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1. 发明申请

WO1996031199A1 PHARMACEUTICAL MICROENCAPSULATION 审中-公开
标题翻译：药物微生物学
公开(公告)号：WO1996031199A1
公开(公告)日：1996-10-10
申请号：PCT/GB1996000809
申请日：1996-04-03
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE , UNIVERSITE DE LAUSANNE , CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS , KIDDLE, Simon, John , JORDAN, Olivier , RANIERI, John , AEBISCHER, Patrick , CLEMENCE, Jean-François
发明人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE , UNIVERSITE DE LAUSANNE , CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS , KIDDLE, Simon, John
IPC分类号： A61K09/50
CPC分类号： A61L27/3804 , A61K9/5026 , A61K9/5089 , A61K2035/128 , C12N5/0677 , C12N11/04
摘要： A method of producing a microencapsulated pharmaceutical formulation is disclosed comprising causing a dye to be attached to the surface of pharmaceutical particles or particle clusters and applying a source of radiant energy to the dye in the presence of a liquid polymeric or polymerisable material so as to cause the material to cross-link, producing a conformal layer of cross-linked polymer on the particulate surfaces. Preferably, the polymer provides an immuno-protective layer around the particles, while allowing therapeutic components to exit the microcapsules. Microencapsulated pharmaceutical formulations and their medical use are also disclosed, especially for the treatment of diabetes by encapsulating insulin secreting cells.
摘要翻译：公开了一种生产微胶囊化药物制剂的方法，其包括使染料附着在药物颗粒或颗粒簇的表面上，并在液体聚合或可聚合材料的存在下将辐射能源施加到染料上，从而引起交联的材料，在颗粒表面上产生交联聚合物的共形层。优选地，聚合物在颗粒周围提供免疫保护层，同时允许治疗成分离开微胶囊。还公开了微囊化药物制剂及其医疗用途，特别是用于通过包封胰岛素分泌细胞治疗糖尿病。

2. 发明申请

WO1996025487A1 MATERIALS AND METHODS RELATING TO THE REGULATION OF POLYPEPTIDE PRODUCTION IN CELLS 审中-公开
标题翻译：关于细胞中多肽生产调节的材料和方法
公开(公告)号：WO1996025487A1
公开(公告)日：1996-08-22
申请号：PCT/GB1996000256
申请日：1996-02-07
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE , UNIVERSITE DE LAUSANNE , CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS , KIDDLE, Simon, John , THORENS, Bernard
发明人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE , UNIVERSITE DE LAUSANNE , CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS , KIDDLE, Simon, John
IPC分类号： C12N05/10
CPC分类号： C12N15/67 , C07K14/4705 , C07K14/575 , C07K14/62 , C07K14/72
摘要： This application relates to cell lines transfected with (a) nucleic acid encoding one or more hormone receptors, the receptors being capable of transmitting a signal, and (b) nucleic acid encoding a desired polypeptide, the nucleic acid encoding the polypeptide being under the control of a promoter containing regulatory elements responsive to the signal transmitted by the receptor(s) so that transcription of the nucleic acid encoding the desired polypeptide is modulated by the level of the hormone(s) in the patient. Preferably, the receptors are the GIP or GLP-1 receptors controlling the production of insulin in the cells in response to changes in the metabolic status of a patient. The application also relates to compositions comprising these cells and their use in methods of medical treatment.
摘要翻译：本申请涉及用（a）编码一种或多种激素受体的核酸转染的细胞系，该受体能够传递信号，和（b）编码所需多肽的核酸，编码该多肽处于控制之下的核酸的启动子，其含有响应于由受体传递的信号的调节元件，使得编码所需多肽的核酸的转录受到患者体内激素水平的调节。优选地，受体是响应于患者的代谢状态的变化而控制细胞中胰岛素产生的GIP或GLP-1受体。本申请还涉及包含这些细胞的组合物及其在医学治疗方法中的用途。

3. 发明申请

WO1997012382A1 PROCESS FOR MANUFACTURING AN ELECTRODE FOR AN ELECTROCHEMICAL DEVICE 审中-公开
标题翻译：用于制造电化学装置的电极的方法
公开(公告)号：WO1997012382A1
公开(公告)日：1997-04-03
申请号：PCT/IB1995000786
申请日：1995-09-25
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE , PAPPAS, Nicholas , GRÄTZEL, Michael
发明人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
IPC分类号： H01G09/20
CPC分类号： H01G9/2031 , Y02E10/542 , Y02P70/521
摘要： The present invention aims at improving the catalytic activity of the metallic platinum deposited on the substrate of the counterelectrode (i.e. the cathode), so as to obtain a high value of the catalytic activity on the reduction reaction of triiodide to iodide essentially independant of the nature of the solvent used in the electrolyte. To that effect, the manufacturing process according to the invention is characterized in that said metallic platinum is deposited in the form of a plurality of spheroidal microcrystallite clusters each having a size of less than about 100 nanometers, dispersed over the surface of said substrate, and in that said deposited metallic platinum is submitted to a thermal treatment, carried out at a temperature in the range of about 375 to 400 DEG C, so as to enhance the catalytic properties of the platinum on the oxido-reduction reaction of iodine and triiodide 3I2 + 2e 2I3 in the redox system iodine/iodide.
摘要翻译：本发明旨在提高沉积在对电极（即阴极）基底上的金属铂的催化活性，从而获得三碘化物与碘化物的还原反应对催化活性的高值，其基本上独立于自然界的电解质中使用的溶剂。为此，根据本发明的制造方法的特征在于，所述金属铂以多个球状微晶簇的形式沉积，每个微球簇具有小于约100纳米的尺寸，分散在所述衬底的表面上，以及因为所述沉积的金属铂进行热处理，在约375-400℃的温度下进行，以提高铂对碘和三碘化物3I2的氧化还原反应的催化性能 + 2e < - > <==> 2I3 < - >在氧化还原体系碘/碘化物中。

4. 发明申请

WO1993017418A1 METHOD AND DEVICE FOR OPTICALLY READING A SOUND RECORDING ON A GROOVED RECORDING MEDIUM 审中-公开
标题翻译：用于光刻读取记录在记录介质上的声音记录的方法和装置
公开(公告)号：WO1993017418A1
公开(公告)日：1993-09-02
申请号：PCT/CH1993000045
申请日：1993-02-22
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE , POLIAK, Juraj
发明人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
IPC分类号： G11B11/18
CPC分类号： G11B7/1384 , G11B7/005 , G11B11/18
摘要： A device for implementing a method for optically reading a sound recording on a grooved recording medium which comprises a spiral groove on a disc or a helical groove on a cylinder, and is rotated about an axis. The device comprises an optical fibre (14) having one end arranged to reflect light injected therein, and being substantially tangentially positioned in the groove (10) so that the modulations etched into said groove generate X and Y movements of the fibre; and a means for injecting light into said fibre. The reflected light beam (18) exiting the optical fibre is focused as a light spot (21) onto an optical position sensor (20) by an optical system (19), and at least one component of the light is analyzed, whereby said recording may be read.
摘要翻译：一种用于实现在凹槽记录介质上光学读取声音记录的方法的装置，其包括盘上的螺旋槽或圆柱体上的螺旋槽，并且绕轴线旋转。该装置包括光纤（14），其一端设置成反射入其中的光，并且基本上切向地定位在凹槽（10）中，使得蚀刻到所述凹槽中的调制产生光纤的X和Y运动; 以及用于将光注入所述光纤的装置。离开光纤的反射光束（18）通过光学系统（19）被聚焦成光点（21）到光学位置传感器（20）上，并且分析光的至少一个分量，从而所述记录可能会被阅读。

5. 发明申请

WO1999005509A1 DETECTION AND INVESTIGATION OF BIOLOGICAL MOLECULES BY FOURIER TRANSFORM INFRA-RED SPECTROSCOPY 审中-公开
标题翻译：通过FOURIER TRANSFORM红外光谱检测和调查生物分子
公开(公告)号：WO1999005509A1
公开(公告)日：1999-02-04
申请号：PCT/IB1997000920
申请日：1997-07-24
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE , VOGEL, Horst , KELLER, Thomas , LILEY, Martha
发明人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
IPC分类号： G01N21/55
CPC分类号： B82Y30/00 , B82Y15/00 , G01N21/552
摘要： Method and apparatus to study biological molecules or biological components at or in self-assembled monolayers (SAMs) on metal surfaces (2) such as gold in aqueous environments (6) using attenuated total internal reflection Fourier transform infra-red (ATR-FTIR) spectroscopy are described. Said method may be used for e.g. the screening for effective substances suitable as agonists or antagonists or - if performed time resolved - for studying kinetics of interactions of e.g. biological molecules adsorption and desorption processes or for the development of materials and surfaces for biological or medical applications.
摘要翻译：在金属表面（2）上的自组装单层（SAM）中或在含水环境中的金（6）中使用衰减的全内反射傅立叶变换红外（ATR-FTIR）研究生物分子或生物成分的方法和装置描述光谱。所述方法可以用于例如。筛选适合作为激动剂或拮抗剂的有效物质，或者 - 如果执行时间解决 - 用于研究例如抗体的相互作用的动力学。生物分子吸附和解吸过程或用于生物或医学应用的材料和表面的开发。

6. 发明申请

WO1997035332A1 ELECTROCHEMICAL DEVICE AND ELECTROLYTE THEREFOR 审中-公开
标题翻译：电化学装置及其电解质
公开(公告)号：WO1997035332A1
公开(公告)日：1997-09-25
申请号：PCT/CH1997000113
申请日：1997-03-19
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE , BONHOTE, Pierre , DLOCZIK, Larissa
发明人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
IPC分类号： H01G09/20
CPC分类号： H01M10/0566 , G02F1/1525 , H01G9/2004 , H01G9/2031 , H01M6/164 , Y02E10/542
摘要： An electrochemical device with enhanced performance stability over time and according to the operating temperature is disclosed. The device contains an electrolytic solution including at least one solution of a salt in a solvent at least mostly consisting of at least one compound selected from aliphatic dinitriles, aliphatic alkoxynitriles and symmetrical or asymmetrical bis-cyanoalkyl ethers, or a mixture of at least two of these compounds considered in isolation or in combination, said compound and said mixture being liquid at room temperature.
摘要翻译：公开了一种随时间和根据工作温度提高性能稳定性的电化学装置。该装置包含电解溶液，其包括至少一种盐在溶剂中的至少一种溶液，其至少主要由至少一种选自脂族二腈，脂族烷氧基腈和对称或不对称双氰基烷基醚的化合物组成，或者至少两种这些化合物分离或组合考虑，所述化合物和所述混合物在室温下为液体。

7. 发明申请

WO1998029819A1 REAL-TIME REMOTE INSPECTION OF HIGH-RESOLUTION IMAGES 审中-公开
标题翻译：实时远程检测高分辨率图像
公开(公告)号：WO1998029819A1
公开(公告)日：1998-07-09
申请号：PCT/IB1997001607
申请日：1997-12-30
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE , BASSO, Andrea , NORO, Raffaele , VERSCHEURE, Olivier , HUBAUX, Jean-Pierre
发明人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
IPC分类号： G06F17/30
CPC分类号： G06T3/40 , G06F17/30277 , H04N1/2166
摘要： There is provided a method for storage, retrieval and transmission comprising: the steps of receiving hierarchical digital image data from the source (1), where images are analysed and further decomposed as a set of elementary areas in which any such area in one image at a given level of hierarchy corresponds to a group of elementary areas in the upper level of the hierarchy and in which for each image of the hierarchy, consecutive elementary areas are sorted out in a first file, where the position in said first file of each area is indexed in a second file and the length in bytes of each area is stored in a third file; the steps of passing and storing the index file and the length file of the areas in each image of the hierarchy in which these files are further used when retrieving from the storage means (3) a portion of a given image in the hierarchy selected by a control signal (5) issued by the display apparatus (10) and where the selection refers to an image or portion of an image at a coarser resolution level in the hierarchy; the steps of buffering the requested portion of the images at higher resolution where the elementary areas are organised in order to form a sequence of consecutive areas to be transmitted across the transmission means (9) and that are suitable for the display apparatus.
摘要翻译：提供了一种用于存储，检索和传输的方法，包括：从源（1）接收分层数字图像数据的步骤，其中图像被分析并进一步分解为一组基本区域，其中一个图像中的任何这样的区域给定级别的层次对应于层次上层的一组基本区域，并且对于层次结构的每个图像，在第一文件中排列连续的基本区域，其中每个区域的所述第一文件中的位置在第二个文件中被索引，并且每个区域的字节长度存储在第三个文件中; 当从存储装置（3）检索在由层级选择的层级中的给定图像的一部分时，进一步使用这些文件的层次结构的每个图像中的区域的区域的传递和存储步骤由所述显示装置（10）发出的所述控制信号（5），并且其中所述选择涉及所述层级中较粗分辨率级别的图像或部分图像; 以更高分辨率缓冲所要求的图像部分的步骤，其中基本区域被组织，以便形成要跨越传输装置（9）并且适合于显示装置的要传输的连续区域的序列。

8. 发明申请

WO1996042101A1 ELECTRON SOURCE AND APPLICATIONS OF THE SAME 审中-公开
标题翻译：电子源及其应用
公开(公告)号：WO1996042101A1
公开(公告)日：1996-12-27
申请号：PCT/IB1996000573
申请日：1996-06-11
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE , DeHEER, Walter, A. , UGARTE, Daniel , CHATELAIN, André
发明人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
IPC分类号： H01J03/02
CPC分类号： B82Y10/00 , H01J3/022 , H01J2201/30434
摘要： The electron source comprises a uniform microscopically flat carbon nanotube film parallel to which and close to which are one or several perforated thin conducting plates, which are electrically insulated from the microscopically flat carbon nanotube film. An electric field at the microscopically flat carbon nanotube film, provided by a voltage applied to the microscopically flat carbon nanotube film and to the conducting plates causes electron emission from the microscopically flat carbon nanotube film by the field emission effect resulting in an electron beam which passes through the perforations in the conducting plates. The electron beam intensity is determined by the electric field at the carbon nanotube film which can be regulated with the voltages applied to perforated thin conducting plates.
摘要翻译：电子源包括平行的微观平坦的碳纳米管薄膜，并且接近于与微观平坦的碳纳米管薄膜电绝缘的一个或多个穿孔的薄导电板。通过施加到显微平面碳纳米管膜和导电板上的电压提供的微观平坦碳纳米管膜上的电场通过场发射效应导致来自显微平面碳纳米管膜的电子发射，导致电子束通过通过导电板中的穿孔。电子束强度由碳纳米管膜上的电场确定，可以用施加到穿孔的薄导电板上的电压进行调节。

9. 发明申请

WO1996036477A1 PROCESS AND EQUIPMENTS FOR THE MANUFACTURE OF POLYMER AND FOR COMPOSITE PRODUCTS 审中-公开
标题翻译：用于制造聚合物和复合产品的工艺和设备
公开(公告)号：WO1996036477A1
公开(公告)日：1996-11-21
申请号：PCT/IB1996000467
申请日：1996-05-17
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE , MANSON, Jan-Anders , BOURBAN, Pierre-Etienne , BONJOUR, François
发明人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
IPC分类号： B29C69/00
CPC分类号： B29C70/38 , B29B15/125 , B29C70/465 , B29C70/54 , B29C70/545 , B29C2791/001
摘要： The invention is concerned with an integrated process aiming at short cycle-time material integration in a sequential operation, using different processing methods as well as material preform types (neat polymer and polymer-based composites). Traditionally each material preform type and processing step is developed by separate companies and semi-products are delivered to the next link in the conversion chain. The proposed concept includes novel preform preparation techniques as well as a methodology for integration of the potential conversion steps for composite manufacturing, from fibre and matrix to finished part. Material and process integration opens interesting perspectives in design freedom and economical production of complex shaped parts exhibiting multifunctionality and well optimized performance. A unique and flexible integrated equipment is described combining various processing techniques and consequently several material processing steps can be selected.
摘要翻译：本发明涉及一种集成方法，其目的在于使用不同的加工方法以及材料预型体类型（纯聚合物和基于聚合物的复合材料）在顺序操作中的短循环时间材料整合。传统上，每种材料预制件类型和加工步骤由单独的公司开发，半成品交付到转化链中的下一个环节。所提出的概念包括新颖的预制件制备技术以及用于将复合制造的潜在转化步骤从纤维和基质到成品的整合的方法。材料和工艺整合在设计自由和经济生产复杂形状零件方面展现了多功能性和良好优化性能的有趣视角。描述了结合各种处理技术的独特和灵活的集成设备，因此可以选择几个材料处理步骤。

10. 发明申请

WO1993023926A1 INTERMEDIARY CIRCUIT BETWEEN A LOW VOLTAGE LOGIC CIRCUIT AND A HIGH VOLTAGE OUTPUT STAGE IN STANDARD CMOS TECHNOLOGY 审中-公开
标题翻译：标准CMOS技术中的低电压逻辑电路和高电压输出级之间的中间电路
公开(公告)号：WO1993023926A1
公开(公告)日：1993-11-25
申请号：PCT/CH1993000124
申请日：1993-05-18
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE , DECLERQ, Michel , SCHUBERT, Martin
发明人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
IPC分类号： H03K17/687
CPC分类号： H03K19/018521
摘要： The present invention relates to an intermediary circuit between a low voltage logic circuit and a high voltage output stage in standard CMOS technology. The output stage (20) is comprised of two transistors, respectively with N channel and P channel, achieved according to a standard CMOS technology. The intermediary circuit is comprised of a voltage level translator (21) coupled between an input logic circuit SL and said output stage (20). The voltage level translator (21) is achieved according to a standard CMOS technology and is comprised of at least two similar base blocks forming voltage mirrors interconnected in a cross-configuration. Said circuit is used to control transducers, plasma screens and electromechanical actuators.

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