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1. 发明申请

WO2014144222A3 COMPOSITIONS AND METHODS OF TREATING FUNGAL AND BACTERIAL PATHOGENS 审中-公开
标题翻译：处理真菌和细菌病原体的组合物和方法
公开(公告)号：WO2014144222A3
公开(公告)日：2014-12-24
申请号：PCT/US2014028535
申请日：2014-03-14
申请人： LOS ANGELES BIOMED RES INST
发明人： YEAMAN MICHAEL R , IBRAHIM ASHRAF S , FILLER SCOTT G , EDWARDS JOHN E JR
IPC分类号： A61K39/00
CPC分类号： A61K39/0002 , A61K39/085 , A61K39/39 , A61K47/48284 , A61K47/4833 , A61K47/643 , A61K47/646 , A61K2039/54 , A61K2039/55505 , A61K2039/6081 , C07K7/06 , C07K7/08 , C07K16/1271 , C07K16/14 , C07K2317/76 , C07K2319/00
摘要： The invention features isolated polypeptides and conjugates including the amino acid sequence of any one of SEQ ID NOs: 3-11, or a variant sequence thereof having up to three substitutions, deletions, or additions to the amino acid sequence of any one of SEQ ID NOs: 3-11, wherein the polypeptide does not include more than 20 contiguous amino acids of SEQ ID NO: 2 or SEQ ID NO: 17. Additional polypeptides includes those of formula (I) [ZNZPVSSBSFSYT]n and formula (II) [ZNUJVOOBUFOYT]n. The invention further features vaccines including such polypeptides or conjugates and methods of vaccination against candidiasis or a staphylococcal infection of both using same. In addition, the invention features antibodies that bind to the polypeptides or conjugates, and methods of passive immunization using same.
摘要翻译：本发明的特征在于分离的多肽和缀合物，其包括SEQ ID NO：3-11中任一个的氨基酸序列或其具有至多三个取代，缺失或添加到SEQ ID NO：3-11中任一个的氨基酸序列的变体序列 NO：3-11，其中多肽不包括SEQ ID NO：2或SEQ ID NO：17的多于20个连续氨基酸。其他多肽包括式（I）[ZNZPVSSBSFSYT] n和式（II）[ ZNUJVOOBUFOYT的n。本发明进一步具有包括这种多肽或缀合物的疫苗以及使用它们的两种疫苗针对念珠菌病或葡萄球菌感染的方法。此外，本发明的特征在于结合多肽或结合物的抗体以及使用其的被动免疫方法。

2. 发明申请

WO2014195382A1 T CELL EPITOPES DERIVED FROM ALT A 1 OR ALT A 5 FOR THE TREATMENT OF ALTERNARIA ALTERNATA ALLERGY 审中-公开
标题翻译：从ALT A 1或ALT A 5衍生的用于治疗ALTERNARIA ALTERNATA过敏症的T细胞抗体
公开(公告)号：WO2014195382A1
公开(公告)日：2014-12-11
申请号：PCT/EP2014/061641
申请日：2014-06-04
申请人： ALERGENETICA SL
发明人： MILLER, Brian S. , MILLER, Laura , DIAZ-TORRES, Maria R. , DUNN-COLEMAN, Nigel S. , CLAVERIE-DIAZ, Laura
IPC分类号： A61K39/35 , C07K14/37 , A61P37/08
CPC分类号： C07K14/37 , A61K39/0002 , A61K39/35 , C07K7/06 , C07K7/08 , G01N33/505 , G01N33/6893
摘要： The application discloses peptides capable of preventing or treating fungal disease, including fungal allergy disease.
摘要翻译：本申请公开了能够预防或治疗真菌性疾病（包括真菌性过敏性疾病）的肽。

3. 发明申请

WO2014144222A2 COMPOSITIONS AND METHODS OF TREATING FUNGAL AND BACTERIAL PATHOGENS 审中-公开
标题翻译：治疗真菌和细菌病原体的组合物和方法
公开(公告)号：WO2014144222A2
公开(公告)日：2014-09-18
申请号：PCT/US2014/028535
申请日：2014-03-14
申请人： LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER
发明人： YEAMAN, Michael, R. , IBRAHIM, Ashraf, S. , FILLER, Scott, G. , EDWARDS, John, E., Jr.
IPC分类号： A61K39/00
CPC分类号： A61K39/0002 , A61K39/085 , A61K39/39 , A61K47/48284 , A61K47/4833 , A61K47/643 , A61K47/646 , A61K2039/54 , A61K2039/55505 , A61K2039/6081 , C07K7/06 , C07K7/08 , C07K16/1271 , C07K16/14 , C07K2317/76 , C07K2319/00
摘要： The invention features isolated polypeptides and conjugates including the amino acid sequence of any one of SEQ ID NOs: 3-11, or a variant sequence thereof having up to three substitutions, deletions, or additions to the amino acid sequence of any one of SEQ ID NOs: 3-11, wherein the polypeptide does not include more than 20 contiguous amino acids of SEQ ID NO: 2 or SEQ ID NO: 17. Additional polypeptides includes those of formula (I) [ZNZPVSSBSFSYT] n and formula (II) [ZNUJVOOBUFOYT] n . The invention further features vaccines including such polypeptides or conjugates and methods of vaccination against candidiasis or a staphylococcal infection of both using same. In addition, the invention features antibodies that bind to the polypeptides or conjugates, and methods of passive immunization using same.
摘要翻译：本发明的特征在于包含SEQ ID NO：3-11中任一项的氨基酸序列或其变体序列的分离的多肽和缀合物，其具有至多3个氨基酸取代，缺失或添加其中所述多肽不包含超过20个连续的氨基酸SEQ ID NO：2或SEQ ID NO：17。另外的多肽包括式（I）的那些[ZNZPVSSBSFSYT ]＆lt; sub＆gt;和式（II）[ZNUJVOOBUFOYT] _{n 。本发明的特征还在于包含这样的多肽或缀合物的疫苗以及使用它们的针对念珠菌病或葡萄球菌感染的疫苗接种方法。另外，本发明的特征在于结合多肽或偶联物的抗体，以及使用它们的被动免疫方法。}

4. 发明申请

WO2014144211A2 COMPOSITIONS AND METHODS FOR TREATING FUNGAL AND BACTERIAL PATHOGENS 审中-公开
标题翻译：用于治疗真菌和细菌病原体的组合物和方法
公开(公告)号：WO2014144211A2
公开(公告)日：2014-09-18
申请号：PCT/US2014/028521
申请日：2014-03-14
申请人： LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER , NOVADIGM THERAPEUTICS, INC.
发明人： IBRAHIM, Ashraf, S. , YEAMAN, Michael, R. , FILLER, Scott, R. , EDWARDS, John, E., Jr. , HENNESSEY, John, P., Jr.
IPC分类号： A61K39/00
CPC分类号： A61K39/0002 , A61K39/39 , A61K2039/54 , A61K2039/55505 , C07K14/40 , C07K16/14 , C07K2317/76 , C07K2319/00
摘要： The invention features fragments of the Candida cell surface proteins Als3 and Hyr1 and combinations thereof useful in immunizing a subject against fungal or bacterial infections or both.
摘要翻译：本发明的特征在于念珠菌细胞表面蛋白Als3和Hyr1的片段及其组合可用于免疫受试者免受真菌或细菌感染或两者的影响。

5. 发明申请

WO2014144024A1 HYR1 COMPOSITIONS AND METHODS FOR TREATING FUNGAL AND BACTERIAL PATHOGENS 审中-公开
标题翻译： HYR1组合物和治疗真菌和细菌病原体的方法
公开(公告)号：WO2014144024A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/028256
申请日：2014-03-14
申请人： LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER , NOVADIGM THERAPEUTICS, INC.
发明人： IBRAHIM, Ashraf, S. , YEAMAN, Michael, R. , FILLER, Scott, G. , EDWARDS, John, E., Jr. , HENNESSEY, John, P., Jr.
IPC分类号： A61K39/00 , A61P31/10
CPC分类号： A61K39/0002
摘要： The invention features fragments of the Candida cell Hyr1 surface protein useful in immunizing a subject against fungal or bacterial infections or both.
摘要翻译：本发明的特征在于可用于免疫受试者免受真菌或细菌感染或两者的念珠菌细胞Hyr1表面蛋白的片段。

6. 发明申请

WO2014006215A1 HYDROGEL VACCINE FORMULATIONS 审中-公开
标题翻译： HYDROGEL VACCINE配方
公开(公告)号：WO2014006215A1
公开(公告)日：2014-01-09
申请号：PCT/EP2013/064327
申请日：2013-07-05
申请人： SIGMOID PHARMA LIMITED
发明人： COULTER, Ivan , MCDONALD, Bernard Francis , AVERSA, Vincenzo , ROSA, Mónica
IPC分类号： A61K39/108 , A61K47/36 , A61K9/50 , A61K9/51
CPC分类号： A61K39/0258 , A61K9/06 , A61K9/146 , A61K9/50 , A61K9/5042 , A61K9/5073 , A61K9/5161 , A61K39/0002 , A61K39/0208 , A61K39/0283 , A61K39/08 , A61K39/107 , A61K39/12 , A61K39/39 , A61K47/36 , A61K2039/52 , A61K2039/521 , A61K2039/522 , A61K2039/525 , A61K2039/5252 , A61K2039/5254 , A61K2039/54 , A61K2039/542 , A61K2039/55511 , Y02A50/474
摘要： This invention relates to compositions for delivering one or more active ingredients, and more particularly to compositions, e.g. beads, comprising a matrix material which matrix material comprises a microorganism. In particular, the invention relates to compositions comprising a microorganism selected from live, killed, attenuated and inactivated microorganisms. The matrix material may also comprise a surfactant and may further comprise an adjuvant. The invention further relates to the manufacture and use of such compositions, and to other subject matter.
摘要翻译：本发明涉及用于递送一种或多种活性成分的组合物，更具体地涉及组合物，例如，珠粒，其包含基质材料，该基质材料包含微生物。特别地，本发明涉及包含选自活的，灭活的，减毒的和灭活的微生物的微生物的组合物。基质材料还可以包含表面活性剂，并且还可以包含佐剂。本发明还涉及这种组合物的制造和使用以及其它主题。

7. 发明申请

WO2012127248A1 METHOD FOR THE PRODUCTION OF PROTEIN COMPLEXES AND VACCINE COMPOSITIONS COMPRISING THE SAME 审中-公开
标题翻译：用于生产蛋白复合物的方法和包含其的疫苗组合物
公开(公告)号：WO2012127248A1
公开(公告)日：2012-09-27
申请号：PCT/GB2012/050650
申请日：2012-03-23
申请人： IMMUNOBIOLOGY LIMITED , COLACO, Camilo , McENTEE, Ian
发明人： COLACO, Camilo , McENTEE, Ian
IPC分类号： A61K39/385 , A61K38/16 , A61K39/00
CPC分类号： C12P21/00 , A61K38/1709 , A61K39/0002 , A61K39/0011 , A61K39/04 , A61K39/08 , A61K39/092 , A61K39/095 , Y02A50/403 , Y02A50/478 , Y02A50/48
摘要： The present invention relates to methods for the production of heat shock protein complexes for use in vaccine compositions. In particular, there is provided a method for increasing the level and immunogenicity of heat shock protein complexes produced in cells by subjecting the cells to specific stress inducing stimuli. The invention further extends to the use of heat shock protein complexes produced according to the methods of the invention in the preparation of vaccine compositions for the prevention and treatment of infectious diseases and cancerous conditions.
摘要翻译：本发明涉及生产用于疫苗组合物的热休克蛋白复合物的方法。特别地，提供了一种通过使细胞经受特定应激诱导刺激而增加细胞中产生的热休克蛋白复合物的水平和免疫原性的方法。本发明进一步延伸到根据本发明的方法制备的热休克蛋白复合物在制备用于预防和治疗感染性疾病和癌症病症的疫苗组合物中的应用。

8. 发明申请

WO2012122618A1 IMMUNOGENIC COMPOSITION FOR IMMUNE SYSTEM MODULATION AND USE THEREOF, METHOD FOR TREATING AND PREVENTING DISEASES, METHOD FOR INDUCING CELL REGENERATION AND METHOD FOR RESTORING IMMUNE RESPONSE 审中-公开
标题翻译：用于免疫系统调节及其用途的免疫组合物，治疗和预防疾病的方法，诱导细胞再生的方法和恢复免疫应答的方法
公开(公告)号：WO2012122618A1
公开(公告)日：2012-09-20
申请号：PCT/BR2012000072
申请日：2012-03-19
申请人： NOWILL ALEXANDRE EDUARDO
发明人： NOWILL ALEXANDRE EDUARDO
IPC分类号： A61K39/00 , A61K39/002 , A61K39/02 , A61K39/12 , A61P37/04
CPC分类号： A61K39/245 , A61K39/0002 , A61K39/0275 , A61K39/04 , A61K39/085 , A61K39/09 , A61K39/092 , A61K39/095 , A61K39/104 , A61K39/145 , A61K39/165 , A61K2039/55533 , A61K2039/585 , A61K2039/70
摘要： The present invention relates to immunogenic compositions for modulating the immune system, comprising a therapeutically effective quantity of two or more immuno-active antigenic agents with pathogen-associated molecular patterns (PAMPs) and/or danger-associated molecular patterns (DAMPs) and one or more physiologically acceptable carriers, excipients, diluents or solvents. The immunogenic compositions according to the present invention are used for producing medicaments for preventing and/or treating, and for preventing and/or treating infectious diseases, auto-immune diseases, allergic diseases, inflammation, arthritis, inflammatory diseases, transplant rejection, affections caused by vascular disorders, diseases caused by haemorrhagic or ischaemic cardiovascular accidents, ischaemia, heart attack and haemorrhagia leading to tissue destruction, heart, kidney, respiratory or liver insufficiency, cancer, malign and benign tumours and neoplasia. The present invention further relates to methods for inducing the regeneration of cells, tissues, organs and organic systems such as the circulatory, nervous and endocrine systems. Finally, the present invention relates to methods for restoring immune response in an animal, in particular a human being.
摘要翻译：本发明涉及用于调节免疫系统的免疫原性组合物，其包含治疗有效量的具有病原体相关分子模式（PAMP）和/或危险相关分子模式（DAMP）的两种或更多种免疫活性抗原试剂，和一种或多种更多生理上可接受的载体，赋形剂，稀释剂或溶剂。根据本发明的免疫原性组合物用于制备用于预防和/或治疗和预防和/或治疗感染性疾病，自身免疫疾病，过敏性疾病，炎症，关节炎，炎性疾病，移植排斥，引起的感染的药物血管疾病，由出血性或缺血性心血管事件引起的疾病，局部缺血，心脏病发作和出血，导致组织破坏，心脏，肾脏，呼吸或肝功能不全，癌症，恶性和良性肿瘤和瘤形成。本发明还涉及诱导细胞，组织，器官和有机系统如循环系统，神经系统和内分泌系统的再生的方法。最后，本发明涉及用于在动物，特别是人中恢复免疫应答的方法。

9. 发明申请

WO2011080595A2 POLYSACCHARIDE IMMUNOGENS CONJUGATED TO E. COLI CARRIER PROTEINS 审中-公开
标题翻译：多糖免疫调节蛋白与大肠杆菌载体蛋白结合
公开(公告)号：WO2011080595A2
公开(公告)日：2011-07-07
申请号：PCT/IB2010/003484
申请日：2010-12-30
申请人： NOVARTIS AG , COSTANTINO, Paolo , SERINO, Laura , ROMANO, Maria, Rosaria , TONTINI, Marta , BERTI, Francesco , MICOLI, Francesca , KABANOVA, Anna
发明人： COSTANTINO, Paolo , SERINO, Laura , ROMANO, Maria, Rosaria , TONTINI, Marta , BERTI, Francesco , MICOLI, Francesca , KABANOVA, Anna
IPC分类号： A61K47/48 , A61K39/02
CPC分类号： A61K47/4833 , A61K39/0002 , A61K39/0258 , A61K39/39 , A61K47/646 , A61K2039/6068 , Y02A50/401 , Y02A50/403 , Y02A50/41 , Y02A50/478 , Y02A50/484
摘要： E. coli proteins have been identified that are useful as carrier proteins to improve a response to a polysaccharide immunogen conjugated to such protein. In particular, AcfD precursor protein (orf3526 polypeptide), Flu antigen 43 protein (orf1364 polypeptide), and Sell repeat-containing protein (upec-5211 polypeptide) have been shown to be effective. Additionally, these E. coli proteins can enhance the immune response to glucans, particularly fungal glucans.
摘要翻译：已经鉴定出大肠杆菌蛋白质可用作载体蛋白，以改善对与这种蛋白质缀合的多糖免疫原的反应。特别地，已证明AcfD前体蛋白（orf3526多肽），Flu抗原43蛋白（orf1364多肽）和含Sell重复蛋白（upec-5211多肽）是有效的。此外，这些大肠杆菌蛋白质可增强对葡聚糖，特别是葡萄糖葡萄糖的免疫应答。

10. 发明申请

WO2010042870A1 ADJUVANT INCORPORATION IN IMMUNONANOTHERAPEUTICS 审中-公开
标题翻译： ADJUVANT INCORPORATION IN IMMUNANANOTHERAPEUTICS
公开(公告)号：WO2010042870A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/060242
申请日：2009-10-09
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , ALEXIS, Frank , IANNACONE, Matteo , SHI, Jinjun , BASTO, Pamela , MOSEMAN, Ashley , VON ANDRIAN, Ulrich , LANGER, Robert , FAROKHZAD, Omid, C. , TONTI, Elena
发明人： ALEXIS, Frank , IANNACONE, Matteo , SHI, Jinjun , BASTO, Pamela , MOSEMAN, Ashley , VON ANDRIAN, Ulrich , LANGER, Robert , FAROKHZAD, Omid, C. , TONTI, Elena
IPC分类号： A61K39/00
CPC分类号： A61K9/14 , A61K38/20 , A61K38/21 , A61K39/00 , A61K39/0002 , A61K39/002 , A61K39/05 , A61K39/08 , A61K39/12 , A61K39/39 , A61K45/06
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
摘要翻译：本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。本发明提供包含免疫表面和免疫刺激部分的纳米载体。在一些实施方案中，免疫刺激部分是佐剂。本发明提供包含本发明纳米载体的药物组合物。本发明提供了设计，制造和使用本发明的纳米载体及其药物组合物的方法。

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