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1. 发明申请

WO1997032893A1 PURIFICATION METHOD 审中-公开
标题翻译：净化方法
公开(公告)号：WO1997032893A1
公开(公告)日：1997-09-12
申请号：PCT/GB1997000642
申请日：1997-03-07
申请人： NATIONAL BLOOD AUTHORITY , MORE, John, Edward , ROTT, Jacqueline , LEWIN, David, Roger
发明人： NATIONAL BLOOD AUTHORITY
IPC分类号： C07K01/20
CPC分类号： C07K14/473 , A61K38/00 , Y10S530/829 , Y10S530/831
摘要： The invention relates to a method of removing endotoxin from preparation of alpha-1-acid glycoprotein (orosomucoid) by contact with a finely divided non-toxic resin such as fumed silica. The invention also relates to a purification process for alpha-1-acid glycoprotein which includes this depyrogenation step, and to the depyrogenated product and its clinical uses.
摘要翻译：本发明涉及通过与细碎的无毒树脂如热解法二氧化硅接触来除去内毒素从制备α-1-酸糖蛋白（orosomucoid）的方法。本发明还涉及包括该去除热解步骤的α-1-酸糖蛋白的纯化方法，以及该脱氢产物及其临床应用。

2. 发明申请

WO1996015150A1 PROCESS FOR PURIFYING FACTOR VIII 审中-公开
标题翻译：净化因子八
公开(公告)号：WO1996015150A1
公开(公告)日：1996-05-23
申请号：PCT/SE1995001351
申请日：1995-11-14
申请人： PHARMACIA AB , ALMSTEDT, Annelie , SANDBERG, Helena , SMEDS, Anna-Lisa , WRANGEL, Maria , ÖSTLIN, Anna
发明人： PHARMACIA AB
IPC分类号： C07K14/755
CPC分类号： C07K14/755 , Y10S530/83 , Y10S530/831
摘要： Proteases generally tend to reduce the activity of coagulation factor VIII by degrading the molecule. The present invention relates to a process for reducing the detrimental influence of metal-dependent proteases upon recombinant factor VIII molecules, by adding an inhibitor of metal-dependent proteases to a solution after harvest. The solution is suitably the harvest solution or any aqueous solution being fed to or leaving the primary isolation, being the initial step of the purifying sequence. The inhibitor is selected from: i) complexing agents with a stronger affinity for the metal ion of the protease than for the ion or ions stabilizing the factor VIII molecule and ii) compounds structurally related to the natural substrate of the protease and containing an electronegative moiety. The presence of an inhibitor, preferably a complexing agent, after harvest allows for a prolonged harvest period and considerably higher yield with essentially retained factor VIII activity. The invention further relates to an aqueous solution containing recombinant factor VIII which has been purified according to the present process and use of such an aqueous solution, for the manufacture of a medicament for administration to a patient having the symptoms of hemophilia. Also, the invention relates to a method for treatment of hemophilia by administration of a therapeutically effective amount of recombinant factor VIII which has been purified according to the present process.
摘要翻译：蛋白酶通常倾向于通过降解分子来降低凝血因子VIII的活性。本发明涉及通过在收获后向溶液中加入金属依赖性蛋白酶抑制剂来减少金属依赖性蛋白酶对重组因子VIII分子的不利影响的方法。该溶液适当地是收集溶液或被加入或离开初级分离的任何水溶液，作为纯化序列的初始步骤。抑制剂选自：i）对蛋白质的金属离子具有更强的亲和力的络合剂，而不是稳定因子VIII分子的离子或离子，和ii）结构上与蛋白酶天然底物相关并含有电负性部分的化合物。在收获之后抑制剂，优选络合剂的存在允许延长的收获期和相当高的产率，基本保留因子VIII活性。本发明还涉及含有根据本发明方法纯化的重组因子VIII的水溶液和这种水溶液的用途，用于制备用于给患有血友病症状的患者施用的药物。此外，本发明还涉及通过给予治疗有效量的根据本方法纯化的重组因子VIII治疗血友病的方法。

3. 发明申请

WO2011061705A1 PROCEDE DE TRAITEMENT DU PLASMA SANGUIN COMPRENANT UNE ETAPE DE LAVAGE PAR DISPERSION 审中-公开
标题翻译：用于通过分散方法处理血液等离子体洗涤步骤的方法
公开(公告)号：WO2011061705A1
公开(公告)日：2011-05-26
申请号：PCT/IB2010/055263
申请日：2010-11-18
申请人： LFB BIOMEDICAMENTS , TRUSGNICH, Thierry
发明人： TRUSGNICH, Thierry
IPC分类号： C07K1/36 , C07K14/745 , C07K14/75
CPC分类号： A61K35/16 , A61M1/36 , B01F3/00 , B01F7/008 , C07K1/36 , Y10S530/83 , Y10S530/831
摘要： La présente invention concerne un procédé de traitement du plasma sanguin comprenant les étapes de précipitation éthanolique du plasma ou d'une fraction de plasma, de récupération du précipité, de lavage dudit précipité, de récupération d'une pâte plasmatique lavée, de solubilisation de ladite pâte plasmatique lavée.
摘要翻译：本发明涉及一种治疗血浆的方法，包括以下步骤：血浆或一部分血浆的乙醇沉淀，回收沉淀物，洗涤所述沉淀物，回收洗涤的浆液，以及使所洗涤的浆液可溶。

4. 发明申请

WO1980002426A1 PROTHROMBIN COMPLEX CONCENTRATES,PREPARATION AND APPLICATION THEREOF 审中-公开
标题翻译：丙泊酚复合浓缩物，其制备和应用
公开(公告)号：WO1980002426A1
公开(公告)日：1980-11-13
申请号：PCT/FR1980000069
申请日：1980-05-05
申请人： MERIEUX INST , LIAUTAUD J , SHANBROM E , CHANAS M , PLA J
发明人： MERIEUX INST
IPC分类号： C07G17/00
CPC分类号： C12N9/6429 , A61K38/00 , C12Y304/21005 , Y10S514/822 , Y10S530/831
摘要： A process for preparing a prothrombin complex concentrate is disclosed. The process, wherein, starting from a prothrombin complex source, an absorption is followed by an elution, is characterized by the fact that a prothrombin complex source is brought in contact with an antithrombin source (III) (or ATIII) with an absorbing agent capable of absorbing both the prothrombin complex and the antithrombin (III), that is carried out, at least during the elution phase, in the presence of heparin, and in that the elution is effected with an elution agent capable of eluting the prothrombin complex, the AT(III) and the heparin. Application of this product particularly to the treatment of the deficiencies of blood coagulation.
摘要翻译：公开了一种制备凝血酶原复合物浓缩物的方法。该方法，其中从凝血酶原复合物源开始，吸收之后是洗脱，其特征在于凝血酶原复合物来源与具有吸收剂能力的抗凝血酶源（III）（或ATIII）接触的事实吸收凝血酶原复合物和抗凝血酶（III），至少在洗脱阶段期间，在肝素存在下进行，并且用洗脱剂进行洗脱，其能够洗脱凝血酶原复合物， AT（III）和肝素。本产品特别适用于治疗血液凝固缺陷。

5. 发明申请

WO2012156963A3 IMMUNOGLOBULIN REDUCED IN THROMBOGENIC AGENTS AND PREPARATION THEREOF 审中-公开
标题翻译：免疫球蛋白减少在血液中的代谢物及其制备
公开(公告)号：WO2012156963A3
公开(公告)日：2013-05-02
申请号：PCT/IL2012000189
申请日：2012-05-14
申请人： OMRIX BIOPHARMACEUTICALS LTD , MINTZ RONI , BELYAEV OLEG , NUR ISRAEL , BAR LILIANA , MEIDLER ROBERTO
发明人： MINTZ RONI , BELYAEV OLEG , NUR ISRAEL , BAR LILIANA , MEIDLER ROBERTO
IPC分类号： C07K1/18 , C07K16/06
CPC分类号： C07K16/065 , A61K39/39591 , A61K2039/505 , C07K1/18 , C07K2317/10 , Y10S530/83 , Y10S530/831
摘要： The invention relates to an immunoglobulin composition reduced in thrombogenic agents and to methods for its preparation. One method comprises subjecting an immunoglobulin containing solution to a negative cation exchanger chromatography at a pH in the range of higher than 3.8 to equal to or lower than 5.3. The solution can also be subjected to a negative anion exchanger chromatography at a pH in the range of 7 to 8.2.
摘要翻译：本发明涉及减少血栓形成剂的免疫球蛋白组合物及其制备方法。一种方法包括在高于3.8至等于或低于5.3的范围内使含有免疫球蛋白的溶液进行负阳离子交换层析。该溶液也可以在7至8.2范围内的pH下进行阴离子交换层析。

6. 发明申请

WO2012156963A2 IMMUNOGLOBULIN REDUCED IN THROMBOGENIC AGENTS AND PREPARATION THEREOF 审中-公开
标题翻译：免疫球蛋白减少在血液中的代谢物及其制备
公开(公告)号：WO2012156963A2
公开(公告)日：2012-11-22
申请号：PCT/IL2012/000189
申请日：2012-05-14
申请人： OMRIX BIOPHARMACEUTICALS LTD. , MINTZ, Roni , BELYAEV, Oleg , NUR, Israel , BAR, Liliana , MEIDLER, Roberto
发明人： MINTZ, Roni , BELYAEV, Oleg , NUR, Israel , BAR, Liliana , MEIDLER, Roberto
IPC分类号： C07K1/18
CPC分类号： C07K16/065 , A61K39/39591 , A61K2039/505 , C07K1/18 , C07K2317/10 , Y10S530/83 , Y10S530/831
摘要： The invention relates to an immunoglobulin composition reduced in thrombogenic agents and to methods for its preparation. One method comprises subjecting an immunoglobulin containing solution to a negative cation exchanger chromatography at a pH in the range of higher than 3.8 to equal to or lower than 5.3. The solution can also be subjected to a negative anion exchanger chromatography at a pH in the range of 7 to 8.2.
摘要翻译：本发明涉及减少血栓形成剂的免疫球蛋白组合物及其制备方法。一种方法包括在高于3.8至等于或低于5.3的pH范围内使含免疫球蛋白的溶液进行负阳离子交换层析。该溶液也可以在7至8.2范围内的pH下进行阴离子交换层析。

7. 发明申请

WO99031138A1 METHOD FOR PREPARING BY FILTRATION A VIRALLY SECURE FACTOR VIII SOLUTION 审中-公开
标题翻译：通过过滤制备一种虚拟安全因子VIII解决方案
公开(公告)号：WO99031138A1
公开(公告)日：1999-06-24
申请号：PCT/FR1998/002715
申请日：1998-12-14
IPC分类号： A61K38/22 , A61K35/16 , A61K38/00 , A61K38/43 , A61P7/04 , C07K1/34 , C07K14/755 , A61K38/37
CPC分类号： C07K14/755 , A61K38/00 , Y10S530/83 , Y10S530/831
摘要： The invention concerns a method for preparing by filtration a virally secure factor VIII solution and essentially free of high molecular weight vWF which consists in: preparing a solution containing high or very high purity factor VIII or essentially free of complexes with VIII-vWf factor high molecular weight; optionally carrying out a step (a) if required, of chemical breakdown of the complexes with VIII-vWF factor high molecular weight and obtaining a solution essentially free of factor VIII associated with high molecular weight vWF; carrying out a step (b) filtering said solution essentially free of factor VIII associated with high molecular weight vWF on a hydrophilic filter with porosity as low as 15 nm.
摘要翻译：本发明涉及通过过滤制备病毒安全因子VIII溶液并基本上不含高分子量vWF的方法，该方法包括：制备含有高或非常高纯度因子VIII或基本上不含VIII-vWf因子高分子的复合物的溶液重量; 任选地，如果需要，用VIII-vWF因子高分子量进行复合物化学分解的步骤（a），并获得基本上不含与高分子量vWF相关的因子VIII的溶液; 进行步骤（b）将基本上不含高分子量vWF的因子VIII的所述溶液过滤到具有低至15nm的孔隙率的亲水性过滤器上。

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