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1. 发明申请

WO2012040331A3 MULTISTAGE NANOPARTICLES 审中-公开
标题翻译：多元纳米粒子
公开(公告)号：WO2012040331A3
公开(公告)日：2012-07-12
申请号：PCT/US2011052555
申请日：2011-09-21
申请人： GEN HOSPITAL CORP , MASSACHUSETTS INST TECHNOLOGY , WONG CLIFF , BAWENDI MOUNGI G , STYLIANOPOULOS TRIANTAFYLLOS , JAIN RAKESH K , FUKUMURA DAI
发明人： WONG CLIFF , BAWENDI MOUNGI G , STYLIANOPOULOS TRIANTAFYLLOS , JAIN RAKESH K , FUKUMURA DAI
IPC分类号： A61K9/127 , A61K9/16 , A61K47/30 , A61K47/36 , A61K47/48 , A61P35/00
CPC分类号： A61K47/48884 , A61K9/127 , A61K9/14 , A61K45/06 , A61K47/6929 , A61K49/0067 , A61K49/0093 , B82Y5/00 , B82Y15/00
摘要： Multistage nanostructures, e.g., for delivery of agents such as imaging agents and therapeutic agents to tumor vasculature.
摘要翻译：多级纳米结构，例如用于将药剂如成像剂和治疗剂递送到肿瘤脉管系统。

2. 发明申请

WO2010065611A3 ELECTRICALLY CONTROLLED CATALYTIC NANOWIRE GROWTH 审中-公开
标题翻译：电动控制纳米生长
公开(公告)号：WO2010065611A3
公开(公告)日：2010-08-26
申请号：PCT/US2009066369
申请日：2009-12-02
申请人： MASSACHUSETTS INST TECHNOLOGY , DORN AUGUST , WONG CLIFF R , BAWENDI MOUNGI G
发明人： DORN AUGUST , WONG CLIFF R , BAWENDI MOUNGI G
IPC分类号： B82B3/00
CPC分类号： B22F9/14 , B22F1/0025 , B22F1/02 , B82Y30/00 , H01L29/02 , H01L29/04 , H01L29/06
摘要： A population of nanowires can be prepared by a method involving electric field catalyzed growth and alteration based on surface charge density.
摘要翻译：可以通过涉及基于表面电荷密度的电场催化生长和改变的方法来制备纳米线群体。

3. 发明申请

WO2011112970A2 COMPOSITIONS AND METHODS FOR BIOCONJUGATION TO QUANTUM DOTS 审中-公开
标题翻译：用于生物量化到量子的组合物和方法
公开(公告)号：WO2011112970A2
公开(公告)日：2011-09-15
申请号：PCT/US2011028154
申请日：2011-03-11
申请人： GEN HOSPITAL CORP , MASSACHUSETTS INST TECHNOLOGY , HAN HEE-SUN , HILDERBRAND SCOTT A , DEVARAJ NEAL K , WEISSLEDER RALPH , BAWENDI MOUNGI G
发明人： HAN HEE-SUN , HILDERBRAND SCOTT A , DEVARAJ NEAL K , WEISSLEDER RALPH , BAWENDI MOUNGI G
IPC分类号： C08G65/48 , A61K49/00 , C08G65/325 , C08K5/3445 , C08L71/02
CPC分类号： A61K49/0067 , A61K49/0056 , C08G65/3348 , C08L101/025 , C08L2203/02
摘要： The present disclosure provides for bio-orthoganl and modular conjugation methods for efficient coupling of organic compounds to quantum dots.
摘要翻译：本公开提供了用于将有机化合物有效耦合到量子点的生物正交和模块共轭方法。

4. 发明申请

WO2004042784A3 STABILIZED SEMICONDUCTOR NANOCRYSTALS 审中-公开
标题翻译：稳定的半导体纳米晶体
公开(公告)号：WO2004042784A3
公开(公告)日：2009-04-09
申请号：PCT/US0325613
申请日：2003-08-15
申请人： MASSACHUSETTS INST TECHNOLOGY , BAWENDI MOUNGI G , KIM SUNGJEE , STOTT NATHAN E
发明人： BAWENDI MOUNGI G , KIM SUNGJEE , STOTT NATHAN E
IPC分类号： B32B5/16 , B05D7/00 , C01B19/00 , C07F9/113 , C30B29/10 , C30B29/46 , H01L20060101 , H01L21/00
CPC分类号： C01B19/007 , B82Y30/00 , C01G9/08 , C01G11/02 , C01G13/00 , C01G21/21 , C01G28/00 , C01P2004/40 , C01P2004/64 , C01P2004/80 , C07F9/5004 , C09K11/02 , C09K11/565 , C09K11/883 , C30B7/00 , C30B29/60 , Y10T428/12597 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2996 , Y10T428/2998
摘要： A semiconductor nanocrystal associated with a polydentate ligand. The polydentate ligand stabilizes the nanocyrstal.
摘要翻译：与多齿配体相关的半导体纳米晶体。多齿配体稳定纳米淀粉。

5. 发明申请

WO2005086782A3 BLUE LIGHT EMITTING SEMICONDUCTOR NANOCRYSTAL MATERIALS 审中-公开
标题翻译：蓝色发光半导体纳米材料
公开(公告)号：WO2005086782A3
公开(公告)日：2008-01-03
申请号：PCT/US2005007454
申请日：2005-03-07
申请人： MASSACHUSETTS INST TECHNOLOGY , STECKEL JONATHAN S , ZIMMER JOHN P , COE-SULLIVAN SETH , STOTT NATHAN E , BULOVIC VLADIMIR , BAWENDI MOUNGI G
发明人： STECKEL JONATHAN S , ZIMMER JOHN P , COE-SULLIVAN SETH , STOTT NATHAN E , BULOVIC VLADIMIR , BAWENDI MOUNGI G
IPC分类号： H01L29/08 , H01L33/18 , H01L33/20 , H01L35/24
CPC分类号： C01G9/08 , B82Y20/00 , B82Y30/00 , C01G11/02 , C01P2004/04 , C01P2004/64 , C01P2004/84 , C01P2006/40 , C09K11/02 , C09K11/565 , H01L33/18 , H01L33/20 , H05B33/14
摘要： A semiconductor nanocrystal includes a core including a first semiconductor material and an overcoating including a second semiconductor material. A monodisperse population of the nanocrystals emits blue light over a narrow range of wavelengths with a high quantum efficiency.
摘要翻译：半导体纳米晶体包括包括第一半导体材料的芯和包括第二半导体材料的外涂层。纳米晶体的单分散群体在具有高量子效率的窄波长范围内发射蓝光。

6. 发明申请

WO2006086551A2 MICROFLUIDIC LASERS 审中-公开
标题翻译：微流感激光
公开(公告)号：WO2006086551A2
公开(公告)日：2006-08-17
申请号：PCT/US2006004577
申请日：2006-02-08
申请人： HARVARD COLLEGE , MASSACHUSETTS INST TECHNOLOGY , MAYERS BRIAN T , CONROY RICHARD S , VEZENOV DMITRI V , SNEE PRESTON , CHAN YINTHAI , BAWENDI MOUNGI G , WHITESIDES GEORGE M
发明人： MAYERS BRIAN T , CONROY RICHARD S , VEZENOV DMITRI V , SNEE PRESTON , CHAN YINTHAI , BAWENDI MOUNGI G , WHITESIDES GEORGE M
CPC分类号： H01S3/05 , H01S3/213
摘要： The present invention generally relates to lasers comprising fluidic channels, such as microfluidic channels. In some instances, the channel contains two or more fluids. The fluids may remain non-mixed within the channel, for example, due to immiscibility and/or laminar flow within the channel. The fluids may be arranged in the channel such that light propagating in a first fluid is prevented by the second fluid from exiting the first fluid, for example, due to differences in the indexes of refraction (e.g., causing internal reflection of the fluid to occur). Thus, in one embodiment, a first fluid may be at least partially surrounded by a second fluid having a second index of refraction lower than the index of refraction of the first fluid. In some embodiments, the fluidic channel is used as a laser, for instance, a dye laser, i.e., a laser created by directing light at a dye to produce coherent light. The dye may be present in one or more fluids within the fluidic channel. The incident light (for example, created by another laser) may be directed at the channel from any angle. In some cases, laser light may be produced in a direction substantially aligned with the longitudinal axis of the channel. In some embodiments, the laser is free of mirrors, prisms, or gratings, or the laser may produce coherent light using a non-resonant photonic pathway. However, in other cases, mirrors, prisms, or gratings may be used to reflect light along the channel to enhance stimulated emission of coherent light. Another aspect of the invention includes optical diffractors, such as prisms or gratings, which can contain a fluid. The optical diffractors, in certain embodiments, are positioned to diffract light, such as coherent light, emanating from the fluidic channel. Still other aspects of the invention provide devices, kits, and methods of making and using such lasers.
摘要翻译：本发明一般涉及包括流体通道的激光器，例如微流体通道。在一些情况下，通道包含两种或更多种流体。流体可以在通道内保持不混合，例如，由于通道内的不混溶和/或层流。流体可以布置在通道中，使得通过第二流体从第一流体中排出的光例如由于折射率的差异（例如，引起流体的内部反射）而被阻止在第一流体中传播的光）。因此，在一个实施例中，第一流体可以至少部分地被具有低于第一流体的折射率的第二折射率的第二流体包围。在一些实施例中，流体通道用作激光器，例如染料激光器，即通过在染料处引导光以产生相干光而产生的激光。染料可存在于流体通道内的一种或多种流体中。入射光（例如，由另一激光产生的）可以从任何角度指向通道。在一些情况下，可以在与通道的纵向轴线基本对准的方向上产生激光。在一些实施例中，激光器不含镜子，棱镜或光栅，或者激光可以使用非共振光子通道产生相干光。然而，在其他情况下，可以使用反射镜，棱镜或光栅来沿着通道反射光以增强相干光的受激发射。本发明的另一方面包括可以包含流体的光学衍射器，例如棱镜或光栅。在某些实施例中，光衍射器被定位成衍射从流体通道发出的光，例如相干光。本发明的其它方面提供了制造和使用这种激光器的装置，套件和方法。

7. 发明申请

WO03025539A2 SEMICONDUCTOR NANOCRYSTAL COMPOSITE 审中-公开
公开(公告)号：WO03025539A2
公开(公告)日：2003-03-27
申请号：PCT/US0229305
申请日：2002-09-17
申请人： MASSACHUSETTS INST TECHNOLOGY , SUNDAR VIKRAM C , EISLER HANS J , BAWENDI MOUNGI G
发明人： SUNDAR VIKRAM C , EISLER HANS J , BAWENDI MOUNGI G
IPC分类号： H01S3/16 , G02B6/122 , G02B6/13 , G02B6/132 , H01S3/063 , H01S5/04 , H01S5/10 , H01S5/30 , H01S5/34 , G01N
CPC分类号： B82Y30/00 , B82Y20/00 , G02B6/122 , G02B6/1221 , G02B6/13 , G02B6/132 , H01S3/063 , H01S3/0632 , H01S3/2308 , H01S5/04 , H01S5/041 , H01S5/10 , H01S5/30 , H01S5/3013 , H01S5/3018 , H01S5/3412
摘要： A composite including a plurality of semiconductor nanocrystals distributed in a metal oxide matrix can be used as an optical amplifier, a waveguide or a laser.
摘要翻译：可以使用包括分布在金属氧化物基体中的多个半导体纳米晶体的复合体作为光放大器，波导管或激光器。

8. 发明申请

WO0017655A8 WATER-SOLUBLE FLUORESCENT SEMICONDUCTOR NANOCRYSTALS 审中-公开
标题翻译：水溶性荧光半导体纳米晶体
公开(公告)号：WO0017655A8
公开(公告)日：2001-03-08
申请号：PCT/US9921375
申请日：1999-09-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BAWENDI MOUNGI G , MIKULEC FREDERICK V , LEE JIN KYU
发明人： BAWENDI MOUNGI G , MIKULEC FREDERICK V , LEE JIN-KYU
IPC分类号： G01N33/53 , B82B3/00 , C09K11/06 , C12N15/09 , C12Q1/68 , C40B20/00 , C40B30/00 , C40B40/02 , C40B50/06 , C40B60/04 , G01N33/532 , G01N33/533 , G01N33/566 , G01N33/58 , G01N35/00 , G01N37/00 , G06K19/06 , H01L33/00 , H05B33/10
CPC分类号： G06K19/06046 , B82Y15/00 , C12Q1/6804 , C12Q1/6841 , C12Q1/686 , C12Q1/6869 , G01N33/532 , G01N33/533 , G01N33/588 , C12Q2565/607 , C12Q2565/101 , C12Q2563/149 , C12Q2563/155
摘要： A water-soluble semiconductor nanocrystal capable of light emission is provided. The nanocrystal including a semiconductor nanocrystal core having a selected band gap energy, a shell layer overcoating the core comprised of a semiconductor material having a band gap energy greater than that of the semiconductor nanocrystal, and an outer layer comprised of a molecule having at least one linking group for attachment of the molecule to the overcoating shell layer and at least one hydrophilic group optionally spaced apart from the linking group by a hydrophobic region sufficient to prevent electron charge transfer across the hydrophobic region.
摘要翻译：提供了能够发光的水溶性半导体纳米晶体。纳米晶体包括具有选定的带隙能的半导体纳米晶体核心，外壳层覆盖由具有大于半导体纳米晶体的带隙能量的带隙能量的半导体材料构成的芯体，以及由具有至少一个连接基团，用于将分子连接到外涂层和至少一个任选与连接基隔开的亲水基团，其疏水性区域足以防止电子电荷转移穿过疏水区域。

9. 发明申请

WO2005001906A3 MATERIALS AND METHODS FOR NEAR-INFRARED AND INFRARED LYMPH NODE MAPPING 审中-公开
标题翻译：近红外和红外线淋巴液滴定图谱的材料与方法
公开(公告)号：WO2005001906A3
公开(公告)日：2005-12-08
申请号：PCT/US2004005529
申请日：2004-02-26
申请人： MASSACHUSETTS INST TECHNOLOGY , BETH ISRAEL HOSPITAL , FRANGIONI JOHN V , BAWENDI MOUNGI G , KIM SUNGJEE , LIM YONG TAIK
发明人： FRANGIONI JOHN V , BAWENDI MOUNGI G , KIM SUNGJEE , LIM YONG TAIK
IPC分类号： A61B6/00 , A61B8/00 , A61K9/16 , A61K49/00 , B32B5/16 , G01N33/58 , H01L20060101
CPC分类号： A61K49/0017 , A61K49/0067 , B82Y15/00 , G01N33/588 , Y10S977/813 , Y10S977/881 , Y10S977/904 , Y10S977/949 , Y10S977/954
摘要： A lymphatic system can be imaged with emissive semiconductor nanocrystals, for example, in the near infrared.
摘要翻译：淋巴系统可以用发射半导体纳米晶体成像，例如在近红外。

10. 发明申请

WO0017655A9 WATER-SOLUBLE FLUORESCENT SEMICONDUCTOR NANOCRYSTALS 审中-公开
标题翻译：水溶性荧光半导体纳米晶
公开(公告)号：WO0017655A9
公开(公告)日：2001-10-04
申请号：PCT/US9921375
申请日：1999-09-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BAWENDI MOUNGI G , MIKULEC FREDERICK V , LEE JIN KYU
发明人： BAWENDI MOUNGI G , MIKULEC FREDERICK V , LEE JIN-KYU
IPC分类号： G01N33/53 , B82B3/00 , C09K11/06 , C12N15/09 , C12Q1/68 , C40B20/00 , C40B30/00 , C40B40/02 , C40B50/06 , C40B60/04 , G01N33/532 , G01N33/533 , G01N33/566 , G01N33/58 , G01N35/00 , G01N37/00 , G06K19/06 , H01L33/00 , H05B33/10
CPC分类号： G06K19/06046 , B82Y15/00 , C12Q1/6804 , C12Q1/6841 , C12Q1/686 , C12Q1/6869 , G01N33/532 , G01N33/533 , G01N33/588 , C12Q2565/607 , C12Q2565/101 , C12Q2563/149 , C12Q2563/155
摘要： A water-soluble semiconductor nanocrystal capable of light emission is provided. The nanocrystal including a semiconductor nanocrystal core having a selected band gap energy, a shell layer overcoating the core comprised of a semiconductor material having a band gap energy greater than that of the semiconductor nanocrystal, and an outer layer comprised of a molecule having at least one linking group for attachment of the molecule to the overcoating shell layer and at least one hydrophilic group optionally spaced apart from the linking group by a hydrophobic region sufficient to prevent electron charge transfer across the hydrophobic region.
摘要翻译：提供了一种能够发光的水溶性半导体纳米晶体。该纳米晶体包括具有选定的带隙能量的半导体纳米晶体核心，覆盖包含半导体材料的核心的壳层，该半导体材料的带隙能量大于半导体纳米晶体的能带隙能量，并且外层由具有至少一个所述交联基团用于将所述分子连接至所述外涂壳层和至少一个亲水基团，所述至少一个亲水基团任选地与所述连接基团隔开足以防止电子电荷穿过所述疏水区域转移的疏水区域。

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