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1. 发明申请

WO1996012189A2 METHODS OF SCREENING FOR ULCERATIVE COLITIS AND CROHN'S DISEASE BY DETECTING VH3-15 AUTOANTIBODY AND pANCA 审中-公开
标题翻译：通过检测VH3-15自身抗体和pANCA检测血清COLITIS和CROHN病变的方法
公开(公告)号：WO1996012189A2
公开(公告)日：1996-04-25
申请号：PCT/US1995013422
申请日：1995-10-05
申请人： CEDARS-SINAI MEDICAL CENTER , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： CEDARS-SINAI MEDICAL CENTER , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BRAUN, Jonathan , TARGAN, Stephan, R.
IPC分类号： G01N33/564
CPC分类号： C07K16/4258 , G01N33/56922 , G01N33/56972 , G01N33/686 , Y10S435/961 , Y10S435/965 , Y10S435/975
摘要： The present invention provides novel methods of screening for ulcerative colitis and Crohn's disease which include the detection of two disparate autoantibodies: pANCA and VH3-15 autoantibody. The present invention also provides kits for screening ulcerative colitis and Crohn's disease.
摘要翻译：本发明提供筛选溃疡性结肠炎和克罗恩病的新方法，其包括检测两种不同的自身抗体：pANCA和VH3-15自身抗体。本发明还提供了用于筛选溃疡性结肠炎和克罗恩病的试剂盒。

2. 发明申请

WO1997038713A1 DIAGNOSIS, PREVENTION AND TREATMENT OF ULCERATIVE COLITIS, AND CLINICAL SUBTYPES THEREOF, USING HISTONE H1 审中-公开
标题翻译：诊断，预防和治疗精神分裂症及其临床亚型，使用HISTONE H1
公开(公告)号：WO1997038713A1
公开(公告)日：1997-10-23
申请号：PCT/US1997006987
申请日：1997-04-11
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CEDARS-SINAI MEDICAL CENTER
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CEDARS-SINAI MEDICAL CENTER , BRAUN, Jonathan , TARGAN, Stephan, R. , EGGENA, Mark
IPC分类号： A61K39/00
CPC分类号： G01N33/564 , A61K39/0008
摘要： The present invention provides a method of diagnosing ulcerative colitis (UC) in a subject suspected of having inflammatory bowel disease by obtaining a sample from the individual; contacting the sample with human histone H1, or pANCA-reactive fragment thereof, under conditions suitable to form a complex of human histone H1, or pANCA-reactive fragment thereof, and antibody to human histone H1; and detecting the presence or absence of the complex, where the presence of the complex indicates that the individual has UC. The invention also provides related methods of diagnosing a perinuclear anti-neutrophil cytoplasmic antibody positive (pANCA-positive) clinical subtype of UC in a patient with UC. In addition, the invention further provides methods of determining susceptibility to UC in an individual. The invention further provides methods of inducing tolerance in a pANCA-positive patient with UC by administering an effective dose of histone H1, or tolerogenic fragment thereof, to the pANCA-positive patient with UC. Compositions of histone H1, or fragment thereof, combined with a tolerogizing molecule also are provided.
摘要翻译：本发明提供一种通过从个体获得样品来诊断疑似患有炎症性肠病的受试者的溃疡性结肠炎（UC）的方法; 在适于形成人组蛋白H1或其pANCA反应性片段的复合物和人组蛋白H1的抗体的条件下，将样品与人组蛋白H1或其pANCA反应性片段接触; 并检测复合物的存在或不存在，其中复合物的存在表明个体具有UC。本发明还提供了在UC患者中诊断UC的核周抗中性粒细胞胞质抗体阳性（pANCA阳性）临床亚型的相关方法。此外，本发明还提供了确定个体对UC的易感性的方法。本发明进一步提供了通过向具有UC的pANCA阳性患者施用有效剂量的组蛋白H1或其耐受性片段来诱导具有UC的pANCA阳性患者的耐受性的方法。还提供组蛋白H1或其片段的组合物与耐受性分子组合。

3. 发明申请

WO1998037415A1 ULCERATIVE COLITIS pANCA SECRETORY VESICLE ANTIGEN AND METHODS OF USING SAME 审中-公开
标题翻译：维生素BANA秘密VESICLE抗原及其使用方法
公开(公告)号：WO1998037415A1
公开(公告)日：1998-08-27
申请号：PCT/US1997013059
申请日：1997-08-06
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CEDARS-SINAI MEDICAL CENTER
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CEDARS-SINAI MEDICAL CENTER , BRAUN, Jonathan , GORDON, Lynn, K. , TARGAN, Stephan, R. , EGGENA, Mark
IPC分类号： G01N33/53
CPC分类号： C07K14/4713 , A61K38/00 , C07K16/18 , G01N33/564 , G01N33/6893
摘要： The present invention provides a substantially pure UC pANCA secretory vesicle antigen, including a protein immunoreactive with NANUC-1 and NANUC-2 and having the characteristic of being selectively expressed in secretory vesicle membrane. Pharmaceutical compositions containing the substantially pure UC pANCA secretory vesicle antigen and a pharmaceutical carrier also are provided. The invention further provides a tolerogenic composition containing the substantially pure UC pANCA secretory vesicle antigen, or tolerogenic fragment thereof, combined with a tolerogizing molecule. In addition, there are provided methods of diagnosing ulcerative colitis in a patient and methods of determining susceptibility to ulcerative colitis in an individual using the substantially pure UC pANCA secretory vesicle antigen. The invention further provides methods of inducing tolerance in a pANCA-positive patient with UC and methods of preventing ulcerative colitis in an individual by administering the substantially pure UC pANCA secretory vesicle antigen, or tolerogenic fragment thereof.
摘要翻译：本发明提供了基本上纯的UC pANCA分泌囊泡抗原，其包括与NANUC-1和NANUC-2免疫反应的蛋白质，并且具有在分泌囊泡膜中选择性表达的特征。还提供了含有基本上纯的UC pANCA分泌囊泡抗原和药物载体的药物组合物。本发明进一步提供含有基本上纯的UC pANCA分泌囊泡抗原或其耐受性片段与耐受性分子组合的耐受性组合物。此外，提供了诊断患者溃疡性结肠炎的方法以及使用基本上纯的UC pANCA分泌囊泡抗原确定个体中溃疡性结肠炎易感性的方法。本发明还提供了在具有UC的pANCA阳性患者中诱导耐受性的方法以及通过施用基本上纯的UC pANCA分泌囊泡抗原或其耐受性片段来预防个体的溃疡性结肠炎的方法。

4. 发明申请

WO1996039186A1 ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY MATERIAL ASSOCIATED WITH ULCERATIVE COLITIS AND RELATED METHODS AND KITS 审中-公开
标题翻译：与中性粒细胞抗体相关的抗体物质与相关方法和试剂盒
公开(公告)号：WO1996039186A1
公开(公告)日：1996-12-12
申请号：PCT/US1996008756
申请日：1996-06-05
申请人： CEDARS-SINAI MEDICAL CENTER , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： CEDARS-SINAI MEDICAL CENTER , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BRAUN, Jonathan , EGGENA, Mark, P. , TARGAN, Stephan, R.
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , C07K2319/00 , G01N33/56972 , G01N33/686
摘要： For the first time, the present invention provides isolated, substantially pure, and/or recombinantly produced pANCA associated with ulcerative colitis (UCpANCA and UCpANCA material) as well as polynucleotides encoding the UCpANCA, UCpANCA material and UCpANCA polypeptides of the present invention. Using the phage display technique, immunoglobulin gene repertoires biased for the immunoglobulin genes utilized by pANCA seropositive UC patients have been isolated, amplified, randomly re-combined to generate phagemid expression vector libraries encoding DNA homologs of the gene repertoire. Methods are provided for enriching these libraries to create libraries of VH- and VL-encoding DNA homologs having immunoreactivity of UCpANCA antigen. Also provided are methods of screening the libraries of the present invention for UCpANCA and UCpANCA material. These libraries may be encapsulated in phage particles or in cells. Methods and kits are also provided for screening for UCpANCA in a sample and isolating UCpANCA antigen.
摘要翻译：本发明首次提供与溃疡性结肠炎（UCpANCA和UCpANCA材料）相关的分离的，基本上纯的和/或重组产生的pANCA，以及编码本发明的UCpANCA，UCpANCA材料和UCpANCA多肽的多核苷酸。使用噬菌体展示技术，已经分离，扩增，随机重新组合由pANCA血清阳性UC患者利用的免疫球蛋白基因偏倚的免疫球蛋白基因库，以产生编码基因库的DNA同源物的噬菌粒表达载体文库。提供用于富集这些文库以产生具有UCpANCA抗原的免疫反应性的VH-和VL编码的DNA同系物的文库的方法。还提供了筛选本发明的文库用于UCpANCA和UCpANCA材料的方法。这些文库可以封装在噬菌体颗粒中或细胞中。还提供了用于筛选样品中的UCpANCA并分离UCpANCA抗原的方法和试剂盒。

5. 发明申请

WO1998009226A1 METHODS FOR DETECTING PROPENSITY FOR FIBRILLATION USING AN ELECTRICAL RESTITUTION CURVE 审中-公开
标题翻译：用于通过电力调节曲线来检测颤振的特性的方法
公开(公告)号：WO1998009226A1
公开(公告)日：1998-03-05
申请号：PCT/US1997014966
申请日：1997-08-14
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： CEDARS-SINAI MEDICAL CENTER , KARAGUEUZIAN, Hrayr, S. , DENTON, Timothy, A.
IPC分类号： G06F17/00
CPC分类号： A61B5/046 , A61B5/7253 , A61B5/7257 , A61N1/08 , A61N1/385 , A61N1/3925
摘要： A method for detecting a heart disorder comprises examination of a phase-plane plot (PPP) of a patient electrocardiogram (EKG). The PPP's degree of deterministic chaos may be measured by a processor. Analysis of the PPP may indicate a propensity for fibrillation, that is, indicate both the risk of fibrillation and its actual onset (cases where risk is 100 percent). A second method for detecting a heart disorder comprises examination of a frequency-domain transform (such as an FFT) of a patient EKG. An automatic defibrillating device may comprise means for delivering a variable shock, the size of which is determined at least in part by the FFT's peak energy. A method for detecting drug toxicity comprises examination of a parameter time constant for an action-potential duration (APD) restitution curve which is constructed for the patient.
摘要翻译：用于检测心脏病的方法包括检查患者心电图（EKG）的相位图（PPP）。 PPP的确定性混沌程度可以由处理器测量。 PPP的分析可能表明纤维性颤动的倾向，即指出纤维性颤动的风险及其实际发作（风险为100％的情况）。用于检测心脏病的第二种方法包括检查患者EKG的频域变换（例如FFT）。自动除颤装置可以包括用于递送可变冲击的装置，其大小至少部分地由FFT的峰值能量确定。用于检测药物毒性的方法包括检查为患者构建的动作电位持续时间（APD）恢复曲线的参数时间常数。

6. 发明申请

WO1997039147A1 METHODS OF IDENTIFYING AND DIAGNOSING INFLAMMATORY BOWEL DISEASE 审中-公开
标题翻译：识别和诊断炎症性皮肤病的方法
公开(公告)号：WO1997039147A1
公开(公告)日：1997-10-23
申请号：PCT/US1997006039
申请日：1997-04-11
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： CEDARS-SINAI MEDICAL CENTER , PLEVY, Scott, E. , YANG, Huiying , TARGAN, Stephan, R. , ROTTER, Jerome, I.
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/172
摘要： The present invention provides methods of identifying, diagnosing and screening for inflammatory bowel disease, particularly Crohn's Disease (CD) comprising identifying alleles and polymorphisms associated with a biological response related to an inflammatory bowel disease. The invention further provides for a method of determining whether a therapy which decreases the levels of TNF- alpha would be effective in treating an inflammatory bowel disease. The invention also provides for an assay system for screening for susceptibility to inflammatory bowel disease.
摘要翻译：本发明提供鉴定，诊断和筛选炎症性肠病，特别是克罗恩氏病（CD）的方法，其包括鉴定与与炎性肠病相关的生物反应相关的等位基因和多态性。本发明进一步提供了确定降低TNF-α水平对治疗炎性肠病有效的疗法的方法。本发明还提供了用于筛选对炎症性肠病易感性的测定系统。

7. 发明申请

WO1997029184A1 ESTROGEN RESPONSE ELEMENT BINDING PROTEINS AND NUCLEOTIDES ENCODING THEREFOR 审中-公开
标题翻译：雌激素反应元件结合蛋白和核苷酸编码
公开(公告)号：WO1997029184A1
公开(公告)日：1997-08-14
申请号：PCT/US1997002208
申请日：1997-02-12
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： CEDARS-SINAI MEDICAL CENTER , ADAMS, John, S.
IPC分类号： C12N05/12
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention relates to the discovery and purification of novel estrogen response element binding proteins. Estrogen response element binding proteins are distinct from the estrogen receptor and other intracellular receptors, e.g. estrogen receptor. Estrogen response element binding proteins can interfere with the biological activity of the estrogen receptor and other related intracellular receptor proteins. One aspect of the invention is to provide purified estrogen response element binding proteins. Another aspect of the invention is to provide antibodies capable of binding to the estrogen response element binding proteins of the invention. Another aspect of the invention is to provide assays for the detection or screening of therapeutic compounds that interfere with the interaction between estrogen response element binding protein and estrogen response elements.
摘要翻译：本发明涉及新型雌激素反应元件结合蛋白的发现和纯化。雌激素反应元件结合蛋白不同于雌激素受体和其他细胞内受体，例如雌激素受体。雌激素反应元件结合蛋白可能干扰雌激素受体和其他相关胞内受体蛋白的生物活性。本发明的一个方面是提供纯化的雌激素反应元件结合蛋白。本发明的另一方面是提供能够结合本发明的雌激素反应元件结合蛋白的抗体。本发明的另一方面是提供用于检测或筛选干扰雌激素反应元件结合蛋白和雌激素反应元件之间的相互作用的治疗化合物的测定。

8. 发明申请

WO1997028688A1 INTRACELLULAR VITAMIN D BINDING PROTEIN 审中-公开
标题翻译：细胞维生素D结合蛋白
公开(公告)号：WO1997028688A1
公开(公告)日：1997-08-14
申请号：PCT/US1997002213
申请日：1997-02-12
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： CEDARS-SINAI MEDICAL CENTER , ADAMS, John, S.
IPC分类号： A01N37/18
CPC分类号： C07K14/57 , A61K38/00
摘要： The invention relates to the discovery and purification of novel intracellular vitamin D binding proteins (IDBPs) and the isolation of polynucleotide sequences encoding the proteins. IDBPs are of interest because they mediate the vitamin D resistance, i.e., insensitivity, observed in new world primates. IDBPs are distinct from the vitamin D receptor and other intracellular receptors, e.g. estrogen receptor. One aspect of the invention is to provide purified IDBPs as pharmaceutical compositions to affect steroid hormone activity. Another aspect of the invention provides polynucleotides encoding the IDBPs of the invention for use in altering the expression of IDBPs. Yet another aspect of the invention is to provide assays for the detection or screening of therapeutic compounds that interfere with the interaction between IDBP and vitamin D (or other ligands that bind to IDBP), and the use of such compounds as pharmaceutical compositions.
摘要翻译：本发明涉及新型细胞内维生素D结合蛋白（IDBPs）的发现和纯化以及编码蛋白质的多核苷酸序列的分离。 IDBPs是有意义的，因为它们介导在新世界灵长类动物中观察到的维生素D抗性，即不敏感性。 IDBPs不同于维生素D受体和其他细胞内受体，例如。雌激素受体。本发明的一个方面是提供纯化的IDBPs作为影响类固醇激素活性的药物组合物。本发明的另一方面提供编码本发明的IDBPs的多核苷酸，用于改变IDBP的表达。本发明的另一方面是提供用于检测或筛选干扰IDBP和维生素D（或与IDBP结合的其它配体）之间的相互作用的治疗化合物的测定，以及使用这些化合物作为药物组合物。

9. 发明申请

WO1995008962A1 FIBER-OPTIC ENDODONTIC APPARATUS AND METHOD 审中-公开
标题翻译：光纤内置装置及方法
公开(公告)号：WO1995008962A1
公开(公告)日：1995-04-06
申请号：PCT/US1994010973
申请日：1994-09-28
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： CEDARS-SINAI MEDICAL CENTER , VARI, Sandor, G.
IPC分类号： A61C05/02
CPC分类号： A61B5/0088 , A61C5/40 , A61C19/004 , A61L2/10
摘要： An endodontic apparatus and related method for the instant detection of the anatomical structure of a tooth and for the restoration of a dead or severely decayed tooth using induced fluorescence spectroscopy. A root canal probe having an optical fiber through its center transmits excitation light into the tooth's root canal. The excitation light induces the tissue within the root canal to fluoresce. The fluorescent light is collected by the optical fiber and transmitted back to a sensor that generates electrical signals indicative of the intensity of light within predetermined wavelength bands. The electrical signals are processed to identify the tissues within the root canal. The probe may include a slightly conical metal surface having flutes for shaving and removing dentin from within the root canal. Using the fluorescent emission properties of the tissues of components of a tooth, the entrance of the root canal is located. The root canal is cleaned and shaped and the apex of the root canal located using the difference between the fluorescence spectrum of the apex and the root canal. The root canal is sealed and filled by a light cure restorative delivered into the root canal through a tube. The light cure restorative is activated by light transmitted into the root canal by an optical fiber. The light activation and polymerization of the light cure restorative can be controlled by monitoring the intensitity of the restorative's fluorescence spectrum.
摘要翻译：用于立即检测牙齿的解剖结构并使用诱导荧光光谱法恢复死亡或严重衰退的牙齿的根管装置和相关方法。通过其中心具有光纤的根管探针将激发光透射到牙齿的根管中。激发光诱导根管内的组织发荧光。荧光灯由光纤收集并传输回传感器，该传感器产生指示预定波长带内的光强度的电信号。处理电信号以识别根管内的组织。探针可以包括略微锥形的金属表面，其具有用于剃刮的槽纹和从根管内去除牙本质。使用牙齿组分的组织的荧光发射特性，定位根管的入口。根管被清洁和成形，根管的顶点使用顶点的荧光光谱与根管之间的差异来定位。根管被密封并由通过管输送到根管中的光固化修复剂填充。光固化修复剂由通过光纤传播到根管中的光激活。可以通过监测恢复性荧光光谱的强度来控制光固化修复剂的光活化和聚合。

10. 发明申请

WO1993004735A1 METHOD AND APPARATUS FOR RESTENOSIS TREATMENT 审中-公开
标题翻译：用于保留治疗的方法和装置
公开(公告)号：WO1993004735A1
公开(公告)日：1993-03-18
申请号：PCT/US1992007447
申请日：1992-09-04
申请人： CEDARS-SINAI MEDICAL CENTER , HESS, Robert, L. , SHEFER, Arie , EIGLER, Neal, L. , WHITING, James, S.
发明人： CEDARS-SINAI MEDICAL CENTER
IPC分类号： A61N05/00
CPC分类号： A61N5/1002 , A61B2017/22068 , A61M2025/1047 , A61N2005/1004 , A61N2005/1023
摘要： Method and apparatus (10) for treatment and post-treatment of the stenosed region (14) of an artery (12) after reduction of the region by angioplasty or other means by applying a radioactive dose (30) to said reduced region of the artery by positioning a radioactive dose to the reduced region is disclosed. Low dose, local ionizing irradiation (38) is delivered to the site of an intravascular intervention to prevent and/or minimize excessive cell proliferation. The irradiating source may be located external to the site or may involve a source located within the vessel. The low dose, local ionizing irradiation may also be delivered during the interventional session or thereafter, preferably within 72 hours of the intervention, in a single dose or a fractionated dose, and alone or in combination with at least one radiosensitizing agent.
摘要翻译：用于通过血管成形术或其他手段减少该区域的动脉（12）的狭窄区域（14）进行治疗和后处理的方法和装置（10），其通过对所述动脉的所述减少区域施加放射性剂量（30）公开了将放射性剂量定位到还原区域。将低剂量局部电离辐射（38）输送到血管内干预部位，以预防和/或最小化过度的细胞增殖。照射源可以位于该场所的外部，或者可以涉及位于容器内的源。低剂量局部电离照射也可以在介入治疗期间或其后，优选在干预的72小时内以单一剂量或分次剂量，单独或与至少一种放射增敏剂组合递送。

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