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1. 发明申请

WO9611712A3 CELL-SPECIFIC GENE DELIVERY VEHICLES CELL-SPECIFIC GENE DELIVERY VEHICLES 审中-公开
标题翻译：细胞特异性基因输送车辆细胞特异性基因交付车辆
公开(公告)号：WO9611712A3
公开(公告)日：1996-11-14
申请号：PCT/US9514621
申请日：1995-10-11
申请人： CALIFORNIA INST OF TECHN , KAYYEM JON F , MEADE THOMAS J , FRASER SCOTT E
发明人： KAYYEM JON F , MEADE THOMAS J , FRASER SCOTT E
IPC分类号： C12N15/09 , A61K38/00 , A61K38/45 , A61K45/00 , A61K47/48 , A61K48/00 , A61K49/00 , A61K49/08 , A61K51/00 , A61P35/00
CPC分类号： A61K49/146 , A61K47/645 , A61K49/085 , Y10S977/808 , Y10S977/927 , Y10S977/93
摘要： A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous physiological agents, particularly paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a polymeric molecule having a net positive charge complexed with another polymeric molecule having a net negative charge. Cell targeting moieties and physiological agents, including contrast agents and therapeutic agents, are attached to one or both of the polymeric molecules. In one embodiment, the polymeric molecule having a net negative charge is a nucleic acid. Thus, the delivery vehicles can be used in clinical protocols in which nucleic acids for gene therapy and agents for MRI contrast are co-transported to specific cells allowing medical imaging monitoring of nucleic acid delivery.

2. 发明申请

WO0206287A3 MACROCYCLIC MRI CONTRAST AGENTS 审中-公开
标题翻译： MACROCYCLIC MRI对比剂
公开(公告)号：WO0206287A3
公开(公告)日：2002-10-17
申请号：PCT/US0122491
申请日：2001-07-17
申请人： CALIFORNIA INST OF TECHN , HUBIN TIMOTHY J , MEADE THOMAS J
发明人： HUBIN TIMOTHY J , MEADE THOMAS J
IPC分类号： A61K49/10 , C07D487/08 , A61K49/06
CPC分类号： C07D487/08 , A61K49/106
摘要： The invention relates to novel magnetic resonance imaging contrast agents of Formula: (I) wherein A-B is a structure selected from the group consisting of -CR2-CR2-, -CR=CR-, -CR2-CR2-CR2-, CR=CR-CR2- and -CR2-CR=CR; X and X are independently selected from the group consisting of CR2 COO, CR2COOH, CR(CR2COO)2, CR(CR2COOH)2; each R is independently selected from the group consisting of hydrogen, alkyl, aryl, alcohol, amine, amido, nitro, ether, ester, ketone, imino, aldehyde, alkoxy, carbonyl, halogen, sulfur containing moiety, phosphorus containing moiety, targeting moiety, moiety, or, together with an adjacent R group forms an alkyl or aryl group.
摘要翻译：本发明涉及式（I）的新型磁共振成像造影剂，其中AB是选自-CR2-CR2-，-CR = CR-，-CR2-CR2-CR2-，CR = CR -CR2-和-CR2-CR = CR; X 1和X 2独立地选自CR 2 COO，CR 2 COOH，CR（CR 2 COO）2，CR（CR 2 COOH）2; 每个R独立地选自氢，烷基，芳基，醇，胺，酰氨基，硝基，醚，酯，酮，亚氨基，醛，烷氧基，羰基，卤素，含硫部分，含磷部分，靶向部分，部分，或与相邻的R基团一起形成烷基或芳基。

3. 发明申请

WO0206287A9 NOVEL MACROCYCLIC MAGNETIC RESONANCE IMAGING CONTRAST AGENTS 审中-公开
标题翻译：新型MACROCYCLIC磁共振成像对比剂
公开(公告)号：WO0206287A9
公开(公告)日：2002-07-18
申请号：PCT/US0122491
申请日：2001-07-17
申请人： CALIFORNIA INST OF TECHN , HUBIN TIMOTHY J , MEADE THOMAS J
发明人： HUBIN TIMOTHY J , MEADE THOMAS J
IPC分类号： A61K49/10 , C07D487/08 , A61K49/06 , C07D255/00
CPC分类号： C07D487/08 , A61K49/106
摘要： The invention relates to novel magnetic resonance imaging contrast agents.
摘要翻译：本发明涉及新型磁共振成像造影剂。

4. 发明申请

WO0228441A9 MAGNETIC RESONANCE IMAGING AGENTS FOR IN VIVO LABELING AND DETECTION OF AMYLOID DEPOSITS 审中-公开
标题翻译：用于体内标记和检测淀粉样沉积物的磁共振成像剂
公开(公告)号：WO0228441A9
公开(公告)日：2003-02-20
申请号：PCT/US0131415
申请日：2001-10-04
申请人： CALIFORNIA INST OF TECHN
发明人： ALLEN MATTHEW J , JACOBS RUSSELL E , MEADE THOMAS J , FRASER SCOTT
IPC分类号： A61K49/08 , A61K49/10
CPC分类号： A61K49/10 , A61K49/085 , A61K49/122 , A61K49/1833 , B82Y5/00
摘要： In accordance with the objects outlined above, the present invention provides MRI agent compositions comprising a chelator, comprising a paramagnetic metal ion and an amyloid binding moiety (ABM). The chelator may be directly attached to the ABM or indirectly attached via a linker. The linker may be attached to either an internal or terminal position of the ABM. In an additional aspect, the invention provides ABMs that are selected from the group consisting of congo red, (trans, trans)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy))-styrylbenzene (BSB), and chyrsamine G. These ABMs can be conjugated to chelators such as DOTA, DTPA and DOTEP comprising Gd(III). In an additional aspect, the invention provides MRI agents comprising chelators linked together using ABMs or polymers. In a further aspect, the provided pharmaceutical composition comprises an MRI agent of the invention and a pharmaceutically acceptable carrier. In an additional aspect, the present invention provides methods of magnetic resonance imaging of a cell, tissue or patient comprising administering an MRI agent of the invention to a cell, tissue or patient and rendering a magnetic resonance image of the cell, tissue or patient.
摘要翻译：根据上述目的，本发明提供包含螯合剂的MRI剂组合物，其包含顺磁性金属离子和淀粉样蛋白结合部分（ABM）。螯合剂可以直接连接到ABM或通过连接体间接连接。连接器可以连接到ABM的内部或终端位置。在另一方面，本发明提供了选自刚果红，（反式，反式）-1-溴-2,5-双 - （3-羟基羰基-4-羟基）） - 苯乙烯基苯（BSB）的ABM ）和chyrsamine G.这些ABM可以与螯合剂结合，例如包含Gd（III）的DOTA，DTPA和DOTEP。在另一方面，本发明提供包含使用ABM或聚合物连接在一起的螯合剂的MRI试剂。在另一方面，所提供的药物组合物包含本发明的MRI试剂和药学上可接受的载体。在另一方面，本发明提供了细胞，组织或患者的磁共振成像方法，包括将本发明的MRI剂施用于细胞，组织或患者，并呈现细胞，组织或患者的磁共振图像。

5. 发明申请

WO9515971A2 NUCLEIC ACID MEDIATED ELECTRON TRANSFER 审中-公开
标题翻译：核酸介电子转移
公开(公告)号：WO9515971A2
公开(公告)日：1995-06-15
申请号：PCT/US9413893
申请日：1994-12-05
申请人： CALIFORNIA INST OF TECHN
发明人： MEADE THOMAS J , KAYYEM JON F , FRASER SCOTT E
IPC分类号： C12N15/09 , C07H21/00 , C07H23/00 , C12Q1/68 , G01N33/566 , G01N33/50
CPC分类号： C07H23/00 , C07H21/00 , C12Q1/6818 , C12Q1/6825 , C12Q1/6827 , C12Q2563/113 , C12Q2565/101 , C12Q2565/301 , C12Q2565/1015 , C12Q2537/101 , C12Q2563/137
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
摘要翻译：本发明提供了用氧化还原活性部分如过渡金属配合物选择性共价修饰核酸。电子供体和电子受体部分在预定位置与核酸的核糖 - 磷酸骨架共价结合。所得的复合物表示一系列新的衍生物，其是能够以非常快的速率在非常大的距离上传递电子的双分子模板。这些复合物具有独特的结构特征，可以使用全新的生物传感器和光敏探针。

6. 发明申请

WO2006093505A3 COMPOSITIONS AND METHODS FOR ANALYTE DETECTION 审中-公开
标题翻译：用于分析物检测的组合物和方法
公开(公告)号：WO2006093505A3
公开(公告)日：2007-01-04
申请号：PCT/US2005016300
申请日：2005-05-10
申请人： UNIV NORTHWESTERN , ECKERMANN AMANDA L , BARKER KYLIE , MEADE THOMAS J
发明人： ECKERMANN AMANDA L , BARKER KYLIE , MEADE THOMAS J
IPC分类号： G01F25/00
CPC分类号： G01N33/58 , G01N33/532
摘要： The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, ?, of an electron transfer process. In particular, the present invention provides probes of the outer-sphere environment of a redox center and methods of correlating changes in electrochemical properties to characterize the same.
摘要翻译：本发明涉及使用电子转移过程的核重组能量β检测分析物的新方法和组合物。特别地，本发明提供了氧化还原中心的外球环境的探针以及使电化学性质的变化相关的方法，以表征其特性。

7. 发明申请

WO2011017690A2 INTRACELLULAR DELIVERY OF CONTRAST AGENTS WITH FUNCTIONALIZED NANOPARTICLES 审中-公开
标题翻译：具有功能化纳米颗粒的造影剂的细胞内递送
公开(公告)号：WO2011017690A2
公开(公告)日：2011-02-10
申请号：PCT/US2010044844
申请日：2010-08-09
申请人： UNIV NORTHWESTERN , MIRKIN CHAD A , MEADE THOMAS J , SONG YING , XU XIAOYANG
发明人： MIRKIN CHAD A , MEADE THOMAS J , SONG YING , XU XIAOYANG
IPC分类号： A61K49/14 , A61K49/06 , A61K49/10
CPC分类号： A61K49/128 , A61K49/0002 , A61K49/1881
摘要： The present invention is directed to compositions and methods for intracellular delivery of a contrast agent with a functionalized nanoparticle.
摘要翻译：本发明涉及用于将造影剂与功能化纳米粒子细胞内递送的组合物和方法。

8. 发明申请

WO2009036441A3 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：WO2009036441A3
公开(公告)日：2009-06-18
申请号：PCT/US2008076423
申请日：2008-09-15
申请人： UNIV NORTHWESTERN , SCHULTZ SIKMA ELISE A , ASLAM MOHAMMED , DRAVID VINAYAK P , MEADE THOMAS J , ULRICH BRADLEY D
发明人： SCHULTZ SIKMA ELISE A , ASLAM MOHAMMED , DRAVID VINAYAK P , MEADE THOMAS J , ULRICH BRADLEY D
IPC分类号： A61K49/00 , A61B5/055
CPC分类号： A61K49/14 , A61B5/055 , A61B5/416 , A61K49/085 , A61K49/1824 , A61K49/183 , A61K49/186 , B82Y5/00 , Y10S977/773 , Y10S977/811 , Y10S977/838 , Y10S977/93
摘要： The present invention relates generally to multimodal magnetic resonance imaging (MRI) contrast agents. In particular, the present invention provides a MRI contrast agent configured to manipulate both the longitudinal (T1) and transverse (T2) relaxation times of surrounding water proton spins.
摘要翻译：本发明一般涉及多模式磁共振成像（MRI）造影剂。特别地，本发明提供了构造成操纵周围水质子旋转的纵向（T1）和横向（T2）弛豫时间的MRI造影剂。

9. 发明申请

WO2010111257A3 TARGETED SCHIFF BASE COMPLEXES 审中-公开
标题翻译：目标SCHIFF基础复合体
公开(公告)号：WO2010111257A3
公开(公告)日：2011-04-07
申请号：PCT/US2010028299
申请日：2010-03-23
申请人： UNIV NORTHWESTERN , HARNEY ALLISON S , LEE JIYOUN , MEADE THOMAS J , LABONNE CAROLE B
发明人： HARNEY ALLISON S , LEE JIYOUN , MEADE THOMAS J , LABONNE CAROLE B
IPC分类号： A61K31/7135
CPC分类号： C07K19/00 , A61K31/7135 , C07H23/00
摘要： The present invention provides targeted Schiff base complexes. In particular the present invention provides biopolymer targeted transition metal complexes configured to inhibit the activity of targeted proteins, methods of synthesis thereof, and pharmaceutical compositions and uses thereof.
摘要翻译：本发明提供目标希夫碱配合物。特别地，本发明提供了配置成抑制靶向蛋白质活性的生物聚合物靶向过渡金属络合物，其合成方法及其药物组合物及其用途。

10. 发明申请

WO2005115105A2 SELF-IMMOLATIVE MAGNETIC RESONANCE IMAGING CONTRAST AGENTS SENSITIVE TO BETA-GLUCURONIDASE 审中-公开
标题翻译：自敏性磁共振成像对比剂对β-葡萄糖苷酸酶敏感
公开(公告)号：WO2005115105A2
公开(公告)日：2005-12-08
申请号：PCT/US2005016301
申请日：2005-05-10
申请人： UNIV NORTHWESTERN , DUIMSTRA JOSEPH A , MEADE THOMAS J
发明人： DUIMSTRA JOSEPH A , MEADE THOMAS J
IPC分类号： A61K47/48 , A61K49/10
CPC分类号： A61K49/085 , A61K47/555 , A61K49/10
摘要： The present invention relates to magnetic resonance imaging (MRI) contrast agent. In particular, the present invention provides MRI contrast agents that are sensitive to the enzyme beta-glucoronidase. The MRI contrast agents provide compositions and methods for non-invasive diagnostic imaging of tissues, including necrotic tumors.
摘要翻译：本发明涉及磁共振成像（MRI）造影剂。特别地，本发明提供对β-葡萄糖醛酸酶敏感的MRI造影剂。 MRI造影剂提供用于组织非侵入性诊断成像（包括坏死性肿瘤）的组合物和方法。

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