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1. 发明申请

WO1997038713A1 DIAGNOSIS, PREVENTION AND TREATMENT OF ULCERATIVE COLITIS, AND CLINICAL SUBTYPES THEREOF, USING HISTONE H1 审中-公开
标题翻译：诊断，预防和治疗精神分裂症及其临床亚型，使用HISTONE H1
公开(公告)号：WO1997038713A1
公开(公告)日：1997-10-23
申请号：PCT/US1997006987
申请日：1997-04-11
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CEDARS-SINAI MEDICAL CENTER
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CEDARS-SINAI MEDICAL CENTER , BRAUN, Jonathan , TARGAN, Stephan, R. , EGGENA, Mark
IPC分类号： A61K39/00
CPC分类号： G01N33/564 , A61K39/0008
摘要： The present invention provides a method of diagnosing ulcerative colitis (UC) in a subject suspected of having inflammatory bowel disease by obtaining a sample from the individual; contacting the sample with human histone H1, or pANCA-reactive fragment thereof, under conditions suitable to form a complex of human histone H1, or pANCA-reactive fragment thereof, and antibody to human histone H1; and detecting the presence or absence of the complex, where the presence of the complex indicates that the individual has UC. The invention also provides related methods of diagnosing a perinuclear anti-neutrophil cytoplasmic antibody positive (pANCA-positive) clinical subtype of UC in a patient with UC. In addition, the invention further provides methods of determining susceptibility to UC in an individual. The invention further provides methods of inducing tolerance in a pANCA-positive patient with UC by administering an effective dose of histone H1, or tolerogenic fragment thereof, to the pANCA-positive patient with UC. Compositions of histone H1, or fragment thereof, combined with a tolerogizing molecule also are provided.
摘要翻译：本发明提供一种通过从个体获得样品来诊断疑似患有炎症性肠病的受试者的溃疡性结肠炎（UC）的方法; 在适于形成人组蛋白H1或其pANCA反应性片段的复合物和人组蛋白H1的抗体的条件下，将样品与人组蛋白H1或其pANCA反应性片段接触; 并检测复合物的存在或不存在，其中复合物的存在表明个体具有UC。本发明还提供了在UC患者中诊断UC的核周抗中性粒细胞胞质抗体阳性（pANCA阳性）临床亚型的相关方法。此外，本发明还提供了确定个体对UC的易感性的方法。本发明进一步提供了通过向具有UC的pANCA阳性患者施用有效剂量的组蛋白H1或其耐受性片段来诱导具有UC的pANCA阳性患者的耐受性的方法。还提供组蛋白H1或其片段的组合物与耐受性分子组合。

2. 发明申请

WO1998037415A1 ULCERATIVE COLITIS pANCA SECRETORY VESICLE ANTIGEN AND METHODS OF USING SAME 审中-公开
标题翻译：维生素BANA秘密VESICLE抗原及其使用方法
公开(公告)号：WO1998037415A1
公开(公告)日：1998-08-27
申请号：PCT/US1997013059
申请日：1997-08-06
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CEDARS-SINAI MEDICAL CENTER
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CEDARS-SINAI MEDICAL CENTER , BRAUN, Jonathan , GORDON, Lynn, K. , TARGAN, Stephan, R. , EGGENA, Mark
IPC分类号： G01N33/53
CPC分类号： C07K14/4713 , A61K38/00 , C07K16/18 , G01N33/564 , G01N33/6893
摘要： The present invention provides a substantially pure UC pANCA secretory vesicle antigen, including a protein immunoreactive with NANUC-1 and NANUC-2 and having the characteristic of being selectively expressed in secretory vesicle membrane. Pharmaceutical compositions containing the substantially pure UC pANCA secretory vesicle antigen and a pharmaceutical carrier also are provided. The invention further provides a tolerogenic composition containing the substantially pure UC pANCA secretory vesicle antigen, or tolerogenic fragment thereof, combined with a tolerogizing molecule. In addition, there are provided methods of diagnosing ulcerative colitis in a patient and methods of determining susceptibility to ulcerative colitis in an individual using the substantially pure UC pANCA secretory vesicle antigen. The invention further provides methods of inducing tolerance in a pANCA-positive patient with UC and methods of preventing ulcerative colitis in an individual by administering the substantially pure UC pANCA secretory vesicle antigen, or tolerogenic fragment thereof.
摘要翻译：本发明提供了基本上纯的UC pANCA分泌囊泡抗原，其包括与NANUC-1和NANUC-2免疫反应的蛋白质，并且具有在分泌囊泡膜中选择性表达的特征。还提供了含有基本上纯的UC pANCA分泌囊泡抗原和药物载体的药物组合物。本发明进一步提供含有基本上纯的UC pANCA分泌囊泡抗原或其耐受性片段与耐受性分子组合的耐受性组合物。此外，提供了诊断患者溃疡性结肠炎的方法以及使用基本上纯的UC pANCA分泌囊泡抗原确定个体中溃疡性结肠炎易感性的方法。本发明还提供了在具有UC的pANCA阳性患者中诱导耐受性的方法以及通过施用基本上纯的UC pANCA分泌囊泡抗原或其耐受性片段来预防个体的溃疡性结肠炎的方法。

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