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1. 发明申请

WO2008024731A2 USING DISC TO EVALUATE THE EMOTIONAL RESPONSE OF AN INDIVIDUAL 审中-公开
标题翻译：使用DISC评估个人的情绪反应
公开(公告)号：WO2008024731A2
公开(公告)日：2008-02-28
申请号：PCT/US2007/076358
申请日：2007-08-21
申请人： ELC MANAGEMENT LLC , AFRIAT, Isabelle , RAFAILOVICH, Miriam
发明人： AFRIAT, Isabelle , RAFAILOVICH, Miriam
IPC分类号： G06T13/00
CPC分类号： G06K9/00268 , G06K9/00302
摘要： The present invention comprises the use of Digital Image Speckle Correlation (DISC) to map facial deformations due to voluntary and/or involuntary, often subtle, facial expressions. The facial expressions may be the result of a response to internal or external stimuli. It is possible to develop quantitative and qualitative characterizations of the individual's response. The techniques of the present invention can be used to extend and improve the FACS, which includes assigning human emotions to facial expressions. It is also possible to use test subject feedback to correlate facial expressions to human emotion.
摘要翻译：本发明包括使用数字图像斑点相关（DISC）来映射由于自愿和/或非自愿的，通常微妙的面部表情引起的面部变形。面部表情可能是对内部或外部刺激的反应的结果。可以对个人的反应进行量化和定性的描述。本发明的技术可用于扩展和改进FACS，其包括将人情感分配给面部表情。也可以使用测试对象反馈来将人脸表情与人的情绪联系起来。

2. 发明申请

WO2007067536A1 METHOD OF EVALUATING THE EFFECTS OF EXOGENOUS AND ENDOGENOUS FACTORS ON THE SKIN 审中-公开
标题翻译：评估外源性和内源性因子对皮肤的影响的方法
公开(公告)号：WO2007067536A1
公开(公告)日：2007-06-14
申请号：PCT/US2006/046388
申请日：2006-12-05
申请人： ELC MANAGEMENT LLC , AFRIAT, Isabelle , RAFAILOVICH, Miriam , GUAN, E
发明人： AFRIAT, Isabelle , RAFAILOVICH, Miriam , GUAN, E
IPC分类号： G01N33/15 , G01N33/483
CPC分类号： A61B5/445 , A61B5/0088 , A61B5/442
摘要： The present invention provides non-invasive, in vivo, DISC-type methods of evaluating structural changes in skin due to a variety of exogenous or endogenous factors. It is possible to develop quantitative and qualitative characterizations of skin. For example, the skin may be characterized based on its structural age rather than its chronological age. Based on the structural age and type of an individual's skin, cosmetic, dermatologic, medicinal or manipulative treatment may be customized. The method is based, in part, on quantification of discontinuities that arise in the skin during normal facial expression. The methods provide for evaluating changes in human skin response that occur over a short term (one day) or long term (one or more years). The methods provide for evaluating the skin's response to cosmetic, dermatologic or medicinal treatment or to any other factor alleged to affect the skin.
摘要翻译：本发明提供了由多种外源或内源因素评价皮肤结构变化的非侵入式体内DISC型方法。可以开发皮肤的定量和定性表征。例如，皮肤可以基于其结构年龄而不是其时间年龄来表征。根据个人皮肤的结构年龄和类型，可以定制化妆品，皮肤病学，药物或操作性治疗。该方法部分地基于在正常面部表情期间在皮肤中产生的不连续性的量化。该方法用于评估短期（一天）或长期（一年或多年）发生的人类皮肤反应变化。该方法用于评估皮肤对化妆品，皮肤病学或药物治疗的反应或任何其他影响皮肤的因素。

3. 发明申请

WO2008024694A2 EVALUATION OF IMMEDIATE-EFFECT SKIN MOLDING AGENTS USING DISC 审中-公开
标题翻译：使用光盘评估立即效果的皮肤成型剂
公开(公告)号：WO2008024694A2
公开(公告)日：2008-02-28
申请号：PCT/US2007/076268
申请日：2007-08-20
申请人： ELC MANAGEMENT LLC , AFRIAT, Isabelle , RAFAILOVICH, Miriam
发明人： AFRIAT, Isabelle , RAFAILOVICH, Miriam
IPC分类号： A61K49/00
CPC分类号： A61K49/0006 , A61K49/0008
摘要： The present invention pertains to methods of characterizing the effects on the skin of skin-molding agents and to methods of characterizing the physical behavior of the skin-molding agents themselves. A preferred embodiment of the present invention uses a non-invasive, in vivo form of digital image speckle correlation to track deformation of human skin caused by the application of a skin-molding agent, in particular, an immediate-effect skin molding agent. The skin-molding agent may or may not be part of a composition. The application to the skin of a skin-molding agent may or may not be part of a treatment regimen. The present invention may be applied to any surface of the human body, to non-humans and to inert matter. Unlike in vitro methods and unlike invasive, in vivo methods that tension the skin with an apparatus, the present invention relies on the applied skin-molding agent to create before and after deformation images. From those images, it is possible to develop quantitative and qualitative characterizations of skin's movement and of the skin-molding agent itself. These characterizations will aid in the development of improved and/or customized skin molding agents and improved compositions comprising skin-molding agents. Generally, the data collected by the methods described herein, may also suggest improved and/or customized treatment regimens for molding the skin.
摘要翻译：本发明涉及表征对皮肤成型剂的皮肤的作用的方法以及表征皮肤成型剂本身的物理性能的方法。本发明的优选实施方案使用数字图像斑点相关性的非侵入式体内形式来跟踪由皮肤成型剂（特别是立即效果的皮肤模塑剂）的应用引起的人体皮肤的变形。皮肤成型剂可以是或可以不是组合物的一部分。对皮肤成型剂的皮肤的应用可以是或可以不是治疗方案的一部分。本发明可以应用于人体的任何表面，非人类和惰性物质。与体外方法不同，不同于用设备拉紧皮肤的侵入性体内方法，本发明依赖于所应用的皮肤成型剂在变形图像之前和之后产生。从这些图像，可以开发皮肤运动和皮肤成型剂本身的定量和定性表征。这些特征将有助于开发改进和/或定制的表皮成型剂和改进的包含表皮成型剂的组合物。通常，通过本文所述方法收集的数据也可以建议用于模塑皮肤的改进和/或定制的治疗方案。

4. 发明申请

WO2007130328A2 A NOVEL MECHANISM FOR IMMISCIBLE POLYMER BLEND COMPATIBILIZATION 审中-公开
标题翻译：一种用于不可分离聚合物混合的新机制
公开(公告)号：WO2007130328A2
公开(公告)日：2007-11-15
申请号：PCT/US2007/010403
申请日：2007-04-30
申请人： RAFAILOVICH, Miriam , ABECASSIS, David
发明人： RAFAILOVICH, Miriam , ABECASSIS, David
IPC分类号： C08K9/00
CPC分类号： C08J3/005 , C08J3/203
摘要： A method of compatibilizing immiscible polymers using the mechanical deformation of quaternary amine treated organoclay particles is described. The mechanism decreases the interstitial energy resulting from immiscible polymer domain interfaces into stored mechanical energy. The polymer domains in the immiscible blend get smaller and the resulting compatibilized microcomposite/nanocomposite blend has superior mechanical properties over non compatibilized blends controls of the same materials.
摘要翻译：描述了使用季胺处理的有机粘土颗粒的机械变形使不混溶的聚合物相容的方法。该机理将由不混溶的聚合物界面界面产生的间隙能降低到储存的机械能。不混溶混合物中的聚合物区域变小，并且所得相容的微复合材料/纳米复合材料混合物相对于相同材料的非相容混合物控制物具有优异的机械性能。

5. 发明申请

WO2011085182A2 BIOLOGICAL SURFACTANTS FOR CONNECTION TO SILICONE-BASED MATERIALS AND MODULATING LEVELS OF IMMUNOLOGICALLY ACTIVE PROTEINS 审中-公开
标题翻译：生物表面活性剂与硅胶材料的连接和免疫活性蛋白的调节水平
公开(公告)号：WO2011085182A2
公开(公告)日：2011-07-14
申请号：PCT/US2011/020494
申请日：2011-01-07
申请人： LIN, Xiaolan , RAFAILOVICH, Miriam
发明人： LIN, Xiaolan , RAFAILOVICH, Miriam
IPC分类号： A61L27/22 , G02B1/04 , A61F9/00 , A61F2/14 , G02C7/04 , A61L27/38
CPC分类号： A61L27/227 , A61L27/18 , A61L29/048 , A61L29/06 , A61L29/14 , C08L83/04
摘要： .Biological surfactants connected to surfaces of silicone-based materials are provided. Compositions of electrolytes and a biological surfactant are also provided. Methods for increasing the surface wettability of a silicone-based material by contacting the silicone-based material with a biological surfactant, methods for increasing evaporation from a silicone-based material by contacting a surface of the silicone-based material with a biological surfactant, methods for increasing levels of interleukin-8 during inflammation by contacting a cell with a biological surfactant, and methods for decreasing expression of a biological surfactant by contacting a cell with an siRNA are further provided.
摘要翻译：提供连接到有机硅基材料表面的生物表面活性剂。还提供电解质和生物表面活性剂的组合物。通过使有机硅类材料与生物表面活性剂接触来提高硅酮类材料的表面润湿性的方法，通过使硅酮类材料的表面与生物体表面活性剂接触来增加由硅酮类材料蒸发的方法用于通过使细胞与生物表面活性剂接触而在炎症期间增加白细胞介素-8的水平，并且还提供了通过使细胞与siRNA接触来降低生物表面活性剂的表达的方法。

6. 发明申请

WO2008134511A1 DETECTION OF CANCER MARKERS 审中-公开
标题翻译：检测癌症标志物
公开(公告)号：WO2008134511A1
公开(公告)日：2008-11-06
申请号：PCT/US2008/061578
申请日：2008-04-25
申请人： POLYTECHNIC UNIVERSITY , THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , LEVON, Kalle , RAFAILOVICH, Miriam , RIGAS, Basil , WANG, Yantian
发明人： LEVON, Kalle , RAFAILOVICH, Miriam , RIGAS, Basil , WANG, Yantian
IPC分类号： G01N27/26
CPC分类号： G01N33/5438 , B82Y15/00 , B82Y30/00 , C12Q1/003 , G01N2610/00
摘要： The present invention relates to combining surface molecular imprinting (SMI) with the production of self-assembled monolayers (SAM) of hydroxyl alkanethiolate molecules on gold coated chip surfaces. In this technique, the sensing element is placed on the transducer and the whole assembly can then be miniaturized and integrated into a smart chip. These sensors can detect, nanomolar quantities of complex biomolecules.
摘要翻译：本发明涉及将表面分子印迹（SMI）与在金涂覆的芯片表面上生产羟基链烷硫醇盐分子的自组装单层（SAM）。在这种技术中，感测元件放置在换能器上，然后可以将整个组件小型化并集成到智能芯片中。这些传感器可以检测纳摩尔量的复合生物分子。

7. 发明申请

WO2013006671A3 COMPOSITIONS AND METHODS FOR SPINAL DISC REPAIR AND OTHER SURGICAL AND NON-SURGICAL INDICATIONS 审中-公开
公开(公告)号：WO2013006671A3
公开(公告)日：2013-01-10
申请号：PCT/US2012/045500
申请日：2012-07-05
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , DAVIS, Raphael , BHATNAGAR, Divya , RAFAILOVICH, Miriam
发明人： DAVIS, Raphael , BHATNAGAR, Divya , RAFAILOVICH, Miriam
IPC分类号： A61L27/14 , A61L27/22 , A61L27/20 , A61F2/44
摘要： The present invention features, inter alia , biocompatible compositions that include a poloxamer and one or more additives such as hyaluronic acid, gelatin, fibronectin, or a peptide fragment of fibronectin. The compositions are useful in tissue repair or remodeling, including repair of an injured spinal disc, in drug delivery, in cell culture, and in inhibiting the formation of adhesions.

8. 发明申请

WO2007061887A2 PARTIALLY COMPATIBILIZED PVC COMPOSITES 审中-公开
标题翻译：部分兼容的PVC复合材料
公开(公告)号：WO2007061887A2
公开(公告)日：2007-05-31
申请号：PCT/US2006/044761
申请日：2006-11-17
申请人： RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , RAFAILOVICH, Miriam , SI, Mayu , ABECASSIS, David
发明人： RAFAILOVICH, Miriam , SI, Mayu , ABECASSIS, David
IPC分类号： H04M3/42
CPC分类号： C08L23/10 , C08K3/346 , C08L23/02 , C08L23/04 , C08L23/06 , C08L27/04 , C08L27/06 , C08L2666/06 , C08L2666/04
摘要： A composite material and a method of making a composite material that includes: a polyolefin; polyvinyl chloride and a compatibilizer, preferably a nanoclay. The polyolefins is preferably polypropylene or polyethylene. In a preferred embodiment, the composite material includes a polypropylene, a polyethylene, polyvinyl chloride and a nanoclay. The nanoclay includes a quaternary ammonium salt based organic group and exfoliates when heated and is most preferably bentonite, smectite, hectorite, sepiolite or montmorillonite.
摘要翻译：复合材料和复合材料的制造方法，其包括：聚烯烃; 聚氯乙烯和增容剂，优选纳米粘土。聚烯烃优选为聚丙烯或聚乙烯。在优选的实施方案中，复合材料包括聚丙烯，聚乙烯，聚氯乙烯和纳米粘土。纳米粘土包括基于季铵盐的有机基团，并在加热时脱落，最优选为膨润土，蒙脱石，锂蒙脱石，海泡石或蒙脱石。

9. 发明申请

WO2006012401A1 COMPATIBILIZING POLYMER BLENDS BY USING ORGANOCLAY 审中-公开
标题翻译：通过使用有机碳兼容聚合物混合物
公开(公告)号：WO2006012401A1
公开(公告)日：2006-02-02
申请号：PCT/US2005/025850
申请日：2005-07-21
申请人： RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , RAFAILOVICH, Miriam , SI, Mayu
发明人： RAFAILOVICH, Miriam , SI, Mayu
IPC分类号： C08K3/34
CPC分类号： C08L27/06 , C08K3/346 , C08K9/04 , C08L25/06 , C08L25/12 , C08L33/12 , C08L33/20 , C08L35/06 , C08L67/02 , C08L69/00 , C08L2666/04 , C08L2666/18
摘要： A method for producing a polymer blend that includes: combining a first polymer, a second polymer and an organoclay to form a mixture, wherein the first polymer is not compatible with the second polymer, and heating the polymer and organoclay mixture to form a compatilized polymer blend. The preferred organoclay is montmorillonite clay functionalized by an intercalation agent. The intercalation agent is a reaction product of a polyamine and an alkyl halide in a polar solvent.
摘要翻译：一种制备聚合物共混物的方法，其包括：将第一聚合物，第二聚合物和有机粘土组合以形成混合物，其中第一聚合物与第二聚合物不相容，并且加热聚合物和有机粘土混合物以形成相容的聚合物混合。优选的有机粘土是由嵌入剂官能化的蒙脱石粘土。插层剂是多胺和烷基卤在极性溶剂中的反应产物。

10. 发明申请

WO2007061883A2 FLAME RETARDANT PLASTIC COMPOSITIONS 审中-公开
标题翻译：阻燃塑料组合物
公开(公告)号：WO2007061883A2
公开(公告)日：2007-05-31
申请号：PCT/US2006/044757
申请日：2006-11-17
申请人： RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , RAFAILOVICH, Miriam , ABECASSIS, David
发明人： RAFAILOVICH, Miriam , ABECASSIS, David
IPC分类号： C08K5/06 , C08K9/04
CPC分类号： C08L23/02 , B82Y30/00 , C08K3/22 , C08K3/346 , C08K5/0066 , C08K5/06 , C08K7/24 , C08K9/04 , C08K2201/011 , C08L23/06 , C08L23/0815 , C08L23/10 , C08L25/18 , C08L2666/02 , C08L25/00 , C08L9/00
摘要： A fire retardant composition that includes: a polyolefm and an additive package that includes a brominated polystyrene or decabromodiphenyl ether; a nanoclay; and metal oxide fillers in the nanometer particle range. The compositions can have high weight percentages of the additive package because of the compatibilizing effect of the nanoclay. The nanoclay is preferably a quantenary amine treated nanoclay, wherein the quantenary amine causes exfoliation of the nanoclay. The polyolefin is a polyethylene or a polypropylene and the preferred metal oxide is antimony oxide.
摘要翻译：一种阻燃剂组合物，其包含：聚烯烃和包含溴化聚苯乙烯或十溴二苯醚的添加剂包; 纳米粘土; 和纳米颗粒范围内的金属氧化物填料。由于纳米粘土的相容作用，组合物可具有高添加剂包的重量百分比。纳米粘土优选是经量子胺处理的纳米粘土，其中量子胺导致纳米粘土的剥落。聚烯烃是聚乙烯或聚丙烯，优选的金属氧化物是氧化锑。

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