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1. 发明申请

WO2010017210A1 MICROFLUIDIC MIXING AND REACTION SYSTEMS FOR HIGH EFFICIENCY SCREENING 审中-公开
标题翻译：用于高效筛选的微流控混合和反应系统
公开(公告)号：WO2010017210A1
公开(公告)日：2010-02-11
申请号：PCT/US2009/052726
申请日：2009-08-04
申请人： FLUIDIGM CORPORATION , WOUDENBERG, Tim , WANG, Jing , CHOU, Hou-Pu
发明人： WOUDENBERG, Tim , WANG, Jing , CHOU, Hou-Pu
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01F13/0059 , B01F13/0094 , B01F13/1013 , B01F13/1022 , B01J2219/00317 , B01J2219/00479 , B01J2219/00585 , B01L3/5025 , B01L3/502723 , B01L3/502738 , B01L3/502746 , B01L7/52 , B01L2200/027 , B01L2200/0605 , B01L2300/0829 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/123 , B01L2300/1805 , B01L2400/0487 , B01L2400/0605 , B01L2400/0655 , B01L2400/082 , B33Y80/00 , G01N1/28 , H04W4/70 , H04W76/30
摘要： Microfluidic devices are described that include a rigid base layer, and an elastomeric layer on the base layer. The elastomeric layer may include at least part of a fluid channel for transporting a liquid reagent, and a vent channel that accepts gas diffusing through the elastomeric layer from the flow channel and vents it out of the elastomeric layer. The devices may also include a mixing chamber fluidly connected to the fluid channel, and a control channel overlapping with a deflectable membrane that defines a portion of the flow channel, where the control channel may be operable to change a rate at which the liquid reagent flows through the fluid channel. The devices may further include a rigid plastic layer on the elastomeric layer.
摘要翻译：描述了包括刚性基层和基层上的弹性体层的微流体装置。弹性体层可以包括用于输送液体试剂的流体通道的至少一部分，以及排气通道，其接纳从流动通道穿过弹性体层扩散的气体并将其从弹性体层排出。装置还可以包括流体连接到流体通道的混合室，以及与限定流动通道的一部分的可偏转膜重叠的控制通道，其中控制通道可操作以改变液体试剂流动的速率通过流体通道。所述装置还可包括弹性体层上的刚性塑料层。

2. 发明申请

WO2013130714A1 METHODS, SYSTEMS, AND DEVICES FOR MULTIPLE SINGLE-CELL CAPTURING AND PROCESSING USING MICROFLUIDICS 审中-公开
标题翻译：用于多单细胞捕获和使用微流控的处理的方法，系统和设备
公开(公告)号：WO2013130714A1
公开(公告)日：2013-09-06
申请号：PCT/US2013/028170
申请日：2013-02-28
申请人： FLUIDIGM CORPORATION , FOWLER, Brian , KIMBALL, Jake , MAUNG, Myo Thu , MAY, Andrew , NORRIS, Michael C. , TOPPANI, Dominique G. , UNGER, Marc A. , WANG, Jing , WEST, Jason A. A.
发明人： FOWLER, Brian , KIMBALL, Jake , MAUNG, Myo Thu , MAY, Andrew , NORRIS, Michael C. , TOPPANI, Dominique G. , UNGER, Marc A. , WANG, Jing , WEST, Jason A. A.
IPC分类号： G01N15/10
CPC分类号： G01N1/28 , B01L3/502761 , B01L7/52 , B01L2200/0668 , B01L2300/0864 , B01L2400/0409 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , B01L2400/086 , B01L2400/088 , C12P19/34 , C12Q1/6813 , C12Q1/6844 , C12Q1/686 , C12Q1/6869 , G01N1/34 , G01N15/1484 , C12Q2565/629
摘要： Methods, systems, and devices are described for multiple single-cell capturing and processing utilizing microfluidics. Tools and techniques are provided for capturing, partitioning, and/or manipulating individual cells from a larger population of cells along with generating genetic information and/or reactions related to each individual cell. Different capture configurations may be utilized to capture individual cells and then processing each individual cell in a multi-chamber reaction configuration. Some embodiments may provide for specific target amplification, whole genome amplification, whole transcriptome amplification, real-time PCR preparation, copy number variation, preamplification, mRNA sequencing, and/or haplotyping of the multiple individual cells that have been partitioned from the larger population of cells. Some embodiments may provide for other applications. Some embodiments may be configured for imaging the individual cells or associated reaction products as part of the processing. Reaction products may be harvested and/or further analyzed in some cases.
摘要翻译：描述了利用微流体的多单细胞捕获和处理的方法，系统和装置。提供的工具和技术用于捕获，分配和/或操纵来自较大群体的细胞的各个细胞以及产生与每个单个细胞相关的遗传信息和/或反应。可以使用不同的捕获配置来捕获单个细胞，然后在多室反应配置中处理每个单独的细胞。一些实施方案可以提供已经从较大群体中划分的多个单个细胞的特异性靶扩增，全基因组扩增，全转录组扩增，实时PCR制备，拷贝数变异，预扩增，mRNA测序和/或单倍型细胞。一些实施例可以提供其他应用。一些实施例可以被配置为用于对作为处理的一部分的各个单元或相关联的反应产物进行成像。在某些情况下可以收获和/或进一步分析反应产物。

3. 发明申请

WO2008089493A2 HIGH EFFICIENCY AND HIGH PRECISION MICROFLUIDIC DEVICES AND METHODS 审中-公开
标题翻译：高效率和高精度微流体装置和方法
公开(公告)号：WO2008089493A2
公开(公告)日：2008-07-24
申请号：PCT/US2008/051728
申请日：2008-01-22
申请人： FLUIDIGM CORPORATION , COHEN, David, S. , WANG, Jing , MAY, Andrew, P. , JONES, Robert, C. , NASSEF, Hany
发明人： COHEN, David, S. , WANG, Jing , MAY, Andrew, P. , JONES, Robert, C. , NASSEF, Hany
IPC分类号： B01L3/00
CPC分类号： B01L3/502738 , B01L3/5025 , B01L7/52 , B01L2200/0684 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2400/0487 , B01L2400/0605 , B01L2400/0638 , B01L2400/0655 , B33Y80/00 , F16K99/0001 , F16K99/0026 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , Y10T137/0318 , Y10T137/85938
摘要： New high density microfluidic devices and methods provide precise metering of fluid volumes and efficient mixing of the metered volumes. A first solution is introduced into a segment of a flow channel in fluidic communication with a reaction chamber. A second solution is flowed through the segment so that the first solution is displaced into the reaction chamber, and a volume of the second solution enters the chamber. The chamber can then be isolated and reactions within the chamber can be initiated and/or detected. High throughput methods of genetic analysis can be carried out with greater accuracy than previously available.
摘要翻译：新的高密度微流体装置和方法提供流体体积的精确计量和计量体积的有效混合。将第一溶液引入与反应室流体连通的流动通道的段中。第二溶液流过该段，使得第一溶液移入反应室，并且第二溶液的体积进入该室。然后可以分离室，并且可以启动和/或检测室内的反应。遗传分析的高通量方法可以比以前更高的精度进行。

4. 发明申请

WO2011066588A1 MICROFLUIDIC DEVICE REGENERATION 审中-公开
标题翻译：微流量器件再生
公开(公告)号：WO2011066588A1
公开(公告)日：2011-06-03
申请号：PCT/US2010/058459
申请日：2010-11-30
申请人： FLUIDIGM CORPORATION , WANG, Jing , WOUDENBERG, Timothy M.
发明人： WANG, Jing , WOUDENBERG, Timothy M.
IPC分类号： A61L2/00
CPC分类号： B08B9/027 , B01L3/5027 , B01L99/00 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , F16K99/0001 , F16K99/0026 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0084
摘要： A method for rendering a microfluidic device suitable for reuse for nucleic acid analysis is provided. The method may include flowing a nucleic acid inactivating solution into a microfluidic channel of the device by pumping; and then flowing a wash solution into the channel by pumping, thereby displacing the nucleic acid inactivating solution from the channel, whereby any residual nucleic acid from a prior use of the device is inactivated.
摘要翻译：提供了一种用于制备适于重新用于核酸分析的微流体装置的方法。该方法可以包括通过泵送将核酸灭活溶液流动到装置的微流体通道中; 然后通过泵送将洗涤溶液流入通道，从而使来自通道的核酸灭活溶液移位，由此来自先前使用该装置的任何残留核酸被灭活。

5. 发明申请

WO2008043046A2 MICROFLUIDIC CHECK VALVES 审中-公开
标题翻译：微流感检查阀
公开(公告)号：WO2008043046A2
公开(公告)日：2008-04-10
申请号：PCT/US2007/080489
申请日：2007-10-04
申请人： FLUIDIGM CORPORATION , WANG, Jing , NASSEF, Hany, R.
发明人： WANG, Jing , NASSEF, Hany, R.
IPC分类号： B01J19/00
CPC分类号： F16K99/0026 , B01L3/502738 , B01L2200/12 , B01L2300/0887 , B01L2400/0605 , B01L2400/0638 , F16K99/0001 , F16K99/0057 , F16K2099/0078 , F16K2099/008
摘要： The present invention is a robust, microfluidic check valve and a method of using the check valve in microfluidic devices. The check valve is comprised two stacked chambers that are separated by a pore-containing membrane. The membrane is composed of an elastomeric material and can be configured in normally open or normally closed state. The normally open check valve can be implemented so that the degree of back pressure necessary to close the valve can be set. The normally closed embodiment can maintain a closed state with essentially no back pressure. Both the normally open and the normally closed version can be readily produced by multilayer soft lithographic techniques and may retain effective functioning through many thousands of opening and closing cycles without failure. Such check valves can substitute for active valve structures in microfluidic devices and, when appropriately implemented, can simplify the design, manufacture, and/or operation of the devices containing them.
摘要翻译：本发明是一种坚固的微流体止回阀和在微流体装置中使用止回阀的方法。止回阀包括由含孔膜隔开的两个堆叠室。膜由弹性体材料构成，并且可以构造成常开或常闭状态。可以实现常开止回阀，使得可以设定关闭阀所需的背压程度。常闭实施例可以保持基本上没有背压的关闭状态。常开和常闭型都可以通过多层软平版印刷技术轻松生产，并可通过数千个开闭周期保持有效的功能，而不会发生故障。这种止回阀可以替代微流体装置中的主动阀结构，并且当适当实施时，可以简化包含它们的装置的设计，制造和/或操作。

6. 发明申请

WO2016011177A1 REAGENTS AND KIT COMPOSITIONS FOR SINGLE-CELL WHOLE GENOME AMPLIFICATION 审中-公开
标题翻译：用于单细胞全基因扩增的试剂和试剂盒组合物
公开(公告)号：WO2016011177A1
公开(公告)日：2016-01-21
申请号：PCT/US2015/040611
申请日：2015-07-15
申请人： FLUIDIGM CORPORATION
发明人： CHEN, Peilin , WANG, Jing , MAY, Andrew
IPC分类号： C12P19/34 , C07H21/04
CPC分类号： C12P19/34 , C12Q1/6846 , C12Q1/6848 , C12Q2525/113 , C12Q2525/179 , C12Q2527/101 , C12Q2527/125 , C12Q2531/119
摘要： The present invention provides reagents, kits, and methods for single-cell whole genome amplification using Phi 29 DNA polymerase.
摘要翻译：本发明提供使用Phi 29 DNA聚合酶的单细胞全基因组扩增的试剂，试剂盒和方法。

7. 发明申请

WO2021141758A1 UNIVERSAL VACCINES AGAINST IMMUNOGENS OF PATHOGENIC ORGANISMS THAT PROVIDE ORGANISM-SPECIFIC AND CROSS-GROUP PROTECTION 审中-公开
公开(公告)号：WO2021141758A1
公开(公告)日：2021-07-15
申请号：PCT/US2020/066059
申请日：2020-12-18
申请人： XU, Jian, Qing , ZHANG, Xiao, Yan , WANG, Jing , ZHU, Ling, Yan , LUBIT, Beverly, W.
发明人： XU, Jian, Qing , ZHANG, Xiao, Yan , WANG, Jing , ZHU, Ling, Yan , LUBIT, Beverly, W.
IPC分类号： A61K39/12 , A61K39/145 , C12N5/0783 , C07K7/06 , C12N15/86 , A61P31/16 , A61K2039/543 , A61K2039/545 , A61K2039/572 , C07K14/005 , C12N2710/10043 , C12N2710/10343 , C12N2710/24143 , C12N2760/16122 , C12N2760/16134 , C12N2795/10343 , C12N2800/00 , C12N7/00
摘要： The present disclosure provides, in part, a priming and boosting vector-based platform to develop vaccines against pathogensthat is tailored to elicit a broad T cell response targeting conserved viral epitopes. The universal vaccines are prepared against an immunogen of an infectious pathogenic organism selected from a virus, a bacteria, a fungus or a protozoan comprising at least one ribonucleic acid (RNA) polynucleotide comprising an open reading frame encoding at least one polypeptide antigen or an immunogenic fragment thereof, wherein the polypeptide antigen, or the immunogenic fragment thereof, comprises a conserved internal protein that is enriched in CD8+ T cell recognition antigens. The effectiveness of the priming and boosting platform is tested in a humanized mouse model comprising a fully functional human immune system.

8. 发明申请

WO2013117028A1 SCHOTTKY BARRIER FIELD EFFECT TRANSISTOR WITH CARBON-CONTAINING INSULATION LAYER AND METHOD FOR FABRICATING THE SAME 审中-公开
标题翻译：具有含碳绝缘层的肖特基栅栏场效应晶体管及其制造方法
公开(公告)号：WO2013117028A1
公开(公告)日：2013-08-15
申请号：PCT/CN2012/072838
申请日：2012-03-22
申请人： TSINGHUA UNIVERSITY , WANG, Wei , WANG, Jing , ZHAO, Mei , LIANG, Renrong
发明人： WANG, Wei , WANG, Jing , ZHAO, Mei , LIANG, Renrong
IPC分类号： H01L29/78 , H01L21/336
CPC分类号： H01L29/66477 , H01L29/0895 , H01L29/66636 , H01L29/66643 , H01L29/78 , H01L29/7839
摘要： A Schottky barrier field effect transistor with a carbon-containing insulation layer and a method for fabricating the same are provided. The Schottky barrier field effect transistor comprises: a substrate (1); a gate stack (2) formed on the substrate (1); a metal source (4) and a metal drain (5) formed in the substrate (1) on both sides of the gate stack (2) respectively; and the carbon-containing insulation layer (3) formed between the substrate (1) and the metal source (4) and between the substrate (1) and the metal drain (5) respectively, in which a material of the carbon-containing insulation layer (3) is organic molecular chains containing an alkyl group.
摘要翻译：提供了具有含碳绝缘层的肖特基势垒场效应晶体管及其制造方法。肖特基势垒场效应晶体管包括：衬底（1）; 形成在所述基板（1）上的栅极叠层（2）; 金属源（4）和形成在所述栅极堆叠（2）的两侧的所述基板（1）中的金属排出口（5）和形成在基板（1）和金属源（4）之间以及基板（1）和金属排出部（5）之间的含碳绝缘层（3），其中含碳绝缘材料层（3）是含有烷基的有机分子链。

9. 发明申请

WO2013056388A1 AN IMPROVED METHOD AND APPARATUS FOR ADAPTIVE MULTI RATE CODEC 审中-公开
标题翻译：一种改进的自适应多速率编解码器的方法和装置
公开(公告)号：WO2013056388A1
公开(公告)日：2013-04-25
申请号：PCT/CN2011/001730
申请日：2011-10-18
申请人： TELEFONAKTIEBOLAGET L M ERICSSON (PUBL) , BRUHN, Stefan , KUANG, Jingming , WANG, Jing , ZHANG, Chunling , ZHAO, Shenghui
发明人： BRUHN, Stefan , KUANG, Jingming , WANG, Jing , ZHANG, Chunling , ZHAO, Shenghui
IPC分类号： G10L19/04
CPC分类号： G10L19/06 , G10L19/07 , G10L25/12
摘要： There is provided an apparatus and method for encoding a speech signal. The encoding comprises: receiving a plurality of current samples of the speech signals; extrapolating a plurality of look-ahead samples from the current samples; and performing linear prediction analysis using the current samples and the extrapolated look-ahead samples.
摘要翻译：提供了一种用于对语音信号进行编码的装置和方法。所述编码包括：接收所述语音信号的多个当前样本; 从当前样本外推多个先行样本; 并使用当前样本和外推先验样本进行线性预测分析。

10. 发明申请

WO2013006478A1 VERTICALLY PHASE-SEPARATING SEMICONDUCTING ORGANIC MATERIAL LAYERS 审中-公开
标题翻译：垂直相分离半导体有机材料层
公开(公告)号：WO2013006478A1
公开(公告)日：2013-01-10
申请号：PCT/US2012/045066
申请日：2012-06-29
申请人： PLEXTRONICS, INC. , BROWN, Christopher T. , CHOPRA, Neetu , SESHADRI, Venkataramanan , WANG, Jing
发明人： BROWN, Christopher T. , CHOPRA, Neetu , SESHADRI, Venkataramanan , WANG, Jing
IPC分类号： C08L65/00 , H01B1/12
CPC分类号： H01L51/0003 , C08G2261/1424 , C08G2261/3162 , C08G2261/3223 , C08G2261/51 , C08K5/18 , C08L65/00 , C08L2205/02 , H01L51/0059 , H01L51/5056 , H01L51/5064 , H01L51/5088 , H01L2251/552 , Y02E10/549
摘要： Improved OLED devices and methods of making the same using vertical phase separation to simplify processing. Vertically phase separated material can include at least one lower first layer disposed on the electrode, and at least one upper second layer different from the first layer and disposed away from the electrode or optionally on one layer comprising at least one semiconducting organic material. The first layer can be enriched with at least one first semiconducting organic material (SOM 1) and the second layer can be enriched with at least one second semiconducting organic material (SOM 2) different from the SOM 1. The ink composition can be adapted so that the film vertically phase separates into the first and second layers. Compositions and devices are also embodied herein.
摘要翻译：改进的OLED器件和使用垂直相分离的方法进行简化处理。垂直相分离的材料可以包括设置在电极上的至少一个下部第一层和与第一层不同的至少一个上部第二层，并且远离电极或者任选地包括至少一个半导体有机材料的一个层。第一层可以富含至少一种第一半导体有机材料（SOM 1），第二层可以富含至少一种与SOM 1不同的第二半导体有机材料（SOM 2）。该油墨组合物可以适应膜垂直相分离成第一层和第二层。组合物和装置也在本文中体现。

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