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1. 发明申请

WO1997039356A1 METHODS OF DIAGNOSING CLINICAL SUBTYPES OF CROHN'S DISEASE 审中-公开
标题翻译：诊断CROHN病的临床亚型的方法
公开(公告)号：WO1997039356A1
公开(公告)日：1997-10-23
申请号：PCT/US1997006791
申请日：1997-04-11
申请人： CEDARS-SINAI MEDICAL CENTER , PROMETHEUS
发明人： CEDARS-SINAI MEDICAL CENTER , PROMETHEUS , TARGAN, Stephan , VASILIAUSKAS, Eric, A. , PLEVY, Scott, E. , BARRY, Mary, J.
IPC分类号： G01N33/564
CPC分类号： C12Q1/6883 , G01N33/56972 , G01N33/6893 , G01N2800/065
摘要： Provided herein is a method of diagnosing a clinical subtype of Crohn's disease (CD) by determining whether perinuclear anti-neutrophil antibody (pANCA) is present in a patient with CD, where the presence of pANCA indicates a clinical subtype of CD with features of ulcerative colitis (UC). The present also provides a method of diagnosing clinical subtypes of Crohn's disease in a patient with CD by determing whether pANCA or speckling anti-pan polymorphonuclear antibody (SAPPA) is present in the patient with CD, where the presence of pANCA indicates a clinical subtype of CD with features of ulcerative colitis and where the presence of SAPPA indicates a clinical subtype of CD having perforating, fistulizing or small bowel obstructive disease. The invention further provides a method of diagnosing clinical subtypes of Crohn's disease in a patient with CD by determining the presence or absence of ANCA, pANCA and SAPPA in the patient with CD and determining the presence or absence of anti-Saccharomyces cerevisiae antibodies (ASCA) in the patient with CD, where the presnece of pANCA combined with the absence of ASCA indicate a clinical subtype of CD with features of UC, the presence of SAPPA indicates a clinical subtype of CD having perforating or fistulizing disease or small bowel obstructive disease, and the presence of ASCA combined with the absence of ANCA indicates a clincial subtype of CD lacking features of ulcerative colitis and having perforating or fistulizing disease or small bowel obstructive disease. Kits for diagnosing clinical subtypes of Crohn's disease, which contain neutrophil and antigen specific for ASCA, also are provided.
摘要翻译：本文提供了通过确定是否存在CD患者中存在核周抗中性粒细胞抗体（pANCA）来诊断克罗恩病（CD）的临床亚型的方法，其中pANCA的存在表示具有溃疡特征的CD的临床亚型结肠炎（UC）。本发明还提供了一种诊断患有CD的克罗恩病的临床亚型的方法，其通过确定患有CD的患者是否存在pANCA或斑点性抗泛多形核抗体（SAPPA），其中pANCA的存在表示临床亚型 CD具有溃疡性结肠炎的特征，并且其中SAPPA的存在表示具有穿孔，瘘管或小肠阻塞性疾病的CD的临床亚型。本发明还提供了一种通过在CD患者中确定ANCA，pANCA和SAPPA的存在或不存在来确定患有CD的患者中克罗恩病的临床亚型的方法，并确定抗酿酒酵母抗体（ASCA）的存在或不存在，在患有CD的患者中，其中pANCA的预后与不存在ASCA指示具有UC特征的CD的临床亚型，SAPPA的存在表示CD具有穿孔或瘘症或小肠阻塞性疾病的临床亚型，以及 ASCA的存在与无ANCA的存在表明CD的临床亚型缺乏溃疡性结肠炎的特征，并且具有穿孔或瘘管疾病或小肠阻塞性疾病。还提供了用于诊断包含嗜中性粒细胞和ASCA特异性抗原的克罗恩病的临床亚型的试剂盒。

2. 发明申请

WO1997039146A1 METHODS OF IDENTIFYING AND DIAGNOSING INFLAMMATORY BOWEL DISEASE 审中-公开
标题翻译：识别和诊断炎症性皮肤病的方法
公开(公告)号：WO1997039146A1
公开(公告)日：1997-10-23
申请号：PCT/US1997005919
申请日：1997-04-10
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： CEDARS-SINAI MEDICAL CENTER , PLEVY, Scott, E. , YANG, Hui-Ying , TARGAN, Stephan, R. , ROTTER, Jerome, I.
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/172
摘要： The present invention provides methods of identifying, diagnosing and screening for inflammatory bowel disease, particularly Crohn's Disease (CD) comprising identifying alleles and polymorphisms, associated with a biological response related to an inflammatory bowel disease. The invention further provides for a method of determining whether a therapy which decreases the levels of TNF- alpha would be effective in treating an inflammatory bowel disease. The invention also provides for an assay system for screening for susceptibility to inflammatory bowel disease.
摘要翻译：本发明提供鉴定，诊断和筛选炎症性肠病，特别是克罗恩病（CD）的方法，其包括鉴定与炎症性肠病相关的生物反应相关的等位基因和多态性。本发明进一步提供了确定降低TNF-α水平对治疗炎性肠病有效的疗法的方法。本发明还提供了用于筛选对炎症性肠病易感性的测定系统。

3. 发明申请

WO1997039147A1 METHODS OF IDENTIFYING AND DIAGNOSING INFLAMMATORY BOWEL DISEASE 审中-公开
标题翻译：识别和诊断炎症性皮肤病的方法
公开(公告)号：WO1997039147A1
公开(公告)日：1997-10-23
申请号：PCT/US1997006039
申请日：1997-04-11
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： CEDARS-SINAI MEDICAL CENTER , PLEVY, Scott, E. , YANG, Huiying , TARGAN, Stephan, R. , ROTTER, Jerome, I.
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/172
摘要： The present invention provides methods of identifying, diagnosing and screening for inflammatory bowel disease, particularly Crohn's Disease (CD) comprising identifying alleles and polymorphisms associated with a biological response related to an inflammatory bowel disease. The invention further provides for a method of determining whether a therapy which decreases the levels of TNF- alpha would be effective in treating an inflammatory bowel disease. The invention also provides for an assay system for screening for susceptibility to inflammatory bowel disease.
摘要翻译：本发明提供鉴定，诊断和筛选炎症性肠病，特别是克罗恩氏病（CD）的方法，其包括鉴定与与炎性肠病相关的生物反应相关的等位基因和多态性。本发明进一步提供了确定降低TNF-α水平对治疗炎性肠病有效的疗法的方法。本发明还提供了用于筛选对炎症性肠病易感性的测定系统。

4. 发明申请

WO1997039148A1 METHODS OF DIAGNOSING A CLINICAL SUBTYPE OF CROHN'S DISEASE WITH FEATURES OF ULCERATIVE COLITIS 审中-公开
标题翻译：诊断CRHIN病的临床亚型的方法与收缩性特征的关系
公开(公告)号：WO1997039148A1
公开(公告)日：1997-10-23
申请号：PCT/US1997006064
申请日：1997-04-11
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： CEDARS-SINAI MEDICAL CENTER , TARGAN, Stephen, R. , VASILIAUSKAS, Eric, A. , PLEVY, Scott, E. , YANG, Huiying , ROTTER, Jerome, I.
IPC分类号： C12Q01/68
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , G01N33/56972 , G01N2800/065
摘要： The present invention provides a method of diagnosing a clinical subtype of Crohn's disease (CD) by determining whether perinuclear anti-neutrophil antibodies (pANCA) are present in a patient with CD, where the presence of pANCA indicates the clinical subtype of CD with features of ulcerative colitis (UC). The invention also provides a method of diagnosing a clinical subtype of CD by detecting an Arg allele at an ICAM-1 locus in a patient with CD, where the Arg allele indicates a clinical subtype of CD with features of ulcerative colitis. In addition, the invention provides a method of diagnosing a pANCA-positive subtype of CD by detecting an Arg allele at an ICAM-1 locus in a patient with CD, where the Arg allele indicates the pANCA-positive subtype of CD.
摘要翻译：本发明提供了一种诊断克罗恩氏病（CD）的临床亚型的方法，该方法是通过确定是否存在CD患者中的核周抗中性粒细胞抗体（pANCA），其中pANCA的存在表示CD的临床亚型，其特征在于溃疡性结肠炎（UC）。本发明还提供了一种通过检测患有CD的患者中ICAM-1位点处的Arg <241>等位基因来诊断CD的临床亚型的方法，其中Arg <241>等位基因指示具有溃疡特征的CD的临床亚型结肠炎。另外，本发明提供了通过检测CD患者的ICAM-1位点处的Arg <241>等位基因来诊断CD的pANCA阳性亚型的方法，其中Arg <241>等位基因指示pANCA阳性亚型的CD。

5. 发明申请

WO1997038642A1 METHODS OF DETERMINING THE RISK OF POUCHITIS DEVELOPMENT 审中-公开
标题翻译：确定发展风险的方法
公开(公告)号：WO1997038642A1
公开(公告)日：1997-10-23
申请号：PCT/US1997005583
申请日：1997-04-03
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： CEDARS-SINAI MEDICAL CENTER , TARGAN, Stephan, R. , FLESCHNER, Phillip , PLEVY, Scott, E.
IPC分类号： A61B19/00
CPC分类号： G01N33/6893 , G01N33/56972 , G01N2800/065
摘要： The present invention provides a method of determining a risk of pouchitis development following a surgical procedure whereby colon is removed and an internal pouch is created in a patient with UC by determining a first pANCA titer, where the first pANCA titer is determined following the surgical procedure; determining a second pANCA titer at a later time; and comparing the first pANCA titer and the second pANCA titer, where a significantly elevated second pANCA titer indicates an increased risk of pouchitis development. In addition, the invention provides a method of determining a risk of pouchitis development following a surgical procedure whereby colon is removed and an internal pouch is created in a patient with UC by determining a first pANCA titer, where the first pANCA titer is determined prior to the surgical procedure; determining a second pANCA titer following said surgical procedure; and comparing the first pANCA titer and the second pANCA titer, where a significantly elevated second pANCA titer indicates an increased risk of pouchitis development.
摘要翻译：本发明提供一种在外科手术之后确定囊泡炎发展的风险的方法，其中结肠被移除，并且通过确定第一pANCA滴度在患有UC的患者中产生内部小袋，其中在手术过程之后确定第一pANCA滴度 ; 在稍后时间确定第二个pANCA滴度; 并比较第一个pANCA滴度和第二个pANCA滴度，其中明显升高的第二个pANCA滴度表明发生囊泡炎的风险增加。另外，本发明提供了一种确定外科手术后肠粘膜炎发展风险的方法，其中结肠被移除并且通过确定第一pANCA滴度来确定第一pANCA滴度，在患有UC的患者中产生内部小袋，其中第一pANCA滴度在外科手术; 在所述外科手术之后确定第二pANCA滴度; 并比较第一个pANCA滴度和第二个pANCA滴度，其中明显升高的第二个pANCA滴度表明发生囊泡炎的风险增加。

6. 发明申请

WO1995031575A1 METHODS OF SCREENING FOR CROHN'S DISEASE USING TNF MICROSATELLITE ALLELES 审中-公开
标题翻译：使用TNF微阵列蛋白筛选克隆病的方法
公开(公告)号：WO1995031575A1
公开(公告)日：1995-11-23
申请号：PCT/US1995006107
申请日：1995-05-17
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： CEDARS-SINAI MEDICAL CENTER , PLEVY, Scott, E. , ROTTER, Jerome, I. , TARGAN, Stephan, R. , TOYODA, Hiroo , YANG, Huiying
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6858 , C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： A novel association between certain tumor necrosis factor microsatellite alleles and Crohn's disease has been discovered. In accordance with the present invention, there is provided methods for screening for Crohn's disease comprising detecting the presence or absence of nucleic acid of a subject encoding TNF microsatellite alleles associated with Crohn's disease, wherein the presence of nucleic acid encoding three or more of the alleles is indicative of Crohn's disease. Kits useful for screening for Crohn's disease are also provided which comprise nucleic acid encoding TNF microsatellite alleles associated with Crohn's disease.
摘要翻译：已经发现了某些肿瘤坏死因子微卫星等位基因与克罗恩病之间的关联。根据本发明，提供了用于筛选克罗恩病的方法，包括检测编码与克罗恩病相关的TNF微卫星等位基因的受试者的核酸的存在或不存在，其中编码三个或更多个等位基因的核酸的存在表明克罗恩病。还提供了用于筛选克罗恩病的试剂盒，其包含编码与克罗恩病相关的TNF微卫星等位基因的核酸。

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