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1. 发明申请

WO2004069333A3 METHOD AND APPARATUS FOR SETTING PACING PARAMETERS 审中-公开
标题翻译：方法和设备的设置参数
公开(公告)号：WO2004069333A3
公开(公告)日：2005-02-10
申请号：PCT/US2004002332
申请日：2004-01-28
申请人： CARDIAC PACEMAKERS INC , DING JIANG , YU YINGHONG , KRAMER ANDREW P , BAUMANN LAWRENCE
发明人： DING JIANG , YU YINGHONG , KRAMER ANDREW P , BAUMANN LAWRENCE
IPC分类号： A61N1/362 , A61N1/368 , A61N1/37
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method and apparatus is disclosed for automatically setting the pacing parameters utilized by an implantable cardiac device in delivering cardiac resynchronization therapy. The selection of the pacing parameters is based at least in part upon measurements of intrinsic cardiac conduction parameters. Among the pacing parameters which may be selected in this way is the atrio-ventricular delay interval used in atrial-tracking and AV sequential pacing modes.
摘要翻译：公开了一种用于自动设置可植入心脏装置在输送心脏再同步治疗中使用的起搏参数的方法和装置。起搏参数的选择至少部分地基于固有心脏传导参数的测量。可以以这种方式选择的起搏参数是在心房跟踪和AV顺序起搏模式中使用的心房延迟间隔。

2. 发明申请

WO2006078519A3 CONTROL OF ELECTRICAL STIMULATION USING HEART RATE VARIABILITY 审中-公开
标题翻译：使用心率变化控制电刺激
公开(公告)号：WO2006078519A3
公开(公告)日：2007-04-19
申请号：PCT/US2006000963
申请日：2006-01-12
申请人： CARDIAC PACEMAKERS INC , PASTORE JOSEPH M , SALO RODNEY W , CARLSON GERRARD M , KRAMER ANDREW P , DING JIANG , YU YINGHONG
发明人： PASTORE JOSEPH M , SALO RODNEY W , CARLSON GERRARD M , KRAMER ANDREW P , DING JIANG , YU YINGHONG
IPC分类号： A61N1/365
CPC分类号： A61N1/36592 , A61B5/02405 , A61B5/4035 , A61N1/36114 , A61N1/368
摘要： A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used to evaluate a plurality of parameter values for selecting an approximately optimal parameter value. In another embodiment, the HRV parameter is used to adjust a maximum tracking rate in an atrial tracking pacing mode. In another embodiment, the HRV parameter is used as a safety check to stop an electrical therapy when it is believed to be potentially harmful to continue the therapy.
摘要翻译：心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。在一个实施例中，HRV参数用于评估用于选择近似最佳参数值的多个参数值。在另一个实施例中，HRV参数用于调整心房跟踪起搏模式中的最大跟踪率。在另一个实施例中，HRV参数用作安全检查以在认为其可能有害以继续治疗时停止电疗法。

3. 发明申请

WO2006115693A2 METHOD AND APPARATUS FOR PACING DURING REVASCULARIZATION 审中-公开
标题翻译：用于在重新血液化期间起搏的方法和设备
公开(公告)号：WO2006115693A2
公开(公告)日：2006-11-02
申请号：PCT/US2006011972
申请日：2006-03-30
申请人： CARDIAC PACEMAKERS INC , SHUROS ALLAN , BAYNHAM TAMARA COLETTE , QU JIHONG , PASTORE JOSEPH M , KRAMER ANDREW P , PRINZEN FRITS W , VANAGT WARD Y R , CORNELUSSEN RICHARD N
发明人： SHUROS ALLAN , BAYNHAM TAMARA COLETTE , QU JIHONG , PASTORE JOSEPH M , KRAMER ANDREW P , PRINZEN FRITS W , VANAGT WARD Y R , CORNELUSSEN RICHARD N
IPC分类号： A61N1/37 , A61B18/14 , A61M25/00
CPC分类号： A61N1/362 , A61B17/22 , A61B18/1492 , A61B2017/22001 , A61B2018/00214 , A61B2018/0041 , A61B2018/00422 , A61N1/056 , A61N1/3625 , A61N5/1001 , A61N2001/0585
摘要： Cardiac protection pacing is applied to prevent or reduce cardiac injury and/or occurrences of arrhythmia associated with an ischemic event including the occlusion of a blood vessel during a revascularization procedure. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto a percutaneous transluminal vascular intervention (PTVI) device used in the revascularization procedure. The pacemaker generates the pacing pulses according to a predetermined cardiac protection pacing sequence before, during, and/or after the ischemic event.
摘要翻译：应用心脏保护起搏以预防或减少心脏损伤和/或与缺血事件相关的心律失常的发生，所述缺血事件包括血管重建术过程中血管的闭塞。起搏脉冲由心脏起搏器产生并通过一个或多个起搏电极输入，所述起搏电极结合到血管再通术中使用的经皮腔内血管介入（PTVI）装置上。起搏器根据预先确定的心脏保护起搏序列在缺血事件之前，期间和/或之后产生起搏脉冲。

4. 发明申请

WO2004008955A3 APPARATUS AND METHOD FOR QUANTIFICATION OF HEART CHAMBER REGIONAL WALL MOTION ASYNCHRONY 审中-公开
标题翻译：用于定量心室区域壁运动的装置和方法
公开(公告)号：WO2004008955A3
公开(公告)日：2004-04-22
申请号：PCT/US0322428
申请日：2003-07-18
申请人： CARDIAC PACEMAKERS INC , KRAMER ANDREW P , HUVELLE ETIENNE
发明人： KRAMER ANDREW P , HUVELLE ETIENNE
IPC分类号： A61B8/08 , A61N1/365
CPC分类号： A61N1/36514 , A61B8/08 , A61N1/36528
摘要： A phase analysis technique provides for quantification of regional wall motion asynchrony from endocardial border contours generated from two-dimensional echocardiographic ventricular images. The technique produces results including a degree of radial ventricular asynchrony in heart failure patients with ventricular conduction delay to predict a magnitude of contractile function improvement with pacing therapy. Quantification of change in ventricular regional wall motion asynchrony in response to a therapy provides for a means to identify candidates to receive the therapy and quantitatively predict the benefit of the therapy. Quantification of changes in ventricular regional wall motion asynchrony in response to a sequence of therapies provides for a means to determine an approximately optimal therapy for an intended patient response.
摘要翻译：相位分析技术提供从二维超声心动图心室图像产生的心内膜边界轮廓的区域壁运动异步的量化。该技术产生的结果包括心室衰竭患者心室传导延迟的一定程度的径向心室不同步，以预测起搏治疗收缩功能改善的程度。量化心室局部壁运动异常响应治疗的变化提供了一种手段来确定接受治疗的候选者并定量预测治疗的益处。针对一系列疗法的室间区域壁运动不同步的变化的量化提供了确定预期患者反应的近似最佳治疗的手段。

5. 发明申请

WO2008030344A3 IMPLANTABLE APPARATUS FOR ENDOLYMPHATIC DRUG DELIVERY 审中-公开
标题翻译：用于内分泌药物输送的可植入装置
公开(公告)号：WO2008030344A3
公开(公告)日：2008-05-15
申请号：PCT/US2007018631
申请日：2007-08-23
申请人： CARDIAC PACEMAKERS INC , SHUROS ALLAN , KRAMER ANDREW P , BAYNHAM TAMARA COLETTE , CAWTHRA JAMES , BROOKE M JASON
发明人： SHUROS ALLAN , KRAMER ANDREW P , BAYNHAM TAMARA COLETTE , CAWTHRA JAMES , BROOKE M JASON
IPC分类号： A61M25/00 , A61F2/958 , A61M5/142 , A61N1/00
CPC分类号： A61M5/14276 , A61M1/3613 , A61M25/1011 , A61M2025/0057 , A61M2025/0063 , A61M2202/0405 , A61N1/056 , A61N1/36135
摘要： Described herein are a method and apparatus for introducing instrumentation like an implantable drug delivery apparatus (1200) with a balloon catheter (1111) and sensors into the lymphatic system. It can be used for physiological monitoring and/or delivery of therapy. Such instrumentation, for example, may include one or more sensors for measuring physiological variables and/or one or more instruments for delivering therapy that is adapted to be disposed within a lymphatic vessel.
摘要翻译：本文描述了一种用于将诸如具有球囊导管（1111）和传感器的可植入药物输送装置（1200））引入仪器的方法和装置，并将其传送到淋巴系统中。它可用于生理监测和/或治疗的递送。例如，这种仪器可以包括用于测量生理变量的一个或多个传感器和/或用于递送适于布置在淋巴管内的治疗的一个或多个仪器。

6. 发明申请

WO2006122148A3 NEURAL STIMULATION SYSTEM CONTROLLING AUTONOMIC BALANCE 审中-公开
标题翻译：神经刺激系统控制自动平衡
公开(公告)号：WO2006122148A3
公开(公告)日：2007-01-18
申请号：PCT/US2006017971
申请日：2006-05-09
申请人： CARDIAC PACEMAKERS INC , LIBBUS IMAD , KRAMER ANDREW P , SPINELLI JULIO C
发明人： LIBBUS IMAD , KRAMER ANDREW P , SPINELLI JULIO C
IPC分类号： A61N1/362 , A61N1/36 , A61N1/372
CPC分类号： A61N1/36057 , A61N1/36114 , A61N1/36139 , A61N1/3621 , A61N1/3627 , A61N1/36585
摘要： A neural stimulation system senses autonomic activities and applies neural stimulation to sympathetic and parasympathetic nerves to control autonomic balance. The neural stimulation system is capable of delivering neural stimulation pulses for sympathetic excitation, sympathetic inhibition, parasympathetic excitation, and parasympathetic inhibition.
摘要翻译：神经刺激系统感知自主活动，并将神经刺激应用于交感神经和副交感神经以控制自主神经平衡。神经刺激系统能够传递神经刺激脉冲，用于交感神经激发，交感神经抑制，副交感神经激动和副交感神经抑制。

7. 发明申请

WO2008024312A2 INTERMITTENT HIGH-ENERGY CARDIAC STIMULATION FOR THERAPEUTIC EFFECT 审中-公开
标题翻译：间歇性高能量心脏刺激治疗效果
公开(公告)号：WO2008024312A2
公开(公告)日：2008-02-28
申请号：PCT/US2007018416
申请日：2007-08-17
申请人： CARDIAC PACEMAKERS INC , PASTORE JOSEPH M , LIBBUS IMAD , KRAMER ANDREW P , SPINELLI JULIO C
发明人： PASTORE JOSEPH M , LIBBUS IMAD , KRAMER ANDREW P , SPINELLI JULIO C
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3627 , A61N1/3622
摘要： A device and method for delivering high-energy electrical stimulation to the heart in order to improve cardiac function in heart failure patients. The high-energy stimulation mimics the effects of exercise and improves symptoms even in patients who are exercise intolerant. The high-energy stimulation may be delivered on an intermittent basis either as pacing pulses in accordance with a programmed pacing mode and with a higher pacing pulse energy than used for conventional pacing or as low energy shock pulses.
摘要翻译：用于向心脏递送高能电刺激以改善心力衰竭患者的心脏功能的装置和方法。高能量刺激模拟运动的影响，即使在运动不耐受的患者中也能改善症状。高能量刺激可以间歇地作为起搏脉冲递送，或者作为起搏脉冲根据编程的起搏模式和较高起搏脉冲能量而不是用于常规起搏或低能量冲击脉冲。

8. 发明申请

WO2011130488A3 AUTONOMIC MODULATION USING TRANSIENT RESPONSE WITH INTERMITTENT NEURAL STIMULATION 审中-公开
标题翻译：使用瞬时响应与间歇性神经刺激的自动调制
公开(公告)号：WO2011130488A3
公开(公告)日：2012-04-12
申请号：PCT/US2011032450
申请日：2011-04-14
申请人： CARDIAC PACEMAKERS INC , KRAMER ANDREW P , HAMANN JASON J
发明人： KRAMER ANDREW P , HAMANN JASON J
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/36053 , A61N1/36114 , A61N1/36117
摘要： In various method embodiments for operating an implantable neural stimulator to deliver a neural stimulation therapy to an autonomic neural target, the method comprises using the implantable neural stimulator to deliver the neural stimulation therapy to the autonomic neural target, and evaluating an evoked response to the neural stimulation bursts. The neural stimulation therapy includes a plurality of neural stimulation bursts where each neural stimulation burst includes a plurality of neural stimulation pulses and successive neural stimulation bursts are separated by a time without neural stimulation pulses. Evaluating the evoked response includes sensing the evoked response to the neural stimulation bursts where sensing the evoked response includes sensing at least one physiological parameter affected by the neural stimulation bursts, comparing the sensed evoked response against a baseline, and determining if the evoked response substantially returns to the baseline between neural stimulation bursts.
摘要翻译：在用于操作可植入神经刺激器以将神经刺激疗法递送至自主神经靶标的各种方法实施例中，该方法包括使用可植入神经刺激器将神经刺激疗法递送至自主神经靶标，以及评估对神经元的诱发反应刺激爆发。神经刺激治疗包括多个神经刺激脉冲串，其中每个神经刺激脉冲串包括多个神经刺激脉冲，并且连续神经刺激脉冲串在没有神经刺激脉冲的情况下被分离一段时间。评估诱发反应包括感测对神经刺激突发的诱发反应，其中感测诱发反应包括感测受神经刺激突发影响的至少一个生理参数，将感测的诱发反应与基线进行比较，以及确定诱发反应是否基本上返回到神经刺激爆发之间的基线。

9. 发明申请

WO2007146490A2 PHYSICAL CONDITIONING SYSTEM 审中-公开
标题翻译：物理调节系统
公开(公告)号：WO2007146490A2
公开(公告)日：2007-12-21
申请号：PCT/US2007066918
申请日：2007-04-19
申请人： CARDIAC PACEMAKERS INC , LIBBUS IMAD , SPINELLI JULIO C , PASTORE JOSEPH M , KRAMER ANDREW P
发明人： LIBBUS IMAD , SPINELLI JULIO C , PASTORE JOSEPH M , KRAMER ANDREW P
CPC分类号： A61N1/36114 , A61N1/36014 , A61N1/37282 , A61N1/37288 , A61N2001/0585
摘要： Various system embodiments comprise a neural stimulator and a controller. The neural stimulator is adapted to generate a stimulation signal adapted to elicit sympathetic activity at a neural target. The controller is adapted to control the neural stimulator to provide a physical conditioning therapy. The controller is adapted to control the neural stimulator to intermittently elicit sympathetic activity at the neural target. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括神经刺激器和控制器。神经刺激器适于产生适于在神经靶标处引起交感神经活动的刺激信号。控制器适于控制神经刺激器以提供物理调理疗法。该控制器适于控制神经刺激器间歇地在神经靶标上引起交感神经活动。本文提供了其它方面和实施例。

10. 发明申请

WO2006107578A3 SYSTEM TO TREAT AV-CONDUCTED VENTRICULAR TACHYARRHYTHMIA 审中-公开
标题翻译：系统治疗房室传导性房室结折返性心律失常
公开(公告)号：WO2006107578A3
公开(公告)日：2006-11-23
申请号：PCT/US2006010092
申请日：2006-03-21
申请人： CARDIAC PACEMAKERS INC , MOFFITT JULIA , KRAMER ANDREW P , LIBBUS IMAD
发明人： MOFFITT JULIA , KRAMER ANDREW P , LIBBUS IMAD
IPC分类号： A61N1/362 , A61B5/0464
CPC分类号： A61N1/36114 , A61B5/0464 , A61N1/0587 , A61N1/3622 , A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/3962 , A61N2001/0585
摘要： Systems are provided to treat AV-conducted ventricular tachyarrhythmia (AVCVT). According to various embodiments, an AVCVT is sensed, an IVC-LA fat pad is stimulated when the AVCVT is sensed to block AV conduction, and bradycardia support pacing is provided while the IVC-LA fat pad is stimulated.
摘要翻译：系统用于治疗房室传导室性快速性心律失常（AVCVT）。根据各种实施例，感测到AVCVT，当感测到AVCVT时刺激IVC-LA脂肪垫以阻断AV传导，并且在IVC-LA脂肪垫被刺激时提供心动过缓支持起搏。

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