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1. 发明申请

WO2022064478A1 HEMOSTATIC FORMULATIONS AND USES THEREOF 审中-公开
公开(公告)号：WO2022064478A1
公开(公告)日：2022-03-31
申请号：PCT/IL2021/051112
申请日：2021-09-13
申请人： OMRIX BIOPHARMACEUTICALS LTD.
发明人： NUR, Israel , MINTZ, Roni , VISNOVEZKY, Damian , YUNUSOV, Marina , LESHETS, Michael
IPC分类号： A61K9/00 , A61K9/08 , A61K9/19 , A61K38/00 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/26 , A61P7/00 , A61K47/42
摘要： Disclosed herein are formulations comprised of concentrated Factor V, vitamin Independent clotting protein and a stabilizer, wherein the stabilizer is at a concentration at which the Factor V or the vitamin K-dependent clotting protein are in the zymogen form. Also disclosed herein are processes for the preparation of the formulations.

2. 发明申请

WO2018116287A1 HEMOSTATIC COMPOSITION COMPRISING AN ANION EXCHANGER AND A CALCIUM SALT 审中-公开
公开(公告)号：WO2018116287A1
公开(公告)日：2018-06-28
申请号：PCT/IL2017/000009
申请日：2017-12-13
申请人： OMRIX BIOPHARMACEUTICALS LTD.
发明人： AUERBACH-NEVO, Tamar , NEGREANU-GILBOA, Tali , ALPERIN, Hadas , NUR, Israel
IPC分类号： A61K33/06 , A61K31/13 , A61L26/00 , A61P7/04
CPC分类号： A61K31/721 , A61K33/06 , A61K33/14 , A61L15/18 , A61L26/0004 , A61L2300/208 , A61L2300/418 , A61L2400/04 , A61P7/04 , A61K2300/00
摘要： Provided are compositions comprising an anion exchanger and a calcium salt for use as a medicament for inducing hemostasis at a site of bleeding; and methods of preparation thereof.

3. 发明申请

WO2016079727A1 SPRAY-DRYING APPARATUS AND METHOD OF USE 审中-公开
标题翻译：喷雾干燥装置及其使用方法
公开(公告)号：WO2016079727A1
公开(公告)日：2016-05-26
申请号：PCT/IL2015/000048
申请日：2015-11-17
申请人： OMRIX BIOPHARMACEUTICALS Ltd.
发明人： ILAN, Eres , GERSHONOVITCH, Assaf , GURMAN, Yotam
IPC分类号： B01J2/04
CPC分类号： B01J2/04
摘要： Provided is a spray drying apparatus comprising a spray nozzle comprising a spray nozzle tip at the distal end of the spray nozzle, a liquid conduit for guiding a liquid to be spray-dried out through the spray nozzle tip, an atomizing component for producing a spray of droplets from the liquid exiting the spray nozzle; a drying gas conduit comprising an outlet for directing a drying gas to dry the spray of droplets; and a drying gas deflector positioned so as to deflect a flow of the drying gas away from the spray nozzle tip.
摘要翻译：提供了一种喷雾干燥装置，其包括喷嘴，该喷嘴包括在喷嘴的远端处的喷嘴尖端，用于引导通过喷嘴头喷雾干燥的液体的液体导管，用于产生喷雾的雾化部件来自离开喷嘴的液体的液滴; 干燥气体管道，其包括用于引导干燥气体干燥液滴喷雾的出口; 以及干燥气体偏转器，其定位成使干燥气体的流动偏离喷嘴尖端。

4. 发明申请

WO2015128858A1 PLASMA-SUPPLEMENTED FORMULATION 审中-公开
标题翻译：等离子体补充配方
公开(公告)号：WO2015128858A1
公开(公告)日：2015-09-03
申请号：PCT/IL2015/000010
申请日：2015-02-25
申请人： OMRIX BIOPHARMACEUTICALS LTD.
发明人： MEIDLER, Roberto , GRIMBERG, Elena , BELYAEV, Oleg , TIBERMAN, Yonit , NUR, Israel , AUERBACH-NEVO, Tamar
IPC分类号： C07K14/75 , A61L24/10
CPC分类号： A61K35/16 , A61K38/363 , A61K38/4833 , A61L24/0005 , A61L24/10 , A61L24/106 , C07K14/75 , C12Y304/21005 , A61K2300/00
摘要： Provided herein is a plasma-supplemented fibrinogen and/or fibrin formulation, method for the preparation and use thereof.
摘要翻译：本文提供了血浆补充的纤维蛋白原和/或纤维蛋白制剂，其制备和使用方法。

5. 发明申请

WO2015079433A1 DRY PAD COMPRISING THROMBIN AND PECTIN 审中-公开
标题翻译：干燥包装硫蛋白和皮质
公开(公告)号：WO2015079433A1
公开(公告)日：2015-06-04
申请号：PCT/IL2014/000055
申请日：2014-10-21
申请人： OMRIX BIOPHARMACEUTICALS LTD.
发明人： ILAN, Erez , GURMAN, Yotam , EAVRI, Ronen , DEKEL, Elya
IPC分类号： A61L15/28 , A61L15/44
CPC分类号： A61L15/44 , A61L15/28 , A61L15/38 , A61L2300/418 , C08L5/06
摘要： The present invention is directed to a dry pad comprising pectin, a divalent cation and thrombin and to its preparation. Preferably, the density of pectin in the dry pad of the invention ranges from about equal to or higher than 1 % to lower than 7% (w/v). The pad according to the invention comprises pectin having a low methoxyl content.
摘要翻译：本发明涉及一种包含果胶，二价阳离子和凝血酶的干垫及其制备方法。优选地，本发明的干垫中果胶的密度在约等于或高于1％至低于7％（w / v）的范围内。根据本发明的垫包含具有低甲氧基含量的果胶。

6. 发明申请

WO2014016819A1 DEVICE AND METHOD FOR THE APPLICATION OF A CURABLE FLUID COMPOSITION TO A BODILY ORGAN 审中-公开
标题翻译：将可固化的流体组合物应用于机体的装置和方法
公开(公告)号：WO2014016819A1
公开(公告)日：2014-01-30
申请号：PCT/IL2013/000060
申请日：2013-07-21
申请人： OMRIX BIOPHARMACEUTICALS LTD.
发明人： ILAN, Erez , GURMAN, Yotam , MERON, Moti
IPC分类号： A61B17/00 , A61B17/11
CPC分类号： A61B17/00491 , A61B17/1114 , A61B2017/00004 , A61B2017/00495 , A61B2017/00862 , A61B2017/00884 , A61B2017/00893
摘要： The invention relates to a device (10,40) suitable for application of a curable fluid composition to encircle a bodily organ. The device comprises a monolithic piece of a flexible material (12) having a length dimension with an inner surface (18) and an outer surface (20), a first end (22) and a second end (24), a width dimension, and two spaced-apart sides (26a, 26b), wherein a portion of the length dimension proximal to the first end is configured to contact a portion of the length dimension proximal to the second end, the inner surface defining a hollow area (31) between the two spaced-apart sides; and at least one inlet (28) providing fluid communication between the outer surface and the inner surface, for introduction of the fluid into the hollow area. The device deployable around the bodily organ such that when the portion of the length dimension proximal to the first end contacts the portion of the length dimension proximal to the second end, an outer surface of the bodily organ and the hollowed area define an enclosed volume encircling the bodily organ, the enclosed volume suitable for containing the fluid therein.
摘要翻译：本发明涉及适于施加可固化流体组合物以环绕身体器官的装置（10,40）。该装置包括具有内表面（18）和外表面（20）的长度尺寸的柔性材料（12）的整体件，第一端（22）和第二端（24），宽度尺寸，和两个间隔开的侧面（26a，26b），其中，所述长度尺寸近似于所述第一端的部分构造成接近所述长度尺寸的靠近所述第二端的部分，所述内表面限定中空区域（31）在两个间隔开的边之间; 以及至少一个入口（28），其在所述外表面和所述内表面之间提供流体连通，用于将所述流体引入所述中空区域。所述装置可围绕所述身体器官展开，使得当所述长度尺寸靠近所述第一端部的部分接近所述长度尺寸的靠近所述第二端的部分时，所述身体器官的外表面和所述中空区域限定围绕身体器官，适合于在其中容纳流体的封闭体积。

7. 发明申请

WO2013098806A1 SYSTEM FOR DELIVERY OF FLUIDS AND USE THEREOF 审中-公开
标题翻译：流体输送系统及其应用
公开(公告)号：WO2013098806A1
公开(公告)日：2013-07-04
申请号：PCT/IL2012/000395
申请日：2012-12-20
申请人： OMRIX BIOPHARMACEUTICALS LTD. , MERON, Moti
发明人： MERON, Moti
IPC分类号： A61M5/19 , A61B17/00 , A61M5/315
CPC分类号： A61B17/00491 , A61B2017/00495 , A61M5/19 , A61M5/31511
摘要： Embodiments of the invention relate to a multi-syringe device where a coupling element causes a plurality of plungers to slide in unison within their respective barrels to simultaneously dispense fluids therefrom. At least one of the plungers is a variable- length plunger that is selectively engagable to the coupling element.
摘要翻译：本发明的实施例涉及一种多注射器装置，其中联接元件使多个柱塞在它们各自的桶内同时滑动以同时从其中分配流体。柱塞中的至少一个是可选择性地与耦合元件接合的可变长度的柱塞。

8. 发明申请

WO2012168933A3 DEVICE FOR SPRAYING AND/OR MIXING FLUIDS IN PROXIMITY TO A SURFACE 审中-公开
标题翻译：用于将表面喷洒和/或混合流体的装置
公开(公告)号：WO2012168933A3
公开(公告)日：2013-03-28
申请号：PCT/IL2012000217
申请日：2012-05-31
申请人： OMRIX BIOPHARMACEUTICALS LTD , MERON MOTI , ATLAS ROEE , GERSHONOVITCH ASSAF , GANTZ AMATZIA , GOODMAN JOHN
发明人： MERON MOTI , ATLAS ROEE , GERSHONOVITCH ASSAF , GANTZ AMATZIA , GOODMAN JOHN
IPC分类号： B05B7/08 , A61B17/00 , A61M11/02 , A61M35/00 , B01F5/02 , B01F13/00 , B05B7/06 , B05B7/24
CPC分类号： B05B7/2472 , A61B17/00491 , A61B2017/00495 , A61B2017/00522 , A61M11/00 , A61M11/007 , A61M11/02 , A61M15/0003 , A61M35/003 , B01F5/0262 , B01F13/0023 , B05B7/061 , B05B7/08
摘要： The invention relates to an applicator tip (9) for spraying and/or mixing at least two fluids that react together, the tip comprising: at least two fluid conduits (11, 12) for carrying the at least two fluids, each conduit having at least one outlet opening (22, 23), the openings (22, 23) are positioned substantially on a same plane (28); at least two gas conduits (10a, 10b)for carrying a gas volume, each gas conduit (10a, 10b) comprises a proximal gas tube (24) and a distal gas tube (25), each distal gas tube (25) is bent as compared to the position of the proximal gas tube (24), and each distal gas tube (25) has one gas opening (13, 13') positioned distal from the plane (28) of the outlet openings (22, 23); and a housing (26) for accommodating the at least two fluid conduits (11, 12) and the at least two gas conduits (10a, 10b). The device allows efficient spraying in close proximity to a surface.
摘要翻译：本发明涉及一种用于喷射和/或混合至少两种反应在一起的流体的施用器尖端（9），所述尖端包括：用于承载至少两种流体的至少两个流体导管（11,12），每个导管具有至少一个出口开口（22,23），所述开口（22,23）基本上位于相同的平面（28）上; 至少两个用于承载气体体积的气体导管（10a，10b），每个气体导管（10a，10b）包括近端气体管（24）和远端气体管（25），每个远端气体管（25）被弯曲与近端气体管（24）的位置相比，每个远端气体管（25）具有位于远离出口（22,23）的平面（28）的一个气体开口（13,13'）; 以及用于容纳所述至少两个流体导管（11,12）和所述至少两个气体导管（10a，10b）的壳体（26）。该装置允许在表面附近有效地喷涂。

9. 发明申请

WO2013001524A1 METHOD FOR REMOVING A LYTIC ENZYME FROM A HETEROGENEOUS MIXTURE 审中-公开
标题翻译：从异构混合物中除去乳酸酶的方法
公开(公告)号：WO2013001524A1
公开(公告)日：2013-01-03
申请号：PCT/IL2012/000258
申请日：2012-06-26
申请人： OMRIX BIOPHARMACEUTICALS LTD. , MEIDLER, Roberto , RAVER-SHAPIRA, Nina , BAR, Liliana , BELYAEV, Oleg , NUR, Israel
发明人： MEIDLER, Roberto , RAVER-SHAPIRA, Nina , BAR, Liliana , BELYAEV, Oleg , NUR, Israel
IPC分类号： C07K1/22 , C12N9/50 , C12N9/64 , C07K14/81
CPC分类号： C12N9/50 , C07K1/22 , C07K14/81 , C07K14/811 , C12N9/6435 , C12Y304/21007
摘要： The invention relates to purification of an intact, non-degraded macromolecule from a biological mixture comprising the macromolecule in the presence of its lytic enzyme. The method comprises providing the biological mixture as a heterogeneous mixture comprising the lytic enzyme, at least partially, in soluble form and the macromolecule, at least partially, in non-soluble form; batch-wise contacting the heterogeneous mixture with an immobilized inhibitor of the lytic enzyme; increasing the solubility of the macromolecule in the mixture; and removing the immobilized inhibitor from the mixture.
摘要翻译：本发明涉及在其溶解酶存在下从包含大分子的生物混合物中纯化完整的未降解的大分子。该方法包括提供生物混合物作为非均质混合物，其包含溶解酶，至少部分可溶形式和大分子，至少部分为非溶解形式; 将非均相混合物与溶解酶的固定化抑制剂分批接触; 增加大分子在混合物中的溶解度; 并从混合物中除去固定化的抑制剂。

10. 发明申请

WO2012077097A1 IMMUNOASSAY FOR THROMBIN DETECTION 审中-公开
标题翻译：免疫检测用于血栓检测
公开(公告)号：WO2012077097A1
公开(公告)日：2012-06-14
申请号：PCT/IL2011/000911
申请日：2011-11-30
申请人： OMRIX BIOPHARMACEUTICALS LTD. , MINTZ, Roni , ORR, Nadav , NUR, Israël
发明人： MINTZ, Roni , ORR, Nadav , NUR, Israël
IPC分类号： G01N33/86
CPC分类号： G01N33/573 , C07K16/36 , G01N33/86 , G01N2333/8128 , G01N2333/815 , G01N2333/974
摘要： The invention relates to an in vitro immunoassay for quantifying thrombin in a sample comprising anti-thrombin III (AT-III) and thrombin. The method comprises the following steps: contacting the sample with a small molecule that recognizes the substrate binding site of thrombin; contacting the thrombin with a thrombin specific antibody raised against a thrombin blocked in the active site; and measuring the level of bound antibody.
摘要翻译：本发明涉及在含有抗凝血酶III（AT-III）和凝血酶的样品中定量凝血酶的体外免疫测定。该方法包括以下步骤：使样品与识别凝血酶底物结合位点的小分子接触; 使凝血酶与在活性部位阻断的凝血酶产生的凝血酶特异性抗体接触; 并测量结合抗体的水平。

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