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1. 发明申请

WO02058690A3 METHODS FOR THE TREATMENT OF DISEASES USING MALONYL-COA DECARBOX YLASE INHIBITORS 审中-公开
标题翻译：使用MALONYL-COA DECARBOX YLASE INHIBITORS治疗疾病的方法
公开(公告)号：WO02058690A3
公开(公告)日：2003-04-24
申请号：PCT/US0201814
申请日：2002-01-22
申请人： CHUGAI PHARMACEUTICAL CO LTD , ARRHENIUS THOMAS , CHEN MI , CHENG JIE FEI , HARAMURA MASAYUKI , HUANG YUJIN , NADZAN ALEX , TITH SOVOUTHY , WALLACE DAVID , ZHANG LIN , BROWN STEVE , HARMON CHARLES
发明人： ARRHENIUS THOMAS , CHEN MI , CHENG JIE FEI , HARAMURA MASAYUKI , HUANG YUJIN , NADZAN ALEX , TITH SOVOUTHY , WALLACE DAVID , ZHANG LIN , BROWN STEVE , HARMON CHARLES
IPC分类号： C07D295/18 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/17 , A61K31/175 , A61K31/18 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/21 , A61K31/215 , A61K31/216 , A61K31/22 , A61K31/221 , A61K31/223 , A61K31/27 , A61K31/275 , A61K31/277 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/416 , A61K31/4164 , A61K31/4172 , A61K31/4178 , A61K31/4188 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/44 , A61K31/4402 , A61K31/4409 , A61K31/4439 , A61K31/444 , A61K31/445 , A61K31/4453 , A61K31/451 , A61K31/455 , A61K31/495 , A61K31/498 , A61K31/5375 , A61K31/5377 , A61P3/04 , A61P3/10 , A61P3/12 , A61P9/00 , A61P9/04 , A61P9/10 , A61P35/00 , A61P43/00 , C07C33/46 , C07C33/48 , C07C215/24 , C07C233/22 , C07C257/22 , C07C279/18 , C07C307/10 , C07C323/14 , C07C335/18 , C07D209/42 , C07D211/14 , C07D211/22 , C07D213/40 , C07D213/56 , C07D213/70 , C07D213/75 , C07D213/81 , C07D213/82 , C07D231/06 , C07D231/12 , C07D231/14 , C07D231/38 , C07D231/40 , C07D233/54 , C07D233/64 , C07D233/84 , C07D233/90 , C07D239/42 , C07D241/24 , C07D257/04 , C07D261/04 , C07D261/08 , C07D261/14 , C07D261/18 , C07D263/34 , C07D271/06 , C07D277/46 , C07D277/48 , C07D277/52 , C07D285/12 , C07D285/135 , C07D295/13 , C07D295/194 , C07D295/21 , C07D295/215 , C07D295/22 , C07D295/28 , C07D307/46 , C07D307/52 , C07D307/68 , C07D333/24 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/06 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08 , C07D498/08 , C07F9/24 , C07F9/40 , C07F9/6539
CPC分类号： C07D231/06 , A61K31/16 , A61K31/165 , A61K31/17 , A61K31/175 , A61K31/18 , A61K31/197 , A61K31/221 , A61K31/275 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/416 , A61K31/4164 , A61K31/4178 , A61K31/4188 , A61K31/4196 , A61K31/42 , A61K31/44 , A61K31/4402 , A61K31/4409 , A61K31/4439 , A61K31/451 , A61K31/5375 , A61K31/5377 , C07C33/46 , C07C33/48 , C07C215/24 , C07C233/22 , C07C257/22 , C07C279/18 , C07C307/10 , C07C323/14 , C07C335/18 , C07D231/14 , C07D233/64 , C07D233/90 , C07D239/42 , C07D261/04 , C07D261/08 , C07D261/14 , C07D261/18 , C07D277/46 , C07D277/48 , C07D277/52 , C07D285/135 , C07D295/13 , C07D295/194 , C07D295/21 , C07D295/215 , C07D295/32 , C07D307/46 , C07D307/52 , C07D401/12 , C07D413/06 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08 , C07F9/247 , C07F9/4021 , C07F9/6539
摘要： The present invention relates to methods for the prophylaxis, management and treatment of certain diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD) by the administration of a composition containing as an active ingredient a compound according to Formula I. In particular, the invention relates to methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the administration of a compound which inhibits malonyl-coenzyme A decarboxylase activity. The present invention also includes within its scope the novel process for the preparation of certain compounds.
摘要翻译：本发明涉及通过施用含有作为活性成分的化合物的组合物来抑制由丙二酰辅酶A脱羧酶（丙二酰辅酶A脱羧酶，MCD）抑制的某些疾病的预防，治疗和治疗方法特别地，本发明涉及通过施用抑制丙二酰辅酶A脱羧酶活性的化合物来预防，治疗和治疗心血管疾病，糖尿病，酸中毒，癌症和肥胖症的方法。本发明在其范围内还包括制备某些化合物的新方法。

2. 发明申请

WO02058698A8 MALONYL-COA DECARBOXYLASE INHIBITORS USEFUL AS METABOLIC MODULATORS 审中-公开
标题翻译：马来酸 - 癸酸脱羧酶抑制剂作为代谢调节剂有用
公开(公告)号：WO02058698A8
公开(公告)日：2005-06-30
申请号：PCT/US0201789
申请日：2002-01-22
申请人： CHUGAI PHARMACEUTICAL CO LTD , ARRHENIUS THOMAS , CHEN MI , CHENG JIE FEI , HUANG YUJIN , NADZAN ALEX , PENULIAR RICHARD , WALLACE DAVID , ZHANG LIN
发明人： ARRHENIUS THOMAS , CHEN MI , CHENG JIE FEI , HUANG YUJIN , NADZAN ALEX , PENULIAR RICHARD , WALLACE DAVID , ZHANG LIN
IPC分类号： A61K31/045 , A61K31/095 , A61K31/133 , A61K31/137 , A61K31/16 , A61K31/165 , A61K31/341 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/505 , A61K31/5375 , A61K31/55 , A61K31/664 , A61P3/04 , A61P3/10 , A61P3/12 , A61P9/00 , A61P9/04 , A61P9/10 , A61P35/00 , A61P43/00 , C07C33/48 , C07C215/24 , C07C233/22 , C07C307/10 , C07C323/14 , C07D233/54 , C07D239/42 , C07D261/04 , C07D261/08 , C07D277/20 , C07D277/46 , C07D277/48 , C07D277/52 , C07D285/12 , C07D285/135 , C07D307/46 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08 , C07D498/08 , C07F9/24 , C07F9/6539 , A61K31/422
CPC分类号： C07D233/64 , A61K31/16 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/44 , A61K31/5375 , C07C33/48 , C07C215/24 , C07C233/22 , C07C307/10 , C07C323/14 , C07D239/42 , C07D261/04 , C07D261/08 , C07D277/46 , C07D277/48 , C07D277/52 , C07D285/135 , C07D307/46 , C07D401/12 , C07D413/06 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08 , C07F9/6539
摘要： The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.
摘要翻译：本发明涉及新型化合物（I），其前药和药学上可接受的盐以及含有这样的化合物的药物组合物，其可用于治疗某些代谢疾病和通过抑制酶丙二酰辅酶A脱羧酶（丙二酰 - CoA脱羧酶，MCD）。特别地，本发明涉及通过抑制丙二酰辅酶A脱羧酶来预防，治疗和治疗心血管疾病，糖尿病，酸中毒，癌症和肥胖的化合物和组合物和方法。

3. 发明申请

WO02076438A2 FLT-1 LIGANDS AND THEIR USES 审中-公开
标题翻译： FLT-1配偶及其用途
公开(公告)号：WO02076438A2
公开(公告)日：2002-10-03
申请号：PCT/US0208862
申请日：2002-03-21
申请人： CHUGAI PHARMACEUTICAL CO LTD , ARRHENIUS THOMAS , HUANG YUJIN , ZHANG LIN , SERAFIMOV ROSSY , NADZAN ALEX , SPINELLA DOMINIC
发明人： ARRHENIUS THOMAS , HUANG YUJIN , ZHANG LIN , SERAFIMOV ROSSY , NADZAN ALEX , SPINELLA DOMINIC
IPC分类号： A61K31/4245 , A61K31/4439 , A61K31/505 , A61K31/506 , A61K31/53 , A61P9/00 , A61P9/10 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D239/26 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/14 , C07D413/14 , A61K31/00
CPC分类号： C07D239/26 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/14 , C07D413/14
摘要： This invention is a method of treatment and prophylaxis of diseases regulatable by angiogenesis, including novel FLT-1 ligands and pharmaceutical compositions containing them, useful in the methods for the treatment and prophylaxis of these diseases, as well as intermediates and processes useful for the preparation of the compounds of the invention as claimed.
摘要翻译：本发明是一种治疗和预防血管生成可调节疾病的方法，包括新型FLT-1配体和含有它们的药物组合物，可用于治疗和预防这些疾病的方法，以及可用于制备的中间体和方法的本发明化合物。

4. 发明申请

WO2010051233A2 ADJUSTABLE GAS DISTRIBUTION APPARATUS 审中-公开
标题翻译：可调式燃气分配装置
公开(公告)号：WO2010051233A2
公开(公告)日：2010-05-06
申请号：PCT/US2009061893
申请日：2009-10-23
申请人： APPLIED MATERIALS INC , ZHANG LIN , TSUEI LUN , TSO ALAN , CHO TOM K , SHIEH BRIAN SY-YUAN
发明人： ZHANG LIN , TSUEI LUN , TSO ALAN , CHO TOM K , SHIEH BRIAN SY-YUAN
IPC分类号： H01L21/205 , H05H1/34
CPC分类号： H01J37/32935 , C23C16/45565 , C23C16/45589 , H01J37/3244
摘要： Embodiments of the present invention generally provide apparatus and methods for altering the contour of a gas distribution plate within a process chamber without breaking vacuum conditions within the chamber. In one embodiment, a central support device adjusted to vary the height of a central region of a gas distribution plate with respect to the periphery of the gas distribution plate. In another embodiment, a plurality of central support devices is adjusted to vary the height of a central region of a gas distribution plate with respect to the periphery of the plate. In yet another embodiment, a plurality of central support devices and a plurality of mid-range support devices are adjusted to vary the height of certain regions of the gas distribution plate with respect to other regions of the gas distribution plate. In one embodiment, the contour of the gas distribution plate is altered based on changes detected within the process chamber.
摘要翻译：本发明的实施例一般提供用于改变处理室内的气体分配板的轮廓而不破坏室内的真空条件的设备和方法。在一个实施例中，调节中央支撑装置以相对于气体分配板的周边改变气体分配板的中心区域的高度。在另一个实施例中，调节多个中央支撑装置以改变气体分配板的中心区域相对于板的周边的高度。在又一个实施例中，调节多个中央支撑装置和多个中档支撑装置以改变气体分配板的某些区域相对于气体分配板的其他区域的高度。在一个实施例中，气体分配板的轮廓基于在处理室内检测到的变化而改变。

5. 发明申请

WO2005004836A3 SAQUINAVIR MESYLATE ORAL DOSAGE FORM 审中-公开
标题翻译： SAQUINAVIR MESYLATE口服剂型
公开(公告)号：WO2005004836A3
公开(公告)日：2005-05-12
申请号：PCT/EP2004007309
申请日：2004-07-05
申请人： HOFFMANN LA ROCHE , ALBANO ANTONIO A , INFELD MARTIN HOWARD , PHUAPRADIT WANTANEE , SHAH NAVNIT-HARGOVINDAS , ZHANG LIN
发明人： ALBANO ANTONIO A , INFELD MARTIN HOWARD , PHUAPRADIT WANTANEE , SHAH NAVNIT-HARGOVINDAS , ZHANG LIN
IPC分类号： A61K9/00 , A61K9/20 , A61K9/28 , A61K31/551
CPC分类号： A61K9/2866 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K9/2086 , A61K31/551
摘要： A solid unit oral pharmaceutical dosage form of saquinavir mesylate is provided comprising micronized saquinavir mesylate in an amount of from 250 mg to 800 mg calculated as free base, and a pharmaceutically acceptable binder, disintegrant, and water soluble carrier. A solid unit dosage form of saquinavir mesylate is provided comprising from 60% to 80% micronized saquinavir mesylate based on the mesylate salt, 4% to 8% water soluble binder, a disintegrant and a carrier, wherein each percentage is of the kernel weight.
摘要翻译：提供甲磺酸沙奎那韦的固体单位口服药物剂型，其包含以游离碱计算的250mg至800mg的微粉化沙奎那韦甲磺酸盐，以及药学上可接受的粘合剂，崩解剂和水溶性载体。提供了甲磺酸沙奎那韦的固体单位剂型，其包含基于甲磺酸盐，4％至8％水溶性粘合剂，崩解剂和载体的60％至80％的微粉化的甲磺酸沙奎那韦，其中每个百分比为核重量。

6. 发明申请

WO03026571A2 PROCESS FOR PREPARING 17-ALLYL AMINO GELDANAMYCIN (17-AAG) AND OTHER ANSAMYCINS 审中-公开
标题翻译：制备17-氨基氨苄青霉素（17-AAG）和其他安慰剂的方法
公开(公告)号：WO03026571A2
公开(公告)日：2003-04-03
申请号：PCT/US0229715
申请日：2002-09-18
申请人： CONFORMA THERAPEUTICS CORP , ZHANG LIN , BOEHM MARCUS F , ZEGAR SIEAD
发明人： ZHANG LIN , BOEHM MARCUS F , ZEGAR SIEAD
IPC分类号： C07D225/06 , A61K
CPC分类号： C07D225/06
摘要： Efficient chemical processes for preparing high yields, purities, and different polymorphic forms of 17-allyl amino geldanamycin (17-AAG) and other ansamycins are described and claimed.
摘要翻译：描述和要求保护高产量，纯度和不同形式的17-烯丙基氨基格尔德霉素（17-AAG）和其他安莎霉素的高效化学方法。

7. 发明申请

WO2011011301A3 A MIXED SILICON PHASE FILM FOR HIGH EFFICIENCY THIN FILM SILICON SOLAR CELLS 审中-公开
标题翻译：用于高效薄膜硅太阳能电池的混合硅胶片
公开(公告)号：WO2011011301A3
公开(公告)日：2011-05-05
申请号：PCT/US2010042392
申请日：2010-07-19
申请人： APPLIED MATERIALS INC , YANG FAN , ZHANG LIN , ZHENG YI , SCHMITT FRANCIMAR , YUAN ZHENG
发明人： YANG FAN , ZHANG LIN , ZHENG YI , SCHMITT FRANCIMAR , YUAN ZHENG
IPC分类号： H01L31/075
CPC分类号： H01L31/03685 , H01L31/03762 , H01L31/075 , H01L31/076 , H01L31/1824 , H01L31/202 , Y02E10/545 , Y02E10/548 , Y02P70/521
摘要： A method and apparatus for forming solar cells is provided. In one embodiment, a photovoltaic device includes a first p-i-n junction cell formed on a substrate, wherein the p-i-n junction cell comprises a p-type silicon containing layer, an intrinsic type silicon containing layer formed over the p-type silicon containing layer, and a n-type silicon containing layer formed over the intrinsic type silicon containing layer, wherein the intrinsic type silicon containing layer comprises a first pair of microcrystalline layer and amorphous silicon layer.
摘要翻译：提供一种用于形成太阳能电池的方法和装置。在一个实施例中，光伏器件包括形成在衬底上的第一pin结单元，其中该pin结单元包括p型含硅层，在p型含硅层上形成本征型含硅层，以及在本征型含硅层上形成n型含硅层，其中本征型含硅层包括第一对微晶层和非晶硅层。

8. 发明申请

WO2011038406A2 HIGHLY ELECTRICALLY CONDUCTIVE SURFACES FOR ELECTROCHEMICAL APPLICATIONS AND METHODS TO PRODUCE SAME 审中-公开
标题翻译：用于电化学应用的高导电性表面和产生同样方法
公开(公告)号：WO2011038406A2
公开(公告)日：2011-03-31
申请号：PCT/US2010050578
申请日：2010-09-28
申请人： TREADSTONE TECHNOLOGIES INC , WANG CONGHUA , ZHANG LIN , GONTARZ GERALD A JR
发明人： WANG CONGHUA , ZHANG LIN , GONTARZ GERALD A JR
IPC分类号： C23C4/12 , B22F1/02 , C23C4/06
CPC分类号： C23C4/04 , B22F1/0088 , B22F1/02 , C23C4/06 , C23C4/10 , C23C4/18 , H01B1/02 , H01B1/06 , H01B1/16 , H01M8/0206 , Y10T428/12056 , Y10T428/256
摘要： A method to use a novel structured metal-ceramic composite powder to improve the surface electrical conductivity of corrosion resistant metal substrates by thermal spraying the structured powder onto a surface of a metallic substrate is disclosed. The structured powder has a metal core and is wholly or partially surrounded by an electrically conductive ceramic material such as a metal nitride material. The metal cores may have the ceramic material formed on them prior to a thermal spraying process performed in an inert atmosphere, or the thermal spraying may be performed in a reactive atmosphere such that the ceramic coating forms on the cores during the thermal spraying process and/or after deposition. The metal cores will bond conductive ceramic material onto the surface of the substrate through the thermal spray process.
摘要翻译：公开了一种使用新型结构化金属陶瓷复合粉末以通过将该结构化粉末热喷涂到金属基材的表面上来改善耐腐蚀金属基材的表面电导率的方法。结构化粉末具有金属芯，并且完全或部分地被诸如金属氮化物材料的导电陶瓷材料包围。在惰性气氛中执行热喷涂工艺之前，金属芯可以具有在其上形成的陶瓷材料，或者可以在反应性气氛中执行热喷涂，使得在热喷涂工艺期间陶瓷涂层在芯上形成和/ 或沉积之后。金属芯将通过热喷涂工艺将导电陶瓷材料结合到基板的表面上。

9. 发明申请

WO2008007062A3 A TORSION SENSOR 审中-公开
标题翻译：扭转传感器
公开(公告)号：WO2008007062A3
公开(公告)日：2008-03-13
申请号：PCT/GB2007002547
申请日：2007-07-09
申请人： UNIV ASTON , BENNION IAN , ZHOU KAIMING , CHEN XIANFENG , ZHANG LIN
发明人： BENNION IAN , ZHOU KAIMING , CHEN XIANFENG , ZHANG LIN
IPC分类号： G01L1/00
CPC分类号： G01M11/088 , G01L3/12
摘要： A torsion sensor (1) using an optical waveguide (2) in optical communication with a diffraction grating (3), preferably a tilted grating, and most preferably a tilted Bragg grating, which provides the optical waveguide and grating with a torsion-dependent collective optical transmission spectrum. Changes in the collective optical transmission spectrum of the waveguide and grating, induced by changes in the amount of torsion applied to the waveguide, may be detected (12) by detecting a corresponding change in the intensity of optical radiation transmitted through the grating from a controlled optical source (5). The degree of change in the collective optical transmission spectrum is dependent upon the degree of torsion (twist) applied to the optical waveguide. Measuring the magnitude and/or sense (i.e. increase/decrease) in the intensity of optical radiation transmitted through the grating from an optical source enables torsion to be sensed.
摘要翻译：一种使用与衍射光栅（3）光学通信的光波导（2）的扭转传感器（1），优选为倾斜光栅，并且最优选为倾斜布拉格光栅，其为光波导和光栅提供扭转相关集合光传输频谱。通过检测通过光栅传输的光辐射强度的相应变化，可以检测（12）由施加到波导的扭转量的变化引起的波导和光栅的集体光透射频谱的变化光源（5）。集体光传输频谱的变化程度取决于施加到光波导的扭曲程度（扭曲）。测量从光源通过光栅透射的光辐射的强度的量值和/或感测（即增加/减少）使得能够感测扭转。

10. 发明申请

WO2007075572A2 ORALLY ACTIVE PURINE-BASED INHIBITORS OF HEAT SHOCK PROTEIN 90 审中-公开
标题翻译： ORALLY ACTIVE PURINE-based抑制剂的热休克蛋白90
公开(公告)号：WO2007075572A2
公开(公告)日：2007-07-05
申请号：PCT/US2006048250
申请日：2006-12-18
申请人： CONFORMA THERAPEUTICS CORP , KASIBHATLA SRINIVAS R , ZHANG LIN , BOEHM MARCUS F , FAN JUNHUA , HONG KEVIN D , BIAMONTE MARCO , SHI JIANDONG
发明人： KASIBHATLA SRINIVAS R , ZHANG LIN , BOEHM MARCUS F , FAN JUNHUA , HONG KEVIN D , BIAMONTE MARCO , SHI JIANDONG
IPC分类号： A61K31/675 , C07D473/00 , C07D473/12
CPC分类号： C07D473/36
摘要： Novel purine compounds and tautomers and pharmaceutically acceptable salts thereof are described, as are pharmaceutical compositions comprising the same, complexes comprising the same, e.g., HSP90 complexes, and methods of using the same. Methods of using the novel purine compounds of the invention,and tautomers and pharmaceutically acceptable salts thereof, include their use in inhibiting heat shock protein 90's (HSP90*s) to thereby treat or prevent HSP90-dependent diseases, e.g., proliferative disorders such as breast cancer.
摘要翻译：描述了新的嘌呤化合物和互变异构体及其药学上可接受的盐，以及包含其的药物组合物，包含其的复合物，例如HSP90复合物，及其使用方法。使用本发明的新型嘌呤化合物及其互变异构体及其药学上可接受的盐的方法包括它们在抑制热休克蛋白90（HSP90 * s）中的用途，从而治疗或预防HSP90依赖性疾病，例如增殖性疾病如乳房癌症。

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