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1. 发明申请

WO2008134511A1 DETECTION OF CANCER MARKERS 审中-公开
标题翻译：检测癌症标志物
公开(公告)号：WO2008134511A1
公开(公告)日：2008-11-06
申请号：PCT/US2008/061578
申请日：2008-04-25
申请人： POLYTECHNIC UNIVERSITY , THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , LEVON, Kalle , RAFAILOVICH, Miriam , RIGAS, Basil , WANG, Yantian
发明人： LEVON, Kalle , RAFAILOVICH, Miriam , RIGAS, Basil , WANG, Yantian
IPC分类号： G01N27/26
CPC分类号： G01N33/5438 , B82Y15/00 , B82Y30/00 , C12Q1/003 , G01N2610/00
摘要： The present invention relates to combining surface molecular imprinting (SMI) with the production of self-assembled monolayers (SAM) of hydroxyl alkanethiolate molecules on gold coated chip surfaces. In this technique, the sensing element is placed on the transducer and the whole assembly can then be miniaturized and integrated into a smart chip. These sensors can detect, nanomolar quantities of complex biomolecules.
摘要翻译：本发明涉及将表面分子印迹（SMI）与在金涂覆的芯片表面上生产羟基链烷硫醇盐分子的自组装单层（SAM）。在这种技术中，感测元件放置在换能器上，然后可以将整个组件小型化并集成到智能芯片中。这些传感器可以检测纳摩尔量的复合生物分子。

2. 发明申请

WO2010048627A2 POTENTIOMETRIC SENSORS BASED ON SURFACE MOLECULAR IMPRINTING, AND NANOPARTICLE COMPOSITION FOR THE DETECTION OF CANCER BIOMARKERS AND VIRUSES AND METHODS OF USE THEREOF 审中-公开
标题翻译：基于表面分子印迹的电位传感器和用于检测癌症生物标记和病毒的纳米颗粒组合物及其使用方法
公开(公告)号：WO2010048627A2
公开(公告)日：2010-04-29
申请号：PCT/US2009/062116
申请日：2009-10-26
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , RIGAS, Basil , RAFAILOVICH, Mirim , LEVON, Kalle
发明人： RIGAS, Basil , RAFAILOVICH, Mirim , LEVON, Kalle
IPC分类号： G01N33/553 , G01N33/574
CPC分类号： G01N33/57484 , A61K31/519 , A61K38/00 , G01N33/54346 , G01N33/5436 , G01N33/54366 , G01N33/553 , G01N2600/00
摘要： Disclosed is a method and apparatus using surface molecular imprinting and nanoparticles for the rapid determination of cancer biomarkers, detection of viruses, and the treatment of cancer, via a treatment that selectively targets cancer cells.
摘要翻译：公开了一种使用表面分子印记和纳米粒子通过选择性靶向癌细胞的治疗来快速确定癌症生物标志物，检测病毒和治疗癌症的方法和设备。

3. 发明申请

WO2005100600A2 IONIC BASED SENSING FOR IDENTIFYING GENOMIC SEQUENCE VARIATIONS AND DETECTING MISMATCH BASE PAIRS, SUCH AS SINGLE NUCLEOTIDE POLYMORPHISMS 审中-公开
标题翻译：用于识别基因组序列变异的基于离子的感知和检测错配基因对，如单核苷酸多态性
公开(公告)号：WO2005100600A2
公开(公告)日：2005-10-27
申请号：PCT/US2005/010171
申请日：2005-03-25
申请人： POLYTECHNIC UNIVERSITY , ZHOU, Yanxiu , YU, Bin , LEVON, Kalle
发明人： ZHOU, Yanxiu , YU, Bin , LEVON, Kalle
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6825 , C12Q2600/156 , G01N27/333 , C12Q2565/518
摘要： Ionic interactions are monitored to detect hybridization. The measurement may be done measuring the potential change in the solution with the ion sensitive electrode (which may be the conducting polymer (e.g., polyaniline) itself), without applying any external energy during the binding. The double helix formation during the complimentary hybridization makes this electrode act as an ion selective electrode -- the nucleotide hydrogen bonding is specific and thus monitoring the ionic phosphate group addition becomes selective. Polyaniline on the surface of nylon film forms a positively charged polymer film. Thiol linkage can be utilized for polyaniline modification and thiol-modified single strand oligonucleotide chains can be added to polyaniline. The sensitivity is because the double helix formation during the complimentary hybridization makes this electrode act as an ion selective electrode as the nucleotide hydrogen bonding is specific and thus monitoring the ionic phosphate group addition becomes selective.
摘要翻译：监测离子相互作用以检测杂交。测量可以通过离子敏感电极（其可以是导电聚合物（例如，聚苯胺）本身））测量溶液中的潜在变化，而在结合期间不施加任何外部能量。在互补杂交期间的双螺旋形成使得该电极用作离子选择性电极 - 核苷酸氢键是特异性的，因此监测离子性磷酸酯基添加成为选择性的。尼龙膜表面的聚苯胺形成带正电的聚合物膜。硫醇连接可用于聚苯胺改性，巯基修饰的单链寡核苷酸链可以加入到聚苯胺中。敏感性是因为互补杂交期间的双螺旋形成使得该电极用作离子选择性电极，因为核苷酸氢键是特异性的，因此监测离子性磷酸酯基添加成为选择性的。

4. 发明申请

WO2005100599A2 CYCLIC VOLTAMMETRY (CV) FOR IDENTIFYING GENOMIC SEQUENCE VARIATIONS AND DETECTING MISMATCH BASE PAIRS, SUCH AS SINGLE NUCLEOTIDE POLYMORPHISMS 审中-公开
标题翻译：用于鉴定基因组序列变异的循环伏安法（CV）和检测错配基因对，如单核多核苷酸多态性
公开(公告)号：WO2005100599A2
公开(公告)日：2005-10-27
申请号：PCT/US2005/010170
申请日：2005-03-25
申请人： POLYTECHNIC UNIVERSITY , ZHOU, Yanxiu , YU, Bin , LEVON, Kalle
发明人： ZHOU, Yanxiu , YU, Bin , LEVON, Kalle
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6825 , B01J2219/00653 , B01J2219/00713 , B01J2219/00722 , C12Q1/6874 , G01N27/48 , C12Q2565/607 , C12Q2565/501
摘要： Cyclic voltammetry (CV) may be used with novel sensors for identifying the presence of target sequences complementary to probe sequences. The sensor may include an electrode layer (which is used as a working electrode in a CV system), a conductive polymer layer, and probes immobilized (e.g., via sulfur) on the conductive polymer layer. The conductive polymer layer may be polyaniline, or the like. The probes may be immobilized on the polymer layer using an electro-chemical immobilization technique in the presence of nucleophiles, such as thiol groups for example. The probes may be oligionucleotides. Thus, the sensors may be used for identifying genomic sequence variations and detecting mismatch base pairs, such as single nucleotide polymorphisms (SNPs) for example.
摘要翻译：循环伏安法（CV）可用于识别存在与探针序列互补的靶序列的新型传感器。传感器可以包括电极层（其用作CV系统中的工作电极），导电聚合物层和在导电聚合物层上固定（例如通过硫）的探针）。导电聚合物层可以是聚苯胺等。探针可以使用电化学固定技术在亲核试剂例如巯基的存在下固定在聚合物层上。探针可以是寡核苷酸。因此，传感器可用于鉴定基因组序列变异并检测错配碱基对，例如单核苷酸多态性（SNP）。

5. 发明申请

WO2005105929A2 METHODS OF PRODUCING A CONJUGATED OLIGOMER EXHIBITING SUPRAMOLECULAR π-CONJUGATION EXTENSION, AND RESULTING PRODUCTS OF SUCH METHODS 审中-公开
标题翻译：生产聚合低聚物的方法，展示了分子结合扩散，并产生了这种方法的产物
公开(公告)号：WO2005105929A2
公开(公告)日：2005-11-10
申请号：PCT/US2005/013755
申请日：2005-04-22
申请人： POLYTECHNIC UNIVERSITY , LEVON, Kalle , SAI, Tsunehiro
发明人： LEVON, Kalle , SAI, Tsunehiro
IPC分类号： C09B59/00
CPC分类号： C09B59/00 , H01B1/128
摘要： Methods for preparing an oligomer exhibiting supramolecular extension of π-conjugation are described. The manipulation of intra -oligomeric properties such as π-conjugation length and the precise architecture(s) resulting from inter -oligomeric variations resulting from supramolecular chemistry offers great promise in the design of nanoscale devices. As shown, self-assembly of the supramolecular structure can be induced by causing a molecule : dopant molar ratio to go beyond the predicted theoretical fully-doped molar ratio.
摘要翻译：描述了制备显示出π共轭的超分子延伸的低聚物的方法。寡聚物性质的操作，例如π共轭长度和由超分子化学引起的低分子变化产生的精确结构在纳米级器件的设计中提供了巨大的前景。如图所示，超分子结构的自组装可以通过使分子：掺杂剂摩尔比超过预测的理论充分掺杂摩尔比来诱导。

6. 发明申请

WO2008020326A2 CONTROLLED ELECTROSPINNING OF FIBERS 审中-公开
标题翻译：控制电纺丝的纤维
公开(公告)号：WO2008020326A2
公开(公告)日：2008-02-21
申请号：PCT/IB2007/003249
申请日：2007-04-09
申请人： BARINOV, Victor , LEVON, Kalle
发明人： BARINOV, Victor , LEVON, Kalle
CPC分类号： D01D5/0092 , D03D15/0061 , D03D41/00
摘要： An electrospinning apparatus and method for spinning a polymer fiber from a fluid that comprises a polymer, comprises: a plurality of collectors; a jet supply device delivering a quantity of fluid; at least one collector of the plurality of collectors in electrical communication with the jet supply device during at least one time duration, the at least one collector and the jet supply device adapted to form an electric field therebetween and draw the quantity of fluid from the jet supply device toward the at least one collector and form the polymer fiber at the at least one collector device during the at least one time duration; a controller controlling sequence and the at least one time duration of which of each the at least one collector of the plurality of collectors is in electrical communication with the jet supply device at least once during a time period.
摘要翻译：一种用于从包含聚合物的流体纺丝聚合物纤维的静电纺丝装置和方法，包括：多个收集器; 喷射供应装置，其输送一定量的流体; 所述多个收集器中的至少一个收集器在至少一个持续时间期间与所述喷射供应装置电连通，所述至少一个收集器和所述喷射供应装置适于在其间形成电场，并从所述射流供应装置朝着所述至少一个收集器并且在所述至少一个持续时间期间在所述至少一个收集器装置处形成所述聚合物纤维; 一个控制器控制顺序以及多个收集器的至少一个收集器中的每一个的至少一个持续时间在一段时间内至少与喷气供应装置电连通。

7. 发明申请

WO2007079488A2 CONTROLLED ELECTROSPINNING OF FIBERS 审中-公开
标题翻译：可控电纺纤维
公开(公告)号：WO2007079488A2
公开(公告)日：2007-07-12
申请号：PCT/US2007/060067
申请日：2007-01-03
申请人： BARINOV, Victor , LEVON, Kalle
发明人： BARINOV, Victor , LEVON, Kalle
IPC分类号： B32B27/10
CPC分类号： D01D5/0092
摘要： Electrospinning apparatus and methods for spinning a polymer fiber from a fluid comprising a polymer in the presence of an electric field established between at least one collector and a jet supply device, in a first embodiment comprising: a) forming an electrospinning jet stream of the fluid directed toward the at least one collector; b) controlling dispersion characteristics of the fluid by applying a magnetic field between the jet supply device and the at least one collector; c) forming at least one polymer fiber at the at least one collector; and in a second embodiment comprising: a) forming an electrospinning jet stream of the fluid directed toward a plurality of collectors; b) controlling dispersion characteristics of the fluid by applying different voltages to at least two collectors of the plurality of collectors; c) forming at least one polymer fiber at at least one collector of the plurality of collectors.
摘要翻译：在第一实施方案中，在至少一个收集器和射流供应装置之间建立的电场存在下，用于从包含聚合物的流体中纺出聚合物纤维的静电纺丝设备和方法包括：a）形成指向所述至少一个收集器的流体的静电纺射流; b）通过在射流供应装置和至少一个收集器之间施加磁场来控制流体的分散特性; c）在所述至少一个收集器中形成至少一种聚合物纤维; 并且在第二实施例中包括：a）形成指向多个收集器的流体的静电纺射流; b）通过向所述多个收集器中的至少两个收集器施加不同的电压来控制流体的扩散特性; c）在多个收集器的至少一个收集器中形成至少一根聚合物纤维。

8. 发明申请

WO2006050340A2 METHODS AND APPARATUS FOR MODIFYING GEL ADHESION STRENGTH 审中-公开
标题翻译：用于修饰凝胶粘附强度的方法和装置
公开(公告)号：WO2006050340A2
公开(公告)日：2006-05-11
申请号：PCT/US2005/039423
申请日：2005-11-01
申请人： BARINOV, Victor , DABROWSKI, Robert , LEVON, Kalle
发明人： DABROWSKI, Robert , LEVON, Kalle
IPC分类号： B32B27/08
CPC分类号： B32B43/006 , B32B37/12 , B32B38/00 , B32B2037/1246 , B32B2038/0052 , C09J5/00 , C09J2205/302 , Y10T29/49755 , Y10T29/49821 , Y10T156/11 , Y10T156/1158 , Y10T156/19
摘要： The invention concerns a method for controlling the adhesive bond between an electric-field responsive material and a substrate, which method comprises using an electric field to control the strength and integrity of the adhesive bond. The method may be used, for example for removing or delaminating a material, which material is responsive to an electric field, from a substrate. The invention further comprises elimination of the application of the electric field and application of the previously removed electric-field-responsive material to the substrate, thereby resuming the strength and integrity of the adhesive bond. The invention includes apparatus for use in the bond controlling process.
摘要翻译：本发明涉及一种用于控制电场响应材料和基底之间的粘合剂结合的方法，该方法包括使用电场来控制粘合剂粘结的强度和完整性。该方法可以用于例如从衬底上去除或分层哪种材料对电场响应的材料。本发明还包括消除电场的应用和将先前去除的电场响应材料应用于衬底，从而恢复粘合剂结合的强度和完整性。本发明包括用于键控制过程的装置。

9. 发明申请

WO2003015936A1 NANOGELS AND THEIR PRODUCTION USING LIPOSOMES AS REACTORS 审中-公开
标题翻译： NANOGELS及其使用脂质体作为反应器的生产
公开(公告)号：WO2003015936A1
公开(公告)日：2003-02-27
申请号：PCT/US2002/026055
申请日：2002-08-15
申请人： POLYTECHNIC UNIVERSITY
发明人： KAZAKOV, Sergey , KAHOLEK, Marian , LEVON, Kalle
IPC分类号： B05D7/00
CPC分类号： A61K9/5138 , A61K9/127 , A61K9/1273 , B01J13/02 , B82Y5/00 , C08J3/075 , Y10T428/2982 , Y10T428/2984 , Y10T428/2985 , Y10T428/2987 , Y10T428/2989 , Y10T428/2991
摘要： The present invention includes a method for preparing polymer hydrogel spherical particles on a nanometer scale (nanogels). The method includes encapsulating hydrogel-forming components into liposomes, diluting the large unilamellar liposomes suspension to prevent polymerization outside the liposomes, and polymerizing the encapsulated hydrogel-forming components. The lipid bilayer may be solubilized with detergent. The phospholipid and detergent molecules and their micelles may then be removed by dialysis. The resulting nanogels may then be dried by evaporation in a temperature gradient. Poly(acrylamide), poly(N- isopropylacrylamide ), and poly(N-isopropylacrylamide- co -1-vinylimidazole) hydrogel particles with a diameter from 30 to 300 nm were detected and characterized by dynamic light scattering technique. The solvent, temperature, pH, and ionic sensitivities of the nanogels were studied.
摘要翻译：本发明包括一种制备纳米尺度聚合物水凝胶球形颗粒的方法（纳米凝胶）。该方法包括将水凝胶形成成分包封在脂质体中，稀释大的单层脂质体悬浮液以防止在脂质体外聚合，并聚合包封的水凝胶形成成分。脂质双层可以用洗涤剂溶解。然后可以通过透析除去磷脂和洗涤剂分子及其胶束。然后可以通过在温度梯度中蒸发来干燥所得的纳米凝胶。检测直径为30〜300nm的聚（丙烯酰胺），聚（N-异丙基丙烯酰胺）和聚（N-异丙基丙烯酰胺 - 共-1-乙烯基咪唑）水凝胶颗粒，并用动态光散射技术表征。研究了纳米凝胶的溶剂，温度，pH和离子敏感性。

10. 发明申请

WO2003106988A1 CHIRAL LIGAND EXCHANGE POTENTIOMETRY AND ENANTIOSELECTIVE SENSORS 审中-公开
标题翻译： CHIRAL LIGAND LIGAN交流电位测量仪和ENANTILECLECTION传感器
公开(公告)号：WO2003106988A1
公开(公告)日：2003-12-24
申请号：PCT/US2003/018830
申请日：2003-06-13
申请人： POLYTECHNIC UNIVERSITY
发明人： LEVON, Kalle , YU, Bin , ZHOU, Yanxiu
IPC分类号： G01N27/327
CPC分类号： G01N27/3335
摘要： Enantiomeric resolution is realized by combining an electrochemical method with ligand exchange (LE) in a novel electrochemical method named chiral ligand exchange potentiometry. Chiral selector ligands preferentially recognize certain enantiomers and undergo ligand exchange with the enantiomeric labile coordination complexes to form diastereomeric complexes. These complexes can form in solution and be recognized by an unmodified electrode, or they can be immobilized on the surface of a modified electrode (chiral sensor) incorporated with chiral selector ligand by polysiloxane monolayer immobilization (PMI).
摘要翻译：通过将电化学方法与配体交换（LE）结合在一种称为手性配体交换电位法的新型电化学方法中来实现对映体拆分。手性选择配体优先识别某些对映异构体，并与对映异构体不稳定配位络合物进行配体交换以形成非对映复合物。这些络合物可以在溶液中形成并被未改性的电极识别，或者它们可以通过聚硅氧烷单层固定化（PMI）固定在掺有手性选择配体的改性电极（手性传感器）的表面上。

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