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1. 发明申请

WO03076937A9 APPARATUS AND METHODS FOR ANALYTE MEASUREMENT AND IMMUNOASSAY 审中-公开
标题翻译：用于分析测量和免疫测定的装置和方法
公开(公告)号：WO03076937A9
公开(公告)日：2004-04-22
申请号：PCT/US0306820
申请日：2003-03-05
申请人： I STAT CORP , DAVIS GRAHAM , LAUKS IMANTS R , LIN CHAO , MILLER CARY JAMES
发明人： DAVIS GRAHAM , LAUKS IMANTS R , LIN CHAO , MILLER CARY JAMES
IPC分类号： B01L3/00 , C12M1/34 , G01N27/28 , G01N27/327 , G01N27/416 , G01N33/543 , G01N35/04 , G01N35/08 , G01N33/483
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及一种用于进行各种测定液体样品中分析物测定的装置，并涉及这种测定方法。特别地，本发明涉及一种设计成能够适用于各种实时测定方案的单次使用的盒，优选使用免疫传感器或其他基于配体/配体受体的生物传感器实施方案来测定生物样品中分析物的测定。该盒提供用于处理样品的计量部分的新颖特征，用于精确和灵活地控制盒内样品或第二流体的运动，用于在测定过程中用附加化合物修饰溶液以及用于构建免疫传感器能够适应不同的分析物测量。所公开的装置和使用方法相对于现有技术具有实质性的益处，包括操作者的简单使用，一种或多种分析物的快速原位测定，以及使操作者和患者的污染风险最小化的一次性方法。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术室，疗养院，重症监护室和非医疗环境中的使用。

2. 发明申请

WO03076937A2 APPARATUS AND METHODS FOR ANALYTE MEASUREMENT AND IMMUNOASSAY 审中-公开
标题翻译：用于分析物测量和免疫测定的装置和方法
公开(公告)号：WO03076937A2
公开(公告)日：2003-09-18
申请号：PCT/US0306820
申请日：2003-03-05
申请人： I STAT CORP , DAVIS GRAHAM , LAUKS IMANTS R , LIN CHAO , MILLER CARY JAMES
发明人： DAVIS GRAHAM , LAUKS IMANTS R , LIN CHAO , MILLER CARY JAMES
IPC分类号： B01L3/00 , C12M1/34 , G01N27/28 , G01N27/327 , G01N27/416 , G01N33/543 , G01N35/04 , G01N35/08 , G01N33/53
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及用于进行液体样品中分析物测定的各种测定的装置，并且涉及用于这种测定的方法。具体而言，本发明涉及设计成适用于各种实时测定方案的一次性盒，优选使用免疫传感器或其他基于配体/配体受体的生物传感器实施方案测定生物样品中分析物的测定。该盒提供用于处理样本的计量部分的新颖特征，用于精确且灵活地控制样本或第二流体在盒内的移动，用于在测定期间修改具有额外化合物的溶液以及构建免疫传感器能够适应不同的分析物测量。所公开的装置和使用方法享有比现有技术显着的益处，包括操作者的简单使用，一种或多种分析物的快速原位测定以及使操作者和患者的污染风险最小化的一次性使用方法。所公开的发明适用于即时临床诊断领域，包括在事故现场，急诊室，手术室，养老院，重症监护室和非医疗环境中的使用。

3. 发明申请

WO2005026690A3 IMMUNOASSAY DEVICE WITH IMPROVED SAMPLE CLOSURE 审中-公开
标题翻译：具有改进的样品封闭的免疫设备
公开(公告)号：WO2005026690A3
公开(公告)日：2006-12-07
申请号：PCT/US2004029502
申请日：2004-09-09
申请人： I STAT CORP , MILLER CARY JAMES , MACZUSZENKO ANDY
发明人： MILLER CARY JAMES , MACZUSZENKO ANDY
IPC分类号： G01P5/00 , B01L3/00 , C12M1/34 , G01N20060101
CPC分类号： G01N33/52 , A61K39/395 , B01L3/502707 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/0689 , B01L2200/10 , B01L2300/045 , B01L2300/0645 , B01L2300/069 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/046 , B01L2400/0481 , B01L2400/0487 , B01L2400/0683 , B01L2400/0688 , G01N31/22 , Y10T436/25 , Y10T436/2575
摘要： An apparatus and method for sealing a fluid sample collection device, comprising: loading a fluid sample collection device with a fluid sample, said device comprising a housing having at least one substantially planar surface that includes an orifice in fluid communication with an internal fluid sample holding chamber which terminates at an internal capillary stop; and slidably moving a sealing element over at least a portion of said substantially planar surface in a way that displaces any excess fluid sample away from the orifice, seals the fluid sample within said holding chamber, and inhibits the fluid sample from prematurely breaking through the internal capillary stop.
摘要翻译：一种用于密封流体样品收集装置的装置和方法，包括：用流体样品装载流体样品收集装置，所述装置包括具有至少一个基本上平坦的表面的壳体，所述表面包括与内部流体样品保持在内部毛细管停止处终止的腔室; 以及将所述基本上平坦的表面的至少一部分上的密封元件以将所述多余的流体样品移离所述孔口的方式滑动移动，将所述流体样品密封在所述保持室内，并且阻止所述流体样品过早地穿过所述内部毛细血管停止。

5. 发明申请

WO2005026689A9 IMMUNOASSAY DEVICE WITH IMMUNO-REFERENCE ELECTRODE 审中-公开
标题翻译：具免疫参比电极的免疫测定装置
公开(公告)号：WO2005026689A9
公开(公告)日：2005-10-13
申请号：PCT/US2004029498
申请日：2004-09-09
申请人： I STAT CORP , MILLER CARY JAMES , CAMPBELL JOHN LEWIS EMERSON
发明人： MILLER CARY JAMES , CAMPBELL JOHN LEWIS EMERSON
IPC分类号： G01N20060101 , G01N27/00 , G01N33/53 , G01N33/537 , G01N33/543
CPC分类号： G01N33/5438 , Y10S436/807
摘要： An electrochemical immunosensor system with reduced interference, comprising: a first immunosensor that generates an electrochemical signal based on the formation of a sandwich between an immobilized antibody, a target analyte and a labeled antibody, wherein a portion of the signal arises from non-specific binding of the labeled antibody in the region of the first immunosensor, and a second immunosensor that acts as an immuno-reference sensor and generates a signal that is the same as or predictably related to the degree of non-specific binding which occurs in the region of the first immunosensor, and has an immunocomplex between an immobilized antibody and an endogenous or exogenous protein that is in the sample and that is not the target analyte.
摘要翻译：一种具有降低的干扰的电化学免疫传感器系统，包括：第一免疫传感器，其基于在固定化抗体，靶分析物和标记抗体之间形成夹心而产生电化学信号，其中信号的一部分来自非特异性结合的第一免疫传感器区域中的标记抗体，以及第二免疫传感器，其作为免疫参考传感器，并产生与非特异性结合程度相同或可预测相关的信号，其发生在第一免疫传感器，并且在固定的抗体和在样品中的内源或外源蛋白质之间具有免疫复合物，而不是靶分析物。

6. 发明申请

WO2005026689A3 IMMUNOASSAY DEVICE WITH IMMUNO-REFERENCE ELECTRODE 审中-公开
标题翻译：具有免疫参考电极的免疫分析装置
公开(公告)号：WO2005026689A3
公开(公告)日：2005-08-04
申请号：PCT/US2004029498
申请日：2004-09-09
申请人： I STAT CORP , MILLER CARY JAMES , CAMPBELL JOHN LEWIS EMERSON
发明人： MILLER CARY JAMES , CAMPBELL JOHN LEWIS EMERSON
IPC分类号： G01N20060101 , G01N27/00 , G01N33/53 , G01N33/537 , G01N33/543
CPC分类号： G01N33/5438 , Y10S436/807
摘要： An electrochemical immunosensor system with reduced interference, comprising: a first immunosensor that generates an electrochemical signal based on the formation of a sandwich between an immobilized antibody, a target analyte and a labeled antibody, wherein a portion of the signal arises from non-specific binding of the labeled antibody in the region of the first immunosensor, and a second immunosensor that acts as an immuno-reference sensor and generates a signal that is the same as or predictably related to the degree of non-specific binding which occurs in the region of the first immunosensor, and has an immunocomplex between an immobilized antibody and an endogenous or exogenous protein that is in the sample and that is not the target analyte.
摘要翻译：一种干扰降低的电化学免疫传感器系统，包括：第一免疫传感器，其基于固定化抗体，靶分析物和标记抗体之间夹层的形成产生电化学信号，其中一部分信号来源于非特异性结合在第一免疫传感器区域中的标记抗体和第二免疫传感器，其作为免疫参考传感器并产生与在区域中发生的非特异性结合程度相同或可预测地相关的信号第一个免疫传感器，并且在固定抗体和样品中的内源性或外源性蛋白质之间具有免疫复合物，该蛋白质不是目标分析物。

7. 发明申请

WO2012075258A2 RATIOMETRIC IMMUNOASSAY METHOD AND BLOOD TESTING DEVICE 审中-公开
标题翻译：比例免疫测定方法和血液检测装置
公开(公告)号：WO2012075258A2
公开(公告)日：2012-06-07
申请号：PCT/US2011062846
申请日：2011-12-01
申请人： ABBOTT POINT OF CARE INC , MILLER CARY JAMES
发明人： MILLER CARY JAMES
IPC分类号： G01N33/543 , G01N33/558
CPC分类号： B01L3/5027 , B01L3/50273 , G01N33/54306 , G01N33/54366 , G01N33/558 , G01N33/76 , G01N2333/4737 , G01N2333/805
摘要： The invention is to devices and methods for rapid determination of analytes in liquid samples. The devices and methods incorporate a sample dilution feature and multiple immunosensors for performing a ratiometric immunoassay on a first analyte and a second analyte, for example, hemoglobin and hemoglobin A1c or albumin and glycosylated albumin. The devices are preferably capable of being used in the point-of-care diagnostic field.
摘要翻译：本发明是用于快速测定液体样品中分析物的装置和方法。所述装置和方法包含样品稀释特征和多个免疫传感器，用于对第一分析物和第二分析物，例如血红蛋白和血红蛋白A1c或白蛋白和糖基化白蛋白进行比例免疫测定。这些装置优选地能够用于护理点诊断领域。

8. 发明申请

WO2012075256A3 SAMPLE METERING DEVICE AND ASSAY DEVICE WITH INTEGRATED SAMPLE DILUTION 审中-公开
标题翻译：具有集成样品稀释的样品测量装置和测定装置
公开(公告)号：WO2012075256A3
公开(公告)日：2012-07-19
申请号：PCT/US2011062843
申请日：2011-12-01
申请人： ABBOTT POINT OF CARE INC , MILLER CARY JAMES
发明人： MILLER CARY JAMES
IPC分类号： B01L3/00 , C12M1/34 , G01N33/53 , G01N33/543
CPC分类号： B01L3/52 , B01L2200/0605 , B01L2200/0631 , B01L2200/16 , B01L2300/0681 , B01L2300/0816 , B01L2300/126 , G01N1/38 , G01N2001/385 , G01N2333/4737 , Y10T436/25625
摘要： In one embodiment, the invention is to a sample metering device, comprising a sample holding chamber oriented between a sample entry port and a sample extraction unit, wherein a portion of said extraction unit defines a metered volume of a sample. A diluent may be transported over and/or through the extraction unit to form a diluted sample for sample analysis. In another embodiment, the invention is to an apparatus and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature, capable of being used in the point-of-care diagnostic field is provided. The devices and methods of the invention preferably are well-suited for high range sample dilution.
摘要翻译：在一个实施例中，本发明涉及一种样品计量装置，其包括定向在样品入口和样品提取单元之间的样品保持室，其中所述提取单元的一部分限定样品的计量体积。稀释剂可以在提取单元上和/或通过提取单元传输以形成用于样品分析的稀释样品。在另一个实施方案中，本发明涉及一种用于通过各种测定法快速测定液体样品中分析物的装置和方法，所述测定包括能够用于诊断点诊断领域的包含样品稀释特征的免疫测定。本发明的装置和方法优选地适合于高范围样品稀释。

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