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1. 发明申请

WO2009142638A1 PROTEIN ASSAY 审中-公开
标题翻译：蛋白质测定
公开(公告)号：WO2009142638A1
公开(公告)日：2009-11-26
申请号：PCT/US2008/064514
申请日：2008-05-22
申请人： ETHICON, INC. , OMRIX BIOPHARMACEUTICALS, INC. , DE ANGLIS, Ashley , MEIDLER, Roberto , GORMAN, Anne , BAR, Liliana , NUR, Israel
发明人： DE ANGLIS, Ashley , MEIDLER, Roberto , GORMAN, Anne , BAR, Liliana , NUR, Israel
IPC分类号： G01N33/86 , C12Q1/56
CPC分类号： C12Q1/56 , G01N33/68 , G01N33/86
摘要： A method is described for the measurement of thrombin activity in the presence of fibrinogen, or for the measurement of the functionality of fibrinogen in the presence of thrombin.
摘要翻译：描述了在纤维蛋白原存在下测量凝血酶活性或在凝血酶存在下测量纤维蛋白原的功能的方法。

2. 发明申请

WO2007117237A1 A REINFORCED ABSORBABLE MULTILAYERED HEMOSTATIC WOUND DRESSING AND METHOD OF MAKING 审中-公开
标题翻译：增强可吸收的多层破裂创伤接头及其制造方法
公开(公告)号：WO2007117237A1
公开(公告)日：2007-10-18
申请号：PCT/US2006/013282
申请日：2006-04-10
申请人： ETHICON, INC. , OMRIX BIOPHARMACEUTICAL, INC. , GORMAN, Anne, Jessica , PENDHARKAR, Sanyog, Manohar , ZHANG, Guanghui , BAR, Liliana , NUR, Israel , MEIDLER, Roberto
发明人： GORMAN, Anne, Jessica , PENDHARKAR, Sanyog, Manohar , ZHANG, Guanghui , BAR, Liliana , NUR, Israel , MEIDLER, Roberto
IPC分类号： A61L15/32 , A61L15/64 , A61F13/15
CPC分类号： A61F13/36 , A61F13/00012 , A61F13/00029 , A61F13/00034 , A61F13/00995 , A61F2013/00106 , A61F2013/00221 , A61F2013/00357 , A61F2013/00463 , A61F2013/00472 , A61F2013/0054 , A61F2013/00604 , A61F2013/00744 , A61F2013/00927 , A61L15/32 , A61L15/64
摘要： The present invention is directed to a reinforced absorbable multilayered hemostatic wound dressing comprising a first absorbable nonwoven fabric, a second absorbable woven or knitted fabric, thrombin and/or fibrinogen, and method of making.
摘要翻译：本发明涉及包含第一可吸收性无纺布，第二可吸收编织物或针织物，凝血酶和/或纤维蛋白原的增强吸收性多层止血敷料及其制造方法。

3. 发明申请

WO2007017859A1 INTRAVENOUS IMMUNOGLOBULIN COMPOSITION 审中-公开
标题翻译：无菌免疫组织化学
公开(公告)号：WO2007017859A1
公开(公告)日：2007-02-15
申请号：PCT/IL2006/000782
申请日：2006-07-06
申请人： OMRIX BIOPHARMACEUTICALS INC. , NUR, Israel , BAR, Liliana , LAUB, Orgad
发明人： NUR, Israel , BAR, Liliana , LAUB, Orgad
IPC分类号： C07K16/08 , A61K39/395 , A61P31/12
CPC分类号： C07K16/081 , A61K38/00 , A61K39/39591 , A61K2039/505 , C07K2319/00
摘要： A method for preparing a concentrated, immunoglobulin composition for treating subjects vaccinated against or infected with a pathogenic microorganism, comprising: (a) selecting a population of individuals previously vaccinated against one or more antigens associated with the pathogenic microorganism; (b) determining the level of specific antibodies immunoreactive with the pathogenic microorganism in a blood or blood component of the individuals to identify very high titre individuals having a very high titre of the specific antibodies; (c) combining blood or blood components comprising immunoglobulins from the very high titre individuals; and (d) purifying and/or concentrating the product of step (c), thereby obtaining a concentrated immunoglobulin composition. Also disclosed is a concentrated immunoglobulin composition comprising specific antibodies immunoreactive with a pathogenic microorganism, characterized in that the titre of specific antibodies of the composition is at least 5 times higher than the average titre of specific antibodies of a population of individuals previously vaccinated against one or more antigens associated with the pathogenic microorganism. The composition has a relatively high protein concentration and a low percentage of protein aggregates, and is therefore suitable for both iv and im administration. In a preferred embodiment, the pathogenic microorganism is smallpox virus or vaccinia virus.
摘要翻译：一种制备用于治疗接种疫苗或感染病原微生物的受试者的浓缩免疫球蛋白组合物的方法，包括：（a）选择先前针对与病原微生物相关的一种或多种抗原接种的个体群体; （b）确定在个体的血液或血液成分中与病原微生物免疫反应的特异性抗体的水平，以鉴定具有非常高的特异性抗体滴度的非常高的滴度个体; （c）从非常高的滴度个体组合包含免疫球蛋白的血液或血液成分; 和（d）纯化和/或浓缩步骤（c）的产物，从而获得浓缩的免疫球蛋白组合物。还公开了包含与病原微生物免疫反应性的特异性抗体的浓缩免疫球蛋白组合物，其特征在于组合物的特异性抗体滴度比先前接种于一种或多种疫苗的个体群体的特异性抗体的平均滴度高至少5倍更多与病原微生物相关的抗原。该组合物具有相对高的蛋白质浓度和低百分比的蛋白质聚集体，因此适用于iv和im施用。在优选的实施方案中，致病微生物是天花病毒或痘苗病毒。

4. 发明申请

WO2012156963A2 IMMUNOGLOBULIN REDUCED IN THROMBOGENIC AGENTS AND PREPARATION THEREOF 审中-公开
标题翻译：免疫球蛋白减少在血液中的代谢物及其制备
公开(公告)号：WO2012156963A2
公开(公告)日：2012-11-22
申请号：PCT/IL2012/000189
申请日：2012-05-14
申请人： OMRIX BIOPHARMACEUTICALS LTD. , MINTZ, Roni , BELYAEV, Oleg , NUR, Israel , BAR, Liliana , MEIDLER, Roberto
发明人： MINTZ, Roni , BELYAEV, Oleg , NUR, Israel , BAR, Liliana , MEIDLER, Roberto
IPC分类号： C07K1/18
CPC分类号： C07K16/065 , A61K39/39591 , A61K2039/505 , C07K1/18 , C07K2317/10 , Y10S530/83 , Y10S530/831
摘要： The invention relates to an immunoglobulin composition reduced in thrombogenic agents and to methods for its preparation. One method comprises subjecting an immunoglobulin containing solution to a negative cation exchanger chromatography at a pH in the range of higher than 3.8 to equal to or lower than 5.3. The solution can also be subjected to a negative anion exchanger chromatography at a pH in the range of 7 to 8.2.
摘要翻译：本发明涉及减少血栓形成剂的免疫球蛋白组合物及其制备方法。一种方法包括在高于3.8至等于或低于5.3的pH范围内使含免疫球蛋白的溶液进行负阳离子交换层析。该溶液也可以在7至8.2范围内的pH下进行阴离子交换层析。

5. 发明申请

WO2013022447A1 TREATMENT OF PERIPHERAL VASCULAR DISEASE USING UMBILICAL CORD TISSUE-DERIVED CELLS 审中-公开
标题翻译：使用脐带组织细胞治疗外周血管疾病
公开(公告)号：WO2013022447A1
公开(公告)日：2013-02-14
申请号：PCT/US2011/047264
申请日：2011-08-10
申请人： ADVANCED TECHNOLOGIES AND REGENERATIVE MEDICINE, LLC , BUENSUCESO, Charito S. , KIHM, Anthony J. , DHANARAJ, Sridevi , ATLAS, Roee , NUR, Israel , MEIDLER, Roberto , BAR, Liliana
发明人： BUENSUCESO, Charito S. , KIHM, Anthony J. , DHANARAJ, Sridevi , ATLAS, Roee , NUR, Israel , MEIDLER, Roberto , BAR, Liliana
IPC分类号： A61K35/44 , A61K38/36 , A61P9/10
CPC分类号： A61K38/36 , A61K35/44
摘要： Compositions and methods of using cells derived from umbilical cord tissue, to stimulate and support angiogenesis, to improve blood flow, to regenerate, repair, and improve skeletal muscle damaged by a peripheral ischemic event, and to protect skeletal muscle from ischemic damage in peripheral vascular disease patients are disclosed. In particular, methods of treating a patient having a peripheral vascular disease with umbilical derived cells and fibrin glue are disclosed.
摘要翻译：使用衍生自脐带组织的细胞刺激和支持血管生成，改善血流量，再生，修复和改善由外周缺血事件损伤的骨骼肌的组合物和方法，以及保护骨骼肌免受外周血管中的缺血性损伤疾病患者被披露。特别地，公开了用脐带血细胞和纤维蛋白胶治疗患有外周血管疾病的患者的方法。

6. 发明申请

WO2013001524A1 METHOD FOR REMOVING A LYTIC ENZYME FROM A HETEROGENEOUS MIXTURE 审中-公开
标题翻译：从异构混合物中除去乳酸酶的方法
公开(公告)号：WO2013001524A1
公开(公告)日：2013-01-03
申请号：PCT/IL2012/000258
申请日：2012-06-26
申请人： OMRIX BIOPHARMACEUTICALS LTD. , MEIDLER, Roberto , RAVER-SHAPIRA, Nina , BAR, Liliana , BELYAEV, Oleg , NUR, Israel
发明人： MEIDLER, Roberto , RAVER-SHAPIRA, Nina , BAR, Liliana , BELYAEV, Oleg , NUR, Israel
IPC分类号： C07K1/22 , C12N9/50 , C12N9/64 , C07K14/81
CPC分类号： C12N9/50 , C07K1/22 , C07K14/81 , C07K14/811 , C12N9/6435 , C12Y304/21007
摘要： The invention relates to purification of an intact, non-degraded macromolecule from a biological mixture comprising the macromolecule in the presence of its lytic enzyme. The method comprises providing the biological mixture as a heterogeneous mixture comprising the lytic enzyme, at least partially, in soluble form and the macromolecule, at least partially, in non-soluble form; batch-wise contacting the heterogeneous mixture with an immobilized inhibitor of the lytic enzyme; increasing the solubility of the macromolecule in the mixture; and removing the immobilized inhibitor from the mixture.
摘要翻译：本发明涉及在其溶解酶存在下从包含大分子的生物混合物中纯化完整的未降解的大分子。该方法包括提供生物混合物作为非均质混合物，其包含溶解酶，至少部分可溶形式和大分子，至少部分为非溶解形式; 将非均相混合物与溶解酶的固定化抑制剂分批接触; 增加大分子在混合物中的溶解度; 并从混合物中除去固定化的抑制剂。

7. 发明申请

WO2009004573A1 KITS, FORMULATIONS AND SOLUTIONS HAVING ENZYMATICALLY-PERMISSIVE AMOUNTS OF VISUALIZATION AGENTS AND USES THEREOF 审中-公开
标题翻译：具有可视化代理商的酶学性质的组合，配方和解决方案及其用途
公开(公告)号：WO2009004573A1
公开(公告)日：2009-01-08
申请号：PCT/IB2008/052636
申请日：2008-07-01
申请人： OMRIX BIOPHARMACEUTICALS LTD. , NUR, Israel , MEIDLER, Roberto , BAR, Liliana
发明人： NUR, Israel , MEIDLER, Roberto , BAR, Liliana
IPC分类号： A61L24/10 , A61L31/04 , A61L24/04
CPC分类号： A61L24/106 , A61L24/043 , A61L24/108 , A61L31/046 , C08L89/00
摘要： The invention relates to a proteolytic enzyme which is capable of forming fibrin when it reacts with fibrinogen, a fibrin-glue kit and a fibrin-glue formulation comprising an enzymatically-permissive concentration of a visualization agent and to their use in methods for prevention and/or reduction of adhesions and/or methods for promotion of blood coagulation sealing or filling body surfaces.
摘要翻译：本发明涉及当与纤维蛋白原反应时能够形成纤维蛋白的蛋白水解酶，纤维蛋白胶试剂盒和包含酶允许浓度的可视化试剂的纤维蛋白胶制剂，以及它们在预防和/ 或减少用于促进血液凝固密封或填充体表面的粘合和/或方法。

8. 发明申请

WO2006044882A2 A REINFORCED ABSORBABLE MULTILAYERED HEMOSTATIC WOUND DRESSING AND METHOD OF MAKING 审中-公开
标题翻译：增强型可吸收多层静脉伤口敷料及其制备方法
公开(公告)号：WO2006044882A2
公开(公告)日：2006-04-27
申请号：PCT/US2005/037407
申请日：2005-10-17
申请人： ETHICON, INC. , OMRIX BIOPHARMACEUTICAL, INC. , GORMAN, Anne Jessica , PENDHARKAR, Sanyog Manohar , ZHANG, Guanghui , BAR, Lillian , NUR, Israel , LAUB, Orgad
发明人： GORMAN, Anne Jessica , PENDHARKAR, Sanyog Manohar , ZHANG, Guanghui , BAR, Lillian , NUR, Israel , LAUB, Orgad
IPC分类号： A61L15/32 , A61L15/64
CPC分类号： A61L15/26 , A61F13/00029 , A61L15/28 , A61L15/32 , A61L15/44 , A61L15/64 , A61L2300/418 , A61L2300/608 , A61L2400/04 , B32B5/022 , B32B5/024 , B32B5/026 , B32B5/26 , B32B23/02 , B32B23/10 , B32B27/36 , B32B2250/20 , B32B2262/0276 , B32B2262/04 , B32B2262/06 , B32B2262/062 , B32B2307/726 , B32B2556/00 , Y10T442/2525 , C08L67/04
摘要： The present invention is directed to a reinforced absorbable multilayered hemostatic wound dressing comprising a first absorbable nonwoven fabric, a second absorbable woven or knitted fabric, thrombin and fibrinogen, and method of making.
摘要翻译：本发明涉及一种增强的可吸收多层止血伤口敷料，其包含第一可吸收非织造织物，第二可吸收机织或针织织物，凝血酶和纤维蛋白原以及制备方法。

9. 发明申请

WO2003099868A3 METHOD FOR OBTAINING ANTI-IDIOTYPE ANTIBODIES 审中-公开
公开(公告)号：WO2003099868A3
公开(公告)日：2003-12-04
申请号：PCT/IL2003/000424
申请日：2003-05-22
申请人： OMRIX BIOPHARMACEUTICALS INC. , NUR, Israel , SHOENFELD, Yehuda
发明人： NUR, Israel , SHOENFELD, Yehuda
IPC分类号： C07K16/42
摘要： A method for identifying molecules which mimic an idiotype of an autoimmune disease-associated auto-antibody (autoantibodies). The method comprises the following steps: (a) purifying autoantibodies from sera of one or more patients afflicted with the autoimmune disease; (b) binding the autoantibodies to a solid phase to form an affinity matrix; (c) contacting pooled plasma or B cells comprising immunoglobulins with the affinity matrix followed by removal of unbound plasma components; (d) eluting bound immunoglobulins, being anti-Idiotypic antibodies (anti-Id) to autoantibodies, from the matrix; (e) providing a molecular library comprising a plurality of molecule members; and (e) contacting the anti-Id with the molecular library and isolating those bound molecules which are bound by the anti-Id, the bound molecules being molecules which mimic an idiotype of autoantibodies. Also disclosed are such molecules.

10. 发明申请

WO2008001353A1 VIRUS REMOVAL BY NANOFILTRATION 审中-公开
标题翻译：病毒除去
公开(公告)号：WO2008001353A1
公开(公告)日：2008-01-03
申请号：PCT/IL2007/000764
申请日：2007-06-25
申请人： OMRIX BIOPHARMACEUTICALS INC. , MINTZ, Roni , NUR, Israel
发明人： NUR, Israel
IPC分类号： C07K1/34 , A61L2/00
CPC分类号： C07K1/34 , A61L2/0017 , B01D61/027 , B01D2315/08 , B01D2315/10
摘要： A method for purifying a protein solution from infective particles comprising (a) adding a macromolecule to the solution; and (b) passing the solution through a nanofilter. The macromolecule may be selected from a polymer of at least 3 monomers of sugars, amino acids, glycols, alcohols, lipids or phospholipids.
摘要翻译：一种从感染性颗粒中纯化蛋白质溶液的方法，包括（a）向溶液中加入大分子; 和（b）使溶液通过纳米过滤器。大分子可以选自糖，氨基酸，二醇，醇，脂质或磷脂中的至少3种单体的聚合物。

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