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1. 发明申请

WO2015183871A1 SYSTEMS AND METHODS FOR BIOCHEMICAL ANALYSIS INCLUDING A BASE INSTRUMENT AND A REMOVABLE CARTRIDGE 审中-公开
标题翻译：用于生物化学分析的系统和方法，包括基础仪器和可移除的盒子
公开(公告)号：WO2015183871A1
公开(公告)日：2015-12-03
申请号：PCT/US2015/032545
申请日：2015-05-27
申请人： ILLUMINA, INC.
发明人： ARAVANIS, Alex , BOYANOV, Boyan , BOWEN, M. Shane , BUERMANN, Dale , HSIAO, Alexander , JAVANMARDI, Behnam , KHURANA, Tarun , SABOUNCHI, Poorya , TRAN, Hai Quang
IPC分类号： B01L3/00 , B01L7/00
CPC分类号： B01L3/502715 , B01L3/502738 , B01L7/525 , B01L2200/025 , B01L2200/027 , B01L2200/04 , B01L2200/0689 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2300/1827 , B01L2400/0633 , B01L2400/0638 , B01L2400/0644 , B01L2400/065 , B01L2400/0655 , F16K99/0013 , F16K99/0015 , F16K99/0028 , F16K2099/0074 , F16K2099/0084
摘要： Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.
摘要翻译：使用基本仪器和可移除墨盒进行指定反应的系统和方法。可拆卸的盒包括流体网络，其接收并流体地引导生物样品以进行指定的反应。可拆卸的盒还包括流量控制阀，其可操作地耦合到流体网络并且可相对于流体网络移动以控制生物样品通过其中的流动。可移除盒被配置为可分离地接合基本仪器。基础仪器包括与可移除盒的流量控制阀接合的阀致动器。由可移除盒或基本仪器中的至少一个保持的检测组件可用于检测指定的反应。

2. 发明申请

WO2019133182A1 DETECTOR WITH REDUCED FLUORESCENCE RANGE NOISE 审中-公开
公开(公告)号：WO2019133182A1
公开(公告)日：2019-07-04
申请号：PCT/US2018/063395
申请日：2018-11-30
申请人： ILLUMINA, INC.
发明人： FUNG, Tracy H. , SABOUNCHI, Poorya , HIRSCHBEIN, Bernard , PINTO, Joseph , KHURANA, Tarun , SMITH, Randall , FENG, Wenyi
IPC分类号： G01N21/64
摘要： There is set forth herein a device comprising structure defining a detector surface configured for supporting biological or chemical substances, and a sensor array comprising light sensors and circuitry to transmit data signals using photons detected by the light sensors. The device can include one or more features for reducing fluorescence range noise in a detection band of the sensor array.

3. 发明申请

WO2015138648A1 DISPOSABLE, INTEGRATED MICROFLUIDIC CARTRIDGE AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：一体化的微流控盒及其制造和使用方法
公开(公告)号：WO2015138648A1
公开(公告)日：2015-09-17
申请号：PCT/US2015/020029
申请日：2015-03-11
申请人： ILLUMINA, INC.
发明人： SABOUNCHI, Poorya , JAVANMARDI, Behnam , KHURANA, Tarun , AGHABABAZADEH, Majid , PAIK, Philip , LIN, Yan-You
IPC分类号： B01L7/00 , B01L3/00
CPC分类号： C12Q1/6869 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/502738 , B01L7/52 , B01L2200/10 , B01L2200/12 , B01L2300/0636 , B01L2300/0654 , B01L2300/0809 , B01L2300/0867 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2300/165 , B01L2300/1827 , B01L2400/0487 , B01L2400/0644 , B01L2400/0655 , C12Q1/6806 , C12Q2531/113 , C12Q2563/159 , C12Q2565/629
摘要： The disclosed embodiments concern microfluidic cartridges for detecting biological reactions. In some embodiments, the microfluidic cartridges are configured to perform sequencing operations on a nucleic acid sample. In one aspect, a microfluidic cartridge includes a stack of fluidics layers defining channels and valves for processing the nucleic acid sample to be sequenced, and a solid state CMOS biosensor integrated in the stack. The biosensor has an active area configured to detect signals of biological reactions, wherein substantially all of the active area is available for reagent delivery and illumination during operation. In another aspect, a microfluidic cartridge includes: (a) a flow cell including a reaction site area encompassing one or more reaction sites; (b) fluidics channels for delivering reactants to and/or removing reactants from the reaction site area; (c) a biosensor having an active area configured to detect signals of biological reactions in the reaction site area. The reaction site area is proximal to the active area of the biosensor and the reaction site area spans substantially all of the active area of the biosensor. In some embodiments, the fluidics channels do not substantially overlap with the active area of the biosensor. Methods for manufacturing and operating the microfluidic cartridges are also disclosed.
摘要翻译：所公开的实施例涉及用于检测生物反应的微流体盒。在一些实施方案中，微流控盒被配置为对核酸样品进行测序操作。在一个方面，微流控筒包括限定用于处理要测序的核酸样品的通道和阀的流体层叠层，以及集成在堆中的固态CMOS生物传感器。生物传感器具有被配置为检测生物反应的信号的有源区域，其中在操作期间基本上所有的有效区域可用于试剂递送和照明。在另一方面，微流控盒包括：（a）流动池，包括包含一个或多个反应位点的反应位点区域; （b）用于将反应物输送到和/或从反应部位区域除去反应物的流体通道; （c）生物传感器，其具有被配置为检测反应部位区域中的生物反应信号的有源区域。反应位置区域靠近生物传感器的有效区域，反应部位区域基本上跨越生物传感器的所有活性区域。在一些实施例中，流体通道基本上与生物传感器的有效区域重叠。还公开了用于制造和操作微流控盒的方法。

4. 发明申请

WO2015031849A1 MANIPULATION OF DROPLETS ON HYDROPHILIC OR VARIEGATED-HYDROPHILIC SURFACES 审中-公开
标题翻译：对疏水性或变性羟基表面进行脱水处理
公开(公告)号：WO2015031849A1
公开(公告)日：2015-03-05
申请号：PCT/US2014/053571
申请日：2014-08-29
申请人： ILLUMINA, INC. , ADVANCED LIQUID LOGIC FRANCE SAS
发明人： JAMSHIDI, Arash , LIN, Yan-You , ARAVANIS, Alex , DELATTRE, Cyril , RIVAL, Arnaud , FOLEY, Jennifer , SABOUNCHI, Poorya , KHURANA, Tarun , BABAZADEH, Majid , AMINI, Hamed , VENKATESAN, Bala, Murali , BOWEN, M., Shane , BARNARD, Steven, M. , ROGERT BACIGALUPO, Maria, Candelaria , DEHLINGER, Dietrich
IPC分类号： B41J2/04
CPC分类号： B01L3/50273 , B01F13/0071 , B01F13/0076 , B01F13/0084 , B01L3/502792 , B01L2200/06 , B01L2300/0636 , B01L2300/0819 , B01L2300/0858 , B01L2300/087 , B01L2300/161 , B01L2300/166 , B01L2400/0427 , B41J2/04 , G01N15/1463 , G01N15/1475 , G01N2015/1006
摘要： Provided herein is a droplet actuator including (a) first and second substrates separated by a droplet- operations gap, the first and second substrates including respective hydrophobic surfaces that face the droplet-operations gap; (b) a plurality of electrodes coupled to at least one of the first substrate and the second substrate, the electrodes arranged along the droplet-operations gap to control movement of a droplet along the hydrophobic surfaces within the droplet-operations gap; and (c) a hydrophilic or variegated-hydrophilic surface exposed to the droplet-operations gap, the hydrophilic or variegated- hydrophilic surface being positioned to contact the droplet when the droplet is at a select position within the droplet-operations gap.
摘要翻译：本文提供的液滴致动器包括（a）由液滴操作间隙分开的第一和第二基板，第一和第二基板包括面对液滴操作间隙的各个疏水表面; （b）耦合到第一衬底和第二衬底中的至少一个的多个电极，电极沿着液滴操作间隙排列，以控制液滴沿着液滴操作间隙内的疏水表面的运动; 和（c）暴露于液滴操作间隙的亲水或杂化亲水表面，当液滴位于液滴操作间隙内的选择位置时，亲水或杂色亲水表面定位成接触液滴。

5. 发明申请

WO2012058096A1 MICRODEVICES AND BIOSENSOR CARTRIDGES FOR BIOLOGICAL OR CHEMICAL ANALYSIS AND SYSTEMS AND METHODS FOR THE SAME 审中-公开
标题翻译：用于生物或化学分析和系统的MICRODEVICES和生物传感器盒及其相关方法
公开(公告)号：WO2012058096A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/057111
申请日：2011-10-20
申请人： ILLUMINA, INC. , ELTOUKHY, Helmy, A. , KHURANA, Tarun , JAVANMARDI, Behnam , SABOUNCHI, Poorya , AGHABABAZADEH, Majid
发明人： ELTOUKHY, Helmy, A. , KHURANA, Tarun , JAVANMARDI, Behnam , SABOUNCHI, Poorya , AGHABABAZADEH, Majid
IPC分类号： B01L3/00 , B01L9/00 , G01N21/05 , G01N35/00 , C12Q1/68 , G01N21/64
CPC分类号： C12Q1/6874 , B01L3/502715 , B01L3/502746 , B01L3/5085 , B01L7/52 , B01L9/527 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0877 , G01N21/05 , G01N21/11 , G01N21/6428 , G01N21/6452 , G01N35/1097 , G01N2021/0346 , G01N2021/058
摘要： A flow cell including inlet (504) and outlet ports (506) in fluid communication with each other through a flow channel (502) that extends therebetween. The flow channel includes a diffuser region (511) and a field region (512) that is located downstream from the diffuser region. The field region of the flow channel directs fluid along reaction sites where desired reactions occur. The fluid flows through the diffuser region in a first flow direction and through the field region in a second flow direction. The first and second flow directions being substantially perpendicular.
摘要翻译：流动池包括通过其间延伸的流动通道（502）彼此流体连通的入口（504）和出口（506）。流动通道包括位于扩散器区域下游的扩散器区域（511）和场区域（512）。流动通道的场区域沿着发生所需反应的反应位置引导流体。流体在第一流动方向上流过扩散器区域，并在第二流动方向上流过场区域。第一和第二流动方向基本垂直。

6. 发明申请

WO2020055732A1 FLOW CELLS AND METHODS RELATED TO SAME 审中-公开
公开(公告)号：WO2020055732A1
公开(公告)日：2020-03-19
申请号：PCT/US2019/050178
申请日：2019-09-09
申请人： ILLUMINA, INC.
发明人： RIVAL, Arnaud , AGAH, Ali , FUNG, Tracy H. , DEHLINGER, Dietrich , SABOUNCHI, Poorya , KHURANA, Tarun , CIESLA, Craig M. , BOWEN, M. Shane
IPC分类号： G01N21/03 , G01N15/14 , G01N33/49 , B01L3/00
摘要： Flow cells and corresponding methods are provided. The flow cells may include a support frame with top and back sides, and at least one cavity extending from the top side. The flow cells may include at least one light detection device with an active area disposed within the at least one cavity. The flow cells may include a support material disposed within the at least one cavity between the support frame and the periphery of the at least one light detection device coupling them together. The flow cells may include a lid extending over the at least one light detection device and coupled to the support frame about the periphery of the at least one light detection device. The lid and at least a top surface of the at least one light detection device form a flow channel therebetween.

7. 发明申请

WO2017201198A1 SELF ASSEMBLED PATTERNING USING PATTERNED HYDROPHOBIC SURFACES 审中-公开
标题翻译：自组装图案化疏水表面图案
公开(公告)号：WO2017201198A1
公开(公告)日：2017-11-23
申请号：PCT/US2017/033169
申请日：2017-05-17
申请人： ILLUMINA, INC.
发明人： WU, Yir-shyuan , LIN, Yan-you , BOWEN, M., Shane , DELATTRE, Cyril , ABEILLE, Fabien , KHURANA, Tarun , RIVAL, Arnaud , SABOUNCHI, Poorya , YUAN, Dajun , ROGERT BACIGALUPO, Maria, Candelaria
IPC分类号： G03F7/40 , B82Y30/00 , C12Q1/68 , G01N33/52
摘要： Embodiments provided herewith are directed to self-assembled methods of preparing a patterned surface for sequencing applications including, for example, a patterned flow cell or a patterned surface for digital fluidic devices. The methods utilize photolithography to create a patterned surface with a plurality of microscale or nanoscale contours, separated by hydrophobic interstitial regions, without the need of oxygen plasma treatment during the photolithography process. In addition, the methods avoid the use of any chemical or mechanical polishing steps after the deposition of a gel material to the contours.
摘要翻译：本文提供的实施方案涉及制备用于测序应用的图案化表面的自组装方法，所述测序应用包括例如用于数字流体装置的图案化流动池或图案化表面。这些方法利用光刻技术来产生具有多个由疏水间隙区域分开的微尺度或纳米尺度轮廓的图案化表面，而无需在光刻工艺期间进行氧等离子体处理。此外，该方法避免了在将凝胶材料沉积到轮廓之后使用任何化学或机械抛光步骤。

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