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1. 发明申请

WO2009005870A2 PRODUCTS FOR PROPHYLAXIS AND/OR TREATMENT OF VIRAL DISEASES AND METHOD OF MAKING AND USING SAME 审中-公开
标题翻译：预防和/或治疗病毒性疾病的产品及其制造和使用方法
公开(公告)号：WO2009005870A2
公开(公告)日：2009-01-08
申请号：PCT/US2008/059891
申请日：2008-04-10
申请人： OMRIX BIOPHARMACEUTICALS LTD, , GERAGHTY, Erin , LAUB, Orgad , NUR, Isreal , ORR, Nadav
发明人： LAUB, Orgad , NUR, Isreal , ORR, Nadav
IPC分类号： C07K16/10 , A61P31/14 , A61K39/42 , G01N33/569 , C07K14/18
CPC分类号： C07K16/06 , A61K39/395 , A61K2039/505 , C07K16/10 , C07K2317/21 , C07K2317/76 , Y02A50/394
摘要： The invention relates to an immunoglobulin composition suitable for prophylaxis and/or treatment of a viral mediated disease, disorder or condition and to methods of its preparation. In one embodiment, the invention provides a potent intravenous immunoglobulin composition useful for the treatment or prevention of a West Nile virus mediated disease, disorder or condition.
摘要翻译：本发明涉及适用于预防和/或治疗病毒介导的疾病，病症或病症的免疫球蛋白组合物及其制备方法。在一个实施方案中，本发明提供了用于治疗或预防西尼罗河病毒介导的疾病，病症或病症的有效静脉内免疫球蛋白组合物。

2. 发明申请

WO2006044882A2 A REINFORCED ABSORBABLE MULTILAYERED HEMOSTATIC WOUND DRESSING AND METHOD OF MAKING 审中-公开
标题翻译：增强型可吸收多层静脉伤口敷料及其制备方法
公开(公告)号：WO2006044882A2
公开(公告)日：2006-04-27
申请号：PCT/US2005/037407
申请日：2005-10-17
申请人： ETHICON, INC. , OMRIX BIOPHARMACEUTICAL, INC. , GORMAN, Anne Jessica , PENDHARKAR, Sanyog Manohar , ZHANG, Guanghui , BAR, Lillian , NUR, Israel , LAUB, Orgad
发明人： GORMAN, Anne Jessica , PENDHARKAR, Sanyog Manohar , ZHANG, Guanghui , BAR, Lillian , NUR, Israel , LAUB, Orgad
IPC分类号： A61L15/32 , A61L15/64
CPC分类号： A61L15/26 , A61F13/00029 , A61L15/28 , A61L15/32 , A61L15/44 , A61L15/64 , A61L2300/418 , A61L2300/608 , A61L2400/04 , B32B5/022 , B32B5/024 , B32B5/026 , B32B5/26 , B32B23/02 , B32B23/10 , B32B27/36 , B32B2250/20 , B32B2262/0276 , B32B2262/04 , B32B2262/06 , B32B2262/062 , B32B2307/726 , B32B2556/00 , Y10T442/2525 , C08L67/04
摘要： The present invention is directed to a reinforced absorbable multilayered hemostatic wound dressing comprising a first absorbable nonwoven fabric, a second absorbable woven or knitted fabric, thrombin and fibrinogen, and method of making.
摘要翻译：本发明涉及一种增强的可吸收多层止血伤口敷料，其包含第一可吸收非织造织物，第二可吸收机织或针织织物，凝血酶和纤维蛋白原以及制备方法。

3. 发明申请

WO2006044882A3 A REINFORCED ABSORBABLE MULTILAYERED HEMOSTATIC WOUND DRESSING AND METHOD OF MAKING 审中-公开
标题翻译：增强可吸收的多层破裂创伤接头及其制造方法
公开(公告)号：WO2006044882A3
公开(公告)日：2006-09-08
申请号：PCT/US2005037407
申请日：2005-10-17
申请人： ETHICON INC , OMRIX BIOPHARMACEUTICAL INC , GORMAN ANNE JESSICA , PENDHARKAR SANYOG MANOHAR , ZHANG GUANGHUI , BAR LILLIAN , NUR ISRAEL , LAUB ORGAD
发明人： GORMAN ANNE JESSICA , PENDHARKAR SANYOG MANOHAR , ZHANG GUANGHUI , BAR LILLIAN , NUR ISRAEL , LAUB ORGAD
IPC分类号： A61L15/32 , A61L15/64
CPC分类号： A61L15/26 , A61F13/00029 , A61L15/28 , A61L15/32 , A61L15/44 , A61L15/64 , A61L2300/418 , A61L2300/608 , A61L2400/04 , B32B5/022 , B32B5/024 , B32B5/026 , B32B5/26 , B32B23/02 , B32B23/10 , B32B27/36 , B32B2250/20 , B32B2262/0276 , B32B2262/04 , B32B2262/06 , B32B2262/062 , B32B2307/726 , B32B2556/00 , Y10T442/2525 , C08L67/04
摘要： The present invention is directed to a reinforced absorbable multilayered hemostatic wound dressing comprising a first absorbable nonwoven fabric, a second absorbable woven or knitted fabric, thrombin and fibrinogen, and method of making.
摘要翻译：本发明涉及包含第一可吸收性无纺布，第二可吸收编织物或针织物，凝血酶和纤维蛋白原的增强吸收性多层止血敷料及其制造方法。

4. 发明申请

WO2010064241A1 SUBCUTANEOUS ADMINISTRATION OF ANTI-HEPATITIS B ANTIBODIES 审中-公开
标题翻译：抗生素B抗体的免疫应答
公开(公告)号：WO2010064241A1
公开(公告)日：2010-06-10
申请号：PCT/IL2009/001139
申请日：2009-12-03
申请人： OMRIX BIOPHARMACEUTICALS LTD. , LAUB, Orgad , ORR, Nadav
发明人： LAUB, Orgad , ORR, Nadav
IPC分类号： A61K39/42
CPC分类号： C07K16/082 , A61K2039/505 , A61K2039/54 , C07K16/06
摘要： The invention relates to the use of a subcutaneous dose of anti-hepatitis B immunoglobulin for hepatitis B therapy. The dose is higher than an intramuscular dose given via the intramuscular route for the same therapy. Such higher subcutaneous dose allows achieving anti-hepatitis B antibodies in the circulation at a similar level and timing as obtained by the intramuscular dose given via the intramuscular route. Advantageously, the subcutaneous dose of anti-hepatitis B of the invention allows rapidly obtaining a predetermined level of anti-hepatitis B antibodies in the circulation such as higher than 100 mIU/ml. The subcutaneous dose of anti-hepatitis B immunoglobulin can be used for prevention of recurrence of hepatitis B following orthotopic liver transplantation (OLT) due to hepatitis B.
摘要翻译：本发明涉及皮下剂量的抗乙型肝炎免疫球蛋白用于乙型肝炎治疗的用途。剂量高于通过肌内途径给予相同疗法的肌内剂量。这种较高的皮下剂量允许在循环中实现抗乙型肝炎抗体，其通过肌内途径给予的肌内剂量所获得的相似水平和时间。有利地，本发明的抗乙型肝炎的皮下剂量允许在循环中快速获得预定水平的抗乙型肝炎抗体，例如高于100mIU / ml。抗乙型肝炎免疫球蛋白的皮下剂量可用于预防乙型肝炎肝移植（OLT）后乙型肝炎复发。

5. 发明申请

WO2009005870A3 PRODUCTS FOR PROPHYLAXIS AND/OR TREATMENT OF VIRAL DISEASES AND METHOD OF MAKING AND USING SAME 审中-公开
标题翻译：用于预防和/或治疗病毒的产品及其制备和使用方法
公开(公告)号：WO2009005870A3
公开(公告)日：2009-03-26
申请号：PCT/US2008059891
申请日：2008-04-10
申请人： OMRIX BIOPHARMACEUTICALS LTD , GERAGHTY ERIN , LAUB ORGAD , NUR ISREAL , ORR NADAV
发明人： LAUB ORGAD , NUR ISREAL , ORR NADAV
IPC分类号： A61K39/395 , A61P31/14 , C07K16/06 , C07K16/10
CPC分类号： C07K16/06 , A61K39/395 , A61K2039/505 , C07K16/10 , C07K2317/21 , C07K2317/76
摘要： The invention relates to an immunoglobulin composition suitable for prophylaxis and/or treatment of a viral mediated disease, disorder or condition and to methods of its preparation. In one embodiment, the invention provides a potent intravenous immunoglobulin composition useful for the treatment or prevention of a West Nile virus mediated disease, disorder or condition.
摘要翻译：本发明涉及适用于预防和/或治疗病毒介导的疾病，病症或病症的免疫球蛋白组合物及其制备方法。在一个实施方案中，本发明提供了用于治疗或预防西尼罗病毒介导的疾病，病症或病症的有效的静脉内免疫球蛋白组合物。

6. 发明申请

WO2007017859A1 INTRAVENOUS IMMUNOGLOBULIN COMPOSITION 审中-公开
标题翻译：无菌免疫组织化学
公开(公告)号：WO2007017859A1
公开(公告)日：2007-02-15
申请号：PCT/IL2006/000782
申请日：2006-07-06
申请人： OMRIX BIOPHARMACEUTICALS INC. , NUR, Israel , BAR, Liliana , LAUB, Orgad
发明人： NUR, Israel , BAR, Liliana , LAUB, Orgad
IPC分类号： C07K16/08 , A61K39/395 , A61P31/12
CPC分类号： C07K16/081 , A61K38/00 , A61K39/39591 , A61K2039/505 , C07K2319/00
摘要： A method for preparing a concentrated, immunoglobulin composition for treating subjects vaccinated against or infected with a pathogenic microorganism, comprising: (a) selecting a population of individuals previously vaccinated against one or more antigens associated with the pathogenic microorganism; (b) determining the level of specific antibodies immunoreactive with the pathogenic microorganism in a blood or blood component of the individuals to identify very high titre individuals having a very high titre of the specific antibodies; (c) combining blood or blood components comprising immunoglobulins from the very high titre individuals; and (d) purifying and/or concentrating the product of step (c), thereby obtaining a concentrated immunoglobulin composition. Also disclosed is a concentrated immunoglobulin composition comprising specific antibodies immunoreactive with a pathogenic microorganism, characterized in that the titre of specific antibodies of the composition is at least 5 times higher than the average titre of specific antibodies of a population of individuals previously vaccinated against one or more antigens associated with the pathogenic microorganism. The composition has a relatively high protein concentration and a low percentage of protein aggregates, and is therefore suitable for both iv and im administration. In a preferred embodiment, the pathogenic microorganism is smallpox virus or vaccinia virus.
摘要翻译：一种制备用于治疗接种疫苗或感染病原微生物的受试者的浓缩免疫球蛋白组合物的方法，包括：（a）选择先前针对与病原微生物相关的一种或多种抗原接种的个体群体; （b）确定在个体的血液或血液成分中与病原微生物免疫反应的特异性抗体的水平，以鉴定具有非常高的特异性抗体滴度的非常高的滴度个体; （c）从非常高的滴度个体组合包含免疫球蛋白的血液或血液成分; 和（d）纯化和/或浓缩步骤（c）的产物，从而获得浓缩的免疫球蛋白组合物。还公开了包含与病原微生物免疫反应性的特异性抗体的浓缩免疫球蛋白组合物，其特征在于组合物的特异性抗体滴度比先前接种于一种或多种疫苗的个体群体的特异性抗体的平均滴度高至少5倍更多与病原微生物相关的抗原。该组合物具有相对高的蛋白质浓度和低百分比的蛋白质聚集体，因此适用于iv和im施用。在优选的实施方案中，致病微生物是天花病毒或痘苗病毒。

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