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1. 发明申请

WO2006089115A1 MEDICAL DEVICES 审中-公开
标题翻译：医疗设备
公开(公告)号：WO2006089115A1
公开(公告)日：2006-08-24
申请号：PCT/US2006/005641
申请日：2006-02-16
申请人： BOSTON SCIENTIFIC SCIMED, INC. , KLISCH, Leo, M. , WEBER, Jan , HOLMAN, Thomas, J. , SCHEWE, Scott, R. , ALI, Afsar , NODDIN, Richard, A. , SHIPPY, James Lee, III , JAGGER, Karl , SEPPALA, Jan
发明人： KLISCH, Leo, M. , WEBER, Jan , HOLMAN, Thomas, J. , SCHEWE, Scott, R. , ALI, Afsar , NODDIN, Richard, A. , SHIPPY, James Lee, III , JAGGER, Karl , SEPPALA, Jan
IPC分类号： A61M25/00
CPC分类号： A61B17/320725 , A61B2017/22061 , A61M25/10 , A61M25/1029 , A61M25/1038 , A61M2025/1031 , A61M2025/1075 , A61M2025/1086 , A61M2025/1088
摘要： Medical devices, for example, those that have balloons, and methods of making the devices are described. In some embodiments, a method includes providing a medical balloon (100) having a first cone portion and a body portion (102), and removing material from an outer surface the body portion of the balloon such that the balloon includes a first region and a second region, the first region (108) being recessed relative to the second region (109).
摘要翻译：描述了医疗设备，例如具有气球的设备，以及制造设备的方法。在一些实施例中，一种方法包括提供具有第一锥形部分和主体部分（102）的医疗气囊（100），以及从气球的主体部分的外表面移除材料，使得气囊包括第一区域和第二区域，第一区域（108）相对于第二区域（109）凹进。

2. 发明申请

WO2008144418A2 MEDICAL DEVICES HAVING COATING WITH IMPROVED ADHESION 审中-公开
标题翻译：具有改善粘合剂的涂层的医疗装置
公开(公告)号：WO2008144418A2
公开(公告)日：2008-11-27
申请号：PCT/US2008/063746
申请日：2008-05-15
申请人： BOSTON SCIENTIFIC SCIMED, INC. , SEPPALA, Jan , EDELMAN, Peter, G. , KANGAS, Steven
发明人： SEPPALA, Jan , EDELMAN, Peter, G. , KANGAS, Steven
IPC分类号： A61L31/02 , A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/00 , A61N1/375
摘要： According to an aspect of the present invention, a medical device is provided which comprises a metallic substrate and polymeric region disposed over and in contact with the metallic substrate. The polymeric region comprises (a) a block copolymer that comprises (i) a hard polymer block that comprises a high Tg monomer and (ii) a soft polymer block that comprises a low Tg monomer, (b) an adhesion promoting copolymer that comprises (i) a first monomer that covalently or non-covalently bonds with the metallic substrate and (ii) a second monomer that is compatible with the low Tg monomer and/or the high Tg monomer and (c) a therapeutic agent. The polymeric region may further comprise an optional polymer that is used to tailor the release rate of the therapeutic agent.
摘要翻译：根据本发明的一个方面，提供一种医疗装置，其包括金属基底和设置在金属基底上并与金属基底接触的聚合物区域。聚合物区域包含（a）嵌段共聚物，其包含（i）包含高Tg单体的硬聚合物嵌段和（ii）包含低Tg单体的软聚合物嵌段，（b）粘合促进共聚物，其包含（ i）与金属基底共价或非共价键合的第一单体和（ii）与低Tg单体和/或高Tg单体相容的第二单体和（c）治疗剂。聚合物区域还可以包含任选的聚合物，其用于定制治疗剂的释放速率。

3. 发明申请

WO2008106121A2 MEDICAL DEVICES HAVING POLYMERIC REGIONS BASED ON STYRENE-ISOBUTYLENE COPOLYMERS 审中-公开
标题翻译：基于苯乙烯 - 异丁烯共聚物的聚合物区域的医疗器械
公开(公告)号：WO2008106121A2
公开(公告)日：2008-09-04
申请号：PCT/US2008/002504
申请日：2008-02-26
申请人： BOSTON SCIENTIFIC SCIMED, INC. , LINDQUIST, Jeffrey, S. , STRICKLER, Frederick, H. , BODEN, Mark , SEPPALA, Jan , MILLER, Paul, J.
发明人： LINDQUIST, Jeffrey, S. , STRICKLER, Frederick, H. , BODEN, Mark , SEPPALA, Jan , MILLER, Paul, J.
IPC分类号： A61L31/04 , A61L29/04 , A61L27/16 , A61L27/34 , A61L31/10 , A61L29/08
CPC分类号： A61L31/048 , A61L27/16 , A61L27/34 , A61L29/041 , A61L29/085 , A61L31/10 , C08L53/02
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions. These polymeric regions, in turn, contain one or more polymers, at least one of which is a copolymer that includes a styrene monomer and an isobutylene monomer. Moreover, the styrene monomer content of the copolymer typically ranges from 25 to 50 mol %.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个聚合物区域。这些聚合物区域又包含一种或多种聚合物，其中至少一种是包括苯乙烯单体和异丁烯单体的共聚物。此外，共聚物的苯乙烯单体含量通常为25〜50摩尔％。

4. 发明申请

WO2019217766A1 LUBRICIOUS COATING COMPOSITIONS 审中-公开
公开(公告)号：WO2019217766A1
公开(公告)日：2019-11-14
申请号：PCT/US2019/031637
申请日：2019-05-09
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： BENNIS, Kendahl , SEPPALA, Jan , SCHNEIDER, Jeffrey
IPC分类号： A61L29/08 , A61L29/14 , A61L31/10 , A61L31/14 , C08L33/00 , C08L39/08
摘要： In one aspect, the present disclosure pertains to lubricous coating compositions that comprise (a) a higher molecular weight polyvinylpyrrolidone, (b) a lower molecular weight polyvinylpyrrolidone, (c) a copolymer of sodium acrylate and acrylamide or a copolymer of acrylic acid and acrylamide, and (d) a polyfunctional unsaturated crosslinking agent. In some embodiments, such lubricous coating compositions are present in crosslinked form on the surface of a medical article. In some embodiments, the lubricous coating compositions further comprise a solvent, in which case such compositions may be, for example, applied to a substrate in the form of a layer and subsequently crosslinked, thereby forming a lubricious coating on the substrate.

5. 发明申请

WO2021163182A1 IMAGING MEDICAL DEVICE SYSTEMS WITH A BUBBLE-REDUCING MEMBER 审中-公开
公开(公告)号：WO2021163182A1
公开(公告)日：2021-08-19
申请号：PCT/US2021/017444
申请日：2021-02-10
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： PLUNGER, Bryan Joseph , IMURA, Haruka , FLEURY, Sean P. , FULLER, Jeffrey Steven , ORTIZ SERRANO, Monica , SEPPALA, Jan , HAMMERSTROM, Jeffrey Adam , SZLAG, Victoria
IPC分类号： A61B8/12 , A61B8/00
摘要： Imaging medical device systems and methods for making and using imaging medical device systems are disclosed. An example imaging medical device system may include an elongate shaft having a distal end region. An imaging assembly may be disposed within the elongate shaft. The imaging assembly may include a drive cable, a housing coupled to the drive cable, and a transducer coupled to the housing. A bubble-reducing member may be disposed adjacent to the drive cable.

6. 发明申请

WO2018085624A1 CONTROLLED EXTENSION STENT 审中-公开
标题翻译：受控扩展支架
公开(公告)号：WO2018085624A1
公开(公告)日：2018-05-11
申请号：PCT/US2017/059868
申请日：2017-11-03
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： DEGRAAF, Kimberly , HARRAH, Timothy P. , BODEN, Mark W. , SEPPALA, Jan
IPC分类号： A61M27/00 , A61F2/88
摘要： The present disclosure relates generally to controlled extension medical stents, and more particularly to controlled extension devices positioned in the body to stent the ureter and facilitate drainage from the kidney to the bladder. The stent 302 being formed of a plurality of filaments 302 wound in groups of coils defining a lumen 306 having a non-extended state in which substantial contact between adjacent groups is prensent and a extended state in which the adjacent groups are separated.
摘要翻译：本公开一般涉及受控伸展医疗支架，并且更具体地涉及定位在体内以控制输尿管并且有利于从肾脏排泄到膀胱的受控伸展装置。支架302由多个长丝302形成，所述多个长丝302以限定腔306的线圈组形成，所述腔306具有其中相邻组之间实质接触的非伸展状态和其中相邻组分离的伸展状态。

7. 发明申请

WO2015009625A1 LUBRICIOUS COATING COMPOSITIONS 审中-公开
标题翻译：润滑涂料组合物
公开(公告)号：WO2015009625A1
公开(公告)日：2015-01-22
申请号：PCT/US2014/046534
申请日：2014-07-14
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： ZENG, Hongxia , SEPPALA, Jan , CHEN, Yen-Lane , GOEL, Raghav
IPC分类号： A61L27/34 , A61L29/08 , A61L31/10 , A61L27/50 , A61L29/14 , A61L31/14
CPC分类号： C10M107/42 , A61L27/34 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/14 , A61L2400/10 , C08L39/06
摘要： In one aspect, the present disclosure pertains to lubricous coating compositions that comprise (a) a higher molecular weight polyvinylpyrrolidone, (b) a lower molecular weight polyvinylpyrrolidone, and (c) a polyfunctional unsaturated crosslinking agent. In some embodiments, such lubricous coating compositions are present in crosslinked form on the surface of a medical article. In some embodiments, the lubricous coating compositions further comprise a solvent, in which case such compositions may be, for example, applied to a substrate in the form of a layer and subsequently crosslinked, thereby forming a lubricious coating on the substrate. In another aspect, the present disclosure is directed to methods for forming various medical articles.
摘要翻译：一方面，本公开内容涉及包含（a）较高分子量聚乙烯吡咯烷酮，（b）较低分子量聚乙烯吡咯烷酮和（c）多官能不饱和交联剂的润滑涂料组合物。在一些实施方案中，这种润滑涂料组合物以交联形式存在于医疗制品的表面上。在一些实施方案中，润滑涂料组合物还包含溶剂，在这种情况下，这种组合物可以例如以层的形式施用于基底并随后交联，从而在基底上形成润滑涂层。在另一方面，本公开涉及用于形成各种医疗制品的方法。

8. 发明申请

WO2013078139A1 FIBROUS MATRIX COATING MATERIALS 审中-公开
标题翻译：纤维基质涂料
公开(公告)号：WO2013078139A1
公开(公告)日：2013-05-30
申请号：PCT/US2012/065896
申请日：2012-11-19
申请人： CARDIAC PACEMAKERS, INC. , POLKINGHORNE, Jeannette C. , ARNHOLT, Devon N. , ROHL, James P. , SCHMIDT, Brian L. , SEPPALA, Jan , TADSEN, Richard L. , WILLOUGHBY, Patrick , ZHANG, Steve , DESAI, Shrojalkumar , DELANEY, JR., Joseph T. , WULFMAN, David R.
发明人： POLKINGHORNE, Jeannette C. , ARNHOLT, Devon N. , ROHL, James P. , SCHMIDT, Brian L. , SEPPALA, Jan , TADSEN, Richard L. , WILLOUGHBY, Patrick , ZHANG, Steve , DESAI, Shrojalkumar , DELANEY, JR., Joseph T. , WULFMAN, David R.
IPC分类号： A61N1/05 , A61L29/08
CPC分类号： A61N1/04 , A61L29/085 , A61L29/14 , A61L2400/12 , A61N1/05 , C08L75/04
摘要： A medical electrical lead may include an insulative lead body, a conductor disposed within the insulative lead body, an electrode disposed on the insulative lead body and in electrical contact with the conductor and a fibrous matrix disposed at least partially over the electrode. The fibrous matrix may be formed from a polyisobutylene urethane, urea or urethane/urea copolymer.
摘要翻译：医疗电引线可以包括绝缘引线体，布置在绝缘引线体内的导体，设置在绝缘引线体上并与导体电接触的电极和至少部分地布置在电极上的纤维基质。纤维基质可以由聚异丁烯氨基甲酸酯，脲或氨基甲酸酯/脲共聚物形成。

9. 发明申请

WO2005067996A1 METHOD AND SYSTEM FOR COATING TUBULAR MEDICAL DEVICES 审中-公开
标题翻译：用于涂敷管状医疗装置的方法和系统
公开(公告)号：WO2005067996A1
公开(公告)日：2005-07-28
申请号：PCT/US2005/000076
申请日：2005-01-05
申请人： SCIMED LIFE SYSTEMS, INC. , SEPPALA, Jan , SEWELL, Jeffrey
发明人： SEPPALA, Jan , SEWELL, Jeffrey
IPC分类号： A61L31/10
CPC分类号： A61L31/10 , A61F2/86 , B05C11/1039
摘要： A system and method for application of therapeutic and protective coatings to multiple tubular medical devices in a high volume production process. One or more tubular medical devices, such as stents, are placed on a coating-absorbent core, and coating is applied to the device(s), for example, as when the device-carrying core is passed through an extrusion coating machine to apply the coating in a uniform manner. Once coated, the medical device(s) may be quickly and efficiently removed from the core by causing the core diameter to decrease, such as by applying elongating tension to the core to cause the core diameter to radially contract, thereby allowing the coated device(s) to be simultaneously freed from the core. Improved coating uniformity, increased coated device removal ease and minimized bridging of openings in the tubular medical device may be obtained with a core that absorbs excess coating.
摘要翻译：一种用于在大量生产过程中将治疗和保护性涂层应用于多个管状医疗装置的系统和方法。一个或多个管状医疗装置（例如支架）被放置在涂层吸收芯上，并且涂层施加到装置上，例如当装置的芯通过挤压涂布机以施加时涂层均匀。一旦被涂覆，医疗设备可以通过使芯直径减小而快速有效地从芯中去除，例如通过对纤芯施加伸长张力以使芯部直径径向收缩，从而允许涂覆的装置（ s）同时摆脱核心。通过吸收多余涂层的芯可以获得改进的涂层均匀性，增加的涂覆装置去除容易性并且使管状医疗装置中的开口的最小化桥接。

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