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1. 发明申请

WO2013001532A1 IMPLANTABLE OPTICAL GLUCOSE SENSING 审中-公开
标题翻译：可植入光学葡萄糖感测
公开(公告)号：WO2013001532A1
公开(公告)日：2013-01-03
申请号：PCT/IL2012/000268
申请日：2012-06-28
申请人： GLUSENSE, LTD. , GIL, Tamir , GROSS, Yossi , GRINBERG, Orly , WEISMAN, Itamar , HYMAN, Tehila , HYMAN, Boaz
发明人： GIL, Tamir , GROSS, Yossi , GRINBERG, Orly , WEISMAN, Itamar , HYMAN, Tehila , HYMAN, Boaz
IPC分类号： C12Q1/54
CPC分类号： A61B5/1459 , A61B5/0071 , A61B5/14532
摘要： Apparatus is provided for detecting an analyte, configured to be implanted in a body of a subject. The apparatus includes an optical fiber (10) having a distal portion and also a membrane (32) permeable to the analyte. The membrane (32) is coupled to the distal portion of the fiber (10) and surrounding a sampling region (26) at least in part, by being fitted over the distal portion of the fiber (10). Other embodiments are also described.
摘要翻译：提供了用于检测分析物的装置，其被配置为植入受试者的身体。该装置包括具有远端部分的光纤（10）以及可分析物可渗透的膜（32）。膜（32）通过装配在光纤（10）的远端部分上而至少部分地耦合到光纤（10）的远端部分并且围绕采样区域（26）。还描述了其它实施例。

2. 发明申请

WO2007110867A2 IMPLANTABLE SENSOR 审中-公开
标题翻译：可植入传感器
公开(公告)号：WO2007110867A2
公开(公告)日：2007-10-04
申请号：PCT/IL2007/000399
申请日：2007-03-28
申请人： GLUSENSE LTD. , GROSS, Yossi , HYMAN, Tehila
发明人： GROSS, Yossi , HYMAN, Tehila
IPC分类号： A61K49/00
CPC分类号： A61B5/14532 , A61B5/14556 , A61B5/1459 , C07K14/43595 , C07K2319/60
摘要： Apparatus is provided for detecting a concentration of an analyte in a subject. The apparatus includes a housing (20) adapted to be implanted in the subject. The housing (20) comprising an optical detector (30) adapted to detect a level of fluorescence resonance energy transfer (FRET). The apparatus also comprises live cells (26) genetically engineered to produce, in a patient's body, a sensor protein comprising a fluorescent protein donor, a fluorescent protein acceptor, and a binding protein for the analyte. Other embodiments are also described. 2
摘要翻译：提供了用于检测受试者中分析物浓度的装置。该装置包括适于植入受试者的壳体（20）。壳体（20）包括适于检测荧光共振能量转移（FRET）的水平的光学检测器（30）。该装置还包括基因工程改造以在患者体内产生包含荧光蛋白供体，荧光蛋白受体和用于分析物的结合蛋白的传感器蛋白的活细胞（26）。还描述了其它实施例。 2

3. 发明申请

WO2016059635A1 ANALYTE-SENSING DEVICE 审中-公开
标题翻译：分析传感装置
公开(公告)号：WO2016059635A1
公开(公告)日：2016-04-21
申请号：PCT/IL2015/051022
申请日：2015-10-13
申请人： GLUSENSE LTD.
发明人： BRILL, Boaz
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1459 , A61B5/1455 , G01N21/64
CPC分类号： A61B5/14556 , A61B5/0071 , A61B5/14532 , A61B5/1459 , G01N21/6428 , G01N21/6456 , G01N2201/021
摘要： An implantable unit (30) includes fluorescent sensor molecules (40), each of which comprises a binding site for an analyte, and at least one fluorescent moiety configured to emit fluorescent light; and an implantable-unit light source (42) configured to generate light having an illumination peak wavelength appropriate for excitation of the fluorescent moiety. An external system (26) includes an external reading unit (32), which comprises a light sensor (44), which is configured to sense fluorescent light emitted from the fluorescent moiety having an emission peak wavelength, wherein the emission peak wavelength is between 100 and 500 nm greater than the illumination peak wavelength; and one or more processors (60), which are configured to: drive the implantable-unit light source (42) to generate the light; receive, from the light sensor (44), at least one measurement of the fluorescent light emitted from the fluorescent moiety; and calculate the concentration of the analyte in a subject based on the at least one measurement.
摘要翻译：可植入单元（30）包括荧光传感器分子（40），每个荧光传感器分子包括分析物的结合位点和被配置为发射荧光的至少一个荧光部分; 以及被配置为产生具有适合于激发荧光部分的照明峰值波长的光的可植入单元光源（42）。外部系统（26）包括外部读取单元（32），其包括光传感器（44），其被配置为感测从具有发射峰值波长的荧光部分发射的荧光，其中发射峰值波长在100 并且比照明峰值波长大500nm; 以及一个或多个处理器（60），其被配置为：驱动所述可植入单元光源（42）以产生所述光; 从所述光传感器（44）接收从所述荧光部分发射的荧光的至少一个测量值; 并且基于所述至少一个测量来计算受试者中的分析物的浓度。

4. 发明申请

WO2007110867A8 IMPLANTABLE SENSOR 审中-公开
标题翻译：可植入传感器
公开(公告)号：WO2007110867A8
公开(公告)日：2009-07-23
申请号：PCT/IL2007000399
申请日：2007-03-28
申请人： GLUSENSE LTD , GROSS YOSSI , HYMAN TEHILA
发明人： GROSS YOSSI , HYMAN TEHILA
IPC分类号： A61K49/00 , A01N1/00 , A01N63/00 , A61B5/00 , A61F13/00 , C12N5/00
CPC分类号： A61B5/14532 , A61B5/14556 , A61B5/1459 , C07K14/43595 , C07K2319/60
摘要： Apparatus is provided for detecting a concentration of an analyte in a subject. The apparatus includes a housing (20) adapted to be implanted in the subject. The housing (20) comprising an optical detector (30) adapted to detect a level of fluorescence resonance energy transfer (FRET). The apparatus also comprises live cells (26) genetically engineered to produce, in a patient's body, a sensor protein comprising a fluorescent protein donor, a fluorescent protein acceptor, and a binding protein for the analyte. Other embodiments are also described. 2
摘要翻译：提供了用于检测受试者中分析物浓度的装置。该装置包括适于植入受试者的壳体（20）。壳体（20）包括适于检测荧光共振能量转移（FRET）的水平的光学检测器（30）。该装置还包括基因工程改造以在患者体内产生包含荧光蛋白供体，荧光蛋白受体和用于分析物的结合蛋白的传感器蛋白的活细胞（26）。还描述了其它实施例。 2

5. 发明申请

WO2006006166A3 IMPLANTABLE POWER SOURCES AND SENSORS 审中-公开
公开(公告)号：WO2006006166A3
公开(公告)日：2006-01-19
申请号：PCT/IL2005/000743
申请日：2005-07-13
申请人： GLUSENSE, LTD. , GROSS, Yossi , GIORINI-SILFEN, Shirley , WILLIGER, Ben-Tsion , HYMAN, Tehila , NEUFELD, Tova
发明人： GROSS, Yossi , GIORINI-SILFEN, Shirley , WILLIGER, Ben-Tsion , HYMAN, Tehila , NEUFELD, Tova
IPC分类号： A61K38/00 , G01N21/76 , C07K14/00
摘要： A protein is provided, including a glucose binding site, cyan fluorescent protein (CFP), and yellow fluorescent protein (YFP). The protein is configured such that binding of glucose to the glucose binding site causes a reduction in a distance between the CFP and the YFP. Substance monitoring apparatus (210) is also provided, including a semi-permeable barrier (212), adapted to be implanted in a body of a subject and to allow passage therethrough of a substance, while inhibiting passage therethrough of immune cells; and microorganisms (214), disposed within the semi-permeable barrier (212) so as to produce a measurable response to a level of the substance. A sensor (220) is adapted to measure the measurable response and not to measure a response of any mammalian cells that may be disposed within the semi-permeable barrier (212).

6. 发明申请

WO2017183030A1 FRET-BASED GLUCOSE-DETECTION MOLECULES 审中-公开
标题翻译：基于FRET的葡萄糖检测分子
公开(公告)号：WO2017183030A1
公开(公告)日：2017-10-26
申请号：PCT/IL2017/050456
申请日：2017-04-19
申请人： GLUSENSE LTD.
发明人： BIRON-SOREK, Zohar , BARKAI, Uriel
IPC分类号： C12Q1/68 , G01N33/542
摘要： Proteins (20) having glucose-binding sites (28) that bind to glucose (30) are described.
摘要翻译：描述了具有与葡萄糖（30）结合的葡萄糖结合位点（28）的蛋白质（20）。

7. 发明申请

WO2015128826A1 CELL-PROTECTED IMPLANT 审中-公开
标题翻译：细胞保护植入物
公开(公告)号：WO2015128826A1
公开(公告)日：2015-09-03
申请号：PCT/IB2015/051427
申请日：2015-02-26
申请人： GLUSENSE LTD.
发明人： BARKAI, Uriel , WEISMAN, Itamar , ROMANO, Jacob , BRILL, Boaz
IPC分类号： A61L27/38 , A61B5/00 , A61N1/05 , A61L31/00 , A61B5/145
CPC分类号： A61L27/3886 , A61B5/14532 , A61B5/1459 , A61B5/4839 , A61L31/005 , A61N1/205 , A61N1/36042
摘要： Apparatus is provided, comprising (a) a tubular structure (912) comprising a circumferential wall (912) that (i) defines a lumen, and (ii) has a molecular weight cut-off of 10-100 kDa; (b) a hydrogel (920, 926), disposed within the lumen; (c) a plurality of producer cells (36), suspended within the hydrogel, the producer cells containing exogenous genetic material that encodes an extracellular molecule; and (d) a plurality of mesenchymal stem cells (26), suspended within the hydrogel. Other embodiments are also described.
摘要翻译：提供了一种装置，其包括（a）包括圆周壁（912）的管状结构（912），其中（i）限定内腔，和（ii）具有10-100kDa的分子量截止值; （b）设置在内腔内的水凝胶（920,926）; （c）悬浮在水凝胶内的多个生产细胞（36），所述生产细胞含有编码细胞外分子的外源遗传物质; 和（d）悬浮在水凝胶内的多个间充质干细胞（26）。还描述了其它实施例。

8. 发明申请

WO2014102743A1 APPARATUS FOR FACILITATING CELL GROWTH IN AN IMPLANTABLE SENSOR 审中-公开
标题翻译：用于促进可植入传感器中的细胞生长的装置
公开(公告)号：WO2014102743A1
公开(公告)日：2014-07-03
申请号：PCT/IB2013/061368
申请日：2013-12-27
申请人： GLUSENSE, LTD.
发明人： BRILL, Boaz , WEISMAN, Itamar , GLADNIKOFF, Micha , ROMANO, Jacob , GIL, Tamir
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1459 , G01N33/543
CPC分类号： A61K49/0045 , A61B5/0071 , A61B5/14532 , A61B5/1459 , A61B2562/0233 , A61B2562/162 , C12N5/0068 , G01N33/54373 , G01N2500/10
摘要： Apparatus is provided for detecting a concentration of an analyte in a subject, the apparatus configured to be implanted in a body of the subject and comprising an optical waveguide (48) having a proximal end and a distal end, and a sensing unit (62) disposed at the distal end of the optical waveguide (48) and configured to detect the analyte. The sensing unit (62) comprises at least a first chamber (55, 57); at least a second chamber (55, 57) disposed around the first chamber (55, 57) at least at a proximal end portion of the first chamber (55, 57); and live cells that are genetically engineered to produce, in a body of the subject, a sensor protein having a binding site for the analyte, the live cells being disposed within at least one chamber selected from the group consisting of: the first chamber (55, 57) and the second chamber (55, 57). Other applications are also described.
摘要翻译：提供了用于检测被检体中的分析物的浓度的装置，所述装置被配置为植入到受试者的身体中并且包括具有近端和远端的光波导（48）和感测单元（62）设置在光波导（48）的远端并被配置为检测分析物。感测单元（62）至少包括第一腔室（55,57）; 至少第二腔室（55,57），其至少在所述第一腔室（55,57）的近端部分周围设置在所述第一腔室（55,57）周围; 和活细胞，所述活细胞在受试者的身体中产生具有分析物结合位点的传感器蛋白质，所述活细胞设置在至少一个室内，所述至少一个室选自：所述第一室（55 ，57）和第二腔室（55,57）。还描述了其它应用。

9. 发明申请

WO2010073249A1 IMPLANTABLE OPTICAL GLUCOSE SENSING 审中-公开
标题翻译：可植入光学葡萄糖感测
公开(公告)号：WO2010073249A1
公开(公告)日：2010-07-01
申请号：PCT/IL2009/001214
申请日：2009-12-24
申请人： GLUSENSE, LTD. , GROSS, Yossi , HYMAN, Tehila , GIL, Tamir
发明人： GROSS, Yossi , HYMAN, Tehila , GIL, Tamir
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/14532 , A61B5/14556 , A61B5/14558 , A61B5/686 , A61B5/6862
摘要： ABSTRACT Apparatus is provided, including a support (21) configured to be implanted within a body of a subject and a sampling region (30, 1430) coupled to the support (21). The apparatus is configured to passively allow passage through the sampling region (30, 1430) of at least a portion of fluid from the subject. The apparatus also includes an optical measuring device in optical communication with the sampling region (30, 1430). The optical measuring device comprises at least one light source (40) configured to transmit light through at least a portion of the fluid, and at least one sensor (42) configured to measure a parameter of the fluid by detecting light passing through the fluid. Other applications are also described.
摘要翻译：摘要提供了一种设备，其包括构造成植入受试者的身体内的支撑件（21）和联接到支撑件（21）的取样区域（30，1430）。该装置被配置为被动地允许通过来自受试者的至少一部分流体的取样区域（30,1430）。该装置还包括与采样区域（30,1430）光学通信的光学测量装置。所述光学测量装置包括被配置为透过至少一部分流体的光的至少一个光源（40）和被配置成通过检测穿过流体的光来测量流体参数的至少一个传感器（42）。还描述了其它应用。

10. 发明申请

WO2007110867A3 IMPLANTABLE SENSOR 审中-公开
标题翻译：可植入传感器
公开(公告)号：WO2007110867A3
公开(公告)日：2008-01-24
申请号：PCT/IL2007000399
申请日：2007-03-28
申请人： GLUSENSE LTD , GROSS YOSSI , HYMAN TEHILA
发明人： GROSS YOSSI , HYMAN TEHILA
IPC分类号： A61K49/00 , A01N1/00 , A01N63/00 , A61B5/00 , A61F13/00 , C12N5/00
CPC分类号： A61B5/14532 , A61B5/14556 , A61B5/1459 , C07K14/43595 , C07K2319/60
摘要： Apparatus is provided for detecting a concentration of an analyte in a subject. The apparatus includes a housing (20) adapted to be implanted in the subject. The housing (20) comprising an optical detector (30) adapted to detect a level of fluorescence resonance energy transfer (FRET). The apparatus also comprises live cells (26) genetically engineered to produce, in a patient's body, a sensor protein comprising a fluorescent protein donor, a fluorescent protein acceptor, and a binding protein for the analyte. Other embodiments are also described. 2
摘要翻译：提供了用于检测受试者中分析物浓度的装置。该装置包括适于植入受试者的壳体（20）。壳体（20）包括适于检测荧光共振能量转移（FRET）的水平的光学检测器（30）。该装置还包括基因工程改造以在患者体内产生包含荧光蛋白供体，荧光蛋白受体和用于分析物的结合蛋白的传感器蛋白的活细胞（26）。还描述了其它实施例。 2

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