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1. 发明申请

WO2007089364A3 DRUG ELUTING VASCULAR CLOSURE DEVICES AND METHODS 审中-公开
标题翻译：药物封闭装置和方法
公开(公告)号：WO2007089364A3
公开(公告)日：2008-06-19
申请号：PCT/US2006061119
申请日：2006-11-20
申请人： CARDIVA MEDICAL INC , YASSINZADEH ZIA
发明人： YASSINZADEH ZIA
IPC分类号： A61F13/00
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00893 , A61B2017/3484 , A61B2090/032
摘要： Drug eluting vascular closure devices and methods for closing a blood vessel puncture site disposed at a distal end of a tissue tract are described. The devices and methods rely on a combination of the body's own natural mechanism to achieve hemostasis with bio-chemical agents to accelerate the hemostatic process. One method includes the steps of introducing a closure device through the tissue tract and deploying an expansible member at a distal end of the device within the blood vessel to occlude the puncture site. A bio-chemical sealing member disposed proximal the expansible member is then displaced so as to expose a bio-chemical region or release region of the device. At least one bio-chemical agent is thereafter released from the device and into the tissue tract to accelerate the occlusion process in the tract.
摘要翻译：描述了药物洗脱血管闭合装置和用于闭合设置在组织管的远端处的血管穿刺部位的方法。装置和方法依赖于身体自身机制的结合，以生物化学剂止血来加速止血过程。一种方法包括以下步骤：通过组织管道引入闭合装置，并在血管内的装置的远端部署可膨胀构件以封闭穿刺部位。设置在可膨胀构件附近的生物化学密封构件然后被移位，以便露出装置的生物化学区域或释放区域。然后至少一种生物化学试剂从该装置释放并进入组织道以加速该道中的闭塞过程。

2. 发明申请

WO2009006482A9 VASCULAR CLOSURE DEVICES AND METHODS PROVIDING HEMOSTATIC ENHANCEMENT 审中-公开
标题翻译：血管闭塞装置和提供血液增生的方法
公开(公告)号：WO2009006482A9
公开(公告)日：2009-12-30
申请号：PCT/US2008068933
申请日：2008-07-01
申请人： CARDIVA MEDICAL INC , YASSINZADEH ZIA , WEITZ JEFFREY I , STAFFORD ALAN
发明人： YASSINZADEH ZIA , WEITZ JEFFREY I , STAFFORD ALAN
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00659 , A61B2017/00676 , A61B2017/00778 , A61B2017/00884 , A61B2017/00889 , A61B2017/00893 , A61B2017/3484 , A61B2090/032
摘要： Drug eluting vascular closure devices and methods for closing a blood vessel puncture site disposed at a distal end of a tissue tract are described. The devices and methods rely on a combination of the body's own natural mechanism to achieve hemostasis with chemical and/or biological agents to accelerate the hemostatic process. One method includes the steps of introducing a closure device through the tissue tract and deploying an expansible member at a distal end of the device within the blood vessel to occlude the puncture site. A chemical and/or biological sealing member disposed proximal the expansible member is then displaced so as to expose a chemical and/or biological region or release region of the device. At least one chemical and/or biological agent is thereafter released from the device and into the tissue tract to accelerate the occlusion process in the tract.
摘要翻译：描述了药物洗脱血管闭合装置和用于闭合设置在组织管的远端处的血管穿刺部位的方法。装置和方法依赖于身体自身机制的组合，以实现与化学和/或生物剂的止血以加速止血过程。一种方法包括以下步骤：通过组织管道引入闭合装置，并在血管内的装置的远端部署可膨胀构件以封闭穿刺部位。设置在可膨胀构件附近的化学和/或生物密封构件然后被移位，以暴露设备的化学和/或生物区域或释放区域。此后，至少一种化学和/或生物剂从该装置中释放并进入组织道，以加速该道中的闭塞过程。

3. 发明申请

WO2008079810A3 HEMOSTASIS-ENHANCING DEVICE AND METHOD FOR ITS USE 审中-公开
标题翻译：无模式增强装置及其使用方法
公开(公告)号：WO2008079810A3
公开(公告)日：2008-08-21
申请号：PCT/US2007087885
申请日：2007-12-18
申请人： CARDIVA MEDICAL INC , YASSINZADEH ZIA
发明人： YASSINZADEH ZIA
IPC分类号： A61M25/04
CPC分类号： A61B17/0057 , A61B2017/00557 , A61B2017/0061 , A61B2017/00623 , A61B2017/00637 , A61B2017/00676 , A61M5/16881
摘要： The present invention advantageously provides devices, systems, and methods for percutaneous access and closure of vascular puncture sites. In an embodiment, the device for enhancing the hemostasis of a puncture site in a body lumen or tract comprises a catheter having one tubular member having a proximal end and a distal end with one inner lumen extending between at least a longitudinal portion of the catheter tubular member. The one tubular member includes external and internal tubular bodies each having proximal and distal ends. At least one of the external and the internal tubular bodies is longitudinally movable with respect to the other. An expansible member with proximal and distal ends is disposed on the distal end of the one tubular member. The distal end of the expansible member is connected to the distal end of internal tubular body and with its proximal end connected to the distal end of external tubular body.
摘要翻译：本发明有利地提供了用于经皮进入和关闭血管穿刺部位的装置，系统和方法。在一个实施例中，用于增强体腔或管道中穿刺部位的止血的装置包括具有一个管状构件的导管，该管状构件具有近端和远端，一个内腔在导管管的至少一个纵向部分会员。一个管状构件包括各自具有近端和远端的外部和内部管状体。外部管状体和内部管状体中的至少一个可相对于另一个纵向移动。具有近端和远端的可膨胀构件设置在一个管状构件的远端上。可膨胀构件的远端连接到内部管状体的远端，并且其近端连接到外部管状体的远端。

4. 发明申请

WO2005099590A3 DEVICE AND METHOD FOR SEALING BLOOD VESSELS 审中-公开
标题翻译：密封血管的装置和方法
公开(公告)号：WO2005099590A3
公开(公告)日：2008-01-17
申请号：PCT/US2005011648
申请日：2005-04-06
申请人： CARDIVA MEDICAL INC , YASSINZADEH ZIA
发明人： YASSINZADEH ZIA
IPC分类号： A61B17/08 , A61B17/00 , A61B17/22 , A61D1/00 , A61M29/00
CPC分类号： A61B17/0057 , A61B2017/00654 , A61B2017/00672 , A61B2017/22065
摘要： The present invention provides devices, systems, and methods for percutaneously sealing a puncture site in tissue tracts and vessels in human or animal bodies. One system includes a locating assembly that is used to locate the puncture site and can also provide temporary hemostasis when the system is used for closing a vessel puncture. The system also includes a compression assembly comprising a tubular member with a balloon on a distal end thereof. This balloon is at a fixed distance from the locator tip which locates the balloon outside the vessel wall at a predetermined distance. Inflation of this balloon causes forward elongation of the balloon which compresses subcutaneous tissue between the distal tip of the balloon and the vessel wall. This tissue compression against the puncture site is the mechanism that provides hemostasis.
摘要翻译：本发明提供了用于经皮密封人或动物体内的组织束和血管中的穿刺部位的装置，系统和方法。一个系统包括用于定位穿刺部位的定位组件，并且当系统用于关闭血管穿刺时也可以提供临时止血。该系统还包括压缩组件，其包括在其远端上具有气囊的管状构件。该气球距离定位器尖端固定的距离，定位器尖端将气囊定位在血管壁外部预定距离处。该气囊的充气引起气囊的向前伸长，其压缩气囊的远端和容器壁之间的皮下组织。针对穿刺部位的这种组织压缩是提供止血的机制。

5. 发明申请

WO2005117715A3 SELF-TENSIONING VASCULAR OCCLUSION DEVICE AND METHOD FOR ITS USE 审中-公开
标题翻译：自张紧血管造影装置及其使用方法
公开(公告)号：WO2005117715A3
公开(公告)日：2006-05-04
申请号：PCT/US2005017688
申请日：2005-05-18
申请人： CARDIVA MEDICAL INC , YASSINZADEH ZIA , PELAYO DELFIN
发明人： YASSINZADEH ZIA , PELAYO DELFIN
IPC分类号： A61B17/00 , A61B17/08 , A61F2/958 , A61B17/03 , A61M29/00
CPC分类号： A61B17/0057 , A61B2017/00659 , A61B2017/00986 , A61B2090/0807
摘要： The present invention advantageously provides self-tensioning occlusion devices, systems, and methods for percutaneous access and closure of vascular puncture sites. One device comprises a catheter body, an occlusion member, and a tensioning member. The occlusion member, such an expansible member, is disposed on a distal end of the body. The tensioning member, such as a spring or coil, is slidably disposed over the body and proximal the expansion member. Generally, during application, the tensioning member will be deployed against subcutaneous tissue so as to apply tension to the expansible member against the puncture site. The substantial hold once the tension is applied is then provided by external means, such as an anchoring clip.
摘要翻译：本发明有利地提供了用于经皮通路和闭合血管穿刺部位的自张紧闭塞装置，系统和方法。一个装置包括导管主体，遮挡构件和张紧构件。这种可膨胀构件的遮挡构件设置在主体的远端上。张紧构件，例如弹簧或线圈，可滑动地设置在身体上并且靠近扩张构件。通常，在施用期间，张紧构件将被展开抵抗皮下组织，从而抵抗穿刺部位向可膨胀构件施加张力。施加张力后的实质上的保持力然后由诸如锚固夹的外部装置提供。

6. 发明申请

WO2005051225A3 EXPANSILE DEVICE FOR USE IN BLOOD VESSELS AND TRACTS IN THE BODY AND METHOD 审中-公开
标题翻译：用于血管中的扩张装置和身体和方法中的跟踪
公开(公告)号：WO2005051225A3
公开(公告)日：2006-07-27
申请号：PCT/US2004037803
申请日：2004-11-12
申请人： CARDIVA MEDICAL INC , EPSTEIN GORDON H , LEMPERT TODD E , MARTIN BRIAN B , TAYLOR DAVID M , ROMLEY RICHARD M , YASSINZADEH ZIA , FOY GLENN
发明人： EPSTEIN GORDON H , LEMPERT TODD E , MARTIN BRIAN B , TAYLOR DAVID M , ROMLEY RICHARD M , YASSINZADEH ZIA , FOY GLENN
IPC分类号： A61B17/04 , A61B17/00 , A61B17/12 , A61F20060101
CPC分类号： A61B17/0057 , A61B17/00491 , A61B17/12022 , A61B17/12099 , A61B17/12109 , A61B17/12136 , A61B2017/00495 , A61B2017/00641
摘要： A device (21) for expansion within a blood vessel having a wall defining a lumen in the body. The device comprises an elongated tubular member (22) having proximal (23) and distal extremities (24) and having a longitudinal axis. An expansile member is carried by the distal extremity of the elongated tubular member and is movable between contracted and expanded configurations. A deformable membrane having proximal and distal outer surfaces at least partially covers the expansile member (32) in the expanded configuration. The proximal and distal outer surfaces have substantially different configurations when the expansile member is in the expanded configuration. Deployment means is carried by the proximal extremity of the elongated tubular member and is coupled to the expansile member for moving the expansile member between the contracted and expanded configurations. A handle assembly is carried by the proximal extremity of the elongated tubular member and coupled to the deployment members.
摘要翻译：一种用于在血管内扩张的装置（21），其具有在体内限定内腔的壁。该装置包括具有近端（23）和远端（24）并且具有纵向轴线的细长管状构件（22）。膨胀构件由细长管状构件的远端承载并且可在收缩和膨胀构型之间移动。具有近端和远端外表面的可变形膜至少部分地覆盖膨胀构型中的膨胀构件（32）。当膨胀构件处于膨胀构型时，近端和远端外表面具有基本上不同的构造。展开装置由细长管状构件的近端承载，并且联接到膨胀构件，用于在收缩和膨胀构型之间移动膨胀构件。手柄组件由细长管状构件的近端承载并联接到展开构件。

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