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1. 发明申请

WO1996028199A1 FLOW ELECTROPORATION CHAMBER AND METHOD 审中-公开
标题翻译：流动电气室和方法
公开(公告)号：WO1996028199A1
公开(公告)日：1996-09-19
申请号：PCT/US1996003211
申请日：1996-03-11
申请人： ENTREMED, INC.
发明人： ENTREMED, INC. , MESEROL, Peter, M. , PRODELL, Rita, C. , ACKER, Jesse, L.
IPC分类号： A61M01/36
CPC分类号： F25B21/02 , A61K35/18 , A61M1/16 , A61M1/34 , A61M1/3403 , A61M1/36 , A61M1/3607 , A61M1/3687 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0429 , A61M2205/3306 , A61M2205/3368 , A61M2205/3382 , A61M2205/3606 , A61M2205/3673 , C12M35/02 , A61M2202/0092
摘要： The present invention relates to a method and apparatus for the encapsulation of biologically-active substances in red blood cells, characterized by an optionally automated, continuous-flow, self-contained electroporation system (5) which allows withdrawal of blood from a patient, separation of red blood cells, and optional recombination of blood plasma and the modified red blood cells thereby producing blood with modified biological characteristics. The present invention is particularly suited for use to encapsulate allosteric effectors of hemoglobin, thereby reducing the affinity of erythrocytes for oxygen and improving the release of oxygen from erythrocytes in tissues. The blood is introduced into the system (5) at inlet (11) and mixed with an anticoagulant (27). The blood and anticoagulant mixture is passed through a filter (18) and to a blood separation and wash bowl (44). Plasma and white blood cells are admitted into the plasma reservoir (89) while the red blood cells are retained in the wash bowl (44). The separated red blood cells are pumped out and admixed at junction (67) withan IHP solution from reservoir (50). This mixture is cooled by cooling coil (68) and then pumped to electroporation chamber (72) for treatment.
摘要翻译：本发明涉及用于将生物活性物质包封在红细胞中的方法和装置，其特征在于可选地自动化的连续流动的独立电穿孔系统（5），其允许从患者中取出血液，分离的红细胞，以及血浆和修饰的红细胞的任选重组，从而产生具有改良的生物特征的血液。本发明特别适用于包封血红蛋白的变构效应物，从而降低红细胞对氧的亲和力，改善组织中红细胞释放的氧。将血液在入口（11）处引入系统（5）中并与抗凝剂（27）混合。血液和抗凝血剂混合物通过过滤器（18）和血液分离洗涤碗（44）。等离子体和白细胞进入血浆容器（89），同时红细胞保留在洗涤碗（44）中。将分离的红细胞泵出并在接合处（67）与储存器（50）的IHP溶液混合。将该混合物通过冷却盘管（68）冷却，然后泵送到电穿孔室（72）进行处理。

2. 发明申请

WO1998024490A1 IMPROVED ELECTRODES AND METHOD OF USE 审中-公开
标题翻译：改进的电极及其使用方法
公开(公告)号：WO1998024490A1
公开(公告)日：1998-06-11
申请号：PCT/US1997022630
申请日：1997-12-04
申请人： ENTREMED, INC.
发明人： ENTREMED, INC. , MESEROL, Peter
IPC分类号： A61M01/02
CPC分类号： A61N1/042 , A61N1/0412 , A61N1/0424 , A61N1/327 , C12M35/02 , C12N13/00
摘要： An improved electrode for use in generating an electrical field in a saline solution is provided. In particular, a continuous crystalline metal nitride coated electrode is provided for use in a variety of saline solution applications, such as in an electrophoresis device for separating proteins or nucleic acids or an electroporation apparatus for the encapsulation of biologically-active substances in various cell populations. A method and apparatus are provided for the encapsulation of biologically-active substances in red blood cells, characterized by an optionally automated, continuous-flow, self-contained electroporation system (10) which allows withdrawal of blood from a patient (11), separation of red blood cells (44), encapsulation of a biologically-active substances in the cells (72), and optional recombination of blood plasma and the modified red blood cells thereby producing blood with modified biological characteristics.
摘要翻译：提供了一种用于在盐水溶液中产生电场的改进的电极。特别地，提供连续的结晶金属氮化物涂覆的电极用于各种盐溶液应用中，例如用于分离蛋白质或核酸的电泳装置或用于将生物活性物质包封在各种细胞群体中的电穿孔装置。提供了一种用于将生物活性物质包封在红细胞中的方法和装置，其特征在于任选地自动化的，连续流动的独立电穿孔系统（10），其允许从患者（11）中取出血液，分离红细胞（44），生物活性物质在细胞中的包封（72），以及血浆和修饰的红细胞的任选重组，从而产生具有改良的生物特征的血液。

3. 发明申请

WO1996013615A1 IDENTIFICATION OF INFECTION WITH FLOW CYTOMETRY 审中-公开
标题翻译：用流式细胞术检测感染的鉴定
公开(公告)号：WO1996013615A1
公开(公告)日：1996-05-09
申请号：PCT/US1995013393
申请日：1995-10-27
申请人： ENTREMED, INC. , LEIBY, David, A. , MCMAHON-PRATT, Diane
发明人： ENTREMED, INC. , TORO, Luis, A. , NACY, Carol, A.
IPC分类号： C12Q01/70
CPC分类号： G01N33/569 , G01N33/56905 , G01N33/56911 , G01N33/56961 , G01N33/56983 , Y02A50/55
摘要： The invention encompasses flow cytometric methods for detecting intracellular pathogens in cells at extremely low levels of infection. In particular, the method provides for the early and accurate detection of Leishmania-infected monocytes in peripheral blood and other body fluids and liquid suspensions of tissue-derived cells. This specific and highly sensitive flow cytometric method is useful as a technique for assessment of parasites in blood, and may also identify persons and animals who are undergoing active infections with Leishmania sp. or other intracellular pathogens.
摘要翻译：本发明包括用于以非常低的感染水平检测细胞中的细胞内病原体的流式细胞术方法。特别地，该方法提供了外周血和其他体液中的利什曼原虫感染的单核细胞的早期和准确检测以及组织衍生细胞的液体悬浮液。这种特异性和高度灵敏的流式细胞术方法作为评估血液中寄生虫的技术是有用的，并且还可以鉴定正在利用利什曼原虫感染的人和动物。或其他细胞内病原体。

4. 发明申请

WO1994027635A1 COMPOSITIONS AND METHODS FOR TREATING CANCER AND HYPERPROLIFERATIVE DISORDERS 审中-公开
标题翻译：用于治疗癌症和高血压病的组合物和方法
公开(公告)号：WO1994027635A1
公开(公告)日：1994-12-08
申请号：PCT/US1994005927
申请日：1994-05-26
申请人： ENTREMED, INC.
发明人： ENTREMED, INC. , NACY, Carol, A. , HOLADAY, John, W.
IPC分类号： A61K39/00
CPC分类号： B82Y5/00 , A61K9/127 , A61K39/0005 , A61K39/0011 , A61K2039/5258 , A61K2039/55555 , C07K16/22
摘要： The present invention encompasses methods for reducing or inhibiting growth factor in cancer cells and tissues. More particularly immunogenic growth factor-containing compositions are administered to a human or animal with a cancer or tumor. The immunogenic compositions elicit the production of antibodies specific for growth factor which reduce the level or circulating growth factor, thus reducing or eliminating the proliferation of cancer. The present invention encompasses growth factor-containing liposomes and vesicles having portions of growth factor externally presented on their surfaces. The present invention also includes antibodies specific for growth factor. Thus, according to the present invention, growth factor levels are reduced either by active immunization of an individual using immunogenic growth factor-containing compositions or by passive immunization via administering to the individual an antibody or a group of antibodies specific for growth factor.
摘要翻译：本发明包括减少或抑制癌细胞和组织中生长因子的方法。更具体地，将具有免疫原性生长因子的组合物施用于具有癌症或肿瘤的人或动物。免疫原性组合物引起产生对生长因子特异性的抗体，其降低水平或循环生长因子，从而减少或消除癌症的增殖。本发明包括含有生长因子的脂质体和囊泡，其中表面上外部存在生长因子的部分。本发明还包括对生长因子特异的抗体。因此，根据本发明，通过使用含免疫原性生长因子的组合物的个体的主动免疫或通过向个体施用针对生长因子特异的抗体或一组抗体的被动免疫来降低生长因子水平。

5. 发明申请

WO1997021099A1 METHOD OF DIAGNOSIS AND TREATMENT OF ATHEROSCLEROSIS USING ANTI-CHOLESTEROL ANTIBODIES 审中-公开
标题翻译：使用抗胆固醇抗体诊断和治疗甲状腺功能亢进症的方法
公开(公告)号：WO1997021099A1
公开(公告)日：1997-06-12
申请号：PCT/US1996019381
申请日：1996-12-05
申请人： ENTREMED, INC.
发明人： ENTREMED, INC. , DIJKSTRA, Jan , SWARTZ, Glenn, M., Jr. , ANIAGOLU, Jacinta , NACY, Carol, A. , GREEN, Shawn, J.
IPC分类号： G01N33/53
CPC分类号： G01N33/92 , G01N33/53 , G01N2800/323
摘要： Methods of use of anti-cholesterol antibodies are described for diagnosis and treatment of atherosclerosis. In one embodiment of the invention, anti-cholesterol antibodies are used to assay samples drawn from atherosclerotic lesions for the amount of VLDL, IDL and LDL, but not HDL molecules. In another embodiment of the invention, the anti-cholesterol antibodies are used as fusiogens to promote fusion of lipoprotein molecules and of liposomes, to promote clearance of cholesterol from the body.
摘要翻译：描述了用于诊断和治疗动脉粥样硬化的抗胆固醇抗体的方法。在本发明的一个实施方案中，使用抗胆固醇抗体来测定从动脉粥样硬化病变获得的VLDL，IDL和LDL的量而不是HDL分子的样品。在本发明的另一个实施方案中，抗胆固醇抗体用作促生成剂以促进脂蛋白分子和脂质体的融合，以促进胆固醇从体内的清除。

6. 发明申请

WO1996037779A1 A SOLID-PHASE METHOD FOR ASSAYING A HYDROPHOBIC-TARGET BINDING SUBSTANCE 审中-公开
标题翻译：用于测定疏水性目标结合物质的固相法
公开(公告)号：WO1996037779A1
公开(公告)日：1996-11-28
申请号：PCT/US1996004589
申请日：1996-04-03
申请人： ENTREMED, INC.
发明人： ENTREMED, INC. , GREEN, Shawn, J. , ANIAGOLU, Jacinta, U.
IPC分类号： G01N33/543
CPC分类号： G01N33/92 , G01N33/54306 , G01N33/82
摘要： An improved solid-phase method for assaying a HTBS comprising immobilizing a hydrophobic-target substance dissolved in an organic solvent on an inert solid-phase hydrophobic support material compatible with the organic solvent, contacting the hydrophobic-target substance with an aqueous sample containing a HTBS, detecting binding of the HTBS to the hydrophobic-target substance and determining the amount of the HTBS in the sample.
摘要翻译：一种用于测定HTBS的改进的固相方法，包括将溶解在有机溶剂中的疏水性目标物质固定在与有机溶剂相容的惰性固相疏水载体材料上，使疏水性目标物质与含有HTBS的含水样品接触检测HTBS与疏水性靶物质的结合并确定样品中HTBS的量。

7. 发明申请

WO1995009612A1 ENCAPSULATED AND NON-ENCAPSULATED NITRIC OXIDE GENERATORS USED AS ANTIMICROBIAL AGENTS 审中-公开
标题翻译：用作抗菌剂的封装和非包埋氮氧化物发生器
公开(公告)号：WO1995009612A1
公开(公告)日：1995-04-13
申请号：PCT/US1994011441
申请日：1994-10-07
申请人： ENTREMED, INC. , THE GOVERNMENT OF THE UNITED STATES OF AMERICA represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES: National Institutes of Healt
发明人： ENTREMED, INC. , THE GOVERNMENT OF THE UNITED STATES OF AMERICA represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES: National Institutes of Healt , GREEN, Shawn, J. , KEEFER, Larry, K.
IPC分类号： A61K09/127
CPC分类号： A61K9/127 , A61K31/13 , A61K31/495 , Y02A50/409
摘要： This invention relates to compositions capable of releasing nitric oxide and therapeutic methods of use thereof for the treatment of microorganism-related disease states. The composition comprises one or more nitric oxide generators, preferably encapsulated in vesicles, such as liposomes. The compositions are used therapeutically by administration to humans and animals via different routes for the treatment of infectious diseases caused by pathogenic microbes.
摘要翻译：本发明涉及能够释放一氧化氮的组合物及其用于治疗微生物相关疾病状态的治疗方法。组合物包含一种或多种一氧化氮发生剂，优选包封在囊泡中，如脂质体。组合物通过不同途径给人和动物治疗而用于治疗由致病微生物引起的感染性疾病。

8. 发明申请

WO1994014454A1 VACCINES AGAINST STEROLS 审中-公开
标题翻译：疫苗对抗甾体药物
公开(公告)号：WO1994014454A1
公开(公告)日：1994-07-07
申请号：PCT/US1993012546
申请日：1993-12-22
申请人： ENTREMED, INC.
发明人： ENTREMED, INC. , ALVING, Carl, R. , KENNER, Julie , SWARTZ, Glenn, M., Jr. , MADSEN, John, W.
IPC分类号： A61K31/59
CPC分类号： G01N33/92 , A61K9/1271 , A61K31/575 , A61K31/58 , A61K31/66 , A61K38/00 , A61K39/0002 , A61K39/0012 , A61K39/39 , A61K2039/55505 , A61K2039/5555 , A61K2039/55555 , A61K2039/55572 , C07K16/18 , C07K16/44 , G01N2800/044
摘要： The present invention relates to immunoreactive compositions and methods for immunizing humans or animals against sterols, such as cholesterol and its derivatives, and their use in methods for reducing the serum cholesterol levels of the immunized individuals and to retard or reduce the severity of atherosclerosis or atherosclerosis plaques caused by ingestion of dietary cholesterol. Another embodiment of the present invention encompasses ergosterol or ergosterol derivative compositions useful for the treatment or prevention of fungal infection, and methods of use thereof. Yet another aspect of the invention is dairy products containing anti-ergosterol antibodies produced by dairy animals immunized against ergosterol according to the present invention and methods of making thereof. A further aspect of the invention is a diagnostic assay for determining whether a human or animal has a fungal infection.
摘要翻译：本发明涉及用于免疫人或动物对甾醇如胆固醇及其衍生物的免疫反应性组合物和方法，以及它们用于降低免疫个体的血清胆固醇水平并延缓或降低动脉粥样硬化或动脉粥样硬化严重程度的方法摄入膳食胆固醇引起的斑块。本发明的另一个实施方案包括可用于治疗或预防真菌感染的麦角甾醇或麦角甾醇衍生物组合物及其使用方法。本发明的另一方面是含有根据本发明的针对麦角甾醇免疫的乳制动物产生的抗麦角甾醇抗体的乳制品及其制备方法。本发明的另一方面是用于确定人或动物是否具有真菌感染的诊断测定。

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