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1. 发明申请

WO2016022533A1 SYSTEMS AND METHODS FOR TREATMENT PLANNING BASED ON PLAQUE PROGRESSION REGRESSION CURVES 审中-公开
标题翻译：基于PLAQUE进程回归曲线的处理规划系统与方法
公开(公告)号：WO2016022533A1
公开(公告)日：2016-02-11
申请号：PCT/US2015/043565
申请日：2015-08-04
申请人： HEARTFLOW, INC.
发明人： SANKARAN, Sethuraman , TAYLOR, Charles, A. , CHOI, Gilwoo , SCHAAP, Michael , ZARINS, Christopher, K. , GRADY, Leo, J.
IPC分类号： A61B5/02 , G06F19/00 , A61B5/00 , A61B6/00 , A61B5/026 , G06T7/00
CPC分类号： A61B34/10 , A61B5/02007 , A61B5/02028 , A61B5/026 , A61B5/7275 , A61B6/032 , A61B6/504 , A61B6/507 , A61B6/5217 , A61B2034/105 , G06F17/50 , G06F17/5009 , G06F19/00 , G06F19/26 , G06F19/325 , G06T7/0012 , G06T2207/30096 , G06T2207/30101 , G16H50/20 , G16H50/30 , G16H50/50
摘要： Systems and methods are disclosed for evaluating a patient with vascular disease. One method includes receiving patient-specific data regarding a geometry of the patient's vasculature; creating an anatomic model representing at least a portion of a location of disease in the patient's vasculature based on the received patient-specific data; identifying one or more changes in geometry of the anatomic model based on a modeled progression or regression of disease at the location; calculating one or more values of a blood flow characteristic within the patient's vasculature using a computational model based on the identified one or more changes in geometry of the anatomic model; and generating an electronic graphical display of a relationship between the one or more values of the calculated blood flow characteristic and the identified one or more changes in geometry of the anatomic model.
摘要翻译：公开了用于评估血管疾病患者的系统和方法。一种方法包括接收关于患者脉管系统的几何形状的患者特定数据; 基于所接收的患者特定数据，创建代表病人脉管系统中疾病位置的至少一部分的解剖模型; 基于在该位置处的疾病的建模进展或消退来识别解剖模型的几何的一个或多个变化; 使用基于所识别的解剖模型的几何形状的一个或多个改变的计算模型来计算患者脉管系统内的血流特性的一个或多个值; 以及生成计算出的血流特性的一个或多个值与所识别的一个或多个解剖模型的几何变化之间的关系的电子图形显示。

2. 发明申请

WO2016073246A1 SYSTEMS AND METHODS FOR SIMULATION OF HEMODIALSIS ACCESS AND OPTIMIZATION 审中-公开
标题翻译： HEMODIALSIS访问和优化的模拟系统和方法
公开(公告)号：WO2016073246A1
公开(公告)日：2016-05-12
申请号：PCT/US2015/057731
申请日：2015-10-28
申请人： HEARTFLOW, INC
发明人： SANKARAN, Sethuraman , GRADY, Leo, J. , TAYLOR, Charles, A. , ZARINS, Christopher, K.
IPC分类号： G06F19/00 , A61M1/00
CPC分类号： A61B34/10 , A61B2034/104 , A61B2034/105 , A61M1/00 , A61M1/3653 , A61M1/3655 , A61M1/3659 , A61M1/3661 , G06F19/00 , G16H50/30 , G16H50/50
摘要： Systems and methods are disclosed for simulating or optimizing hemodialysis access. One method includes receiving a patient-specific anatomic model of a patient's vasculature; computing a pre-treatment hemodynamic characteristic of a pre-treatment geometry of a portion of the anatomic model; simulating a post-treatment geometry of a vascular access in the portion of the anatomic model; computing a post-treatment hemodynamic characteristic of the post-treatment geometry of the portion of the anatomic model having the vascular access; and generating a representation of the pre-treatment hemodynamic characteristic or the post-treatment hemodynamic characteristic.
摘要翻译：公开了用于模拟或优化血液透析通路的系统和方法。一种方法包括接收患者脉管系统的患者特异性解剖模型; 计算解剖模型的一部分的预处理几何形状的预处理血流动力学特征; 模拟解剖模型部分中的血管通路的后处理几何形状; 计算具有血管通路的解剖模型部分的后处理几何形状的后处理血流动力特性; 并产生预处理血液动力学特征或后处理血液动力学特性的表示。

3. 发明申请

WO2016161293A1 SYSTEMS AND METHODS FOR PROVIDING PERSONALIZED ESTIMATES OF BIOHEAT TRANSFER 审中-公开
标题翻译：用于提供生物转移的个性化估计的系统和方法
公开(公告)号：WO2016161293A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/025567
申请日：2016-04-01
申请人： HEARTFLOW, INC.
发明人： GRADY, Leo , TAYLOR, Charles, A. , ZARINS, Christopher, K.
IPC分类号： G06F19/00
CPC分类号： A61B34/10 , A61B18/02 , A61B18/12 , A61B34/00 , A61B2018/00577 , A61B2034/104 , A61F7/00 , A61N7/02 , G06F19/00 , G16H50/50
摘要： Systems and methods are disclosed for providing personalized estimates of bioheat transfer through a patient's body or a portion of a patient's body. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; receiving a patient-specific tissue model including at least a portion of tissue of the patient's anatomy; receiving an estimate of heat content of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue; determining an estimate of heat distribution of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue based on the vascular model, the tissue model, or the received estimate of heat content; and output the determined estimate of heat distribution to a storage medium or user display.
摘要翻译：公开了用于提供通过患者身体或患者身体的一部分的生物热转移的个性化估计的系统和方法。一种方法包括接收患者解剖结构的患者特异性血管模型，包括患者的至少一个血管; 接收包括患者解剖结构的组织的至少一部分的患者特异性组织模型; 接收患者特定组织模型或组织周围的组织的组织部分的热含量的估计值; 基于所述血管模型，所述组织模型或所接收的热量估计，确定所述患者特异性组织模型或组织周围组织的组织部分的热分布的估计; 并将确定的热分布估计输出到存储介质或用户显示器。

4. 发明申请

WO2016069715A1 SYSTEMS AND METHODS FOR VESSEL REACTIVITY TO GUIDE DIAGNOSIS OR TREATMENT OF CARDIOVASCULAR DISEASE 审中-公开
标题翻译：用于指导诊断或治疗心血管疾病的船只反应性的系统和方法
公开(公告)号：WO2016069715A1
公开(公告)日：2016-05-06
申请号：PCT/US2015/057754
申请日：2015-10-28
申请人： HEARTFLOW, INC.
发明人： GRADY, Leo, J. , TAYLOR, Charles, A. , ZARINS, Christopher, K.
IPC分类号： A61B5/02 , G06F19/00
CPC分类号： G16H50/50 , A61B5/02007 , A61B5/026 , A61B5/7267 , G06F19/00 , G06F19/3456 , G06F19/3481 , G16H50/20
摘要： Systems and methods are disclosed for using vessel reactivity to guide diagnosis or treatment for cardiovascular disease. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; determining, by measurement or estimation, a first vessel size at one or more locations of a vessel of the patient-specific vascular model at a first physiological state; determining a second vessel size at the one or more locations of the vessel of the patient-specific vascular model at a second physiological state using a simulation or learned information; comparing the first vessel size to the corresponding second vessel size; and estimating a characteristic of the vessel of the patient-specific vascular model based on the comparison.
摘要翻译：公开了使用血管反应性来指导心血管疾病诊断或治疗的系统和方法。一种方法包括接收患者解剖结构的患者特异性血管模型，包括患者的至少一个血管; 通过测量或估计在第一生理状态下确定患者特异性血管模型的血管的一个或多个位置处的第一血管大小; 使用模拟或学习的信息在第二生理状态下确定患者特异性血管模型的血管的一个或多个位置处的第二血管尺寸; 将第一容器尺寸与对应的第二容器尺寸进行比较; 并且基于该比较来估计患者特异性血管模型的血管的特征。

5. 发明申请

WO2017083401A1 SYSTEMS AND METHODS FOR ANATOMICAL MODELING USING INFORMATION FROM A PROCEDURE 审中-公开
标题翻译：用过程信息进行解剖学建模的系统和方法
公开(公告)号：WO2017083401A1
公开(公告)日：2017-05-18
申请号：PCT/US2016/061155
申请日：2016-11-09
申请人： HEARTFLOW, INC.
发明人： GRADY, Leo , TAYLOR, Charles, A. , ROGERS, Campbell , ZARINS, Christopher, K. , CHOI, Gilwoo
IPC分类号： G06F19/00
CPC分类号： G16H50/50 , G06F19/00
摘要： Systems and methods are disclosed herein for anatomical modeling using information obtained during a medical procedure, whereby an initial anatomical model is generated or obtained, a correspondence is determined between the initial model and additional data and/or measurements from an invasive or noninvasive procedure, and, if a discrepancy is found between the initial model and the additional data, the anatomical model is updated to incorporate the additional data and reduce the discrepancy.
摘要翻译：本文公开了使用在医疗过程期间获得的信息进行解剖建模的系统和方法，由此生成或获得初始解剖模型，确定初始模型与附加数据和/或测量值之间的对应关系如果在初始模型和附加数据之间发现差异，则更新解剖模型以结合附加数据并减少差异。

6. 发明申请

WO2016115206A1 SYSTEMS AND METHODS FOR EMBOLISM PREDICTION USING EMBOLUS SOURCE AND DESTINATION PROBABILITIES 审中-公开
标题翻译：使用EMBOLUS来源和目标概率进行嵌体预测的系统和方法
公开(公告)号：WO2016115206A1
公开(公告)日：2016-07-21
申请号：PCT/US2016/013165
申请日：2016-01-13
申请人： HEARTFLOW, INC.
发明人： GRADY, Leo, J. , CHOI, Gilwoo , TAYLOR, Charles, A. , ZARINS, Christopher, K.
IPC分类号： G06F19/00
CPC分类号： G16H50/20 , G06F17/18 , G06F19/00 , G06N7/005 , G16H50/50
摘要： Systems and methods are disclosed for determining a patient risk assessment or treatment plan based on emboli dislodgement and destination. One method includes receiving a patient-specific anatomic model generated from patient- specific imaging of at least a portion of a patient's vasculature; determining or receiving a location of interest in the patient-specific anatomic model of the patient's vasculature; using a computing processor for calculating blood flow through the patient-specific anatomic model to determine blood flow characteristics through at least the portion of the patient's vasculature of the patient-specific anatomic model downstream from the location of interest; and using a computing processor for particle tracking through the simulated blood flow to determine a destination probability of an embolus originating from the location of interest in the patient- specific anatomic model, based on the determined blood flow characteristics.
摘要翻译：公开了用于确定基于栓塞移动和目的地的患者风险评估或治疗计划的系统和方法。一种方法包括接收由病人对患者血管系统的至少一部分的患者特异性成像产生的患者特异性解剖模型; 在患者的脉管系统的患者特异性解剖模型中确定或接收感兴趣的位置; 使用计算处理器来计算通过所述患者特异性解剖模型的血流，以通过所述患者特定解剖模型的患者特定解剖模型的至少部分来自感兴趣位置的下游来确定血流特性; 以及使用计算处理器通过所述模拟血流进行粒子跟踪，以基于所确定的血流特性来确定源自所述患者特异性解剖模型中的感兴趣位置的栓塞的目的地概率。

7. 发明申请

WO2016073249A1 SYSTEMS AND METHODS FOR SIMULATION OF OCCLUDED ARTERIES AND OPTIMIZATION OF OCCLUSION-BASED TREATMENTS 审中-公开
标题翻译：系统和方法，用于模拟受试动物和优化基于卵巢的治疗
公开(公告)号：WO2016073249A1
公开(公告)日：2016-05-12
申请号：PCT/US2015/057743
申请日：2015-10-28
申请人： HEARTFLOW, INC.
发明人： SANKARAN, Sethuraman , GRADY, Leo, J. , TAYLOR, Charles, A. , ZARINS, Christopher, K.
IPC分类号： G06F19/00
CPC分类号： G16H50/50 , G06F17/18 , G06F19/00 , G06F19/3418 , G06F19/3481
摘要： Systems and methods are disclosed for simulation of occluded arteries and/or optimization of occlusion-based treatments. One method includes obtaining a patient-specific anatomic model of a patient's vasculature; obtaining an initial computational model of blood flow through the patient's vasculature based on the patient-specific anatomic model; obtaining a post-treatment computational model by modifying portions of the initial computational model based on an occlusion-based treatment; generating a pre-treatment blood flow characteristic using the initial computational model or computing a post-treatment blood flow using the post- treatment computational model; and outputting a representation of the pre-treatment blood flow characteristic or the post-treatment blood flow characteristic.
摘要翻译：公开了用于模拟闭塞动脉和/或基于阻塞的治疗的优化的系统和方法。一种方法包括获得患者脉管系统的患者特异性解剖模型; 基于患者特异性解剖模型获得通过患者脉管系统的血流的初始计算模型; 通过基于基于遮挡的处理修改初始计算模型的部分来获得后处理计算模型; 使用初始计算模型产生预处理血流特征或使用后处理计算模型计算后处理血流量; 并输出预处理血流特性或后处理血流特性的表示。

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