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1. 发明申请

WO2004069333A3 METHOD AND APPARATUS FOR SETTING PACING PARAMETERS 审中-公开
标题翻译：方法和设备的设置参数
公开(公告)号：WO2004069333A3
公开(公告)日：2005-02-10
申请号：PCT/US2004002332
申请日：2004-01-28
申请人： CARDIAC PACEMAKERS INC , DING JIANG , YU YINGHONG , KRAMER ANDREW P , BAUMANN LAWRENCE
发明人： DING JIANG , YU YINGHONG , KRAMER ANDREW P , BAUMANN LAWRENCE
IPC分类号： A61N1/362 , A61N1/368 , A61N1/37
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method and apparatus is disclosed for automatically setting the pacing parameters utilized by an implantable cardiac device in delivering cardiac resynchronization therapy. The selection of the pacing parameters is based at least in part upon measurements of intrinsic cardiac conduction parameters. Among the pacing parameters which may be selected in this way is the atrio-ventricular delay interval used in atrial-tracking and AV sequential pacing modes.
摘要翻译：公开了一种用于自动设置可植入心脏装置在输送心脏再同步治疗中使用的起搏参数的方法和装置。起搏参数的选择至少部分地基于固有心脏传导参数的测量。可以以这种方式选择的起搏参数是在心房跟踪和AV顺序起搏模式中使用的心房延迟间隔。

2. 发明申请

WO2006078519A3 CONTROL OF ELECTRICAL STIMULATION USING HEART RATE VARIABILITY 审中-公开
标题翻译：使用心率变化控制电刺激
公开(公告)号：WO2006078519A3
公开(公告)日：2007-04-19
申请号：PCT/US2006000963
申请日：2006-01-12
申请人： CARDIAC PACEMAKERS INC , PASTORE JOSEPH M , SALO RODNEY W , CARLSON GERRARD M , KRAMER ANDREW P , DING JIANG , YU YINGHONG
发明人： PASTORE JOSEPH M , SALO RODNEY W , CARLSON GERRARD M , KRAMER ANDREW P , DING JIANG , YU YINGHONG
IPC分类号： A61N1/365
CPC分类号： A61N1/36592 , A61B5/02405 , A61B5/4035 , A61N1/36114 , A61N1/368
摘要： A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used to evaluate a plurality of parameter values for selecting an approximately optimal parameter value. In another embodiment, the HRV parameter is used to adjust a maximum tracking rate in an atrial tracking pacing mode. In another embodiment, the HRV parameter is used as a safety check to stop an electrical therapy when it is believed to be potentially harmful to continue the therapy.
摘要翻译：心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。在一个实施例中，HRV参数用于评估用于选择近似最佳参数值的多个参数值。在另一个实施例中，HRV参数用于调整心房跟踪起搏模式中的最大跟踪率。在另一个实施例中，HRV参数用作安全检查以在认为其可能有害以继续治疗时停止电疗法。

3. 发明申请

WO2008063535A3 CARDIAC RESYNCHRONIZATION THERAPY OPTIMIZATION USING CARDIAC ACTIVATION SEQUENCE INFORMATION 审中-公开
标题翻译：使用心脏激活序列信息的心脏再生治疗优化
公开(公告)号：WO2008063535A3
公开(公告)日：2008-07-10
申请号：PCT/US2007023988
申请日：2007-11-15
申请人： CARDIAC PACEMAKERS INC , ARCOT-KRISHNAMURTHY SHANTHA , ZHANG YI , DING JIANG , YU YINGHONG , DONG YANTING
发明人： ARCOT-KRISHNAMURTHY SHANTHA , ZHANG YI , DING JIANG , YU YINGHONG , DONG YANTING
IPC分类号： A61N1/362 , A61B5/04 , A61B5/0452 , A61N1/365
CPC分类号： A61N1/3627 , A61B5/04011 , A61B5/0452 , A61N1/365 , A61N1/36535 , A61N1/36542
摘要： Systems and methods provide for pacing a heart to improve pumping efficiency of the heart, such as by producing a cardiac fusion response for patient's subject to cardiac resynchronization therapy. A pacing parameter, such as an A-V delay, V-V delay, lead/electrode configuration or vector, is adjusted and a cardiac signal vector representative of all or a portion of one or more cardiac activation sequences is monitored during pacing parameter adjustment. A change in a characteristic of the cardiac signal vector is detected in response to an adjusted pacing parameter, the change indicative of a cardiac fusion response. A pacing therapy may be delivered to produce the cardiac fusion response using the adjusted pacing parameter.
摘要翻译：系统和方法提供心脏起搏以改善心脏的泵送效率，例如通过为患者进行心脏再同步治疗产生心脏融合反应。调整起搏参数，例如A-V延迟，V-V延迟，引线/电极配置或载体，并且在起搏参数调整期间监测表示一个或多个心脏激活序列的全部或一部分的心脏信号载体。响应于调整的起搏参数，指示心脏融合反应的变化来检测心脏信号载体的特性变化。可以使用调整的起搏参数来递送起搏治疗以产生心脏融合反应。

4. 发明申请

WO2012087758A3 LEFT VENTRICULAR PACING PROTECTION FOR MULTI-SITE LEFT VENTRICULAR PACING 审中-公开
标题翻译：用于多位置左心室的左心室保护
公开(公告)号：WO2012087758A3
公开(公告)日：2012-12-13
申请号：PCT/US2011065255
申请日：2011-12-15
申请人： CARDIAC PACEMAKERS INC , STAHMANN JEFFREY E , GILKERSON JAMES O , SIEJKO KRZYSZTOF Z , YU YINGHONG
发明人： STAHMANN JEFFREY E , GILKERSON JAMES O , SIEJKO KRZYSZTOF Z , YU YINGHONG
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3684
摘要： In a pacing mode where the left ventricle is paced upon expiration of an escape interval that is reset by a right ventricular sense, there is the risk that the left ventricular pace may be delivered in the so-called vulnerable period that occurs after a depolarization and trigger an arrhythmia. To reduce this risk, a left ventricular protective period (LVPP) may be provided. Methods and devices for implementing an LVPP in the context of multi-site left ventricular pacing are described.
摘要翻译：在起搏模式中，左心室在由右心室感觉复位的逃避间隔期满时起搏，存在左心室速度可能在去极化后发生的所谓脆弱期内传播的风险，引发心律失常。为了降低这种风险，可以提供左心室保护期（LVPP）。描述了在多位点左心室起搏背景下实现LVPP的方法和装置。

5. 发明申请

WO2008005270A8 LOCAL AND NON-LOCAL SENSING FOR CARDIAC PACING 审中-公开
公开(公告)号：WO2008005270A8
公开(公告)日：2008-06-05
申请号：PCT/US2007014968
申请日：2007-06-27
申请人： CARDIAC PACEMAKERS INC
发明人： SATHAYE ALOK S , MCCABE AARON R , YU YINGHONG
IPC分类号： A61N1/368 , A61B5/042 , A61N1/362
CPC分类号： A61B5/0452 , A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3684
摘要： Systems and methods for determining pacing timing intervals based on the temporal relationship between the timing of local and non-local cardiac signal features are described. A device includes a plurality of implantable electrodes electrically coupled to the heart and configured to sense local and non-local cardiac signals. Sense circuitry coupled to first and second electrode pairs senses a local cardiac signal via a first electrode pair and a non-local cardiac signal via a second electrode pair. Detection circuitry is used to detect a feature of the local signal associated with activation of a heart chamber and to detect a feature of the non-local signal associated with activation of the heart chamber. A control processor times delivery of one or more pacing pulses based on a temporal relationship between timing of the local signal feature and timing of the non-local signal feature.

6. 发明申请

WO2015095581A9 SYSTEMS AND METHODS FOR FACILITATING SELECTING OF ONE OR MORE VECTORS IN A MEDICAL DEVICE 审中-公开
标题翻译：用于促进在医疗设备中选择一个或多个向量的系统和方法
公开(公告)号：WO2015095581A9
公开(公告)日：2015-10-08
申请号：PCT/US2014071253
申请日：2014-12-18
申请人： CARDIAC PACEMAKERS INC
发明人： ROCKWEILER HOLLY E , SAHA SUNIPA , HERRMANN KEITH L , YU YINGHONG , KRUEGER JOEL A
IPC分类号： A61N1/372 , A61N1/36 , A61N1/368 , A61N1/37
CPC分类号： A61N1/3686 , A61N1/36185 , A61N1/36521 , A61N1/371 , A61N1/37247
摘要： Some systems and methods may facilitate selection of a vector for delivering electrical stimulation to a patient's heart. One method may include displaying a plurality of vectors on a display screen wherein each vector represents a different combination of three or more electro-stimulation electrodes, determining an electrical impedance for each of the plurality of vectors, displaying on the display screen the electrical impedance for each of the plurality of vectors, receiving a selection of a set of the plurality of vectors, determining, for each of the vectors in the set of vectors, a capture threshold, displaying on the display screen the capture threshold for each of the vectors in the set of vectors, receiving a selection of a vector from the set of vectors for delivery of electrical stimulation to the patient's heart, and programming the electro-stimulation device electrical stimulation to the patient's heart via the selected vector.
摘要翻译：一些系统和方法可以有助于选择用于向患者的心脏递送电刺激的载体。一种方法可以包括在显示屏上显示多个矢量，其中每个矢量表示三个或更多个电刺激电极的不同组合，确定多个矢量中的每一个的电阻抗，在显示屏上显示用于所述多个矢量中的每一个接收对所述多个矢量的集合的选择，针对所述矢量集合中的每个矢量确定捕获阈值，在显示屏幕上显示每个矢量的捕获阈值，该组矢量从用于向患者的心脏递送电刺激的矢量集合中接收矢量的选择，并且经由选择的矢量将电刺激设备电刺激编程到患者的心脏。

7. 发明申请

WO2014099595A2 METHOD AND APPARATUS FOR RIGHT VENTRICULAR RESYNCHRONIZATION 审中-公开
标题翻译：用于右心室再生的方法和装置
公开(公告)号：WO2014099595A2
公开(公告)日：2014-06-26
申请号：PCT/US2013074618
申请日：2013-12-12
申请人： CARDIAC PACEMAKERS INC
发明人： SHUROS ALLAN C , DING JIANG , MASKARA BARUN , YU YINGHONG
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/056 , A61N1/365 , A61N1/36514 , A61N1/3682 , A61N1/3684
摘要： An apparatus comprises a cardiac signal sensing circuit and a first implantable electrode pair. At least one electrode of the first implantable electrode pair is configured for placement at a location in a right branch of a His bundle of the subject. The apparatus can include a therapy circuit and a control circuit. The control circuit can include an AH delay calculation circuit configured to calculate an optimal paced AH delay interval. The pacing stimulation location is distal to a location of RV conduction block in a right branch of the His bundle. The control circuit initiates delivery of an electrical stimulation pulse to the stimulation location in the His bundle according to the calculated paced AH delay interval and in response to an intrinsic depolarization event sensed in an atrium of the subject.
摘要翻译：一种装置包括心脏信号感测电路和第一可植入电极对。第一可植入电极对的至少一个电极被配置用于放置在受试者的His束的右分支中的位置处。该装置可以包括治疗电路和控制电路。控制电路可以包括AH延迟计算电路，配置为计算最佳起搏AH延迟间隔。起搏刺激位置在His束的右侧分支中位于RV传导阻滞位置的远端。控制电路根据计算的起搏AH延迟间隔和响应于在受试者的心房中感测到的内在去极化事件，开始将电刺激脉冲传送到His束中的刺激位置。

8. 发明申请

WO2008005270A3 LOCAL AND NON-LOCAL SENSING FOR CARDIAC PACING 审中-公开
标题翻译：心脏起搏的局部和非局部感测
公开(公告)号：WO2008005270A3
公开(公告)日：2008-04-10
申请号：PCT/US2007014968
申请日：2007-06-27
申请人： CARDIAC PACEMAKERS INC
发明人： SATHAYE ALOK S , MCCABE AARON R , YU YINGHONG
IPC分类号： A61N1/368 , A61B5/042 , A61N1/362
CPC分类号： A61B5/0452 , A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3684
摘要： Systems and methods for determining pacing timing intervals based on the temporal relationship between the timing of local and non-local cardiac signal features are described. A device includes a plurality of implantable electrodes electrically coupled to the heart and configured to sense local and non-local cardiac signals. Sense circuitry coupled to first and second electrode pairs senses a local cardiac signal via a first electrode pair and a non-local cardiac signal via a second electrode pair. Detection circuitry is used to detect a feature of the local signal associated with activation of a heart chamber and to detect a feature of the non-local signal associated with activation of the heart chamber. A control processor times delivery of one or more pacing pulses based on a temporal relationship between timing of the local signal feature and timing of the non-local signal feature.
摘要翻译：描述了用于基于局部和非局部心脏信号特征的定时之间的时间关系来确定起搏定时间隔的系统和方法。一种装置包括多个可植入电极，所述多个可植入电极电耦合至心脏并被配置为感测局部和非局部心脏信号。连接到第一和第二电极对的感测电路经由第一电极对感测局部心脏信号，并经由第二电极对感测非局部心脏信号。检测电路被用于检测与激活心室有关的本地信号的特征并检测与心室激活有关的非局部信号的特征。控制处理器基于本地信号特征的定时与非本地信号特征的定时之间的时间关系来对一个或多个起搏脉冲的输送进行时间定时。

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