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    • 2. 发明申请
    • UV FILTER COMBINATIONS COMPRISING BENZYLIDENE MALONATES
    • 包含苯甲酸二甲酯的UV过滤器组合
    • WO2011003774A3
    • 2011-04-21
    • PCT/EP2010059181
    • 2010-06-29
    • BASF SEGRUMELARD JULIEEHLIS THOMASHANSCH MARKUSSOHN MYRIAM
    • GRUMELARD JULIEEHLIS THOMASHANSCH MARKUSSOHN MYRIAM
    • A61K8/29A61K8/35A61K8/37A61K8/40A61K8/41A61K8/49A61K8/58A61Q17/04
    • A61Q17/04A61K8/37
    • Disclosed is the use of a UV filter combination, comprising (a) a first UV filter selected from benzylidene malonates of formula (1), wherein R1 methyl; ethyl; propyl; or n-butyl; if R1 is methyl, then R is tert. butyl; formula (II); formula (III); a radical of formula (1a); or a radical of formula (1b); wherein R2 and R3, independently from each other are hydrogen; or methyl; R4 is methyl; ethyl; or n-propyl; R5 and R6 independently from each other are hydrogen; or C1-C3alkyl; if R1 is ethyl; propyl; or n-butyl, then R is isopropyl; and (b) a second UV filter selected from (b1) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine; (b2) Butyl Methoxydibenzoylmethane; (b3)Diethylhexyl Butamido Triazone; (b4) Ethylhexyl Triazone; (b5) Diethylamino Hydroxy Benzoyl Hexyl Benzoate; (b6) Ethylhexyl Methoxycinnamate; (b7) Ethylhexyl Salicylate; (b8) Homosalate; (b9) Octocrylene; (b10) micronized Methylene Bis-Benzotriazolyl Tetramethylbutylphenol; (b11) Phenylbenzimidazole Sulfonic Acid; (b12) Titanium Dioxide; (b13) micronized Tris-Biphenyl Triazine; and (b14) micronized (2-{4-[2-(4-Diethylamino-2-hydroxy-benzoyl)-benzoyl]-piperazine-1-carbonyl}-phenyl)-(4-diethylamino-2-hydroxy-phenyl)-methanone; (b15) benzoicacid,4,4-[[3-[1,3,3,3-tetramethyl-1-[trimethylsilyl)oxy]-1-disiloxanyl]propyl]amino]-1,3,5-triazine-2,4-diyl]diimino]bis-, dibutyl ester wherein the UV filter combination comprises at least 2 UV filters of component (b1)-(b14); for the protection of human and animal hair and skin against UV radiation.
    • 公开了UV过滤剂组合的用途,其包含(a)选自式(1)的亚甲基丙二酸酯的第一UV过滤剂,其中R 1甲基; 乙基; 丙基; 或正丁基; 如果R1是甲基,则R是叔。 丁基; 公式(II); 公式(III); 式(1a)的基团; 或式(1b)的基团; 其中R 2和R 3彼此独立地为氢; 或甲基; R4是甲基; 乙基; 或正丙基​​; R5和R6彼此独立地为氢; 或C 1 -C 3烷基; 如果R1是乙基; 丙基; 或正丁基,则R是异丙基; 和(b)选自(b1)双 - 乙基己氧基苯酚甲氧基苯基三嗪的第二UV过滤剂; (b2)丁基甲氧基二苯甲酰基甲烷; (b3)二乙基己基丁酰氨基三嗪酮; (b4)乙基己基三嗪酮; (b5)二乙氨基羟苯甲酰基苯甲酸己酯; (b6)甲氧基肉桂酸乙基己酯; (b7)水杨酸乙基己酯; (b8)胡莫柳油; (b9)奥克立林; (b10)微粉化的亚甲基双 - 苯并三唑基四甲基丁基苯酚; (b11)苯基苯并咪唑磺酸; (b12)二氧化钛; (b13)微粉化的三联苯三嗪; 和(b14)微粉化(2- {4- [2-(4-二乙基氨基-2-羟基 - 苯甲酰基) - 苯甲酰基] - 哌嗪-1-羰基} - 苯基) - (4-二乙基氨基-2-羟基 - 苯基) - 甲酮; (b15)苯甲酸,4,4 - [[3- [1,3,3,3-四甲基-1- [三甲基甲硅烷基]氧基] -1-二硅氧烷基]丙基]氨基] -1,3,5-三嗪-2 (b1) - (b14)的至少2个紫外线过滤剂;其中所述紫外线过滤剂组合物包含至少2种组分(b1) - (b14)的紫外线过滤剂; 用于保护人类和动物毛发和皮肤免受紫外线辐射。
    • 4. 发明申请
    • GRINDING AIDS FOR MICRONIZED ORGANIC UV ABSORBERS
    • 微波有机紫外线吸收剂研磨艾滋病
    • WO2009068469A2
    • 2009-06-04
    • PCT/EP2008/065916
    • 2008-11-20
    • CIBA HOLDING INC.MONGIAT, SébastienGRUMELARD, JulieEHLIS, Thomas
    • MONGIAT, SébastienGRUMELARD, JulieEHLIS, Thomas
    • A61K8/35A61K8/49A61Q17/04
    • A61Q17/04A61K8/494A61K2800/412
    • A method of preparing a composition, comprising (a) a micronised insoluble organic UV absorber, which method comprises grinding the insoluble organic UV absorber, in coarse particle form, in a grinding apparatus, in the presence of a grinding aid selected from the groups (b 1 ) carboxylic acids and their salts; (b 2 ) fatty acid esters (b 3 ) alkyl phosphates or phosphoric acid esters; (b 4 ) ethoxylated carboxylic acids or polyethyleneglycol (PEG) esters; (b 5 ) fatty alcohol polyethyleneglycol (PEG) ethers of fatty alcohols; (b 6 ) polyethylene/polypropylene -glycol ethers of saturated or unsaturated C 4 - C 28 fatty acids; (b 7 ) ethoxylated alkylphenols or ethoxylated alkylphenyl ethers; (b 8 ) esters of polyol and mono-, di- or tri-glycerides; (b 9 ) esters of fatty acids and saccharose; (b 10 ) sorbitan mono- and di-esters of saturated and/or unsaturated C 6 - C 22 fatty acids and ethylene oxide groups; and (b 11 ) surfactants which are mainly acting as detergent or cleansing agents.
    • 一种制备组合物的方法,包括(a)微粉化的不溶性有机UV吸收剂,该方法包括在研磨装置中,在选自以下组的研磨助剂的存在下研磨粗颗粒形式的不溶性有机UV吸收剂( b1)羧酸及其盐; (b2)脂肪酸酯(b3)磷酸烷基酯或磷酸酯; (b4)乙氧基化羧酸或聚乙二醇(PEG)酯; (b5)脂肪醇的脂肪醇聚乙二醇(PEG)醚; (b6)饱和或不饱和C4-C28脂肪酸的聚乙烯/聚丙二醇醚; (b7)乙氧基化烷基酚或乙氧基化烷基苯基醚; (b8)多元醇和甘油单酯,甘油二酯或甘油酯的酯; (b9)脂肪酸和蔗糖的酯; (b10)饱和和/或不饱和C6-C22脂肪酸和环氧乙烷基团的脱水山梨糖醇单酯和二酯; 和(b11)主要作为洗涤剂或清洁剂的表面活性剂。
    • 6. 发明申请
    • TRIAZINE DERIVATIVES
    • TRIAZINE衍生物
    • WO2007128744A2
    • 2007-11-15
    • PCT/EP2007054239
    • 2007-05-02
    • CIBA SC HOLDING AGEHLIS THOMASBORSOS ELEK
    • EHLIS THOMASBORSOS ELEK
    • C07D251/52A61Q17/04C07D251/70
    • C07D251/52C07D251/70
    • Disclosed are triazine derivatives of formula (1), wherein X 1 is a bivalent radical of formula (1a) -NR 9 -A-NR 9 -; (1b); or (1c) *-O-A-O-* A and A' independently from each other are unsubstituted or substituted, straight-chain or branched C 1 -C 12 alkylene, which is optionally interrupted by C 5 -C 12 cycloalkylene, N, O or S; C 5 -C 12 cycloalkylene; biphenylene; C 6 -C 10 arylene; or C 5 -C 10 arylene-(C 1 -C 12 alkylene); R 1 is a radical of formula (1d); (1e); (1f); (1g); or (1h); R 2 and R 3 independently from each other are hydrogen; C 1 -C 12 alkyl; OR 7 ; NR 7 R 8 ; C 6 -C 10 aryl; X 2 is O, or NH; W 1 is C 1 -C 20 alkyl; or a group Sp-Sil; Sp is a straight-chain or branched saturated or single or multiple unsaturated C 3 -C 12 hydrocarbon; Sil is a silane; an oligosiloxane; or a polysiloxane moiety; and R 4 , R 5 R 6 , R 7 , R 8 and R 9 independently from each other are hydrogen; C 1 -C 12 alkyl; or C 3 -C 12 cycloalkyl.
    • 公开了式(1)的三嗪衍生物,其中X 1是式(1a)的二价基团-NR 9 -A-NR 9 - ; (1B); 或(1c)* -OAO- * A和A'彼此独立地是未取代或取代的直链或支链C 1 -C 12亚烷基,其是 任选被C 5 -C 12亚环烷基,N,O或S中断; ç 5 -C 12 亚环烷基; 联苯; ç 6 -C 10 亚芳基; 或C 5 -C 10亚芳基 - (C 1 -C 12 - 亚烷基); R 1是式(1d)的基团; (1E); (1F); (1G); 或(1h); R 2和R 3彼此独立地是氢; ç 1 -C 12 烷基; OR 7 ; NR 7 - [R 8 ; ç 6 -C 10 芳基; X 2是O或NH; W 1是C 1 -C 20烷基; 或一组Sp-Sil; Sp是直链或支链饱和或单或多不饱和C 3 -C 12烃; 硅是硅烷; 低聚硅氧烷; 或聚硅氧烷部分; 和R 4,R 5 R 6,R 7,R 8和R 8,和 R 9彼此独立地是氢; ç 1 -C 12 烷基; 或C 3 -C 12环烷基。
    • 9. 发明申请
    • DIMERIC BENZYLIDENE MALONATES
    • 二甲苯胆碱
    • WO2009112403A3
    • 2009-11-12
    • PCT/EP2009052531
    • 2009-03-04
    • BASF SEHANSCH MARKUSEHLIS THOMASWAGNER BARBARA
    • HANSCH MARKUSEHLIS THOMASWAGNER BARBARA
    • A61K8/37A61Q17/04C07C67/347C07C69/618
    • A61Q17/04A61K8/37A61K8/585C07C67/03C07C67/31C07C67/343C07C69/734C07C2601/14C07F7/0889C07C69/732
    • Disclosed is the use of benzylidene malonates of formula (1), wherein R1 and R2, independently from each other are hydrogen; OH; C1-C12alkyl; C1-C12alkoxy; C1-C12alkylamino; C1-C12dialkylamino; water-solubilizing groups, selected from carboxylate, sulfonates or ammonium radicals; R3 is COOR5; COR5; CONR5R6; CN; or SO2R7, R4 is COOR8; COR9; CONR8R9; CN; or SO2R10; R5, R6, R7, R8, R9 and R10 independently from each other are C1-C18alkyl; unsubstituted or by one or more than one C1-C4alkyl substituted C3-C12-cycloalkyl; unsubstituted or C1-C6alkyl-substituted C6-C20aryl; organosilanyl, or organosiloxanyl; A is -C1-C20alkylene-, -CH2CH(OH)CH2-, -C5-C20cycloalkylene, --C2-C20alkenylene-, -C5- C10arylene-, or -C5-C10arylene-(C1-C10alkylene)- which are unsubstituted or substituted, straight-chain or branched, optionally interrupted by one or more than one heteroatoms selected from -O, -S- or -NH-; for the protection of human and animal hair and skin against UV radiation.
    • 公开了式(1)的亚苄基丙二酸酯的用途,其中R 1和R 2彼此独立地为氢; 哦; C1-C12烷基; C1-C12烷氧基; C1-C12alkylamino; C1-C12dialkylamino; 选自羧酸盐,磺酸盐或铵基的水溶性基团; R3为COOR5; COR5; CONR5R6; CN; 或SO 2 R 7,R 4为COOR 8; COR 9; CONR8R9; CN; 或SO2R10; R 5,R 6,R 7,R 8,R 9和R 10彼此独立地为C 1 -C 18烷基; 未取代或被一个或多个C 1 -C 4烷基取代的C 3 -C 12 - 环烷基取代; 未取代的或C 1 -C 6烷基取代的C 6 -C 20芳基; 有机硅烷基或有机硅氧烷基; A是未取代的-C 1 -C 20亚烷基 - , - CH 2 CH(OH)CH 2 - , - C 5 -C 20亚环烷基,-C 2 -C 20亚烯基,-C 5 -C 10亚芳基或-C 5 -C 10亚芳基 - (C 1 -C 10亚烷基) 任选被一个或多于一个选自-O,-S-或-NH-的杂原子间隔的取代的,直链或支链的; 用于保护人和动物的头发和皮肤免受紫外线辐射。
    • 10. 发明申请
    • GRINDING AIDS FOR MICRONIZED ORGANIC UV ABSORBERS
    • 研磨艾滋病微生物有机紫外线吸收剂
    • WO2009068469A3
    • 2009-07-16
    • PCT/EP2008065916
    • 2008-11-20
    • CIBA HOLDING INCMONGIAT SEBASTIENGRUMELARD JULIEEHLIS THOMAS
    • MONGIAT SEBASTIENGRUMELARD JULIEEHLIS THOMAS
    • A61K8/35A61K8/49A61Q17/04
    • A61K8/411A61K8/0241A61K8/494A61K8/496A61K8/4966A61K2800/412A61Q17/04
    • A method of preparing a composition, comprising (a) a micronised insoluble organic UV absorber, which method comprises grinding the insoluble organic UV absorber, in coarse particle form, in a grinding apparatus, in the presence of a grinding aid selected from the groups (b1) carboxylic acids and their salts; (b2) fatty acid esters (b3) alkyl phosphates or phosphoric acid esters; (b4) ethoxylated carboxylic acids or polyethyleneglycol (PEG) esters; (b5) fatty alcohol polyethyleneglycol (PEG) ethers of fatty alcohols; (b6) polyethylene/polypropylene -glycol ethers of saturated or unsaturated C4 - C28 fatty acids; (b7) ethoxylated alkylphenols or ethoxylated alkylphenyl ethers; (b8) esters of polyol and mono-, di- or tri-glycerides; (b9) esters of fatty acids and saccharose; (b10) sorbitan mono- and di-esters of saturated and/or unsaturated C6 - C22 fatty acids and ethylene oxide groups; and (b11) surfactants which are mainly acting as detergent or cleansing agents.
    • 一种制备组合物的方法,该方法包括(a)微粉化的不溶性有机紫外线吸收剂,该方法包括在研磨装置中,在选自以下的研磨助剂存在下以粗颗粒形式研磨不溶性有机紫外线吸收剂: b1)羧酸及其盐; (b2)脂肪酸酯(b3)烷基磷酸酯或磷酸酯; (b4)乙氧基化羧酸或聚乙二醇(PEG)酯; (b5)脂肪醇的脂肪醇聚乙二醇(PEG)醚; (b6)饱和或不饱和C 4 -C 28脂肪酸的聚乙烯/聚丙二醇醚; (b7)乙氧基化烷基酚或乙氧基化烷基苯基醚; (b8)多元醇与甘油单酯,甘油二酯或甘油三酯的酯; (b9)脂肪酸和蔗糖的酯; (b10)饱和和/或不饱和C6-C22脂肪酸和环氧乙烷基团的脱水山梨糖醇单酯和二酯; 和(b11)主要用作清洁剂或清洁剂的表面活性剂。