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1. 发明申请

WO2009006482A1 VASCULAR CLOSURE DEVICES AND METHODS PROVIDING HEMOSTATIC ENHANCEMENT 审中-公开
标题翻译：血管闭合装置和提供静脉内增强的方法
公开(公告)号：WO2009006482A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/068933
申请日：2008-07-01
申请人： CARDIVA MEDICAL, INC. , YASSINZADEH, Zia , WEITZ, Jeffrey I. , STAFFORD, Alan
发明人： YASSINZADEH, Zia , WEITZ, Jeffrey I. , STAFFORD, Alan
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00659 , A61B2017/00676 , A61B2017/00778 , A61B2017/00884 , A61B2017/00889 , A61B2017/00893 , A61B2017/3484 , A61B2090/032
摘要： Drug eluting vascular closure devices and methods for closing a blood vessel puncture site disposed at a distal end of a tissue tract are described. The devices and methods rely on a combination of the body's own natural mechanism to achieve hemostasis with chemical and/or biological agents to accelerate the hemostatic process. One method includes the steps of introducing a closure device through the tissue tract and deploying an expansible member at a distal end of the device within the blood vessel to occlude the puncture site. A chemical and/or biological sealing member disposed proximal the expansible member is then displaced so as to expose a chemical and/or biological region or release region of the device. At least one chemical and/or biological agent is thereafter released from the device and into the tissue tract to accelerate the occlusion process in the tract.
摘要翻译：描述药物洗脱血管闭合装置和关闭布置在组织管道远端的血管穿刺部位的方法。该装置和方法依靠人体自身机制的组合来实现止血与化学和/或生物制剂以加速止血过程。一种方法包括通过组织管道引入闭合装置并在血管内的装置的远端部署可膨胀构件以闭塞穿刺部位的步骤。然后置于可膨胀构件附近的化学和/或生物密封构件移位，以暴露装置的化学和/或生物学区域或释放区域。之后从装置释放至少一种化学和/或生物制剂并进入组织道以加速道内的阻塞过程。

2. 发明申请

WO1996000614A1 SAMPLE COLLECTION AND MANIPULATION APPARATUS AND METHOD 审中-公开
标题翻译：样本收集和处理装置和方法
公开(公告)号：WO1996000614A1
公开(公告)日：1996-01-11
申请号：PCT/US1995008280
申请日：1995-06-30
申请人： YASSINZADEH, Zia , LINGANE, Paul, J.
IPC分类号： B01L03/02
CPC分类号： B01L7/00 , A61B5/14532 , A61B5/150022 , A61B5/150076 , A61B5/150099 , A61B5/150129 , A61B5/150396 , A61B5/150503 , A61B5/150786 , A61B5/15105 , A61B5/15142 , A61B5/157 , A61B2562/0295 , B01L3/502 , G01N2035/00425 , Y10T436/25375 , Y10T436/2575
摘要： A sample collection and manipulation apparatus (2), typically used for collecting and manipulating a blood sample and measuring a component of that sample with the use of a reagent or ion-selective electrodes, includes a body member (4, 6, 8) defining a thermal pressure chamber (22) and a sample port (10). A measurement chamber (26) is formed along a fluid passageway (42, 16, 24) connecting the thermal pressure chamber with the sample port. The air within the thermal pressure chamber is preheated (54, 56, 60, 62, 63/65) to reduce its density and the sample port is then placed in contact with the liquid. As the gas cools, a partial vacuum is created within the thermal pressure chamber to draw a liquid sample through the passageway and into the measurement chamber. Appropriate analyte measurement techniques, such as optical or electrochemical, can then be carried out. Applications include the testing of blood gases, glucose, hemoglobin, electrolytes, coagulation and therapeutic drugs.
摘要翻译：通常用于收集和操作血液样品并使用试剂或离子选择性电极测量该样品的组分的样品收集和操作装置（2）包括：体部件（4,6,8），其限定热压力室（22）和采样口（10）。沿着将热压力室与样品端口连接的流体通道（42,16,24）形成测量室（26）。热压室内的空气被预热（54,56,60,62,63 / 65）以减小其密度，然后将样品端口与液体接触。当气体冷却时，在热压力室内产生部分真空，以将液体样品通过通道并进入测量室。然后可以进行适当的分析物测量技术，例如光学或电化学。应用范围包括测试血气，葡萄糖，血红蛋白，电解质，凝血和治疗药物。

3. 发明申请

WO2010002918A1 APPARATUS AND METHODS FOR DELIVERING HEMOSTATIC MATERIALS FOR BLOOD VESSEL CLOSURE 审中-公开
标题翻译：用于输送用于血管闭塞的HEMOSTATIC材料的装置和方法
公开(公告)号：WO2010002918A1
公开(公告)日：2010-01-07
申请号：PCT/US2009/049297
申请日：2009-06-30
申请人： CARDIVA MEDICAL, INC. , YASSINZADEH, Zia , PELAYO, Delfin
发明人： YASSINZADEH, Zia , PELAYO, Delfin
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00623 , A61B2017/00654 , A61B2017/00893 , A61B2017/00898 , A61B2017/22067 , A61B2090/3966
摘要： Apparatus for sealing a vascular wall penetration disposed at the end of the tissue tract comprises a shaft, an occlusion element, a hemostatic implant, and a protective sleeve. The apparatus is deployed through the tissue tract with the occlusion element temporarily occluding the vascular wall penetration and inhibiting backbleeding therethrough. The hemostatic implant, which will typically be a biodegradable polymer such as collagen carrying an anti-proliferative agent or coagulation promoter, will then be deployed from the sealing apparatus and left in place to enhance closure of the vascular wall penetration with minimum scarring. The implant may be radiopaque to allow observation before release.
摘要翻译：用于密封设置在组织管道末端处的血管壁穿透物的装置包括轴，闭塞元件，止血植入物和保护套管。该装置通过组织道展开，闭塞元件暂时阻塞血管壁穿透并阻止其通过其反渗透。通常是可生物降解的聚合物（例如携带抗增殖剂或凝血促进剂的胶原）的止血植入物将从密封装置展开并留在原位以增强血管壁穿透的封闭，同时具有最小的瘢痕形成。植入物可以是不透射线的，以便在释放之前观察。

4. 发明申请

WO2007089364A3 DRUG ELUTING VASCULAR CLOSURE DEVICES AND METHODS 审中-公开
标题翻译：药物封闭装置和方法
公开(公告)号：WO2007089364A3
公开(公告)日：2008-06-19
申请号：PCT/US2006061119
申请日：2006-11-20
申请人： CARDIVA MEDICAL INC , YASSINZADEH ZIA
发明人： YASSINZADEH ZIA
IPC分类号： A61F13/00
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00893 , A61B2017/3484 , A61B2090/032
摘要： Drug eluting vascular closure devices and methods for closing a blood vessel puncture site disposed at a distal end of a tissue tract are described. The devices and methods rely on a combination of the body's own natural mechanism to achieve hemostasis with bio-chemical agents to accelerate the hemostatic process. One method includes the steps of introducing a closure device through the tissue tract and deploying an expansible member at a distal end of the device within the blood vessel to occlude the puncture site. A bio-chemical sealing member disposed proximal the expansible member is then displaced so as to expose a bio-chemical region or release region of the device. At least one bio-chemical agent is thereafter released from the device and into the tissue tract to accelerate the occlusion process in the tract.
摘要翻译：描述了药物洗脱血管闭合装置和用于闭合设置在组织管的远端处的血管穿刺部位的方法。装置和方法依赖于身体自身机制的结合，以生物化学剂止血来加速止血过程。一种方法包括以下步骤：通过组织管道引入闭合装置，并在血管内的装置的远端部署可膨胀构件以封闭穿刺部位。设置在可膨胀构件附近的生物化学密封构件然后被移位，以便露出装置的生物化学区域或释放区域。然后至少一种生物化学试剂从该装置释放并进入组织道以加速该道中的闭塞过程。

5. 发明申请

WO2008079810A3 HEMOSTASIS-ENHANCING DEVICE AND METHOD FOR ITS USE 审中-公开
标题翻译：无模式增强装置及其使用方法
公开(公告)号：WO2008079810A3
公开(公告)日：2008-08-21
申请号：PCT/US2007087885
申请日：2007-12-18
申请人： CARDIVA MEDICAL INC , YASSINZADEH ZIA
发明人： YASSINZADEH ZIA
IPC分类号： A61M25/04
CPC分类号： A61B17/0057 , A61B2017/00557 , A61B2017/0061 , A61B2017/00623 , A61B2017/00637 , A61B2017/00676 , A61M5/16881
摘要： The present invention advantageously provides devices, systems, and methods for percutaneous access and closure of vascular puncture sites. In an embodiment, the device for enhancing the hemostasis of a puncture site in a body lumen or tract comprises a catheter having one tubular member having a proximal end and a distal end with one inner lumen extending between at least a longitudinal portion of the catheter tubular member. The one tubular member includes external and internal tubular bodies each having proximal and distal ends. At least one of the external and the internal tubular bodies is longitudinally movable with respect to the other. An expansible member with proximal and distal ends is disposed on the distal end of the one tubular member. The distal end of the expansible member is connected to the distal end of internal tubular body and with its proximal end connected to the distal end of external tubular body.
摘要翻译：本发明有利地提供了用于经皮进入和关闭血管穿刺部位的装置，系统和方法。在一个实施例中，用于增强体腔或管道中穿刺部位的止血的装置包括具有一个管状构件的导管，该管状构件具有近端和远端，一个内腔在导管管的至少一个纵向部分会员。一个管状构件包括各自具有近端和远端的外部和内部管状体。外部管状体和内部管状体中的至少一个可相对于另一个纵向移动。具有近端和远端的可膨胀构件设置在一个管状构件的远端上。可膨胀构件的远端连接到内部管状体的远端，并且其近端连接到外部管状体的远端。

6. 发明申请

WO2005099590A3 DEVICE AND METHOD FOR SEALING BLOOD VESSELS 审中-公开
标题翻译：密封血管的装置和方法
公开(公告)号：WO2005099590A3
公开(公告)日：2008-01-17
申请号：PCT/US2005011648
申请日：2005-04-06
申请人： CARDIVA MEDICAL INC , YASSINZADEH ZIA
发明人： YASSINZADEH ZIA
IPC分类号： A61B17/08 , A61B17/00 , A61B17/22 , A61D1/00 , A61M29/00
CPC分类号： A61B17/0057 , A61B2017/00654 , A61B2017/00672 , A61B2017/22065
摘要： The present invention provides devices, systems, and methods for percutaneously sealing a puncture site in tissue tracts and vessels in human or animal bodies. One system includes a locating assembly that is used to locate the puncture site and can also provide temporary hemostasis when the system is used for closing a vessel puncture. The system also includes a compression assembly comprising a tubular member with a balloon on a distal end thereof. This balloon is at a fixed distance from the locator tip which locates the balloon outside the vessel wall at a predetermined distance. Inflation of this balloon causes forward elongation of the balloon which compresses subcutaneous tissue between the distal tip of the balloon and the vessel wall. This tissue compression against the puncture site is the mechanism that provides hemostasis.
摘要翻译：本发明提供了用于经皮密封人或动物体内的组织束和血管中的穿刺部位的装置，系统和方法。一个系统包括用于定位穿刺部位的定位组件，并且当系统用于关闭血管穿刺时也可以提供临时止血。该系统还包括压缩组件，其包括在其远端上具有气囊的管状构件。该气球距离定位器尖端固定的距离，定位器尖端将气囊定位在血管壁外部预定距离处。该气囊的充气引起气囊的向前伸长，其压缩气囊的远端和容器壁之间的皮下组织。针对穿刺部位的这种组织压缩是提供止血的机制。

7. 发明申请

WO2005117715A3 SELF-TENSIONING VASCULAR OCCLUSION DEVICE AND METHOD FOR ITS USE 审中-公开
标题翻译：自张紧血管造影装置及其使用方法
公开(公告)号：WO2005117715A3
公开(公告)日：2006-05-04
申请号：PCT/US2005017688
申请日：2005-05-18
申请人： CARDIVA MEDICAL INC , YASSINZADEH ZIA , PELAYO DELFIN
发明人： YASSINZADEH ZIA , PELAYO DELFIN
IPC分类号： A61B17/00 , A61B17/08 , A61F2/958 , A61B17/03 , A61M29/00
CPC分类号： A61B17/0057 , A61B2017/00659 , A61B2017/00986 , A61B2090/0807
摘要： The present invention advantageously provides self-tensioning occlusion devices, systems, and methods for percutaneous access and closure of vascular puncture sites. One device comprises a catheter body, an occlusion member, and a tensioning member. The occlusion member, such an expansible member, is disposed on a distal end of the body. The tensioning member, such as a spring or coil, is slidably disposed over the body and proximal the expansion member. Generally, during application, the tensioning member will be deployed against subcutaneous tissue so as to apply tension to the expansible member against the puncture site. The substantial hold once the tension is applied is then provided by external means, such as an anchoring clip.
摘要翻译：本发明有利地提供了用于经皮通路和闭合血管穿刺部位的自张紧闭塞装置，系统和方法。一个装置包括导管主体，遮挡构件和张紧构件。这种可膨胀构件的遮挡构件设置在主体的远端上。张紧构件，例如弹簧或线圈，可滑动地设置在身体上并且靠近扩张构件。通常，在施用期间，张紧构件将被展开抵抗皮下组织，从而抵抗穿刺部位向可膨胀构件施加张力。施加张力后的实质上的保持力然后由诸如锚固夹的外部装置提供。

8. 发明申请

WO2009006482A9 VASCULAR CLOSURE DEVICES AND METHODS PROVIDING HEMOSTATIC ENHANCEMENT 审中-公开
标题翻译：血管闭塞装置和提供血液增生的方法
公开(公告)号：WO2009006482A9
公开(公告)日：2009-12-30
申请号：PCT/US2008068933
申请日：2008-07-01
申请人： CARDIVA MEDICAL INC , YASSINZADEH ZIA , WEITZ JEFFREY I , STAFFORD ALAN
发明人： YASSINZADEH ZIA , WEITZ JEFFREY I , STAFFORD ALAN
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00659 , A61B2017/00676 , A61B2017/00778 , A61B2017/00884 , A61B2017/00889 , A61B2017/00893 , A61B2017/3484 , A61B2090/032
摘要： Drug eluting vascular closure devices and methods for closing a blood vessel puncture site disposed at a distal end of a tissue tract are described. The devices and methods rely on a combination of the body's own natural mechanism to achieve hemostasis with chemical and/or biological agents to accelerate the hemostatic process. One method includes the steps of introducing a closure device through the tissue tract and deploying an expansible member at a distal end of the device within the blood vessel to occlude the puncture site. A chemical and/or biological sealing member disposed proximal the expansible member is then displaced so as to expose a chemical and/or biological region or release region of the device. At least one chemical and/or biological agent is thereafter released from the device and into the tissue tract to accelerate the occlusion process in the tract.
摘要翻译：描述了药物洗脱血管闭合装置和用于闭合设置在组织管的远端处的血管穿刺部位的方法。装置和方法依赖于身体自身机制的组合，以实现与化学和/或生物剂的止血以加速止血过程。一种方法包括以下步骤：通过组织管道引入闭合装置，并在血管内的装置的远端部署可膨胀构件以封闭穿刺部位。设置在可膨胀构件附近的化学和/或生物密封构件然后被移位，以暴露设备的化学和/或生物区域或释放区域。此后，至少一种化学和/或生物剂从该装置中释放并进入组织道，以加速该道中的闭塞过程。

9. 发明申请

WO2007089364A2 DRUG ELUTING VASCULAR CLOSURE DEVICES AND METHODS 审中-公开
标题翻译：药物封闭装置和方法
公开(公告)号：WO2007089364A2
公开(公告)日：2007-08-09
申请号：PCT/US2006/061119
申请日：2006-11-20
申请人： CARDIVA MEDICAL, INC. , YASSINZADEH, Zia
发明人： YASSINZADEH, Zia
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00893 , A61B2017/3484 , A61B2090/032
摘要： Drug eluting vascular closure devices and methods for closing a blood vessel puncture site disposed at a distal end of a tissue tract are described. The devices and methods rely on a combination of the body's own natural mechanism to achieve hemostasis with bio-chemical agents to accelerate the hemostatic process. One method includes the steps of introducing a closure device through the tissue tract and deploying an expansible member at a distal end of the device within the blood vessel to occlude the puncture site. A bio-chemical sealing member disposed proximal the expansible member is then displaced so as to expose a bio-chemical region or release region of the device. At least one bio-chemical agent is thereafter released from the device and into the tissue tract to accelerate the occlusion process in the tract.
摘要翻译：描述了药物洗脱血管闭合装置和用于闭合设置在组织管的远端处的血管穿刺部位的方法。装置和方法依赖于身体自身机制的结合，以生物化学剂止血来加速止血过程。一种方法包括以下步骤：通过组织管道引入闭合装置，并在血管内的装置的远端部署可膨胀构件以封闭穿刺部位。设置在可膨胀构件附近的生物化学密封构件然后被移位，以便露出装置的生物化学区域或释放区域。然后至少一种生物化学试剂从该装置释放并进入组织道以加速该道中的闭塞过程。

10. 发明申请

WO2005099590A2 DEVICE AND METHOD FOR SEALING BLOOD VESSELS 审中-公开
标题翻译：密封血管的装置和方法
公开(公告)号：WO2005099590A2
公开(公告)日：2005-10-27
申请号：PCT/US2005/011648
申请日：2005-04-06
申请人： CARDIVA MEDICAL, INC. , YASSINZADEH, Zia
发明人： YASSINZADEH, Zia
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B2017/00654 , A61B2017/00672 , A61B2017/22065
摘要： The present invention provides devices, systems, and methods for percutaneously sealing a puncture site in tissue tracts and vessels in human or animal bodies. One system includes a locating assembly that is used to locate the puncture site and can also provide temporary hemostasis when the system is used for closing a vessel puncture. The system also includes a compression assembly comprising a tubular member with a balloon on a distal end thereof. This balloon is at a fixed distance from the locator tip which locates the balloon outside the vessel wall at a predetermined distance. Inflation of this balloon causes forward elongation of the balloon which compresses subcutaneous tissue between the distal tip of the balloon and the vessel wall. This tissue compression against the puncture site is the mechanism that provides hemostasis.
摘要翻译：本发明提供了用于经皮密封人或动物体内的组织束和血管中的穿刺部位的装置，系统和方法。一个系统包括用于定位穿刺部位的定位组件，并且当系统用于关闭血管穿刺时也可以提供临时止血。该系统还包括压缩组件，其包括在其远端上具有气囊的管状构件。该气球距离定位器尖端固定的距离，定位器尖端将气囊定位在血管壁外部预定距离处。该气囊的充气引起气囊的向前伸长，其压缩气囊的远端和容器壁之间的皮下组织。针对穿刺部位的这种组织压缩是提供止血的机制。

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