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1. 发明申请

WO2015183871A1 SYSTEMS AND METHODS FOR BIOCHEMICAL ANALYSIS INCLUDING A BASE INSTRUMENT AND A REMOVABLE CARTRIDGE 审中-公开
标题翻译：用于生物化学分析的系统和方法，包括基础仪器和可移除的盒子
公开(公告)号：WO2015183871A1
公开(公告)日：2015-12-03
申请号：PCT/US2015/032545
申请日：2015-05-27
申请人： ILLUMINA, INC.
发明人： ARAVANIS, Alex , BOYANOV, Boyan , BOWEN, M. Shane , BUERMANN, Dale , HSIAO, Alexander , JAVANMARDI, Behnam , KHURANA, Tarun , SABOUNCHI, Poorya , TRAN, Hai Quang
IPC分类号： B01L3/00 , B01L7/00
CPC分类号： B01L3/502715 , B01L3/502738 , B01L7/525 , B01L2200/025 , B01L2200/027 , B01L2200/04 , B01L2200/0689 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2300/1827 , B01L2400/0633 , B01L2400/0638 , B01L2400/0644 , B01L2400/065 , B01L2400/0655 , F16K99/0013 , F16K99/0015 , F16K99/0028 , F16K2099/0074 , F16K2099/0084
摘要： Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.
摘要翻译：使用基本仪器和可移除墨盒进行指定反应的系统和方法。可拆卸的盒包括流体网络，其接收并流体地引导生物样品以进行指定的反应。可拆卸的盒还包括流量控制阀，其可操作地耦合到流体网络并且可相对于流体网络移动以控制生物样品通过其中的流动。可移除盒被配置为可分离地接合基本仪器。基础仪器包括与可移除盒的流量控制阀接合的阀致动器。由可移除盒或基本仪器中的至少一个保持的检测组件可用于检测指定的反应。

2. 发明申请

WO2011093939A1 FOCUSING METHODS AND OPTICAL SYSTEMS AND ASSEMBLIES USING THE SAME 审中-公开
标题翻译：聚焦方法和光学系统和使用它的组件
公开(公告)号：WO2011093939A1
公开(公告)日：2011-08-04
申请号：PCT/US2010/056844
申请日：2010-11-16
申请人： ILLUMINA, INC. , BUERMANN, Dale , KINDWALL, Alexander, P.
发明人： BUERMANN, Dale , KINDWALL, Alexander, P.
IPC分类号： G02B21/24
CPC分类号： G02B21/247 , G02B21/245
摘要： A method for controlling a focus of an optical system. The method includes providing a pair of incident light beams to a conjugate lens. The incident light beams are directed by the lens to converge toward a focal region. The method also includes reflecting the incident light beams with an object positioned proximate to the focal region. The reflected light beams return to and propagate through the lens. The method also includes determining relative separation measured between the reflected light beams and determining a degree-of- focus of the optical system with respect to the sample based upon the relative separation.
摘要翻译：一种用于控制光学系统的焦点的方法。该方法包括将一对入射光束提供给共轭透镜。入射光束被透镜引导以朝向焦点区域会聚。该方法还包括用邻近聚焦区域定位的物体反射入射光束。反射光束返回并传播通过透镜。该方法还包括确定在反射光束之间测量的相对间隔，并基于相对间隔确定光学系统相对于样品的聚焦度。

3. 发明申请

WO2012096703A1 SYSTEMS, METHODS, AND APPARATUSES TO IMAGE A SAMPLE FOR BIOLOGICAL OR CHEMICAL ANALYSIS 审中-公开
标题翻译：用于生物或化学分析的图像的系统，方法和装置
公开(公告)号：WO2012096703A1
公开(公告)日：2012-07-19
申请号：PCT/US2011/057221
申请日：2011-10-21
申请人： ILLUMINA, INC. , REED, Mark, T. , WILLIAMSON, Erik , CRANE, Bryan , LEUNG, Patrick , BUERMANN, Dale , KINDWALL, Alexander, P. , ERIE, Frederick , PRATT, Mark , HARRIS, Jason , CARSON, Andrew, James , HONG, Stanley, S. , BRYANT, Jason , WANG, Mark , VERKADE, Drew
发明人： REED, Mark, T. , WILLIAMSON, Erik , CRANE, Bryan , LEUNG, Patrick , BUERMANN, Dale , KINDWALL, Alexander, P. , ERIE, Frederick , PRATT, Mark , HARRIS, Jason , CARSON, Andrew, James , HONG, Stanley, S. , BRYANT, Jason , WANG, Mark , VERKADE, Drew
IPC分类号： B01L3/00 , B01L9/00
CPC分类号： B01L3/502715 , B01L7/52 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/04 , B01L2200/0689 , B01L2300/022 , B01L2300/041 , B01L2300/043 , B01L2300/0816 , B01L2300/0877 , G01N21/05 , G01N2021/058 , Y10T436/25
摘要： A fluidic device (300) for analyzing samples. The fluidic device (300) includes a flow cell (200) having inlet (224) and outlet (222) ports and a flow channel extending there between. The flow cell (200) is configured to hold a sample-of-interest. The fluidic device (300) also includes a housing (302) having a reception space (308) that is configured to receive the flow cell (200). The reception space (308) is sized and shaped to permit the flow cell (200) to float relative to the housing (302). The fluidic device (300) also includes a gasket (342) that is coupled to the housing (302). The gasket (342) has inlet (346) and outlet (344) passages and comprises a compressible material. The gasket (342) is positioned relative to the reception space (308) so that the inlet (224) and outlet (222) ports of the flow cell (200) are approximately aligned with the inlet (346) and outlet (344) passages of the gasket (342), respectively.
摘要翻译：一种用于分析样品的流体装置（300）。流体装置（300）包括具有入口（224）和出口（222）端口的流动池（200）和在其间延伸的流动通道。流动池（200）被配置为保持感兴趣的样本。流体装置（300）还包括具有接收空间（308）的壳体（302），该接收空间被构造成接收流动池（200）。接收空间（308）的尺寸和形状被设计成允许流动池（200）相对于壳体（302）浮动。流体装置（300）还包括联接到壳体（302）的垫圈（342）。垫圈（342）具有入口（346）和出口（344）通道并且包括可压缩材料。衬垫（342）相对于接收空间（308）定位，使得流动池（200）的入口（224）和出口（222）端口与入口（346）和出口（344）通道大致对准的垫片（342）。

4. 发明申请

WO2011112465A1 SYSTEMS, METHODS, AND APPARATUSES FOR DETECTING OPTICAL SIGNALS FROM A SAMPLE 审中-公开
标题翻译：用于从样品中检测光信号的系统，方法和装置
公开(公告)号：WO2011112465A1
公开(公告)日：2011-09-15
申请号：PCT/US2011/027271
申请日：2011-03-04
申请人： ILLUMINA, INC. , TRIENER, Alexander , ALLEGOREN, Erik , WENYI, Feng , BUERMANN, Dale , OLSON, Erik , OSMUS, James
发明人： TRIENER, Alexander , ALLEGOREN, Erik , WENYI, Feng , BUERMANN, Dale , OLSON, Erik , OSMUS, James
IPC分类号： G01N21/64
CPC分类号： C12Q1/6874 , C12Q1/6837 , G01N21/6428 , G01N21/645 , G01N21/6456
摘要： An optical system (203) configured to detect optical signals during imaging sessions. The optical system (203) includes an objective lens (220) that has a collecting end that is positioned proximate to a sample (212) and configured to receive optical signals therefrom. The optical system also includes a removable path compensator (221) that is configured to be located at an imaging position between the collecting end of the objective lens (220) and the sample (212). The path compensator (221) adjusts an optical path of the light emissions when in the imaging position. Also, the optical system includes a transfer device that is configured to move the path compensator. The transfer device locates the path compensator at the imaging position for a first imaging session and removes the path compensator from the imaging position for a second imaging session.
摘要翻译：一种配置成在成像会话期间检测光信号的光学系统（203）。光学系统（203）包括物镜（220），该物镜具有位于样品（212）附近并被配置为从其接收光信号的收集端。光学系统还包括被配置为位于物镜（220）的收集端与样本（212）之间的成像位置处的可移除路径补偿器（221）。路径补偿器（221）在成像位置调整发光的光路。此外，光学系统包括被配置为移动路径补偿器的传送装置。传送装置将路径补偿器定位在用于第一成像会话的成像位置处，并从第二成像会话的成像位置移除路径补偿器。

5. 发明申请

WO2009137435A1 COMPENSATOR FOR MULTIPLE SURFACE IMAGING 审中-公开
标题翻译：用于多个表面成像的补偿器
公开(公告)号：WO2009137435A1
公开(公告)日：2009-11-12
申请号：PCT/US2009/042778
申请日：2009-05-05
申请人： ILLUMINA, INC. , FENG, Wenyi , BRYANT, Jason , BUERMANN, Dale
发明人： FENG, Wenyi , BRYANT, Jason , BUERMANN, Dale
IPC分类号： G01N21/05 , G01N21/64 , G02B21/00
CPC分类号： C12Q1/6874 , C12Q1/6825 , C12Q1/6869 , G01N21/05 , G01N21/6458 , G01N2021/0346 , G01N2021/6419 , G01N2021/6421 , G02B21/0024 , G02B2207/113
摘要： A system and method for imaging biological samples on multiple surfaces of a support structure are disclosed. The support structure may, for instance, be a flow cell through which a reagent fluid is allowed to flow and interact with the biological samples. Excitation radiation from at least one radiation source may be used to excite the biological samples on multiple surfaces. In this manner, fluorescent emission radiation may be generated from the biological samples and subsequently captured and detected by detection optics and at least one detector. The captured and detected fluorescent emission radiation may then be used to generate image data. This imaging of multiple surfaces may be accomplished either sequentially or simultaneously. In addition, the techniques of the present invention may be used with any type of imaging system. For instance, both epifluorescent and total internal reflection (TIR) methods may benefit from the techniques of the present invention. In addition, the biological samples imaged may be present on the surfaces of the support structure in a random special pattern and need not be at known locations in order for the imaging to be performed.
摘要翻译：公开了用于在支撑结构的多个表面上成像生物样品的系统和方法。支撑结构例如可以是允许试剂流体流过并与生物样品相互作用的流动池。可以使用来自至少一个辐射源的激发辐射来激发多个表面上的生物样品。以这种方式，可以从生物样品产生荧光发射辐射，随后由检测光学器件和至少一个检测器捕获和检测。捕获和检测到的荧光发射辐射然后可用于产生图像数据。多个表面的这种成像可以顺序地或同时地完成。此外，本发明的技术可以与任何类型的成像系统一起使用。例如，荧光和全内反射（TIR）方法都可以受益于本发明的技术。此外，成像的生物样品可以以随机特殊图案存在于支撑结构的表面上，并且不需要在已知位置处以便进行成像。

6. 发明申请

WO2015187868A2 SYSTEMS AND METHODS INCLUDING A ROTARY VALVE FOR AT LEAST ONE OF SMAPLE PREPARATION OR SAMPLE ANALYSIS 审中-公开
标题翻译：包括旋转阀的系统和方法，用于至少一个简单的准备或样品分析
公开(公告)号：WO2015187868A2
公开(公告)日：2015-12-10
申请号：PCT/US2015/034053
申请日：2015-06-03
申请人： ILLUMINA, INC.
发明人： BOHM, Sebastian , ARAVANIS, Alex , HSIAO, Alexander , JAVANMARDI, Behnam , KHURANA, Tarun , TRAN, Hai, Quang , AGHABABAZADEH, Majid , BOWEN, M., Shane , BOYANOV, Boyan , BUERMANN, Dale
IPC分类号： B01L3/00
CPC分类号： B01L3/502738 , B01L3/502715 , B01L3/50273 , B01L7/52 , B01L2200/10 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487 , B01L2400/0644 , B01L2400/0655 , C12Q1/6869 , F16K99/0013 , F16K99/0015 , F16K99/0028 , F16K2099/0084
摘要： Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.
摘要翻译：用于进行指定反应的系统和方法，其包括具有样品通道的流体网络，反应室和储存器。样品通道与样品端口流通。该系统还包括具有流动通道并被配置为在第一和第二阀位置之间旋转的旋转阀。当旋转阀处于第一阀位置时，流动通道流体耦合反应室和样品通道，并且当旋转阀处于第二阀位置时，流体流动地联接储存器和反应室。当旋转阀处于第一阀位置时，泵组件将生物样品流向反应室，当旋转阀处于第二阀位置时，泵组件将反应组分从储存器流向反应室。

7. 发明申请

WO2014143010A1 SYSTEM AND METHOD FOR GENERATING OR ANALYZING A BIOLOGICAL SAMPLE 审中-公开
标题翻译：用于生成或分析生物样品的系统和方法
公开(公告)号：WO2014143010A1
公开(公告)日：2014-09-18
申请号：PCT/US2013/032309
申请日：2013-03-15
申请人： ILLUMINA, INC.
发明人： BUERMANN, Dale , BOHM, Sebastian
IPC分类号： B01L3/00 , G01N35/10
CPC分类号： C12Q1/6869 , B01L3/502715 , B01L3/502738 , B01L2300/0803 , B01L2300/0864 , B01L2300/0877 , B01L2400/0487 , B01L2400/0644 , B01L2400/065 , G01N35/1097
摘要： A system including a reaction valve having a mating side and a valve inlet. The reaction valve includes a sample chamber, and the valve inlet is in fluid communication with the sample chamber. The system also has a manifold having an engagement surface. The manifold may include first and second manifold ports at the engagement surface. The engagement surface and the mating side of the reaction valve may be positioned adjacent to each other along an interface. The system may also include a positioning assembly that is operatively coupled to at least one of the reaction valve or the manifold. The positioning assembly is configured to move at least one of the reaction valve or the manifold along the interface to fluidly disconnect the valve inlet from the first manifold port and to fluidly connect the valve inlet to the second manifold port.
摘要翻译：一种包括具有配合侧和阀入口的反应阀的系统。反应阀包括样品室，并且阀入口与样品室流体连通。该系统还具有具有接合表面的歧管。歧管可以包括在接合表面处的第一和第二歧管端口。反应阀的接合表面和配合侧可以沿着界面彼此相邻地定位。该系统还可以包括可操作地联接到反应阀或歧管中的至少一个的定位组件。定位组件构造成沿着界面移动反应阀或歧管中的至少一个，以将阀入口与第一歧管端口流体地分离，并将阀入口流体连接到第二歧管端口。

8. 发明申请

WO2013151622A1 INTEGRATED OPTOELECTRONIC READ HEAD AND FLUIDIC CARTRIDGE USEFUL FOR NUCLEIC ACID SEQUENCING 审中-公开
标题翻译：用于核酸序列的集成光电读头和流体盒
公开(公告)号：WO2013151622A1
公开(公告)日：2013-10-10
申请号：PCT/US2013/025963
申请日：2013-02-13
申请人： ILLUMINA, INC.
发明人： BUERMANN, Dale , MOON, John A. , CRANE, Bryan , WANG, Mark , HONG, Stanley S. , HARRIS, Jason , HAGE, Matthew , NIBBE, Mark J.
IPC分类号： G01N21/64 , G01N21/03 , G01N21/05
CPC分类号： B01L3/527 , B01L3/502715 , B01L2200/16 , B01L2300/0877 , B01L2400/0487 , B01L2400/06 , C12Q1/6869 , C12Q1/6874 , G01N21/6428 , G01N21/6486 , G01N2021/0307 , G01N2021/0325 , G01N2021/058 , G01N2021/6417 , G01N2021/6441 , G01N2021/6482
摘要： A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.
摘要翻译：一种检测装置，具有包括多个微量荧光计的读取头，所述多个微量荧光计定位成在公共平面中同时获取多个所述宽视场图像; 和（b）平移台，其配置成沿着位于公共平面中的基板移动读取头。基底可以是包含在药筒中的流动池，药筒还包括用于（i）样品储存器的壳体; （ii）样品储存器和流动池之间的流体管线; （iii）与所述流动池流体连通的若干试剂储存器，（iv）至少一个构造成介导所述储存器与所述流动池之间的流体连通的阀; 和（v）至少一个压力源，其构造成将液体从储存器移动到流动池。检测装置和盒可以一起使用或彼此独立使用。

9. 发明申请

WO2010062965A3 ELECTROOSMOTIC PUMP WITH IMPROVED GAS MANAGEMENT 审中-公开
公开(公告)号：WO2010062965A3
公开(公告)日：2010-06-03
申请号：PCT/US2009/065938
申请日：2009-11-25
申请人： ILLUMINA INC. , THE ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY , POSNER, Jonathan , SALLOUM, Kamil , LEBL, Michal , REED, Mark , BUERMANN, Dale , HAGE, Matthew , CRANE, Bryan , HEINER, David , KAIN, Robert
发明人： POSNER, Jonathan , SALLOUM, Kamil , LEBL, Michal , REED, Mark , BUERMANN, Dale , HAGE, Matthew , CRANE, Bryan , HEINER, David , KAIN, Robert
IPC分类号： F04B19/00 , F04B37/00 , F04B37/10
摘要： An electroosmotic (EO) pump is provided that includes a housing having a pump cavity, a porous core medium and electrodes. The porous core medium is positioned within the pump cavity to form an exterior reservoir that extends at least partially about an exterior surface of the porous core medium. The porous core medium has an open inner chamber provided therein. The inner chamber represents an interior reservoir. The electrodes are positioned in the inner chamber and are positioned proximate the exterior surface. The electrodes induce flow of a fluid through the porous core medium between the interior and exterior reservoirs, wherein a gas is generated when the electrodes induce flow of the fluid. The housing has a fluid inlet to convey the fluid to one of the interior reservoir and the exterior reservoir. The housing has a fluid outlet to discharge the fluid from another of the interior reservoir and the exterior reservoir. The housing has a gas removal device to remove the gas from the pump cavity.

10. 发明申请

WO2009102688A3 FLOW CELLS AND MANIFOLDS HAVING AN ELECTROOSMOTIC PUMP 审中-公开
公开(公告)号：WO2009102688A3
公开(公告)日：2009-08-20
申请号：PCT/US2009/033637
申请日：2009-02-10
申请人： ILLUMINA, INC.
发明人： LEBL, Michal , BUERMANN, Dale , REED, Mark, T. , HEINER, David L. , TRIENER, Alexander
IPC分类号： G01N35/00
摘要： A flow cell for use in a microfluidic detection system is provided. The flow cell includes a flow cell body having a channel that is configured to convey a solution through the flow cell body. The flow cell also includes a bottom surface and a top surface. The bottom surface is configured to be removably held by the detection system, and the top surface is transparent and permits light to pass therethrough. The flow cell body also includes fluidic inlet and outlet ports that are in fluid communication with the channel. A pump cavity is also provided in the flow cell body. The pump cavity fluidly communicates with, and is interposed between, an end of the channel and one of the fluidic inlet and outlet ports. An electroosmotic (EO) pump is held in the pump cavity. The EO pump induces flow of the solution through the EO pump and channel between the fluidic inlet and outlet ports.

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