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1. 发明申请

WO2008135421A2 CRYSTAL MODIFICATIONS OF TRANSMISSION DYES 审中-公开
标题翻译：传染性染色体的晶体修饰
公开(公告)号：WO2008135421A2
公开(公告)日：2008-11-13
申请号：PCT/EP2008/055139
申请日：2008-04-28
申请人： CIBA HOLDING INC. , VOGT, Martin , MÜLLER, Stefan , GRUMELARD, Julie , DESHAYES, Cyrille , PAUL, Holger , HAASE, Jürg , EHLIS, Thomas
发明人： VOGT, Martin , MÜLLER, Stefan , GRUMELARD, Julie , DESHAYES, Cyrille , PAUL, Holger , HAASE, Jürg , EHLIS, Thomas
IPC分类号： A61K8/49 , A61Q17/04 , A61Q19/08
CPC分类号： C07D295/192 , A61K8/04 , A61K8/494 , A61K31/495 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic benzophenone derivative of formula (1), selected from the crystal modifications (B) and (C), wherein the crystal modification (B) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.70 Å; and wherein the crystal modification (C) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.06 Å; and (b) a dispersing agent selected from anionic, non-ionic and amphoteric surfactants; for protecting the human skin from browning and skin aging. The new crystal modification (C) represents a thermodynamically stable compound of formula (1) at 25°C. This modification is therefore suitable in dispersions comprising micro-fine particles.
摘要翻译：公开了含有（a）选自结晶改性物（B）和（C）的式（1）的微粉化的微溶有机二苯甲酮衍生物的水性分散体的用途，其中所述结晶改性（B）的特征在于峰在X射线衍射图中，d-间距约为7.70; 并且其中所述晶体改性（C）的特征在于在约7.06的d间距处的X射线衍射图中的峰; 和（b）选自阴离子，非离子和两性表面活性剂的分散剂; 用于保护人体皮肤免受褐变和皮肤老化。新的结晶改性（C）在25℃下代表热力学稳定的式（1）化合物。因此，该修饰适用于包含微细颗粒的分散体。

2. 发明申请

WO2008107347A2 METHOD FOR THE STABILIZATION OF ORGANIC MICRONIZED UV ABSORBERS 审中-公开
标题翻译：有机微波紫外线吸收剂稳定化方法
公开(公告)号：WO2008107347A2
公开(公告)日：2008-09-12
申请号：PCT/EP2008/052336
申请日：2008-02-27
申请人： CIBA HOLDING INC. , DESHAYES, Cyrille , EHLIS, Thomas , GRUMELARD, Julie
发明人： DESHAYES, Cyrille , EHLIS, Thomas , GRUMELARD, Julie
IPC分类号： A61K8/04 , A61K8/35 , A61K8/41 , A61K8/42 , A61K8/49 , A61Q17/04
CPC分类号： A61K8/41 , A61K8/35 , A61K8/494 , A61K2800/52 , A61Q17/04
摘要： Disclosed is the use of amines and amides for the stabilization of a cosmetic composition comprising: (a) an organic micronized UV absorber selected from a benzophenone derivative and (b) a dibenzoylmethane derivative. The use of the amines and amides results in the stabilization of the end-product formulations.
摘要翻译：公开了胺和酰胺用于稳定化妆品组合物的用途，包括：（a）选自二苯甲酮衍生物和（b）二苯甲酰甲烷衍生物的有机微粉化UV吸收剂。使用胺和酰胺导致最终产品配方的稳定化。

3. 发明申请

WO2007071584A2 USE OF TRANSMISSION DYES 审中-公开
标题翻译：使用传染性染色体
公开(公告)号：WO2007071584A2
公开(公告)日：2007-06-28
申请号：PCT/EP2006/069519
申请日：2006-12-11
申请人： CIBA SPECIALTY CHEMICALS HOLDING INC. , MÜLLER, Stefan , HAASE, Jürg , EHLIS, Thomas , KREYER, Gilbert , GIESINGER, Jochen , VOGT, Martin
发明人： MÜLLER, Stefan , HAASE, Jürg , EHLIS, Thomas , KREYER, Gilbert , GIESINGER, Jochen , VOGT, Martin
CPC分类号： C07D295/192 , A61K8/411 , A61K8/42 , A61K8/49 , A61K8/494 , A61K2800/43 , A61Q17/04
摘要： Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic compound which has a UV-Vis spectrum with a maximum from 380 to 420 nm; and (b) an anionic dispersing agent for protecting the human skin from browning and skin aging.
摘要翻译：公开了包含（a）微波化的微溶有机化合物的水分散体的使用，其具有最大值为380至420nm的UV-Vis光谱; 和（b）用于保护人体皮肤免于褐变和皮肤老化的阴离子分散剂。

4. 发明申请

WO2009068469A2 GRINDING AIDS FOR MICRONIZED ORGANIC UV ABSORBERS 审中-公开
标题翻译：微波有机紫外线吸收剂研磨艾滋病
公开(公告)号：WO2009068469A2
公开(公告)日：2009-06-04
申请号：PCT/EP2008/065916
申请日：2008-11-20
申请人： CIBA HOLDING INC. , MONGIAT, Sébastien , GRUMELARD, Julie , EHLIS, Thomas
发明人： MONGIAT, Sébastien , GRUMELARD, Julie , EHLIS, Thomas
IPC分类号： A61K8/35 , A61K8/49 , A61Q17/04
CPC分类号： A61Q17/04 , A61K8/494 , A61K2800/412
摘要： A method of preparing a composition, comprising (a) a micronised insoluble organic UV absorber, which method comprises grinding the insoluble organic UV absorber, in coarse particle form, in a grinding apparatus, in the presence of a grinding aid selected from the groups (b 1 ) carboxylic acids and their salts; (b 2 ) fatty acid esters (b 3 ) alkyl phosphates or phosphoric acid esters; (b 4 ) ethoxylated carboxylic acids or polyethyleneglycol (PEG) esters; (b 5 ) fatty alcohol polyethyleneglycol (PEG) ethers of fatty alcohols; (b 6 ) polyethylene/polypropylene -glycol ethers of saturated or unsaturated C 4 - C 28 fatty acids; (b 7 ) ethoxylated alkylphenols or ethoxylated alkylphenyl ethers; (b 8 ) esters of polyol and mono-, di- or tri-glycerides; (b 9 ) esters of fatty acids and saccharose; (b 10 ) sorbitan mono- and di-esters of saturated and/or unsaturated C 6 - C 22 fatty acids and ethylene oxide groups; and (b 11 ) surfactants which are mainly acting as detergent or cleansing agents.
摘要翻译：一种制备组合物的方法，包括（a）微粉化的不溶性有机UV吸收剂，该方法包括在研磨装置中，在选自以下组的研磨助剂的存在下研磨粗颗粒形式的不溶性有机UV吸收剂（ b1）羧酸及其盐; （b2）脂肪酸酯（b3）磷酸烷基酯或磷酸酯; （b4）乙氧基化羧酸或聚乙二醇（PEG）酯; （b5）脂肪醇的脂肪醇聚乙二醇（PEG）醚; （b6）饱和或不饱和C4-C28脂肪酸的聚乙烯/聚丙二醇醚; （b7）乙氧基化烷基酚或乙氧基化烷基苯基醚; （b8）多元醇和甘油单酯，甘油二酯或甘油酯的酯; （b9）脂肪酸和蔗糖的酯; （b10）饱和和/或不饱和C6-C22脂肪酸和环氧乙烷基团的脱水山梨糖醇单酯和二酯; 和（b11）主要作为洗涤剂或清洁剂的表面活性剂。

5. 发明申请

WO2007090832A1 HYDROXYBENZOPHENONE DERIVATIVES 审中-公开
标题翻译：羟基苯并噻吩衍生物
公开(公告)号：WO2007090832A1
公开(公告)日：2007-08-16
申请号：PCT/EP2007/051117
申请日：2007-02-06
申请人： CIBA SPECIALTY CHEMICALS HOLDING INC. , HAASE, Jürg , MÜLLER, Stefan , EHLIS, Thomas
发明人： HAASE, Jürg , MÜLLER, Stefan , EHLIS, Thomas
IPC分类号： C07F7/08 , A61Q17/04 , A61K8/58
CPC分类号： C07F7/0854 , A61K8/585 , A61Q17/04
摘要： Disclosed are hydroxyphenylbenzophenone derivatives of formula (1), wherein R 1 and R 2 independently from each other are hydrogen; C 1 -C 20 alkenyl; C 3 - C 10 cycloalkyl; or R 1 and R 2 together with the linking nitrogen atom form a 5- 6-membered heterocyclic ring; R 3 , R 4 and R 5 independently from each other are C 1 -C 4 alkyl; C 1 -C 4 alkoxy; or a radical of formula (1a) R 6 is C 1 -C 6 alkyl; and A is a straight-chain or branched C 3 -C 6 alkylene, which is optionally interrupted by one or more *-O-*, or *-O-(CO)-* groups; and m is 0; or anumber from 1 to 5. The compounds are useful as cosmetic UV filters with outstanding solubility properties in cosmetic oils.
摘要翻译：公开了式（1）的羟基苯基二苯甲酮衍生物，其中R 1和R 2彼此独立地是氢; ç_{1 -C _{20 烯基; C 3 -C 10环烷基; 或R 1和R 2与连接氮原子一起形成5-6元杂环; R 3，R 4和R 5彼此独立地是C 1 -C 4烷基， / SUB>烷基; ç_{1 -C _{4 烷氧基; 或式（1a）的基团R 6是C 1 -C 6烷基; 并且A是直链或支链C 3 -C 6亚烷基，其任选地被一个或多个* -O- *或* -O-（ CO） - *组; m为0; 或1至5的编号。该化合物可用作化妆品油中具有优异溶解性的化妆品UV过滤器。}}}}

6. 发明申请

WO2004052837A2 AMINO SUBSTITUTED HYDROXYPHENYL BENZOPHENONE DERIVATIVES 审中-公开
标题翻译：氨基取代的羟基苯并噻吩酮衍生物
公开(公告)号：WO2004052837A2
公开(公告)日：2004-06-24
申请号：PCT/EP2003/050937
申请日：2003-12-03
申请人： CIBA SPECIALTY CHEMICALS HOLDING INC. , HAASE, Jürg , EHLIS, Thomas , BORSOS, Elek , MÜLLER, Stefan
发明人： HAASE, Jürg , EHLIS, Thomas , BORSOS, Elek , MÜLLER, Stefan
IPC分类号： C07C229/52
CPC分类号： C07D295/192 , A61K8/42 , A61K8/44 , A61K8/49 , A61K8/4973 , A61Q17/04 , C07C229/52 , C07C237/32 , C07C237/34 , C07C237/40 , C07C237/42 , C07D277/46 , C07D277/66 , C07D313/12
摘要： Described are amino substituted hydroxyphenyl benzophenone derivatives of formula (I), wherein R 1 , and R 2 independently from each other are; C 1 ,-C 20 alkyl; C 2 -C 20 alkenyl; C 3 -C 10 ,cycloalkyl; C 3 -C 10 cycloalkenyl; or R 1 , and R 2 together with the linking nitogen atom form a 5- or 6-membered heterocyclic ring; n 1 is a number from 1 to 4; when n 1 =1, R 3 is a saturated or unsaturated heterocyclic radical; hydroxy-C 1 -C 5 alkyl; cyclohexyl optionally substituted with one or more C 1 ,-C 5 alkyl; phenyl optionally substituted with a heterocyclic radical, aminocarbonyl or C 1 -C 5 alkylcarboxy; wenn n 1 is 2, R 3 is an alkylene-, cycloalkylene- or alkenylene radical which is optionally substituted by a carbonyl- or carboxy group; o R 3 together with A forms a bivalent radical of the formula (Ia), wherein n 2 is a number from 1 to 3; when n 1 is 3, R 3 is an alkanetriyl radical; wenn n 1 is 4, R 3 is an alkanetetrayl radical; A is -O-; or -N(R 5 )-; and R 5 is hydrogen; C 1 -C 5 alkyl; or hydroxy-C 1 -C 5 alkyl. The compounds are useful as UV filters in sunscreen applications.
摘要翻译：描述了式（I）的氨基取代的羟基苯基二苯甲酮衍生物，其中R1和R2彼此独立地是; C1，-C20alkyl; C2-C20alkenyl; C3-C10，环烷基; C3-C10cycloalkenyl; 或R1和R2与连接的硝原子一起形成5-或6-元杂环; n1是从1到4的数字; 当n1 = 1时，R3是饱和或不饱和杂环基; 羟基C1-C5烷基; 任选被一个或多个C 1 -C 5烷基取代的环己基; 任选被杂环基取代的苯基，氨基羰基或C 1 -C 5烷基羧基; wn1是2，R3是任选被羰基或羧基取代的亚烷基，亚环烷基或亚烯基; O与A一起形成式（Ia）的二价基团，其中n2为1至3的数; 当n1为3时，R3为烷三基; wenn n1为4，R3为烷基四氢呋喃基; A为-O- 或-N（R 5） - ; R5是氢; C1-C5烷基; 或羟基-C 1 -C 5烷基。这些化合物可用作防晒霜中的紫外线过滤器。

7. 发明申请

WO2008090066A2 STABILIZATION OF UV-SENSITIVE ACTIVE INGREDIENTS 审中-公开
标题翻译：紫外线敏感活性成分的稳定性
公开(公告)号：WO2008090066A2
公开(公告)日：2008-07-31
申请号：PCT/EP2008/050440
申请日：2008-01-16
申请人： CIBA HOLDING INC. , WAGNER, Barbara , HERZOG, Bernd , MÜLLER, Stefan , EHLIS, Thomas
发明人： WAGNER, Barbara , HERZOG, Bernd , MÜLLER, Stefan , EHLIS, Thomas
IPC分类号： A61K8/41 , A61K8/44 , A61K8/49 , A61Q17/04
CPC分类号： A61K8/41 , A61K8/35 , A61K8/44 , A61K2800/52 , A61Q5/00 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/12 , A61Q17/04 , A61Q19/004 , A61Q19/04
摘要： Disclosed is the use of merocyanine derivatives of formula (1) for stabilizing UV-sensitive active ingredients like dibenzoylmethane derivatives.
摘要翻译：公开了式（1）的部花青衍生物用于稳定紫外线敏感活性成分如二苯甲酰甲烷衍生物的用途。

8. 发明申请

WO2007137958A3 SELF TANNING COMPOSITION 审中-公开
公开(公告)号：WO2007137958A3
公开(公告)日：2007-12-06
申请号：PCT/EP2007/054864
申请日：2007-05-21
申请人： CIBA HOLDING INC. , EHLIS, Thomas , MÜLLER, Stefan , MONGIAT, Sébastien
发明人： EHLIS, Thomas , MÜLLER, Stefan , MONGIAT, Sébastien
IPC分类号： A61K8/04 , A61K8/60 , A61K8/19 , A61K8/49 , A61Q19/04
摘要： Disclosed is a method for the colouration of skin or a keratinic fibre, characterized in that the skin or keratinic fibre is contacted with a formulation containing a dispersion of solid particles of a tanning substance selected from a compound of the formula (I) wherein i is 0 or 1 and each of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 independently of each other is selected from group consisting of hydrogen, OH, C 1 -C 6 alkyl, C 1 -C 6 hydroxyalkyl and C 2 -C 6 al- kenyl; in an organic liquid of low polarity or non-polar organic liquid.

9. 发明申请

WO2011003774A2 UV FILTER COMBINATIONS COMPRISING BENZYLIDENE MALONATES 审中-公开
标题翻译：紫外线过滤器组合包含苄基胆碱酯
公开(公告)号：WO2011003774A2
公开(公告)日：2011-01-13
申请号：PCT/EP2010/059181
申请日：2010-06-29
申请人： BASF SE , GRUMELARD, Julie , EHLIS, Thomas , HANSCH, Markus , SOHN, Myriam
发明人： GRUMELARD, Julie , EHLIS, Thomas , HANSCH, Markus , SOHN, Myriam
IPC分类号： A61K8/35
CPC分类号： A61Q17/04 , A61K8/37
摘要： Disclosed is the use of a UV filter combination, comprising (a) a first UV filter selected from benzylidene malonates of formula (1), wherein R 1 methyl; ethyl; propyl; or n-butyl; if R 1 is methyl, then R is tert. butyl; formula (II); formula (III); a radical of formula (1a); or a radical of formula (1b); wherein R 2 and R 3 , independently from each other are hydrogen; or methyl; R 4 is methyl; ethyl; or n-propyl; R 5 and R 6 independently from each other are hydrogen; or C 1 -C 3 alkyl; if R 1 is ethyl; propyl; or n-butyl, then R is isopropyl; and (b) a second UV filter selected from (b 1 ) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine; (b 2 ) Butyl Methoxydibenzoylmethane; (b 3 )Diethylhexyl Butamido Triazone; (b 4 ) Ethylhexyl Triazone; (b 5 ) Diethylamino Hydroxy Benzoyl Hexyl Benzoate; (b 6 ) Ethylhexyl Methoxycinnamate; (b 7 ) Ethylhexyl Salicylate; (b 8 ) Homosalate; (b 9 ) Octocrylene; (b 10 ) micronized Methylene Bis-Benzotriazolyl Tetramethylbutylphenol; (b 11 ) Phenylbenzimidazole Sulfonic Acid; (b 12 ) Titanium Dioxide; (b 13 ) micronized Tris-Biphenyl Triazine; and (b 14 ) micronized (2-{4-[2-(4-Diethylamino-2-hydroxy-benzoyl)-benzoyl]-piperazine-1-carbonyl}-phenyl)-(4-diethylamino-2-hydroxy-phenyl)-methanone; (b 15 ) benzoicacid,4,4-[[3-[1,3,3,3-tetramethyl-1-[trimethylsilyl)oxy]-1-disiloxanyl]propyl]amino]-1,3,5-triazine-2,4-diyl]diimino]bis-, dibutyl ester wherein the UV filter combination comprises at least 2 UV filters of component (b 1 )-(b 14 ); for the protection of human and animal hair and skin against UV radiation.
摘要翻译：公开了使用UV过滤器组合，其包含（a）选自式（1）的亚苄基丙二酸酯的第一UV过滤器，其中R 1甲基; 乙基; 丙基; 或正丁基; 如果R1是甲基，则R是叔丁基。丁基; 式（II）; 式（III）; 式（1a）的基团; 或式（1b）的基团; 其中R2和R3彼此独立地是氢; 或甲基; R4是甲基; 乙基; 或正丙基; R5和R6彼此独立地是氢; 或C 1 -C 3烷基; 如果R1是乙基; 丙基; 或正丁基，那么R是异丙基; 和（b）选自（b1）双 - 乙基己氧基苯酚甲氧基苯基三嗪的第二UV过滤器; （b2）丁基甲氧基二苯甲酰甲烷; （b3）丁酰己二酸二乙基己酯; （b4）乙基己基三嗪酮; （b5）二乙基氨基羟基苯甲酰己基苯甲酸酯; （b6）甲氧基肉桂酸乙基己酯; （b7）水杨酸乙基己酯; （b8）均质酸; （b9）（b10）微米亚甲基双苯并三唑基四甲基丁基苯酚; （b11）苯基苯并咪唑磺酸; （b12）二氧化钛; （b13）微粉化的三联苯三嗪; 和（b14）微粉化（2- {4- [2-（4-二乙基氨基-2-羟基 - 苯甲酰基） - 苯甲酰基] - 哌嗪-1-羰基} - 苯基） - （4-二乙基氨基-2-羟基 - 苯基） - 甲酮; （b15）苯甲酸，4,4 - [[3- [1,3,3,3-四甲基-1- [三甲基甲硅烷基]氧基] -1-二硅氧烷基]丙基]氨基] -1,3,5-三嗪-2 ，4-二基]二亚氨基]双 - 二丁酯，其中UV滤光器组合包含至少2个组分（b1） - （b14）的UV滤光剂; 用于保护人和动物的头发和皮肤免受紫外线辐射。

10. 发明申请

WO2003075875A1 UV ABSORBER COMPOSITIONS COMPRISING A HYDROXYPHENYLTRIAZINE COMPOUND 审中-公开
标题翻译：含有羟基苯乙烯化合物的紫外线吸收剂组合物
公开(公告)号：WO2003075875A1
公开(公告)日：2003-09-18
申请号：PCT/EP2003/002200
申请日：2003-03-04
申请人： CIBA SPECIALTY CHEMICALS HOLDING INC. , HAASE, Jürg , EHLIS, Thomas , BORSOS, Elek , HÜGLIN, Dietmar , HERZOG, Bernd
发明人： HAASE, Jürg , EHLIS, Thomas , BORSOS, Elek , HÜGLIN, Dietmar , HERZOG, Bernd
IPC分类号： A61K7/42
CPC分类号： A61K8/4966 , A61Q17/04
摘要： UV absorber compositions are described, comprising (a) from 1 to 99 % by weight of a hydroxyphenyltriazine compound of formula (I) wherein R 1 , R 2 and R 3 are each independently of the others C 1 -C 18 alkyl; C 2 -C 10 ,alkenyl; or phenyl-C,-C 4 alkyl; R 4 is hydrogen; or C 1 -C 5 alkyl; and (b) from 99 to 1 % by weight of a further UV absorber selected from the group of (b) hydroxyphenyltriazines that are different from component (a), (b 2 ) benzotriazoles, (b 3 ) dibenzoylmethane derivatives and (b 4 ) camphor derivatives. The compositions are suitable as UV filters in cosmetic compositions.
摘要翻译：描述了紫外线吸收剂组合物，其包含（a）1至99重量％的式（I）的羟基苯基三嗪化合物，其中R 1，R 2和R 3各自独立地为C 1 -C 18烷基; C2-C10烯基; 或苯基-C 1 -C 4烷基; R4是氢; 或C 1 -C 5烷基; 和（b）99重量％至1重量％的另外的紫外线吸收剂，其选自（b）不同于组分（a），（b 2）苯并三唑，（b3）二苯甲酰甲烷衍生物和（b4）樟脑）的羟苯基三嗪衍生物。该组合物适用于化妆品组合物中的UV过滤器。

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