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    • 3. 发明申请
    • SYMMETRICAL TRIAZINE DERIVATIVES
    • 对称TRIAZINE衍生物
    • WO2004085412A2
    • 2004-10-07
    • PCT/EP2004/050331
    • 2004-03-19
    • CIBA SPECIALTY CHEMICALS HOLDING INC.EHLIS, ThomasMÜLLER, StefanHAYOZ, Pascal
    • EHLIS, ThomasMÜLLER, StefanHAYOZ, Pascal
    • C07D251/24
    • C07D251/24A61K8/4966A61Q17/04
    • Disclosed is the use of the compounds of formula wherein A is a radical of formula (1a) or (1b) R, R 1 and R 5 independently from each other are hydrogen; C 1 -C 18 alkyl; or C 6 -C 12 aryl; R 2 , R 3 and R 4 independently from each other are hydrogen; or a radical of formula wherein at least one of the radicals R 2 , R 3 and R 4 are a radical of formula (1c); R 6 , R 7 , R 8 , R 9 and R 10 independently from each other are hydrogen; hydroxy; C 1 -C 18 alkyl; C 1 -C 18 alkoxy;C 6 -C 12 aryl; C 6 -C 12 aryloxy; C 1 -C 18 alkylthio; carboxy; -COOM; C 1 -C 18 alkylcarboxyl; aminocarbonyl; or mono- or di-C 1 -C 18 alkylamino; M is an alkali metal ion; x is 1 or 2; and y is a number from 2 to 10; for the protection of human and animal hair and skin against the damaging effect of UV radiation. The compounds of formula (1) are high effective UV absorbers for cosmetic formulations aund can - depending on their physical properties - be used in micronized or soluble form.
    • 公开了下式化合物的用途其中A是式(1a)或(1b)的基团,R,R 1和R 5彼此独立地是氢; C1-C18烷基; 或C6-C12芳基; R2,R3和R4彼此独立地是氢; 或下式的基团,其中基团R 2,R 3和R 4中的至少一个为式(1c)的基团; R 6,R 7,R 8,R 9和R 10彼此独立地为氢; 羟基; C1-C18烷基; C1-C18烷氧基; C 6 -C 12芳基; C6-C12aryloxy; C1-C18alkylthio; 羧基; -COOM; C1-C18alkylcarboxyl; 羰基; 或单或二C1-C18烷基氨基; M是碱金属离子; x为1或2; y为2〜10的数; 用于保护人体和动物毛发和皮肤免受紫外线辐射的破坏作用。 式(1)的化合物是用于化妆品制剂的高效紫外线吸收剂,可根据其物理性质 - 以微粉化或可溶形式使用。
    • 7. 发明申请
    • AMINO SUBSTITUTED HYDROXYPHENYL BENZOPHENONE DERIVATIVES
    • 氨基取代的羟基苯并噻吩酮衍生物
    • WO2004052837A2
    • 2004-06-24
    • PCT/EP2003/050937
    • 2003-12-03
    • CIBA SPECIALTY CHEMICALS HOLDING INC.HAASE, JürgEHLIS, ThomasBORSOS, ElekMÜLLER, Stefan
    • HAASE, JürgEHLIS, ThomasBORSOS, ElekMÜLLER, Stefan
    • C07C229/52
    • C07D295/192A61K8/42A61K8/44A61K8/49A61K8/4973A61Q17/04C07C229/52C07C237/32C07C237/34C07C237/40C07C237/42C07D277/46C07D277/66C07D313/12
    • Described are amino substituted hydroxyphenyl benzophenone derivatives of formula (I), wherein R 1 , and R 2 independently from each other are; C 1 ,-C 20 alkyl; C 2 -C 20 alkenyl; C 3 -C 10 ,cycloalkyl; C 3 -C 10 cycloalkenyl; or R 1 , and R 2 together with the linking nitogen atom form a 5- or 6-membered heterocyclic ring; n 1 is a number from 1 to 4; when n 1 =1, R 3 is a saturated or unsaturated heterocyclic radical; hydroxy-C 1 -C 5 alkyl; cyclohexyl optionally substituted with one or more C 1 ,-C 5 alkyl; phenyl optionally substituted with a heterocyclic radical, aminocarbonyl or C 1 -C 5 alkylcarboxy; wenn n 1 is 2, R 3 is an alkylene-, cycloalkylene- or alkenylene radical which is optionally substituted by a carbonyl- or carboxy group; o R 3 together with A forms a bivalent radical of the formula (Ia), wherein n 2 is a number from 1 to 3; when n 1 is 3, R 3 is an alkanetriyl radical; wenn n 1 is 4, R 3 is an alkanetetrayl radical; A is -O-; or -N(R 5 )-; and R 5 is hydrogen; C 1 -C 5 alkyl; or hydroxy-C 1 -C 5 alkyl. The compounds are useful as UV filters in sunscreen applications.
    • 描述了式(I)的氨基取代的羟基苯基二苯甲酮衍生物,其中R1和R2彼此独立地是; C1,-C20alkyl; C2-C20alkenyl; C3-C10,环烷基; C3-C10cycloalkenyl; 或R1和R2与连接的硝原子一起形成5-或6-元杂环; n1是从1到4的数字; 当n1 = 1时,R3是饱和或不饱和杂环基; 羟基C1-C5烷基; 任选被一个或多个C 1 -C 5烷基取代的环己基; 任选被杂环基取代的苯基,氨基羰基或C 1 -C 5烷基羧基; wn1是2,R3是任选被羰基或羧基取代的亚烷基,亚环烷基或亚烯基; O与A一起形成式(Ia)的二价基团,其中n2为1至3的数; 当n1为3时,R3为烷三基; wenn n1为4,R3为烷基四氢呋喃基; A为-O- 或-N(R 5) - ; R5是氢; C1-C5烷基; 或羟基-C 1 -C 5烷基。 这些化合物可用作防晒霜中的紫外线过滤器。