONVERTERS 审中-公开
标题翻译：可配置功能实现系统和数字到模拟转换器
公开(公告)号：WO2004042931A2
公开(公告)日：2004-05-21
申请号：PCT/GB2003/004828
申请日：2003-11-06
申请人： TOUMAZ TECHNOLOGY LIMITED , SIM, Calvin , TOUMAZOU, Christofer
发明人： SIM, Calvin , TOUMAZOU, Christofer
IPC分类号： H03M1/00
CPC分类号： H03M1/66
摘要： Apparatus for converting an M-bit digital signal into an analogue signal. The apparatus comprising means (12,13) for mapping the M-bit digital signal to first and second digital values, so that the ratio of the first to the second digital value is equal to or approximates the value of the M-bit digital signal. First and second digital to analogue converters (14,15) are provided, the first digital to analogue converter (14) having an input for receiving said first digital value and the second digital to analogue converter (15) having an input for receiving said second digital value. Circuit means (16) is coupled to the analogue outputs of the digital to analogue converters (14,15) for dividing one of the analogue outputs by the other, and for providing the result to an output.
摘要翻译：用于将M位数字信号转换成模拟信号的设备。该装置包括用于将M位数字信号映射成第一和第二数字值的装置（12,13），以便第一和第二数字值的比率等于或接近M位数字信号的值。提供第一和第二数模转换器（14,15），第一数模转换器（14）具有用于接收所述第一数字值的输入端和第二数模转换器（15），所述第二数模转换器具有用于接收所述第二数字值。电路装置（16）耦合到数模转换器（14,15）的模拟输出端，用于将另一个模拟输出端分开，并将结果提供给输出端。

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